Модифицированные ДНК-дуплексы с включениями тимидингликоля.
Физико-химические свойства и взаимодействие с ДНК-узнающими белками
Диссертация
Анализ взаимодействия ДНК-узнающих белков разных классов: фосфодиэстераз, эндонуклеаз рестрикции, ДНК-метилтрансфераз, фактора транскрипции NF-кВ, репликативных ДНК-полимераз Р и X, с олигонуклеотидными дуплексами, содержащими в заданном положении участка узнавания/связывания остатки тимидингликоляизучение влияния потери ароматичности гетероциклическим основанием на функционирование указанных… Читать ещё >
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- Автор выражает благодарность своим научным руководителям Т. С. Орецкой и Е. А. Кубаревой за руководство и помощь в освоении методов органической химии и работе с ферментами.
- Автор также благодарит членов своей семьи, родственников и друзей за помощь и поддержку.