Влияние заместительной гормональной терапии на эндотелиальную и эректильную функцию у больных с эректильной дисфункцией и гипогонадизмом
Диссертация
Диссертация изложена на 209 страницах, состоит из введения, обзора литературы (глава 1), общей характеристики больных, методов диагностики и лечения (глава 2), 2-х глав собственных исследований, заключения, выводов, практических рекомендаций, списка литературы (25 отечественных и 320 зарубежный источник) и приложения. Работа содержит 63 таблицы и 3 рисунка. После восстановления гормональных… Читать ещё >
Список литературы
- Аголецкая A.M., Вартапетов Б. А. К вопросу о применении тестостерон-пропионата при стенокардии // Проблемы эндокринологии и гормонотерапии.- 1956. № 2.- С. 109.
- Аляев Ю.Г., Григорян В. А., Чалый М. Е., Пронин B.C., Смыкова О. В. Возрастной андрогенный дефицит и современные методы его медикаментозной коррекции // Врачебное сословие.- 2006.- № 5−6. С. 5053.
- Аляев Ю.Г., Ронкин М. А., Есилевский Ю. М. и др. Системный подход к изучению действия препарата Левитры у больных хроническим простатитом и эректильной дисфункцией // Урология. 2005. — № 2. — С. 53−59.
- Борисов В.В. Особенности лечения больных эректильной дисфункцией // Лечащий врач 2005.- № 10, С. 86−88.
- Вартапетов Б.А., Демченко А. Н. Сердечно-сосудистые нарушения при патологическом климаксе у мужчин и их лечение // М.: Медицина, 1975.-С. 192.
- Велиев Е.И., Лоран О. Б. Лечение эректильной дисфункции после нервосберегающей позадилобковой простатэктомии // Урология. — 2006. -№ 1. С. 28−33.
- Верткин А.Л., Пушкарь Д. Ю., Тополянский А. В., Сегал А. С. Эректильная дисфункция // Лечащий врач 2003.- № 7, С. 54−60.
- Иванова О.В., Балахонова Т. В., Соболева Г. Н. и др. Состояние эндотелийзависимой дилатации плечевой артерии у больных гипертонической болезнью, оцениваемое с помощью ультразвука высокого разрешения // Кардиология. 1997. — № 7. — С. 41−47.
- П.Камалов А. А., Ефремов Е. А., Дорофеев С. Д., Охоботов Д. А. Селективные ингибиторы фосфодиэстеразы 5 типа в терапии эректильной дисфункции: внедрение новых препаратов // Consilium medicum. 2003. -№ 7. — С. 422−426.
- Королева О.С., Затейщиков Д. А. Биомаркеры в кардиологии: регистрация внутрисосудистого воспаления // Фарматека. 2007.- № 8/9 .- С.
- Мазо Е.Б., Гамидов С. И., Овчинников Р. И., Андранович С. В., Иремашвили В. В. Посткомпрессионный тест в диагностике васкулогенной эректильной дисфункции // Урология.- 2005.- № 4.- С. 6469.
- Мазо Е.Б., Гамидов С. И., Овчинников Р. И., Иремашвили В. В. Безопасность сексуальной активности у больных сердечно- сосудистыми заболеваниями // Фарматека.- 2004.- № 11.- С. 8−13.
- Мазо ЕБ, Гамидов СИ, Овчинников РИ, Иремашвили ВВ. Эректильная дисфункция у больных сахарным диабетом // Терапевтический архив. 2005.-№ 11.-С. 88−92.
- Мазо Е.Б., Гамидов С. И., Овчинников Р. И., Иремашвили В. В. Эректильная дисфункция у больных сахарным диабетом: современные методы лечения // Фарматека.- 2004.-№ 5.- С. 52−7.
- Мазо Е.Б., Гамидов С. И., Овчинников Р. И., Иремашвили В. В. Этиология, патогенез, диагностика и лечение эректильной дисфункции у пожилых // Фарматека.- 2004.- № 4/5.- С. 40−45.
- Малая Л.Т., Корж А. Н., Балковая Л. Б. Эндотелиальная дисфункция при патологии сердечно-сосудистой системы // Харьков.- ТОРСИНГ.- 2000. -С. 432 с.
- Малколм Каррузерс // Революция тестостерона М.- 2005.
- Марков X. М. Молекулярные механизмы дисфункции сосудистого эндотелия // Кардиология. 2005. — № 12. — С. 62−67.21 .Небиеридзе Д. В. Дисфункция эндотелия и её коррекция при артериальной гипертонии // Русский Медицинский Журнал. 2006. — Т.14.-С. 127−131.
- Петров С.Б., Лоран О. Б., Велиев Е. И. Современные аспекты лечения эректильной дисфункции // Consilium medicum. 2003. — № 2. — С. 3−6.
- Соболева Е.В. Гомоцистеинемия // РМЖ.- том 15, — 2007, — № 5.- С. 340−3.
- Соболева Г. Н., Балахонова Т. В., Рогоза А. Н. и др. Вазопротекция при гипертонической болезни: влияние рамиприла на функциональное состояние эндотелия плечевой артерии // Кардиология. 1998. — № 6. — С. 44−48.
- Соболева Г. Н., Иванова О. В., Карпов Ю. А. Состояния эндотелия при артериальной гипертонии и других факторах риска развития атеросклероза (часть 2-я) // Тер. Арх. 1997. — № 9. — С. 80−83.
- Ahn GJ, Yu JY, Choi SM et al. Chronic administration of phosphodiesterase 5 inhibitor improves erectile and endothelial function in a rat model of diabetes // Int J Androl. 2005. — Vol. 28. — P. 260−266.
- Alexander Muller, John P. Mulhall. Cardiovascular disease, metabolic syndrome and erectile dysfunction // Cur Opin Urol.- 2006.- Vol. 16. P. 435 443.
- Amar E, Grivel T, Hamidi K, Lemaire A, et al. Ageing men’s sexual functions decline and the erectile dysfunction (ED) increase // Prog Urol.- 2005.- Vol.15.-P. 6−9.
- American Association of Clinical Endocrinologists Medical Guidelines forclinical practice for the evaluation and treatment of hypogonadism in adult male patients 2002 update // Endocr Pract. — 2002.- Vol. 8.- P. 440−456.
- Andersson KE, Wagner G. Physiology of penile erection // Physiol Rev. -1995.-Vol. 75.-P. 191−236.
- Anderson TJ, Gerhard MD, Meredith IT et al. Systemic nature of endothelial dysfunction in atherosclerosis // Am J Cardiol. 1995. — Vol. 75. — P. 71−74.
- Armagan A, Kim NN, Goldstein I, et al. Dose-response relationship between testosterone and erectile function: evidence for the existence of a critical threshold //J Androl.- 2006. Vol. 27.- P. 517−26.
- Audran M et al., Bone metabolism in men // Prog Urol. 2003. — Vol. 13. (2 Suppl 1) — P. 3−8.
- Aversa A, Bruzziches R, Greco EA, Pili M, Spera G. Possible involvement of gonadic steroids in determining erectile response to pharmacoerection test in men with erectile dysfunction // It J Sex Report Med.- 2006.- Vol. 13.- P. 3−9.
- Aversa A, Bruzziches R, Spera G. A rationale for the use on testosterone «salvage» in treatment of men with erectile dysfunction failing phosphodiesterase inhibitors // The Endocrinologist. 2005.- Vol.15.- P. 99 105.
- Aversa A, Isidori AM, De Martino MU. Androgens and penile erection: evidence for a direct relationship between free testosterone and cavernous vasodilatation in men with erectile dysfunction // Clin Endocrinol. 2000.-Vol. 53.- P.517−22.
- Aversa A, Isidori AM, Spera G, Lenzi A, Fabbri A. Androgens improve cavernous vasodilatation and response to sildenafil in patient with erectile dysfunction // Clin Endocrinol.- 2003.- Vol. 58.- P. 632−8.
- Aversa A, Isidori AM, Greco EA, et al. Hormonal supplementation and erectile dysfunction // Eur Urol.- 2004.- Vol. 45.- P. 535−8.
- Aversa A, Pili M, Fabbri A, Spera E, Spera G. Erectile dysfunction: expectation beyond phosphodiesterase type 5 inhibition // J Endocrinol Invest.2004.-Vol. 27.-P. 192−206.
- Azadzoi KM, Schulman RN, Aviram M, Siroky MB. Oxidative stress in arteriogenic erectile dysfunction: prophylactic role of antioxidants // J Urol.2005. Vol. 174. — P. 386−393.
- Baba K, Yajima M, Carrier S, et al. Delayed testosterone replacement restores. nitric oxide synthase-containing nerve fibres and the erectile response in rat penis // BJU Int.- 2000.- Vol. 85.- P. 953−8.
- Baba K, Yajima M, Carrier S, et al. Effect of testosterone on the number of NADPH diaphorase-stained nerve fibers in the rat corpus cavernosum and dorsal nerve // Urology.- 2000, — Vol. 56, — P. 533−8.
- Barrett-Connor E, Goodman-Gruen D, Patay B. Endogenous sex hormones and cognitive function in older men // J Clin Endocrinol Metab.- 1999.- Vol. 84.- P. 3681−3685.
- Barrett-Connor E, Mueller JE, von Muhlen DG, et al. Low levels of estradiol, are associated with vertebral fractures in older men, but not women: the Rancho Bernardo Study // J Clin Endocrinol Metab.- 2000.- Vol. 85.- P. 219 223.
- Basaria S, Dobs AS. Hypogonadism and androgen replacement therapy in elderly men//Am J Med.-2001.-Vol. 110.-P. 563−572.
- Behrendt D, Ganz P. Endothelial function: from vascular biology to clinical applications // Am J Cardiol. 2002. — Vol. 90. — P. 40L-48L.
- Bellamy MF, McDowell IFW, Ramsey MW et al. Oral folate enhances endothelial function in hyperhomocysteinaemic subjects // Eur J Clin Invest. -1999. Vol. 29. — P. 659−662.
- Bemelmans BL, Meuleman EJH, Doesburg WH et al. Erectile dysfunction in diabetic men: the neurological factor revisited // J Urol.- 1994.- Vol. 151.- P. 884−6.
- Betancourt- Albrecht M, Cunningham GR. Hypogonadism and diabetes // Int J Impot Res. -2003. Vol. 15(Suppl 4).- P. S14−20.
- Bhasin S, Storer TW, Berman N, Yarasheski KE, Clevenger B, Phillips J, Lee WP, Bunnell TS, Casaburi R. Testosterone replacement increases fat-free mass and muscle size in hypogonadal men // J Clin Endocrinol Metab. 1997. — Vol. 82(2).-P. 407−113.
- Billups KL, Kaiser DR, Kelly AS, Wetterling RA, Tsai MY, Hanson N, Bank ¦ AJ. Relation of C-reactive protein and other cardiovascular risk factors to penile vascular disease in men with ED // Int J Impot Res. 2003.- Vol. 15(4).-P. 231−6.
- Bivalacqua TJ, Burnett AL, Ignarro U et al. Increased gene expression and enzyme activity of arginase impairs erectile function in aged mice abstract. // Int J Impot Res. 2002. — Vol. 14. — В 1.5.
- Bivalacqua TJ, Hellstrom WJ, Kadowitz PJ, Champion HC. Increased expression of arginase II in human diabetic corpus cavernosum: in diabetic-associated erectile dysfunction // Biochem Biophys Res Commun. 2001. — ¦ Vol. 283.-P. 923−927.
- Bivalacqua TJ, Usta MF, Cnampion HC et al. Endothelial dysfunction in erectile dysfunction: role of the endothelium in erectile physiology and disease // J Androl. 2003. — Vol. 24. — P. S17-S37.
- Bodie J, Lewis J, Schow D, Monga M. Laboratory evaluations of erectile dysfunction: An evidence based approach // J Urol.- 2003.- Vol. 169.- P. 2262−2264.
- Boger RH, Bode-Boger SM, Szuba A et al. Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia // Circulation. 1998. — Vol. 98. — P. 1842−1847.
- Boger RH, Bode-Boger SM, Thiele W et al. Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease // Circulation. 1997. — Vol. 95. — P. 2068−2074.
- Bots M, Launer L, Lindemans J et al. Homocysteine and short-term risk of myocardial infarction and stroke in the elderly. The Rotterdam Study // Arch Intern Med.- 1999.- Vol. 159.- P. 38.
- Boyanov MA, Boneza Z, Christov VG. Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency // Aging Male.- 2003.- Vol. 6.- P. l-7.
- Brattstrom L., Israelsson В., Jeppson J O. et al. Folic acid — an innocuons means to reduce plasma homocysteine // Scand J Clin Lab Invest.- 1988.- Vol. 48.-P. 215−221.
- Braun M, Wassner G, Klotz T et al. Epidemiology of erectile dysfunction: results of the «Cologne Male Survey» // Int J Impot Res. 2000. — Vol. 12. — P. 305−311.
- Brock GB, McMahon CG, Chen KK et al. Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analysis // J Urol. -2002.-Vol. 168.-P. 1332−1336.
- Brodsky 1G, Balagopal P, Nair KS. Effects of testosterone replacement on muscle mass and muscle protein synthesis in hypogonadal men a clinical research center study // J Clin Endocrinol Metab.- 1996.- Vol. 81(10).- P. 3469−3475.
- Brown-Sequard CE. Note on the effects produced on man by subcutaneous injections of a liquid obtained from the testicles of animals // Lancet. -1889.-Vol. 2.- P. 105−107.
- Burnett AL, Lowenstein CJ, Bredt DS et al. Nitric oxide: a physiologic mediator of penile erection // Science. 1991. — Vol. 257. — P. 401−403.
- Butenandt F.J. Uber die chemische Untersuchung der Sexual- hormone// Z.Angew. Chem. -1931.- 44.-P. 905- 908.
- Butenandt F.J., Hanish G. Uber Testosteron. Umwanlung des Dehydroandrosterons in Androstendiol und Testosteron: ein Weg zur Darstellung desTestosterons aus Cholesterin Hoppe- Seylers// Z.Angew. Chem. -1935, — 237.-P. 89- 98.
- Buvat J, Lemaire A. Endocrine screening in 1,022 men with erectile dysfunction: clinical significance and cost-effective strategy // J Urol.- 1997.-Vol. 158.-P. 1764−1767.
- Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress // Circ Res. 2000. — Vol. 87. — P. 840−844.
- Cardillo C, Kilcoyne CM, Cannon RO III et al. Xanthine oxidase inhibition with oxypurinol improves endothelial function in hypercholesterolemic but not in hypertensive patients // Hypertension. 1997. — Vol. 30. — P. 57−83.
- Caretta N, Palego P, Ferlin A et al. Resumption of spontaneous erections in selected patients affected by erectile dysfunction and various degrees of carotid wall alteration: role of tadalafil // Eur Urol. 2005. — Vol. 48. — P. 326−332.
- Carr AC, Zhu BZ, Frei B. Potential Antiatherogenic Mechanisms of Ascorbate (Vitamin C) and -Tocopherol (Vitamin E) // Circ Res. 2000. — Vol. 87. — P. 349−354.
- Carson CC, Burnett AL, Levine LA Nehra A. The efficacy of Sildenafil citrate (Viagra) in patients with erectile dysfunction // Urology. 2002. — Vol. 60. -P. 12−27.
- Carson CC, Rajfer J, Eardley I et al. The efficacy and safety of tadalafil: an update // BJU Int. 2004.- Vol. 93.- P. 1276−1281.
- Celermajer DS, Sorensen KE, Georgakopoulos D et al. Cigarette smoking is associated with dose-related and potentially reversible impairment ofendothelium-dependent dilation in healthy young adults I I Circulation. 1993. -Vol. 88.-P. 2149−2155.
- Celermajer DS, Sorensen KE, Gooch VM et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis // Lancet. 1992. — Vol. 340. — P. 1111−1115.
- Celermajer DS. Endothelial disfunction: Does it matter? Is it reversible? // Am Coll Cardiol. 1997. — Vol. 30. — P. 325−333.
- Chang C, Saltzman A, Yeh S, et al. Androgen receptor: an overview // Crit Rev Eukaryot Gene Expr.- 1995.- Vol. 5.- P. 97−125.
- Chew KK, Earle CM, Stuckey BGA et al. Erectile dysfunction in general medicine practice: prevalence and clinical correlates // Int J Impot Res. 2000. -Vol. 12.-P. 41−45.
- S2.Chou TM, Sudhir K, Hutchison SJ, et al. Testosterone induces dilatation in canine coronary conductance and resistance arteries in vivo // Circulation.-1996, — Vol. 94.- P. 2614−9.
- Cook JP. Does ADMA cause endothelial dysfunction? // Arterioscler Thromb Vase Biol. 2000. — Vol. 20. — P. 2032−2037.
- Cooke JP, Dzau VJ. Nitric oxide synthase: Role in the genesis of vascular disease // Annu Rev Med. 1997. — Vol. 48. — P. 489−509.
- Cooke JP, Rossitch E, Andon N et al. Flow activates an endothelium potassium channel to release an endogenous nitrovasodilator // J Clin Invest. 1991. -Vol. 88.-P. 1663−1667.
- Corretti MC, Anderson TJ, Benjamin EJ et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery // J Am Coll Cardial. V. 39. — P. 257−265. ко 2 главе
- Cox DA, Cohen ML. Effects of oxidized low-density lipoprotein on vascular contraction and relaxation: Clinical and pharmacological implications in atherosclerosis // Pharmacol Rev. 1996. — Vol. 48. — P. 3−19.
- Creager MA, Gallagher SJ, Girerd XJ et al. L Arginine improves endothelium dependent vasodilation in hypercholesterolemic humans // J Clin Invest. ' 1992. — Vol. 90. — P. 1248 1253.
- D’Uscio LU, Milstien S, Richardson D et al. Long-term vitamin С treatment increases vascular tetrahydrobiopterin levels and nitric oxide synthase activity // Circ Res. 2003. — Vol. 92. — P. 88 — 95.
- Danesh J, Whincup P, Walker M, et al. Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses // BMJ.- 2000.-Vol. 321.-P. 199−204.
- David K, Dingemanse E, Freud J, Laqueur E. Uber krystallinisches mannliches Hormon aus Hoden (Testosteron), wirksamer als aus Harn oder aus Cholesterin bereitetes Androsteron // Hoppe Seyler Z Physiol Chem.- 1935.- Vol. 233.- P. 281−282.
- De Graaf JC, Banga JD, Moncada S et al. Nitric oxide inhibitor of platelet adhesion under flow conditions // Circulation. 1992. — Vol. 85. — P. 22 842 290.
- De Vriese AS, Verbeuren TJ, Van de Voorde J et al. Endothelial dysfunction in diabetes // Br J Pharmacol. 2000. — Vol. 130. — P. 963−974.
- DeBusk R, Drory Y, Goldstein I et al. Management of sexual dysfunction in patients with cardiovascular disease: recommendations of the Princeton Consensus Panel // Am J Cardiol. 2000. — Vol. 86. — P. 175−181. ко 2 главе
- Demir T, Comlekci A, Demir O. Hyperhomocysteinemia: a novel risk factor for ED // Metabolism.- 2006.- Vol. 55 (12).- P. 1564−8.
- Desouza С, Parulkar A, Lumpkin D et al. Acute and prolonged effects of sildenafil on brachial artery flow-mediated dilatation in type 2 diabetes // Diabetes Care. 2002. — Vol. 25. — P. 1336−1339.
- Dhindsa S, Prabhakar S, Sethi M, Bandyopadhyay A, Chaudhuri A, Dandona P. Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes // J Clin Endocrinol Metab.- 2004.- Vol. 89, — P. 5462−8.
- Dimmeler S, Fleming I, Fisslthaler В et al. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation // Nature. 1999. — Vol. 399.-P. 601−605.
- Dishy V, Harris PA, Pierce R et al. Sildenafil does not improve nitric oxide-mediated endothelium-dependent vascular responses in smokers // Br J Clin Pharmacol. 2004. — Vol. 57. — P. 209−212.
- Dishy V, Sofowora G, Harris PA et al. The effect of sildenafil on nitric oxide-mediated vasodilation in healthy men // Clin Pharmacol Ther. — 2001. -Vol. 70. P. 270−279.
- Diver MJ, Imtiaz KE, Ahmad AM, et al. Diurnal rhythms of serum total, free and bioavailable testosterone and of SHBG in middle-aged men compared with those in young men // Clin Endocrinol.- 2003.- Vol. 58.- P. 710−717.
- Doshi SN, McDowell IF, Moat SJ et al. Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide? // Arterioscler Thromb Vase Biol. 2001. — Vol. 21. -P. 1196−1202.
- Durante W, Sen AK, Sunahara FA. Impairment of endothelium dependent relaxation in aortae from spontaneously diabetic rats // Br J Pharmacol. 1988. — Vol. 94. — P. 463−468.
- Eaton CB, Liu YL, Mittleman MA, Miner M, Glasser DB, Rimm ЕВ. A retrospective study of the relationship between biomarkers of atherosclerosis and ED in 988 men // Int J Impot Res. 2007.- Vol. 19(2).- P. 218−25.
- Ebert T, Jockenhovel F, Morales A, Shabsigh R. The current status of therapy for symptomatic late- onset hypogonadism with transdermal testosterone gel // Eur Urol.- 2005.- Vol. 47.- P. 137−46.
- Ebert Т., Clinical experience testosterone therapy, prostate safety// The Aging Male.- 2004.- Vol. 7.- P. 304−311.
- Egashira K, Inou T, Hirooka Y et al. Impaired coronary blood flow response to acetylcholine in patients with coronary risk factors and proximal atherosclerotic lesions // J Clin Invest. 1993. — Vol. 91. — P. 29−37.
- El-Sakka Al, Lin CS, Chui RM et al. Effects of diabetes on nitric oxide synthase and growth factor genes and protein expression in an animal model // Int JInipotRes.- 1999.-Vol. 11.-P. 123−132.
- El-Sakka Al. Efficacy of sildenafil citrate in treatment of erectile dysfunction: effect of type 2 diabetes // Eur Urol. 2004. — Vol. 46. — P. 503 509.
- EpsteinFH. Atherosclerosis — an inflammatory disease //N Engl J Med. 1999. — Vol. 340. — P. 115−126.
- Escrig A, Marin R, Abreu P et al. Changes in mating behavior, erectile function, and nitric oxide levels in penile corpora cavernosa in streptozotocin-diabetic rats // Biol Reprod. 2002. — Vol. 66. — P. 185−189.
- Esposito K, Giugliano F, Di Palo С et al. Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial // JAMA. -2004. Vol. 291(24). — P. 2978−2984.
- Esposito К, Giugliano F, Martedi E. High proportions of erectile dysfunction in men with the metabolic syndrome // Diabetes Care.- 2005.- Vol. 28.-P. 1201−3.
- Faerman I, Glocer L, Fox D, Jadzinsky MN, Rapaport M. Impotence and diabetes: histological studies of the autonomic nervous fibres of the corpora cavernosa in Impotent diabetic males // Diabetes.- 1974.- Vol. 23.- P. 971−976.
- Feldman HA, Goldstein I, Hatzichristou DG et al. Impotence and its medical and psychological correlates: results of the Massachusetts Male Aging Study // J Urol. 1994. — Vol. 151. — P. 54−61.
- Ferrini RL, Barrett-Connor E. Sex hormones and age: A cross-sectional study of testosterone and estradiol and their bioavailable fractions in community-dwelling men // Am J Epidemiol.- 1998.- Vol. 147.- P. 750−754.
- Fonseca V, Jawa A. Endothelial and erectile dysfunction, diabetes mellitus, and the metabolic syndrome: common pathways and treatments? // Am J Cardiol.- 2005.- Vol. 96.- P. 13M-18M.
- Francis SH, Corbin JD. Molecular mechanisms and pharmacokinetics of phosphodiesterase-5 antagonists // Cur Urol Rep. 2003. — Vol. 4. — P. 457 465.
- Frei B. On the role of vitamin С and other antioxidants in atherogenesis and vascular dysfunction // Proc Soc Exp Biol Med. 1999. — Vol. 222. — P. 196−204.
- Fu W, Dudman N, Perry M, Wang X. Homocysteinemia attenuates hemodynamic responses to nitric oxide in vivo // Atherosclerosis.- 2002.- Vol. 161 (1).-P. 169−76.
- Furchgott RF, Zawadski JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine // Nature. 1980. -Vol. 288.-P. 373−376.
- Ganz P, Vita J A. Testing endothelial vasomotor function. Nitric oxide, a multipotent molecule // Circulation. 2003. — Vol. 108. — P. 2049−2053.
- Genser D. Homocysteine, vitamins, and restenosis after percutaneous coronary intervention // Cardiovasc Rev Rep.- 2003.- Vol. 24 (5).- P. 253−8.
- Gimbrone MA, Topper JN, Nagel T et al. Endothelial Dysfunction, Hemodynamic Forces, and Atherogenesis // Ann. N.Y. Acad. Sci. 2000. -Vol. 902.-P. 230−240.
- Gokce N, Keaney JF, Frei В et al. Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease // Circulation. 1999. — Vol. 99. — P. 3234−3240.
- Gooren L. Visceral obesity, metabolic syndrome, androgens and estrogens // Aging Male.- 2006.- Vol. 9(2).- P. 75−79.
- Gooren LJ, Saad F. Recent insights into androgen action on the anatomical and physiological substrate of penile erection // Asian J Androl.-2006.- Vol. 8.- P. 3−9.
- Graham M, Daly L, Refsum H et al. Plasma homocysteine as a risk ' factor for vascular disease: the European concerted action project // JAMA.-1997.- Vol. 277 (22).- P. 1775−81.
- Gray A, Berlin JA, McKinlay JB, Longcope C. An examination of research design effects on the association of testosterone and male aging: Results of a meta-analysis // J Clin Epidemiol.- 1991.- Vol. 44.- P. 671−684. '
- Gray A, Feldman HA, McKinlay JB, Longcope C. Age, disease, and changing sex hormone levels in middle-aged men: Results of the Massachusetts Male Aging Study // J Clin Endocrinol Metab.- 1991.- Vol. 73.-P. 1016−1025.
- Greco E.A., Spera G., Aversa A. Combining testosterone and PDE5 inhibitors in erectile dysfunction: basic rationale and clinical evidences // European Urology.- 2006.- Vol. 50.- P. 940- 947.
- Guay A.T. Testosterone and erectile physiology // Aging Male.- 2006.-Vol. 9(4).- P. 201−206.
- Guay AT, Perez JB, Jacobson J, Newton RA. Efficacy and safety of sildenafil citrate for treatment of erectile dysfunction in a population with associated organic risk factors // J Androl.- 2001, — Vol. 22.- P. 793−797.
- Guay AT, Velasquez E, Perez JB. Characterization of patients in a medical endocrine-based center for male sexual dysfunction // Endocr Pract.-1999.- Vol. 5,-P. 314−321.
- Giuliano F, Rampin O, Schirar A, et al. Autonomic control of penile erection: modulation by testosterone in the rat // J Neuroendocrinol.- 1993.-Vol. 5.-P. 677- 83.
- Gunduz MI, Gumus B. H, Sekrui C. Relationship between metabolic syndrome and erectile dysfunction // Asian J Androl.- 2004.- Vol. 6.- P. 355−8.
- Hak AE, Witteman JC, de Jong FH, et al. Low levels of endogenous androgens increase the risk of atherosclerosis in elderly men: the Rotterdam study // J Clin Endocrinol Metab.- 2002.- Vol. 87.- P. 3632−3639.
- Hamdy O, Ledbury S, Mullooly С et al. Lifestyle modification improves endothelial function in obese subjects with the insulin resistance syndrome // Diabetes Care. 2003. — Vol. 26. — P. 2119−2125.
- Hanke H, Lenz C, Hess B, Spindler KD, Weidemann W. Effect of testosterone on plaque development and androgen receptor expression in the arterial vessel wall // Circulation.- 2001, — Vol. 103.- P. 1382- 5.
- Haji M, Tanaka S, Nishi Y, Yanase T, Takayanagi R, Hasegawa Y, Sasamoto S, Nawata H. Sertoli cell function declines earlier than Leydig cell function in aging Japanese men // Maturitas.- 1994.- Vol. 18.- P. 143−153.
- Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR. Longitudinal effects of aging on serum total and free testosterone levels inhealthy men. Baltimore Longitudinal Study of Aging // J Clin Endocrinol Metab.- 2001.- Vol. 86.- P. 724−731.
- Harrison DG, Venema RC, Arnal JF et al. The endothelial cell nitric, oxide synthase. Is it really costitutively expressed? // Agents Actions. 1995. -Vol. 45.-P. 107−117.
- Harrison DG. Cellular and molecular mechanisms of endothelial cell dysfunction// J Clin Invest. 1997. — Vol. 100. — P. 2153−2157.
- Hatzichristou D, Hatzimouratidis K, Bekas M et al. Diagnostic steps in the evaluation of patients with erectile dysfunction // J Urol. — 2002. Vol. 168.-P. 615−620.
- Hatzichristou D, Montorsi F, Buvat J et al. The efficacy and safety of flexible-dose vardenafil (Levitra) in a broad population of European men // Eur. Urol. 2004. — Vol. 45. — P. 634−641.
- Hatzichristou D, Vardi Y, Papp G, Pushkar D et al. Effect of tadalafil on sexual timing behavior patterns in men with erectile dysfunction: integrated analysis of randomized, placebo controlled trials // J Urol. 2005. — Vol. 174. -P. 1356−1359.
- Hatzimouradis K., Hatzichristou D. Testosterone and erectile function: an unresolved enigma // European Urology.- 2007.- Vol. 52.- P. 26- 28.
- Heinlein С A, Chang C. Androgen receptor (AR) coregulators: an overview //Endocr Rev.- 2002.- Vol. 23.- P. 175−200.
- Heinlein С A, Chang C. The roles of androgen receptors: and androgen-binding proteins in nongenomic androgen actions // Mol Endocrinol.- 2002.-Vol. 16.- P. 2181−7.
- Heitzer T, Yla Herttuala S, Wild E et al. Effect of vitamin E on endothelial vasodilator function in patients with hypercholesterolemia, chronic smoking or both // J Am Coll Cardiol. 1999. — Vol. 33. — P. 499−505.
- Hijazir A, Betancourt- Albrecht M, Cunningham GR. Gonadal and erectile dysfunction in diabetics // Med Clin North Am.- 2004.- Vol. 88.- P. 933−45.
- Hwang TS, Chen HE, Tsai TF, Lin YC. Combined use of androgen and sildenafil for hypogonadal patients unresponsive to sildenafil alone // Int J Impot Res.- 2006.- Vol. 18.- P. 400−4.
- Ignarro LJ, Byms RE, Buga GM, Wood KS. Endothelium-derived relaxing factor from pulmonary artery and vein possess pharmacologic and chemical properties identical to those of NO radical // Circ Res. 1987. — Vol. 61.-P. 866−879.
- Inoue T, Tomoike H, Hisano K, Nakamura M. Endothelium determines flow-dependent dilation of the epicardial coronary in dogs // J Am Col Cardiol. 1988.- Vol. 11.-P. 187−191.
- Isidori AM, Giannetta E, Gianfrilli D, et al. Effects of testosterone on sexual function in men: results of a metaanalysis // Clin Endocrinol.- 2005.-Vol. 63.- P. 381−94.
- Joannides R, Haefeli WE, Linder L et al. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo // Circulation. 1995. — Vol. 91. — P. 1314−1319.
- Jockenhovel F. Testosterone therapy: When, how, why? // The Aging Male 2004- 7:319−324.
- Jones RW, Rees RW, Minhas S et al. Oxygen free radicals and the penis // Expert Opin Pharmacother. 2002. — Vol. 3. — P. 213−225.
- Juan PC, Leonelo EB, Steve EH et al. Endothelial nitric oxide synthase ' genotype and ischemic heart disease: meta-analysis of 26 studies involving 23 028 subjects//Circulation.-2004.-Vol. 109.-P. 1359−1365.
- Kalinchenko SY, Kozlov GI, Gontcharov NP, Katsiya GV. Oral testosterone undecanoato reverses erectile dysfunction associated with diabetes mellitus in patients failing on sildenafil citrate therapy alone // Aging Male.-2003.- Vol. 6.-P. 94−9.
- Kanani PM, Sinkey CA, Browning RL et al. Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocysteinemia in humans //Circulatin. 1999. -Vol. 100.-P. 1161−1168.
- Kapoor D, Malkin С J, Channer KS, Jones TH. Androgens, insulin resistance and vascular disease in men // Clin Endocrinol (Oxf).- 2005.- Vol. 63(3).- P. 239−250.
- Katz SD, Balidemaj K, Homma S, et al. Acute type 5 phosphodiesterase inhibition with sildenafil enhances flow-mediated vasodilation in patients with chronic heart failure // J Am Coll Cardiol. 2000. — Vol. 36. — P. 845−851.
- Kaufman JM, Seftel AD. Hypogonadism and androgen replacement therapy. In: Seftel AD, ed. Male and female sexual dysfunction // Edinburgh, Mosby.- 2004.-P. 203−218.
- Kaufman JM, Vermeulen A. Declining gonadal function in elderly men // Baillieres Clin Endocrinol Metab.- 1997.- Vol. 11.- P. 289−309.
- Kaukua J, Pekkarinen T, Sane T, et al. Sex hormones and sexual function in obese men losing weight // Obes Res.- 2003.- Vol. 11.- P. 689−94.
- Keaney JF, Guo Y, Cunningham D et al. Vascular incorporation of -tocopherol prevents endothelial dysfunction due to oxidized LDL by inhibiting protein kinase С stimulation // J Clin Invest. 1996. — Vol. 98. — P. 386−394.
- Keast JR, Gleeson RJ, Shulkes A, et al. Maturational and maintenance effects of testosterone on terminal axon density and neuropeptide expression in the rat vas deferens // Neuroscience.- 2002.- Vol. 112.- P. 391−8.
- Khaw KT, Barrett-Connor E. Lower endogenous androgens predict central adiposity in men // Ann Epidemiol.- 1992.- Vol. 2(5).- P. 675−682.
- Kim SC, Kim IK, Seo KK et al. Involvement of superoxide radical in the impaired endothelium-dependent relaxation of cavernous smooth muscle in hypercholesterolemia rabbits // Urol Res. 1997. — Vol. 25. — P. 341−346.
- Kimura M, Higashi Y, Нага К et al. PDE5 inhibitor sildenafil citrate augments endothelium-dependent vasodilation in smokers // Hypertension. — 2003.-Vol. 41.-P. 1106−1110.
- Korantzopoulos P, Galaris D. The protective role of vitamin С on endothelial dysfunction // J Clin Basic Cardiol. 2003. — Vol. 6. — P. 3−5.
- Korenman SG, Morley JE, Mooradian AD, Davis SS, Kaiser FE, Silver AJ, Viosca SP, Garza D. Secondary hypogonadism in older men: Its relation to impotence // J Clin Endocrinol Metab.- 1990.- Vol. 71.- P. 963−969.
- Kratzik CW, Schatzl G, Lunglmayr G, Rbcklinger E, Huber J. The. impact of age, body mass index and testosterone on erectile dysfunction // J Urol. -2005.- Vol. 174(1).- P. 240−3.
- Kung AW, Androgen and bone mass in men // Asian J Androl 2003- 5 (2): 148−54.
- Kupelian V, Shabsigh R, Araujo AB, O’Donnell AB, McKin-layJB, Erectile dysfunction as a predictor of the metabolic syndrome in aging men: results from the Massachusetts Male Aging Study // J Urol.- 2006, — Vol. 176.-P. 222−6.
- Kuvin JT, Karas RH. Clinical utility of endothelial function testing. Ready for prime time? // Circulation. 2003. — Vol. 107. — P. 3243−3247.
- Laaksonen DE, Niskanen L, Punnonen K, Nyssonen K. Testosterone and sex hormone binding globulin predict the metabolic syndrome and diabetes in middle- aged men // Diabetes Care.- 2004.- Vol. 27.- P. 1036- 41.
- Lang D., Kredan M. В., Lang D., Moat S. J. et al. Homocysteine -induced inhibition of endothelium-dependent relaxation in rabbit aorta: Role for superoxide anions // Arterioscler. Thromb. Vase. Biol. 2000.
- Lavrencic A, Salobir BG, Keber I. Physical training improves flow-mediated dilation in patients with the polymetabolic syndrome // Arterioscler Thromb Vase Biol. 2000. — Vol. 20.-P. 551−555.
- Lazarou S, Reyes-Vallejo L, Morganthaler A. Wide variability in laboratory reference values for serum testosterone // J Sex Med.- 2006.- Vol. 3.-P. 1085−9.
- Lee KWJ, Hill JS, Walley KR, et al. Relative value of multiple plasma biomarkers as risk factors for coronary artery disease and death in an angiography cohort // CMAJ.- 2006.- Vol.174.- P. 461−66.
- Leeson P, Thorne S, Donald A et al. Non-invasive measurement of endothelial function: effect on brachial artery dilation of graded endothelial dependent and independent stimuli // Heart. 1997. — Vol. 78. — P. 22−27.
- Lepage R. Measurement of testosterone and its sub-fractions in Canada // Clin Biochem.- 2006.- Vol. 39.- P. 97−108.
- Levine GN, Frei BN, Koulouris SN et al. Ascorbic acid reverses ¦ endothelial vasomotor dysfunction in patients with coronary artery disease // Circulation. 1996.-Vol. 93.-P. 1107−1113.
- Li H., Lewis A. et al. Homocysteine induces 3-hydroxy-3-methilglutaril coenzyme a reductase in vascular endothelial cells. A mechanism for development of atherosclerosis? // Circulation.- 2002.- Vol. 105.- P. 10 371 042.
- Liao JK. Endothelium and acute coronary syndromes // Clin Chem. — 1998.- Vol. 44.-P. 1799−1808.
- Lin CS, Chow S, Lau A, Tu R, Lue TF. Identification and regulation of human PDE% A gene promoter // Biochem Biophys Res Coramun.- 2001.-Vol. 280.- P. 684−92.
- Lindberg MK et al, Androgens and the skeleton // Minerva Endocrinol -2005- 30(1) 15−25.
- Littleton- Kearney M, Hum PD. Testosterone as a modulator of vascular behavior // Biol Res Nurs. 2004.- Vol. 5(4).- P. 276−85.
- Lizza EF, Rosen RC. Definition and classification of erectile dysfunction: Report of the Nomenclature Committee of the International Society of Impotence Research // Int J Impot Res. 1999. — Vol. 11. — P. 141— 143.
- Liu PY, Death AK, Handelsman DJ. Androgens and cardiovascular disease // Endocr Rev.- 2003.- Vol. 24(3).- P. 313−340.
- Lockette W, Otsuka Y, Carretero O. The loss of endothelium-dependent vascular relaxation in hypertension // Hypertension. 1986. — Vol. 8. — P. 1161−1166.
- Luboshitzky R, Shen-Orr Z, Herer P. Middle-aged men secrete less testosterone at night than young healthy men // J Clin Endocrinol Metab.-2003.- Vol. 88.-P. 3160−6.
- Ludmer PL, Selwyn AP, Shook TL et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries // N Engl J Med. -1986.-Vol. 315.-P. 1046−1051.
- Ludwikowski G et. Al Symptoms of andropausal syndrome in smoking and non-smoking males // Przegl Lek. 2004- 61 (10): 1033−4.
- Lugg JA, Rajfer J, Gonzalez-Cadavid NF. Dihydrotestosterone is the active androgen in the maintenance of nitric oxidemediated penile erection in the rat//Endocrinology.- 1995.- Vol. 136.-P. 1495−1501.
- Lusher TF, Vanhoutte PM. The endothelium: modulator of cardiovascular function // Boca Raton: CRC Press.- 1990.- Vol. 1.- P. 250.
- Maas R, Wenske S, Zabel M et al. Elevation of Asymmetrical Dimethylarginine (ADMA) and Coronary Arteiy Disease in Men with Erectile Dysfunction // Eur Urol. 2005. — Vol. 48. — P. 1004−1012.
- Maas R- Schwedhelm E- Albsmeier J- Boger RH. The pathophysiology of erectile dysfunction related to endothelial dysfunction and mediators of vascular function // Vase Med. 2002. — Vol. 7. — P. 213−225.
- Maiorana A, O’Driscoll G, Cheetham С et al. The effect of combined aerobic and resistence exercise training on vascular function in type 2 diabetes // J Am Coll Cardiol. 2001. — Vol. 38. — P. 860−866.
- Makhsida N, Shah J, Yan G, Fisch H, Shabsing R. Hypogonadism and metabolic syndrome: implications for testosterone therapy // J Urol.- 2005.-Vol. 174.- P. 827−34.
- Martin A, Frei B. Both intracellular and extracellular vitamin С inhibit atherogenic modification of LDL by human vascular endothelial cells // Arterioscler Thromb Vase Biol. 1997. — Vol. 17. — P. 1583−1590.
- Martin-Morales A, Sanchez-Cruz JJ, Saenz de Tejada I et al. Prevalence and independent risk factors for erectile dysfunction in Spain: results of the Epidemiologia de la Disfunction Erectil Masculina Study // J Urol. 2001. — Vol. 166.-P. 569−575.
- Mayer E, Jacobsen D, Robinson K. Homocysteine and coronary atherosclerosis // J Am Coll Cardiol.- 1996.- Vol. 27.- P. 517−27.
- McCully K.S. Vascular pathology of homocysteinemia: implications for the pathogenesis of atherosclerosis.// Amer. J. Pathol. — 1969. — V. 56. P. 111−128.
- McKinlay JB. The worldwide prevalence and epidemiology of erectile dysfunction // Int J Impot Res. 2000. — Vol. 12 (suppl.). — P. 6−10.
- McQuillan В. M., Beilby J. P., Nidorf M., Thompson P. L. Hyperhomocysteinemia but not the C677T mutation of MTHFR is an ' independent risk determinant of carotid wall thickening // Circulation.- 1999.-Vol. 99.- P. 2383−2388.
- Melman A, Gingell JC. The epidemiology and pathophysiology of erectile dysfunction // J Urol. 1999. — Vol. 161. — P. 5−11.
- Meusburger SM, Keast JR. Testosterone and nerve growth factor have distinct but interacting effects on structure and neurotransmitter expression of adult pelvic ganglion cells in vitro // Neuroscience.- 2001.- Vol. 108.- P. 33 140.
- Mills TM, Reilly CM, Lewis RW. Androgens and penile erection: a ' review // J Androl.- 1996.- Vol. 17.- P. 633−638.
- Mills TM, Lewis RW. The role of androgens in the erectile response. A prospective // Mol Urol.- 1999, — Vol. 3, — P. 75−86.
- Mohazzab KM, Kaminski PM, Wolin MS. NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium // Am J Physiol. 1994. — Vol. 266. — P. H2568 H2572.
- Mohr BA, Guay A, O’Donnell AB, McKinlay JB. Normal, bound, non-bound testosterone levels in apparently health midlife men: results from the Massachusetts Male Aging Study // Clin Endocrinol.- 2005.- Vol. 62.- P. 6473.
- Moncada S, Palmer R.M., Higgs E.A. Nitric oxide: physiology, pathophysiology, and pharmacology// Pharmacol. Rev.-1991.- 43, — P. 109−142.
- Montorsi F, Maga T, Strambi LF et al. Sildenafil taken at bedtime significantly increases nocturnal erections: results of a placebo-controlled study // Urology.- 2000.- Vol. 20(56).- P. 906−911.
- Montorsi F, MeDermott ТЕ, Morgan R et al. Efficacy and safety of fixed dose oral Sildenafil in the treatment of erectile dysfunction of various etiologies //Urology.- 1999.- Vol. 53.- P. 1011 1018.
- Montorsi F, Oettel M. Testosterone and sleep-related erections: an overview // J Sex Med.- 2005.- Vol. 2.- P. 771−84.
- Montorsi F, Salonia A, Deho F et al. Pharmacological management of erectile dysfunction // BJU Int. 2003. — Vol. 91. — P. 446−454.
- Montorsi P, Roumeguere T, Montorsi F et al. Is there a link between erectile dysfunction and coronary artery disease? // EAU Update series. 2004. -Vol. 2.-P. 43−48.
- Mooradian AD, Morey JE, Korenman SG. Biological actions of androgens // Endocrinol Rev.- 1987.- Vol. 8.- P. 1−28.
- Morales A, Buvat J, Gooren LJ, et al. Endocrine aspects of sexual dysfunction in men // J Sex Med.- 2004.- Vol. 1.- P. 69−81.
- Morales A, Heaton JPW, Carson CC. Andropause: a misnomer for a true clinical entity // J Urol.- 2000.- Vol. 163.- P. 705−712.
- Morales A. Andropause or symptomatic late-onset hypogonadism // The Aging Male. 2004.- Vol. 7, — P. 297−303.
- Morelli A, Filippi S, Mancina R, et al. Androgens regulate phosphodiesterase type 5 expression and functional activity in corpora cavernosa // Endocrinology.- 2004.- Vol. 145.- P. 2253−63.
- Morelli A, Filippi S, Zhang XH, et al. Peripheral regulatory mechanisms in erection // Int J Androl.- 2005.- Vol. 28.- P.23−7.
- Morelli A, Vignozzi L, Filippi S, et al. Erectile dysfunction: molecular biology, pathophysiology and pharmacological treatment // Minerva Urol Nefrol.- 2005.- Vol. 57.- P. 85−90.
- Morley JE. Impotence // Am J Med.- 1986.- Vol. 80.- P. 897−905.
- Morley JE, Kaiser FE, Perry HM et al. Longitudinal changes in testosterone, luteinizing hormone and follicle stimulating hormone in healthy older men // Metabolism.- 1997.- Vol. 46.- P. 410−421.
- Morris PD, Malkin CJ, Channer KS, et al. A mathematical comparison of techniques to predict biologically available testosterone in a cohort of 1072 men // Eur J Endocrinol.- 2004, — Vol. 151.- P.241−9.
- Motoyama T, Kawano H, Kugiyama К et al. Vitamin E administration improves impairment of endothelium-dependent vasodilation in patients with coronaiy spastic angina // J Am Coll Cardiol. 1998. — Vol. 32. — P. 16 721 679.
- Mulhall JP, Valenzuela R, Aviv N, Parker M. Effect of testosterone supplementation on sexual function of hypogonadal men erectile dysfunction // J Urol.- 2004.- Vol. 63(2).- P. 348−52.
- Musuda H, Tsujii T, Okuno T et al. Accumulated endogenous NOS inhibitors, decreased NOS activity, and impaired cavernosal relaxation with ischemia // Am J Physiol Regul Integr Comp Physiol. 2002. — Vol. 282. — P. R1730-R1738.
- Nakayama M, Yasue H, Yoshimura M et al. A T-786 -C mutation in the 5-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm // Circulation. 1999. — Vol. 99. — P. 2864−2870.
- Nieschlag E., Behre H.M. Testosteron: Action, deficiency, substitution // Heidelberg Springer Verlag.- 1990. P. 51−71.
- Nieschlag E., Swerdloff R, Behre HM. Investigation, treatment and monitoring of late-onset hypogonadism in males ISA, ISSAM, and EAU recommendations // Eur Urol.- 2005.- Vol. 48.- P. 14.
- Niskanen L, Laaksonen DE, Punnonen K, et al. Changes in sex hormone-binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome // Diabetes Obes Metab.- 2004.- Vol. 6.- P. 208−15.
- Orshal JM, Khalil RA. Gender sex hormones, and vascular tone // Am J Physiol Regul Integr Comp Physiol.- 2004.- Vol. 286.- P. R233−49.
- Oyama Y, Kawasaki H, Hattori Y, Kanno M. Attenuation of endothelium-dependent relaxation in aorta from diabetic rats // Eur J Pharmacol. 1986. — Vol. 132. — P. 75−78.
- Padma-Nathan H, Christ G, Adaikan G, et al. Pharmacotherapy for erectile dysfunction // J Sex Med.- 2004.- Vol. 1.- P. 128−40.
- Palmer RMJ, Ashton D, Moncada S. Vascular endothelial cells synthesise NO from L-arginine // Nature. 1988. — Vol. 333. — P. 664−666.
- Palmer R.M., Ferrige A.G., Moncada S. Nitric oxide release accounts for the biological activity of endothelium- derived relaxing factor //Nature.- 1987.-327.-P. 524−526.
- Parazzini F, Menchini FF, Bortolotti A et al. Frequency and determinants of erectile dysfunction in Italy // Eur Urol. 2000. — Vol. 37. — P. 43−49.
- Park KH, Kim SW, Kim KD, Paick JS. Effects of androgens on the expression of nitric oxide synthase mRNAs in rat corpus cavemosum // BJU Int.- 1999.- Vol. 83.- P. 327−333.
- Circulation.- 2003.- Vol. 107.- P. 499−551.
- Plotnick GD, Corretti MC, Vogel RA. Effect of antioxidant vitamins on the transient impairment of endothelium-dependent brachial artery vasoactivity following a single high-fat meal // JAMA. 1997. — Vol. 278. — P. 1682−1686.
- Pohl U, Holtz J, Busse R, Bassenge E. Crucial role of endothelium in the vasodilator response to increased flow in vivo // Hypertension. 1986. — Vol. 8.-P. 37−44.
- Ponholzer A, Temml C, Mock К et al. Prevalence and risk factors for erectile dysfunction in 2869 men using a validated questionnaire // Eur Urol. -2005.-Vol. 47.-P. 80−85.
- Pritchard J, Despres JP, Gagnon J, Tchernof A, Nadeau A, Tremblay A, Bouchard C. Plasma adrenal, gonadal, and conjugated steroids before and after long-term overfeeding in identical twins // J Clin Endocrinol Metab.- 1998.-Vol. 83(9).- P. 3277−3284.
- Rajfer J. Endothelial dysfunction as a cause of erectile dysfunction— misdiagnosis or misnomer? // Urology. 2004. — Vol. 64. — P. 193−194.
- Reilly CM, Lewis RW, Stopper VS, Mills TM. Androgenic maintenance of the rat erectile response via a non-nitric-oxide-dependent pathway // J Androl.- 1997.- Vol. 18.- P. 588−594.
- Rhoden EL, Telcken C, Mafessoni R, Souto CA. Is there any relation between serum levels of total testosterone and the severity of erectile dysfynction? // Int J Impot Res.- 2002.- Vol. 14(3).- P. 167−71.
- Richard F. Spark, МГ). Testosterone, Diabetes Mellitus, and the Metabolic Syndrome // Current urology reports.- 2007.- Vol. 8.- P. 467−471.
- Ridker PM. High-sensitivity C-reactive protein: potential adjunct forglobal risk assessment in the primary prevention of cardiovascular disease // Circulation.-2001.-Vol. 103.-P. 1813−18.
- Ridker PM, Danielson E, Rifai N, et al. Blood pressure reduction, and C-reactive protein: primary report of the Val-MARC trial // Hypertension.- 2006.-Vol. 48.- P. 73−79.
- Ridker PM, Rifai N, Rose L, et al. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events //N Engl J Med.- 2002.- Vol. 347.- P. 1557−65.
- Rosano GM. Androgens and coronary artery disease. A sex-specific effect of sex hormones? // Eur Heart J.- 2000.- Vol. 21.- P. 868−71.
- Rosano GM, Aversa A, Vitale С et al. Chronic treatment with tadalafil improves endothelial function in men with increased cardiovascular risk // Eur Urol. 2005. — Vol. 47. — P. 214−220.
- Rosano GM, Leonardo F, Pagnotta P, et al. Acute anti-ischemic effect of testosterone in men with coronary artery disease // Circulation.- 1999.- Vol. 99.-P. 1666−70.
- Roumeguere T, Wespes E, Carpentier Y et al. Erectile dysfunction is associated with a high prevalence of hyperlipidemia and coronary heart disease risk // Eur Urol. 2003. — Vol. 44. — P. 355−359.
- Rubanyi GM, Vanhoutte PM. Superoxide anions and hyperoxia inactivate endothelium-derivert relaxing factor // Am J Physiol. — 1986. Vol. 250. — P. H822-H827.
- Rubbo H, Trostchansky A, Botti H et al. Interactions of nitric oxide and peroxynitrite with low-density lipoprotein // Biol Chem. 2002. — Vol. 383. -P. 547−552.
- Ruzicka L., Wettstein A. Synthetische Darstellung der Testishhormons, Testosteron (Androsten 3 on l-o)ll Helv. Chim. Acta. 1935. — 18. — P. 1264- 1275.
- Saenz de Tejada I, Angulo J, Cellek S et al. Physiology of erectile function // J Sex Med. 2004. — Vol. 1. — P. 254−265.
- Saltzman EA, Guay AT, Jacobson J. Improvement in erectile function in men with organic erectile dysfunction by correction of elevated cholesterol levels: A clinical observation // J Urol. 2004. — Vol. 172. — P. 255−258.
- Sasaki S, Higashi Y, Nakagawa К et al. A low-calorie diet improves endothelium-dependent vasodilation in obese patients with essential hypertension // Am J Hypertens. 2002. — Vol. 15. — P. 302−309.
- Schroeder ET, Zheng L, Ong MD, Martinez C, Flores C, Stewart Y,. Azen C, Sattler FR. Effects of androgen therapy on adipose tissue and metabolism in older men // J Clin Endocrinol Metab.- 2004.- Vol. 89(10).- P. 4863−4872.
- Seidell JC, Bjorntorp P, Sjostrom L, Kvist H, Sannerstedt R. Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels // Metabolism.- 1990.-Vol. 39(9).- P. 897−901.
- Seo KK, Yun HY, Kim H, Kim SC. Involvement of entiothelial nitric oxide synthase in the impaired endothelium-dependent relaxation of cavernous smooth muscle in hypercholesterolemic rabbit // J Androl. — 1999. — Vol. 20. — P. 298−306.
- Shabsigh R, Fishman IJ, Schum С et al. Cigarette smoking and other vascular risk factors in vasculogenic impotence // Urology. 1991. — Vol. 38. -P. 227−232.
- Shabsigh R, Perelman MA, Lockhart DC et al. Health issues of men: prevalence and correlates of erectile dysfunction // J Urol. 2005. — Vol. 174. -P. 662−667.
- Shabsigh R. Hypogonadism and erectile dysfunction: the role for testosterone therapy // Int J Impot Res.- 2003.- Vol. 15. Suppl 4, — P. S9- 13.
- Shabsigh R. Testosteron therapy in erectile dysfunction // The Aging Male.- 2004.- Vol. 7.- P. 312−318.
- Shamloul R, Ghanem H, Fahmy I. Testosterone therapy can enhance erectile function response to sildenafil in patient with PADAM: a pilot study // J Sex Med.- 2005.- Vol. 2.- P. 559−64.
- Shen ZJ, Zhou XL, Lu YL, et al. Effect of androgen deprivation on penile ultrastructure // Asian/Androl.- 2003.- Vol. 5.- P. 33−6.
- Simons LA, von Konigsmark M, Simons J et al. Vitamin E ingestion does not improve arterial endothelial dysfunction in older adults // Atherosclerosis. 1999. — Vol. 143. — P. 193−199.
- Siu SC, Lo SK, Wong KW et al. Prevalence of and risk factors for erectile dysfunction in Hong Kong diabetic patients // Diabet Med.- 2001.-Vol. 18.-P. 732−738.
- Smith MR, Lee H, Nathan DM. Insulin sensitivity during combined androgen blockade for prostate cancer // J Clin Endocrinol Metab.- 2006.- Vol. 91.-P. 1305−8.
- Snyder PJ, Peachey H, Berlin JA, Hannoush P, Haddad G, Dlewati A, Santanna J, Loh L, Lenrow DA, Holmes JH, et al. Effects of testosterone replacement in hypogonadal men // J Clin Endocrinol Metab.- 2000.- Vol. 85(8).- P. 2670−2677.
- Solzbach U, Hornig B, Jeserich M, Just H. Vitamin С improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients // Circulation. 1997. — Vol. 96. — P. 1513−1519.
- Stampfer M, Malinow M. Can lowering homocysteine levels reduce cardiovascular risk? // N Engl J Med.- 1995.- Vol. 332.- P. 328−9.
- Suzuki N, Sato Y, Hisasue SI, et al. Effect of testosterone on intracavemous pressure elicited with electrical stimulation of the medial preoptic area and cavernous nerve in male rats // J Androl.- 2007.- Vol. 28.- P. 218−22.
- Surdacki S, Nowicki M, Sanmann J et al. Reduced urinary excretion of nitric oxide metabolites and increased plasma levels of asymmetric dimethylarginine in men with essential hypertension // J Cardiovasc Pharmacol.- 1999.- Vol. 33, — P. 652−658.
- Svartberg J Should men be treated with testosterone? // Tidsskr Nor Laegeforen 2005- 125 (7): 879−82.
- Tas A, Ersoy A, Ersoy C, Gullulu M, Yurtkuran M. Efficacy of sildenafil in male dialysis patients with erectile dysfunction unresponsive toerythropoietin and/or testosterone treatments // Int J Impot Res.- 2006.- Vol. 18.- P. 61−8.
- Tawakol A, Omland T, Gerhard M et al. Hyperhomocyst (e)inemia is associate with impaired endothelium—dependant vasodilatation in humans // Curculation.- 1997.- Vol. 95, — P. 1119−21.
- The Endocrine Society. Testosterone therapy in adult men with androgen deficiency syndromes: an Endocrine Society Clinical Practice Guideline // J Clin Endocrinol Metab.- 2006.- Vol. 91.- P. 1995−2010.
- Thompson J, Khalil RA. Gender differences in the regulation of vascular tone // Clin Exp Pharmacol Physiol.- 2003.- Vol. 30.- P. 1−15.
- Thomson L, Trujillo M, Telleri R et al. Kinetics of cytochrome c2+ oxidation by peroxynitrite: implications for superoxide measurements in nitric oxide producing biological systems // Arch Biochem. Biophys. 1995. — Vol. 319.-P. 491 497.
- Tibblin G, Adlerberth A, lindstedt G, Bjorntorp P. The pituitary-gonadal axis and health in elderly men: A study of men born in 1913 // Diabetes.-1996.- Vol. 45.- P. 1605−1609.
- Ting HH, Timimi FK, Boles KS et al. Vitamin С improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus // J Clin Invest. 1996. — Vol. 97. — P. 22−28.
- Tomita H, Egashira K, Kubo-Inoue M et al. Ingibition of NO synthesis induces inflammatory changes and monocyte chemoattractant protein-1expression in rat hearts and vessels // Arterioscler Thromb Vase Biol. 1998. -Vol. 18.-P. 1456−1464.
- Traish A, Kim N. The physiological role of androgens in penile erection: regulation of corpus cavemosum structure and function // J Sex Med.- 2005.-Yol. 2.- P. 759−70.
- Traish AM, Goldstein I, Kim NN. Testosterone and erectile function: from basic research to a new clinical paradigm for managing men with androgen insufficiency and erectile dysfunction // Eur Urol.- 2007.- Vol. 52.-P. 54−70.
- Traish AM, Guay AT, Are androgens critical for penile erections in humans? Examining the clinical and preclinical evidence // J Sex Med.- 2006.-Yol.3.-P. 382−404.
- Traish AM, Munarriz R, O’Connell L Choi S, Kim SW, Kim NN, Huang YH, Goldstein I. Effects of medical or surgical castration on erectile function in an animal model // J Androl.- 2003.- Vol. 24.- P. 381−387.
- Traish AM, Park K, Dhir V, Kim NN, Moreland RB, Goldstein I. Effects of castration and androgen replacement on erectile function in a rabbit model//Endocrinology.- 1999.-Vol. 140.-P. 1861−1868.
- Traish AM, Toselli P, Jeong SJ, et al. Adipocyte accumulation in penile corpus cavernosum of the orchiectomized rabbit: a potential mechanism for venoocclusive dysfunction in androgen deficiency // J Androl.- 2005.- Vol. 26.- P. 242−8.
- Travison TG- Morley JE- Araujo AB- O’Donnell AB- McKinlay JB, The. relationship between libido and testosterone levels in aging men // J Clin Endocrinol Metab. 2006- 91(7):2509−13. (ISSN: 0021−972X)
- Tsai EC, Boyko EJ, Leonetti DL, Fujimoto WY. Low serum testosterone level as a predictor of increased visceral fat in Japanese-American men // Int J Obes Relat Metab Disord.- 2000.- Vol. 24(4).- P. 485−491.
- Uel P. M., Refsum H. Plasma homocysteine, a risk factor for vascular disease plasma levels in health, disease, and drug therapy // J Lab Clin Med.-1989.-Vol. 114.- P. 473−501.
- Uslu N, Gorgulu S, Alper AT et al. Erectile dysfunction as a generalized vascular dysfunction // J Am Soc Echocardiogr. 2006. — Vol. 19. — P. 341 r 346.
- Usui M, Matsuoka H, Miyazaki H et al. Increased endogenous nitric oxide synthase inhibitor in patients with congestive heart failure // Life Sci. — 1998. Vol. 62. — P. 2425−2430.
- Van den Beld AW, Bots ML, Janssen JA, et al. Endogenous hormones and carotid atherosclerosis in elderly men // Am J Epidemiol.- 2003.- Vol. 157.-P. 25−31.
- Vanderschueren D et al., Androgens and bone // Endocr Rev 2004- 25 (3) 389−425.
- Vane J, Anggard E, Botting R. Regulatory function of the vascular endothelium // N Engl J Med. 1990. — Vol. 323. — P. 27−36.
- Vanhoutte PM. Endothelial Control of Vasomotor Function // Circ J. — 2003. Vol. 67. — P. 572−575.
- Verhaar MC, Stroes E, Rabelink TJ. Folates and Cardiovascular Disease // Arterioscler Thromb Vase Biol. 2002. — Vol. 22. — P. 6−13.
- Vermeulen A, Kaufman JM, Goemaere S, van Pottelberg I. Estradiol in elderly men // Aging Male.- 2002.- Vol. 5(2).- P. 98−102.
- Vermuelen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum // J Clin Endocrinol Metab.- 1999.- Vol. 84.- P. 3666−72.
- Vignozzi L, Corona G, Petrone L, et al. Testosterone and sexual activity // J Endocrinol Invest.- 2005.- Vol. 28(Suppl 3).- P. 39−44.
- Virag R, Floresco J, Richard C. Impairment of shear-stress-mediated vasodilation of cavernous arteries in erectile dysfunction // Int J Impot Res. -2004.-Vol. 16.-P. 39−42.
- Virag R. Flow-dependent dilatation of the cavernous artery. A potential • test of penile NO content // J Mai Vase. 2002. — Vol. 27. — P. 214−217.
- Vlachopoulos C, Tsekoura D, Alexopoulos N et al. Type 5 phosphodiesterase inhibition by sildenafil abrogates acute smoking-induced endothelial dysfunction // Am J Hypertens. 2004. — Vol. 17. — P. 1040−1044.
- Wang C. Challenges in the diagnosis of right patient for testosterone ' replacement therapy // Eur Urol Suppl. 2007.- Vol. 6.- P. 862- 867.
- Wespes E, Amar E, Hatzichristou D et al. EAU Guidelines on Erectile Dysfunction: An Update // Eur Urol. 2006. — Vol. 49 — P. 806−815.
- Wessells H., Teal Т.Н., Engel К et al. Fluid shear stress-induced nitric oxide production in human cavernosal endothelial cells: inhibition by ' hyperglycaemia // BJU Int. 2006. — Vol. 97. — P. 1047−1052.
- Williams SB, Goldfine AB, Timini FK et al. Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo // Circulation. 1998.-Vol. 97.-P. 1695−1701.
- Winquist RJ, Bunting PB, Baskin EP, Wallace AA. Decreased endothelium-dependent relaxation in New Zealand genetic hypertensive rats // J Hypertens. 1984. — Vol. 2. — P. 541−545.
- Wishart JM, Need AG, Horowitz M, Morris HA, Nordin BE. Effect of age on bone density and bone turnover in men // Clin Endocrinol (Oxf).-1995.-Vol. 42.-P. 141−146.
- Wu FC, von Eckardstein A. Androgens and coronary artery disease // Endocr Rev.- 2003.- Vol. 24.- P. 183- 217.
- Wynne FL, Khali 1 RA. Testosterone and coronary vascular tone: implications in coronary artery disease // J Endocrinol Invest.- 2003.- Vol. 26.-P. 181−6.
- Yavuzgil O, Altay B, Zoghi M et al. Endothelial function in patients with vasculogenic erectile dysfunction // Int J Cardiol. 2005. — Vol. 103. — P. 1926.
- Zeiher AM, Drexler H, Saurbier В et al. Endothelium-mediated coronary blood flow modulation in humans: Effects of age, atherosclerosis, hypercholesterolemia, and hypertension // J Clin Invest. 1993. — Vol. 92. — P. 652−662.
- Zeiher AM, Drexler H, Wollschlager H et al. Modulation of coronary vasomotor tone in humans: progressive endothelial dysfunction with different early stages of coronary atherosclerosis // Circulation. 1991. — Vol. 83. — P. 391−401.
- Zhang XH, Filippi S, Morelli A, et al. Testosterone restores diabetes-induced erectile dysfunction and sildenafil responsiveness in two distinct animal models of chemical diabetes // J Sex Med.- 2006.- Vol. 3.- P. 253−64.
- Zhang XH, Morelli A, Luconi M, et al. Testosterone regulates PDE5 expression and in vivo responsiveness to tadalafil in rat corpus cavernosum // Eur Urol.- 2005, — Vol. 47.- P. 409−16.
- Zitzmann M, Brune M, Nieschlag E. Vascular reactivity in hypogonadal men is reduced by androgen substitution // J Clin Endocrinol Metab.- 2002.-Vol. 87.- P. 5030−7.
- Zitzmann M, Faber S, Nieschlag E. Association of specific symptoms and metabolic risks with serum testosterone in older men // J Clin Endocrinol Metab.- 2006, — Vol. 91.- P. 4335−3.