Исследование структуры и функции гена Trithorax-like Drosophila melanogaster
Диссертация
Наконец, картирование с помощью EST последовательностей регуляторной области гена Tri предоставляет широкие возможности для исследования тонкого строения и функции регуляторных районов гена. Представленный контекстный анализ этих районов позволил более точно указать месторасположение промотора, управляющего синтезом подавляющего большинства известных на настоящий момент транскриптов гена, и, как… Читать ещё >
Список литературы
- Баричева Э.М., Катохин А. В. и Перелыгина Л.М. Особенности экспрессии гена, кодирующего транскрипционный фактор GAGA D. melanogaster: тканеспецифичность и зависимость от температуры. / / Докл. Акад. Наук РАН. 1997. Т.355. С.827−830.
- Блинов А.Г. Выделение ДНК фага X. / / Методы молекулярной генетики и генной инженерии. Новосибирск: Наука. 1990. С.7−9.
- Богачев С.С. и Чикаев Н.А. Метод получения делеций с использованием экзонукпеазы III и S1 нукпеазы. // Методы молекулярной генетики и генной инженерии. Новосибирск: Наука. 1990. С. 103−107.
- Вингендер Э. Классификация транскрипционных факторов эукариот. / / Мол Биол. 1997. Т. 31.№ 4. С.584−600.
- Жимулев И.Ф. Гетерохроматин и эффект положения гена. // Новосибирск: Наука, 1993. 490 с.
- Кокоза В.А., Баричева Э. М. и Катохин А.В. Клонирование и цитогенетическая локализация эволюционно-консервативных, экспрессирующихся в головах имаго геномных последовательностей D. melanogaster. II Генетика. 1991 .Т.27. С.51−60.
- Мазин А.В., Кузнеделов К. Д., Краев А. С. и др. Методы молекулярной генетики и генной инженерии. Новосибирск: Наука. 1990. 248с.
- Маниатис Т., Фрич Э. и Сэмбрук Дж. Методы генетической инженерии. II Молекулярное клонирование. М.: Мир. 1984. 480 с.
- Мглинец В.А. Гомеозисные мутации у дрозофилы и проблемы генетики развития. / / Дрозофила в экспериментальной генетике. 1978. Новосибирск: Наука. 1978. С.41−71.
- Наякшин A.M. Трансформация Е.coli плазмидной ДНК. // Методы молекулярной генетики и генной инженерии. Новосибирск: Наука. 1990. С.39−40.
- Перелыгина Л.М., Баричева Э. М., Себелева Т. Е., Катохин А. В., Соловьева И. В. и Кокоза В.А. Изучение особенностей экспрессии последовательностей Nc18A, Nc34CD, Nc70 °F и Nc98 °F из генома Drosophila melanogaster. 11 Генетика. 1992. Т.28. С.98−103.
- Холодилов Н.Г. Выделение плазмидной ДНК методом щелочного лизиса. / / Методы молекулярной генетики и генной инженерии. Новосибирск:Наука. 1990.С.9−10.
- Agianian В. Leonard K., Bonte Е., et al. The glutamine-rich domain of the Drosophila GAGA factor is Necessary for amyloid fibre formation in vitro, but not for chromatin remodeling. // J. Mol. Biol. 1998. V.285. P.527−544.
- Arkhipova I. Promoter elements in Drosophila melanogaster revealed by sequence analysis. // Genetics. 1995. V. 139. P. 1359−1369.
- Armstrong J.A. and Emerson B.M. Transcription of chromatin: these are complex times. // Curr.Opin.Gen.Devel. 1998. V.8. P.165−172.
- Arnone M.I. and Davidson E.H. The hardwiring of development: organization and function of genomic regulatory systems. // Development. 1997. V. 124. P. 1851−1864.
- Ayer S. and Benyajati C. Conserved enhancer and silencer elements responsible for differential Adh transcription in Drosophila cell lines. // Mol. Cell. Biol. 1990. V.10. P.3512−3523.
- Bardwell V.J. and Treisman R. The POZ domain: a conserved protein-protein interaction motif. // Genes Dev. 1994. V.8. P. 1664−1677.
- Baricheva E.M., Katokhin A.V. and Perelygina L.M. Expression of Drosophila melanogaster gene encoding transcription factor GAGA is tissue-specific and temperature-dependent. // FEBS Letters. 1997. V.414. P.285−288.
- Benyajati C., Ewel A., McKeon J. et al. Characterization and purification of Adh distal promoter factor 2, Adf-2, a cell-specific and promoter-specific repressor in Drosophila. II Nucl. Acids Res. 1992. V.20. P.4481−4489.
- Benyajati C., Mueller L., Xu N. et al. Multiple isoforms of GAGA factor, a critical component of chromatin structure. // Nucl. Acids Res. 1997. V.25. P.3345−3353.
- Bermingham J.R., Martinez-Arias A., Petitt M.G. et al. Different patterns of transcription from the two Antennapedia promoters during Drosophila embryogenesis. / / Development. 1990. V.109. P.553−566.
- Bhat K.M., Farkas G., Karch F. etal. The GAGA factor is required in the early Drosophila embryo not only for transcriptional regulation but also for nuclear division. / / Development. 1996. V. 122. P. 1113−1124.
- Biggin M.D. and McGinnis W. Regulation of segmentation and segment identity by Drosophila homeoproteins: the role of DNA binding in functional activity and specificity. // Development. 1997. V. 124. P.4425−4423.
- Biggin M.D. and Tjian R. Transcription factors that activate the Ultrabithorax promoter in developmentally staged extracts. // Cell. 1988. V.53. P.699−711.
- Blackman R.K. and Meselson M. Interspecific nucleotide sequence comparisons used to identify regulatory and structural features of the Drosophila hsp82 gene. / / J.Mol.Biol. 1986. V.188. P.499−515.
- Brown J.L. and Wu C. Repression of Drosophila pair-rule segmentation genes by ectopic expression of tramtrack. // Development. 1993. V. 117. P.45−58.
- Bucher P. Weight matrix descriptions of four eukaryotic RNA polymerase II promoter elements derived from 502 unrelated promoter sequences. // J.Mol.Biol. 1990. V.212. P.563−578.
- Burke T.W. and Kadonaga J.T. Drosophila TFIID binds to a conserved downstream1. lbasal promoter element that is present in many TATA-box-deficient promoters. / / Genes Dev. 1996. V. 11. P.711 -724.
- Burke T.W. and Kadonaga J.T. The downstream core promoter element, DPE, is conserved from Drosophila to humans and is recognized by TAFn60 of Drosophila. // Genes Dev. 1997. V.11. P.3020−3031.
- Cairns B.R. Chromatin remodeling machines: similar motors, ulterior motives. // Trends Biol. Sci. 1998. V.23. P. 19−24.
- Cavalli G. and Paro R. The Drosophila Fab-7 chromosomal element conveys epigenetic inheritance during mitosis and meiosis. // Cell. 1998. V.93. P.505−518.
- Cavarec L., Jensen S., Casella J.-F. et al. Molecular cloning and characterization of a transcription factor for the copia retrotransposon with homology to the BTB-containing Lola neurogenic factor. // Mol. Cell. Biol. 1997. V.17. № 1. P.482−494.
- Chen W., Zollman S., Couderc J.-L. and Laski F.A. The BTB domain of brie a brae mediates dimerization in vitro. // Mol. Cell. Biol. 1995. V.15. № 6. P.3424−3429.
- Chiwalla V., Jane E.P. and HarteP.J. The Drosophila trithorax protein binds to specific chromosomal sites and is co-localized with Polycomb at many sites. / / EMBO J. 1995. V.14. P.2056−2065.
- Chomchinski P. and Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroforme extraction. // Anal.Biochem. 1987. V.162. P.156−159.
- Chung Y.-T. and Keller E.B. Positive and negative regulatory elements mediating transcription from the Drosophila melanogaster actin 5C distal promoter. // Mol.Cell.Biol. 1990. V.10. P.6172−6180.
- Chung Y.-T. and Keller E.B. The TATA-dependent and TATA-independent promoters of the Drosophila melanogaster actin 5C-encoding gene. // Gene. 1991 .V. 106. P.237−241.
- Colgan D.F. and Manley J.L. Mechanism and regulation of mRNA polyadenylation. / / Genes Dev. 1997. V.11. P.2755−2766.
- Corces V.G. Keeping enhancers under control. // Nature. 1995. V.376. P.462−463.
- Csink AK and Henikoff S. Something from nothing: the evolution and utility of satellite repeats. // Trends Genet. 1998. V.14. P. 200−204.
- DiBello P.R., Withers D.A., BayerC.A., et al. The Drosophila Broad-Complex encodes a family of related proteins containing zinc fingers. // Genetics. 1991. V. 129. P.385−397
- Dorn R., Szidonya J., Korge G., et al. P transposon-induced dominant enhancer mutations of position-effect variegation in Drosophila melanogaster. II Genetics. 1993. V.133. P.279−290.
- Eisen J.A., Sweder K.S. and Hanawalt P.C. Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions. 11 Nucl. Acids Res. 1995. V.23 P.2715−2723
- Elfring L.K., Daniel C., Papoulas 0., et al. Genetic analysis of brahma: the Drosophilahomolog of the yeast chromatin remodeling factor SWI2/SNF2. // Genetics. 1998. V.148. P.251−265.
- EspinasM.L., Jimenez-Garcia E., VaqueroA. et al., the N-terminal POZ domain of GAGA mediates the formation of oligomers that bind DNA with high affinity and specificity. 11 J.Biol.Chem. 1999. V.274. P. 16 461−16 469.
- Farkas G., Gausz J., Galloni M., Reuter G., Gyurkovics H. and Karch F. The Trithorax-like gene encodes the Drosophila GAGA factor. // Nature. 1994. V.371. P.806−808.
- Felsenfeld G. Chromatin unfolds. // Cell. 1996. V.86. P. 13−19.
- Fernandes M., Xiao H. and Lis J.T. Binding of heat shock factor to and transcriptional activation of heat shock genes in Drosophila // Nucl. Acids Res. 1995.V.23.P.4799−4804.
- Fickett J.W. and Hatzigeorgiou A.G. Eukaryotic promoter recognition. // Genome Res. 1997. V.7. P.861−878.
- Fletcher J.C., D'Avino P.P. and Thummel C.S. A steroid-triggered switch in E74 transcription factor isoforms regulates the timing of secondary-response gene expression. II Proc. Natl. Acad. Sci. USA 1997. V.94. P.4582−4586.
- Fletcher J.C. and Thummel C.S. The Drosophila E74 gene is required for the proper stage- and tissue-specific transcription of ecdyson-regulated genes at the onset of metamorphosis. // Development. 1995. V.121. P. 1411−1421.
- Galloni M., Gyurkovitcs H., Schedl P. and Karch F. The bluetail transposon: evidence for independent cis-regulatory domains and domain boundaries in the bithorax complex. // EMBO J. 1993. V.12. P. 1087−1097.
- Gellon G. and McGinnis W. Shaping animal body plans in development and evolution by modulation of HOX expression patterns. // BioEssays. 1998. V.20. P. 116−125.
- Georgel P.T., Tsukiyama T. and Wu C. Role of histone tails in nucleosome remodeling by Drosophila NURF. 11 EMBO J. 1997. V.16. P.4717−4726.
- Georgiev P. and Kozycina M. Interaction between mutations in the suppressor of Hairy wing and modifier of mdg4 genes of Drosophila melanogaster affecting the phenotype of gypsy-induced mutations. // Genetics. 1996. V. 142. P.425−436.
- Gerasimova T.I., Gdula D.A., Gerasimov D.V. et al. A Drosophila protein that imparts directionality on chromatin insulator is an enhancer of position-effect variegation. / / Cell. 1995. V.82. P.587−597.
- Gerasimova T.I. and Corces V.G. Polycomb and trithorax group proteins mediate the function of a chromatin insulator. // Cell. 1998. V.92. P. 511−521.
- Gilmour D.S., Thomas G.H. and Elgin S.C.R. Drosophila nuclear proteins bind to regions of alternating C and T residues in gene promoters. // Science. 1989.V.245. P. 14 871 490.
- Giniger E., Tietje K., Jan L.Y. and Jan Y.N. lola encodes a putative transcription factor required for axon grouth and guidance in Drosophila. // Development. 1994.1. V. 120. P. 1385−1398.
- Glaser R.L.Thomas G.H., Siegfried E. et al. Optimal heat-induced expression of the Drosophila hsp26 gene requires a promoter sequence containing (CT)n • (GA) n repeats. // J.Mol.Biol. 1990. V.211. P.751−761.
- Granok H., Leibovitch B.A., Shaffer C.D. and Elgin S.C.R. Chromatin. Ga-ga over GAGA factor. // Curr. Biol. 1995. V.5. P.238−241.
- Greenberg A.J., Yanowitz J.L. and Schedl P.D. GAGA factor’s role in dosage compensation. // A. Dros. Res. Conf. 1999.V. 40. P.59.
- Greenblatt J. RNA polymerase II holoenzyme and transcriptional regulation. // Curr. Opin. Cell Biol. 1997. V.9. P. 310−319.
- Hagstrom K., Muller M. and Schedl P. Fab-7functions as a chromatin domain boundary to ensure proper segment specification by the Drosophila bithorax complex. / / Genes Dev. 1996. V.10. P.3202−3215.
- Hagstrom K., Muller M. and Schedl P. A Polycomb and GAGA dependent silencer adjoins the Fab-7 boundary in the Drosophila bithorax complex. II Genetics. 1997. V.146. P. 1365−1380.
- Han W., Yu Y., Su K., et al. A binding site for multiple transcriptional activators in the fushi tarazu proximal enhancer is essential for gene expression in vivo. // Mol. Cell. Biol. 1998. V.18. P.3384−3394.
- Harris N.L. Genotator: A workbench for sequence annotation. / / Genome Research 1997. V.7. P.754−762.
- Harrison S. D and Travers A.A. The tramtrack gene encodes a Drosophila finger protein that interacts with the ftz transcriptional regulatory region and shows a novel embryonic expression pattern. II EMBO J. 1990. V.9. P.207−216.
- Henikoff S. Dosage-dependent modification of position-effect variegation in Drosophila. II BioEssays. 1996. V.18. P.401−409.
- Hirose S. Chromatin remodeling and transcription. / /J. Biochem.1998. V. 124. P. 106 064
- Hoffmann A., Oelgeschlager T. and Roeder R.G. Considerations of transcriptional control mechanisms: do TFIID-core promoter complexes recapitulate nucleosome-like functions? II Proc. Natl. Acad. Sci. USA 1997. V.94. P.8928−8935.
- Horowitz H. and Berg C.A. The Drosophila pipsqueak gene encodes a nuclear BTB-domain-containing protein required early in oogenesis. II Development. 1996. V. 122. P. 1859−1871.
- Hsu T., Gogos J.A., Kirsh S.A. and Kafatos F.C. Multiple zinc fingers forms resultingfrom developmentally regulated alternative splicing of a transcription factor gene. // Science. 1992. V.257. P.1946−1950.
- Hu S., Fambrough D., Atashi J.R., Goodman C.S. and Crews S.T. The Drosophila abrupt gene encodes a BTB-zinc finger regulatory protein that controls the specificity of neuromuscular connections. // Genes Dev. 1995. V.9. P.2936−2948.
- Huet F., Ruiz C. and Richards G. Sequential gene activation by ecdyson in Drosophila melanogaster. the hierarchical equivalence of early and early late. / / Development. 1995. V.121. P.1195−1204.
- Jackson S.P. and Tjian R. O-Glycosylation of eukaryotic transcription factors: implications for mechanisms of transcriptional regulation. // Cell.1988.V.55.P.125−133
- Jimenez-Garcia E., Vaquero A., Espinas M.L. et ai, The GAGA factor of Drosophila binds triple-stranded DNA. JI J. Biol.Chem.1998.V.273.P.24 640−24 648.
- Kadonaga J.T. Eukaryotic transcription: an interlaced network of transcription factors and chromatin-modifying machines. // Cell.1998.V. 92. P.307−313.
- Karlin S. and Burge C. Trinucleotide repeats and long homopeptides in genes and proteins associated with nervous system disease and development. / / Proc. Natl. Acad. Sei. USA 1996. V.93. P. 1560−1565.
- Katsani K.R., Hajibagheri N. and Verrijzer C.P. Co-operative DNA binding by GAGA transcription factor requires the conserved BTB/POZ domain and reorganizes promoter topology. // EMBO J. 1999. V.18. P.698−708.
- Kaufman T.C., Seeger M.A. and Olsen G. Molecular and genetic organization of the Antennapedia gene complex of Drosophila melanogaster. / / Adv Genet. 1990. V.27. P.309−362.
- Kennison J.A. Transcriptional activation of Drosophila homeotic genes from distant regulatory elements. // Trends Genet. 1993. V.9. P.75−79.
- Kerrigan L.A., Croston G.E., Lira L.M. and Kadonaga J.T. Sequence-specific transcriptional antirepression of the Drosophila Kruppel gene by the GAGA factor. // J. Biol. Chem. 1991. V.266. P.574−582.
- Kingston R.E.Bunker C.A. and Imbalzano A.N. Repression and activation by multiprotein complexes that alter chromatin structure. / / Genes Dev. 1996. V.10. P.905−920
- Kidd S. Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins. // Cell. 1992. V. 71. P. 623−635.
- Klug A. and Schwabe J.W. Protein motifs 5. Zinc fingers. // FASEB J. 1995. V.9. P.597−604
- Knudsen S. Promoter2.0: for the recognition of Pol II promoter sequences. / / Bioinformatics. 1999. V.15. P.354−361.
- Kokoza V.A., Baricheva E.M. and Katokhin A.V. conservative brain specific sequences of D. 1991. V.70. P.121−123.
- Cloning and chromosomal localization of melanogaster. II Drosophila Inf.Serv.
- Kokoza V., Perelygina L., Baricheva E., Katokhin A., Solovyeva I. and Sebeleva T. Molecular cloning and analysis of a set of evolutionary conserved neurogenes in Drosophila. II CSH Meeting on Mol. Neurobiology of Drosophila. 1991. P. 101 (abstract)
- Kondrakhin Y.V., Kel A.E., Kolchanov N.A., Romashchenko A.G. and Milanesi L. Eukaryotic promoter recognition by binding sites for transcription factors. // CABIOS. 1995. V.11. P. 477−488
- Kuziora M.A. and McGinnis W. Different transcripts of the Drosophila Abd-B gene correlate with distinct genetic sub-functions. 11 EMBO J. 1988. V.10. P.3233−3244.
- Q., Wallrath L.L., Granok H. and Elgin S.C.R. (CT)n (GA)n repeats and heat shock elements have distinct roles in chromatin structure and transcriptional activation of theDrosophila hsp26 gene. // Mol.Cell.Biol. 1993. V.13. P.2802−2814.
- Q., Wallrath L.L., Emanuel P.A., et al. Insensitivity of the preset hsp26 chromatin structure to a TATA box mutation in Drosophila. l / J.Biol.Chem.1994.V.269.P.15 906−11
- Mace H.A.F., Pelham H.R.B. and Travers A.A. Association of Si nuclease-sensitive structure with short direct repeats 5' of Drosophila heat shock genes. / / Nature. 1983. V.304. P.555−557.
- Mackay J.P. and Crossley M. Zinc fingers are sticking together. // Trends Biol.Sci.1998. V.23. P. 1−4.
- Martin C.H., Mayeda C.A., Davis C.A., etal. Complete sequence of the bithorax complex of Drosophila. II Proc. Natl. Acad. Sci. 1995. V.92. P.8398−8402.
- Martinez-Balbas M.A., Dey A., Rabindran S.K. et al. Displacement of sequence-specific transcription factors from mitotic chromatin. / / Cell. 1995. V.83. P.29−38.
- Martinez-Balbas M.A., Tsukiyama T., Gdula D. and Wu C. Drosophila NURF-55, a WD repeat protein involved in histone metabolism. // Proc. Natl. Acad. Sci. 1998. V.95. P. 132−137.
- Mazina O.M., Belyaeva E.S. and Zhimulev I.F. Cytogenetical analysis of 2B3−4-2B11 region of the X chromosome of Drosophila melanogaster. II Mol. Gen. Genet. 1991 .V.225. P99−105
- McGinnis W. and Krumlauf R. Homeobox genes and axial patterning. // Cell. 1992. V.68. P. 283−302.
- Mihaly J., Hogga l., Gausz J. et al. In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb-response element. // Development. 1997. V.124. P. 1809−1820.
- Milanesi L., Rogozin I.B. and D’Angelo D. WEBgene: interactive tools for prediction and analysis of protein-coding genes structure in Internet. / / Proc. 1st Int. Conf. Bioinform. Genome Reg. & Str., Novosibirsk. 1998. V.2. P.251−253.
- Mironov A.A. and Gelfand M.S. Gene recognition using EST data: unexpectedly frequent alternative splicing of human genes. // Proc. 1st Int. Conf. Bioinform. Genome Reg. & Str., Novosibirsk. 1998. V.2. P.249−250.
- Mironov A.A., Fickett J.W. and Gelfand M.S. Frequent alternative splicing of human genes. // Genome Res. 1999. V.9. P. 1288−1293.
- Mizuguchi G., Tsukiyama T., Wisniewski J. and Wu C. Role of nucleosome remodeling factor NURF in transcriptional activation of chromatin. // Molec. Cell. 1997. V.1. P. 141−150.
- Mount S.M., Burks C., Hertz G. et al. Splicing signals in Drosophila: intron size, information content, and consensus sequences. // Nucl. Acids Res. 1992. V.20. P.4255−4262.
- Murakami K. and Takagi T. Gene recognition by combination of several gene-finding programs. II Bioinformatics. 1998. V.14. P.665−675.
- Mutsuddi M. and Lakhotia S.C. Spatial expression of hsr-omega (93D) gene in different tissues of Drosophila melanogaster and identification of promoter element controlling its developmental expression. / / Dev.Genet. 1995. V. 17. P.303−311.
- Nigg E.A. Nucleocytoplasmic transport: signals, mechanisms and regulation. // Nature. 1997. V.386. P.779−787.
- Nightingale K.P., Wellinger R.E., Sogo J.M. and Becker P.B. Histone acetylation facilitates RNA polymerase II transcription of the Drosophila hsp26 gene in chromatin. // EMBO J. 1998. V.17. P.2865−2876.
- Neugebauer K.M. and Roth M.B. Transcription units as RNA processing units. // Genes Dev. 1997. V.11. P.3279−3285.
- O’Brien T., Hardin S., Greenleaf A. and Lis J.T. Phosphorylation of RNA polymerase II C-terminal domain and transcriptional elongation. // Nature. 1994. V.370. P.75−77.
- O’Brien T., Wilkins R.C., Giardina C. and Lis J.T. Distribution of GAGA protein on Drosophila genes in vivo. // Genes Dev. 1995. V.9. P. 1098−1110.
- O’Connor M.B., Binari R., Perkins L.A. and Bender W. Alternative RNA products from the Ultrabithorax domain of the bithorax complex. / / EMBO J.1988.V.7.P.435−445.
- O’Donnell K.H. and Wensink P. S. GAGA factor and TBF1 bind DNA elements that direct ubiquitous transcription of the Drosophila a1-tubulin gene. // Nucl. Acids Res. 1994. V.22. P.4712−4718.
- Okada M. and Hirose S. Chromatin remodeling mediated by Drosophila GAGA factor and ISWI activates fushi tarazu gene transcription in vitro. // Mol.Cell.Biol. 1998. V.18. P.2455−2461.
- Omichinski J.G., Pedone P.V., Felsenfeld G. et al. The solution structure of a specific GAGA factor-DNA complex reveals a modular binding mode. / / Nature Struct.Biol.1997. V.4. P.122−132.
- Orenic T.V., Slusarski D.C., Kro! l K.L. and Holmgren R.A. Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila. / / Genes Dev. 1990. V.4. P. 1053−1067.
- Ohtsuki S. and Levine M. GAGA mediates the enhancer blocking activity of the eve promoter in the embryo. // Genes Dev. 1998. V. 12. P.3325−3330.
- Paro R. Propagating memory of transcriptional states. // Trends Genet. 1995. V.11. P.295−297
- Patikoglou G. and Burley S.K. Eukaryotic transcription factor-DNA complexes. // Annu. Rev. Biophys.Biomol.Struct. 1997. V.26. P.289−325.
- Pazin M.J. and Kadonaga J.T. SWI2/SNF2 and related proteins: ATP-driven motors that disrupt protein-DNA interaction? / / Cell. 1997. V.88. P.737−740.
- Pedone P.V., Ghirlando R., Clore G.M. et al. The single Cys2-His2 zinc finger domain of the GAGA protein flanked by basic residues is sufficient for high-affinity specific DNA binding. // Proc. Nat. Acad. Sci. 1996. V.93. P.2822−2826.
- Pedersen A.G., Baldi P., Chauvin Y. and Brunak S. the biology of eukaryotic promoter prediction a review. 11 Computers&Chemistry. 1999. V. 23. P. 191−207.
- Perkins K.K., Dailey G.M. and Tjian R. In vitro analysis of the Antennapedia P2 promoter: identification of a new Drosophila transcription factor. // Genes Dev. 1988. V.2. P. 1615−1626.
- Perutz M. Polar zippers: their role in human disease. // Prot.Sci.1994.V.3. P.1629−1637.
- Perutz M. Glutamine repeats and neurodegenerative diseases: molecular aspects. / / Trends Biol. Sci. 1999. V.24. P. 58−63.
- Pirrotta V. PcG complexes and chromatin silencing. // Cur. Opin. Gen. Dev. 1997. V.7. P.249−258
- Pirrotta V. Polycombing the genome: PcG, trxG, and chromatin silencing. // Cell 1998. V.93. P.333−336.
- Platero J.S., Csink A.K., Quintanilla A. and Henikoff S. Changes in chromosomal localization of heterochromatin-binding proteins during the cell cycle in Drosophila. / / J.Cell.Biol. 1998. V.140. P.1297−1306.
- Prestridge D.S. SIGNAL SCAN: A computer program that scans DNA sequences for eukaryotic transcriptional elements. // CABIOS. 1991. V.7. P.203−206.
- Prestridge D.S. Prediction of Pol II promoter sequences using transcription factor binding sites. // J.Mol. Biol. 1995. V.249.P.923−932.
- Promega protocols and applications guide. / / Promega corporation. Second edition.1991.P.90−98.
- Ptitsyn A.A., Rogozin I.B., Streletc V.B., Milanesi L. and Kolchanov N. A AUTOGENE v1.0 the operating media for molecular genetic research. / / 1994. http://wwwicg.bionet.nsc.ru/SRCG/AUG/Title.html- ftp.bionet.nsc.ru- директория pub/biology/aug/manual.txt
- Purnell B.A., Emanuel P.A. and Gilmour D.S. TFIID sequence recognition of the initiator and sequences farther downstream in Drosophila class II genes. // Genes Dev. 1994. V.8. P.830−842.
- Raff J.W., Kellum R. and Alberts B. The Drosophila GAGA transcriptional factor is associated with specific regions of heterochromatin throughout the cell cycle. II EMBO J. 1994. V.13. P.5977−5983.
- Rand N.K. Crystal violet can be used to visualize DNA bands during gel electrophoresis and to improve cloning efficiency. /1 Technical Tips Online. Elsevier Science. 1996.
- Read D., Nishigaki T. and Manley J.L. The Drosophila even-skipped promoter is transcribed in a stage-specific manner in vitro and contains multiple, overlapping factor-binding sites. // Mol. Cell. Biol. 1990. V.10. P.4334−4344.
- Read D. and Manley J.L. Alternatively spliced transcripts of the Drosophila tramtrack gene encode zinc finger proteins with distinct DNA binding specificities. / / EMBO J.1992. V.11. P. 1035−1044.
- Read C.M. and Driscoll P.C. GAGA over the nucleosome. // Nature Struct. Biol. 1997. V.4. P.87−99.
- Reese M.G., Harris N.L. and Eeckman F.H. Large scale sequencing specific neural networks for promoter and splice site recognition. / / Biocomputing: Proceed, of the
- Pacific Symp. 1996.(ed. by L. Hunter and T.E. Klein, World Scientific Publishing Co) Singapore.
- Ren B. and Maniatis T. Regulation of Drosophila Adh promoter switching by an initiator-targeted repression mechanism. // EMBO J. 1998. V.17. P. 1076−1086.
- Reuter G. and Spierer P. Position effect variegation and chromatin proteins. / / BioEssays. 1992. V.14. P.605−612.
- Robinson D.N. and Cooley L. Drosophila kelch is an oligomeric ring canal actin organizer. // J. Cell Biol. 1997. V.138. P.799−810.
- Rorth P. A modular miswxpression screen in Drosophila detecting tissue-specific phenotypes. // Proc. Nat. Acad. Sci. 1996. V.93. P. 12 418−12 422.
- Rosenberg U.B., Schroder C., Preiss A. et al. Structural homology of the product of Drosophila Kruppel gene with transcription factor IIIA. // Nature. 1986. V.319. P.336−339
- Rudolph K., Morganelli C. and Berger E.M. Regulatory elements near the Drosophila hsp 22 gene required for ecdysterone and heat shock induction. // Dev. Genetics 1991. V.12. P.212−218.
- Quandt K., Freeh K., Karas H., Wingender E. and Werner T. Matlnd and Matlnspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. // Nucleic Acids Res. 1995. V. 23. P. 4878−4884.
- Sandaltzopoulos R. and Becker P.B. Heat shock factor increases the reinitiation rate from potentiated chromatin templates. // Mol.Cell.Biol. 1998. V.18 P.361−367.
- Sass G.L. and Henikoff S. Comparative analysis of position-effect variegation mutations in Drosophila melanogaster delineates the targets of modifiers. / / Genetics. 1998. V.148. P.733−741.
- Satijn D.P.E. and Otte A.P. Polycomb group protein complexes: do different complexes regulate distinct target genes? // Biochim.Biophys.Acta. 1999. V. 1447.P. 1−16.
- Schug J. and Overton G.C. «TESS: Transcription Element Search Software on the WWW». // 1997. Technical Report CBIL-TR--1001-v0.0, of the Computational Biology and Informatics Laboratory, School of Medicine, University of Pennsylvania.
- Schwartz C. and Kornberg T.B. Getting from A to P in imaginal discs: reconstructing a transcriptional switch. // A. Conf. Dros. Res. 1997. V. 38. P. 157B.
- Sharp P.A. Splicing of messenger RNA precursors. / / Science. 1986.V.235.P.776−771.
- Sharp P.A. Split genes and RNA splicing. // Cell. 1994. V.77. P.805−815.
- Shopland L.S., Hirayoshi K., Fernandes M. and Lis J.T. HSF access to heat shock elements in vivo depends critically on promoter architecture defined by GAGA factor, TFIID, and RNA polymerase II binding sites. // Genes Dev. 1995. V.9. P.2756−2769
- Simon J. Locking in stable states of gene expression: transcriptional control during Drosophila development. // Curr.Opin.Cell Biol. 1995. V.7. P.376−385 .
- Small S., Blair A. and Levin M. Regulation of even-skipped stripe 2 in the Drosophila embryo. // EMBO J. 1992. V.11. P.4047−4057.
- Soeller W.C., Poole S.J. and Kornberg T.B. In vitro transcription of the Drosophila engrailed gene. // Genes Dev. 1988. V.2. P.68−81.
- Soeller W.C., Oh C.E. and Kornberg T.B. Isolation of cDNAs encoding the Drosophila GAGA transcription factor. // Mol. Cell. Biol. 1993. V. 13. P.7961−7970.
- Sun F.-L. and Elgin S.C.R. Putting boundaries on silence. // Cell. 1999. V. 99. P.459−462.
- Steger D.J. and Workman J.L. Remodeling chromatin structures for transcription: what happens to the histones? // Bioessays 1996. V.18. P.875−884.
- Stott K., Blackburn J.M., Butler P.J.G. and Perutz M. Incorporation of glutamine repeats makes protein oligomerize: implications for neurodegenerative diseases. // Proc. Nat. Acad. Sci. 1995. V.92. P.6509−6513.
- Strutt H., Cavalli G. and Paro R. Co-localization of Polycomb protein and GAGA factor on regulatory elements responsible for the maintenance of homeotic gene expression. II EMBO J. 1997. V. 16 P.3621−3632.
- Talbot W.S., Swyryd E.A. and Hogness D.S. Drosophila tissues with different metamorphic responses to ecdysone express different ecdyson receptor isoforms. / / Cell. 1993. V.73. P. 1323−1337.
- Talerico M. and Berget S.M. Intron definition in splicing of small Drosophila introns. II Mol. Cell. Biol. 1994. V.14. P.3434−3445.
- Tan S. and Richmond S.T. Eukaryotic transcription factors. I / Curr. Opin. Struct. Biol. 1998. V. 8. P.41—48.
- Technical Bulletin № 159, 160, Ambion. II http://www.ambion.com
- Thummel C. The Drosophila E74 promoter contains essential sequences downstream from the start site of transcription. // Genes Dev. 1989. V.3. P.782−792.
- Topol J., Dearolf C.R., Prakash K. and Parker C.S. Synthetic oligonucleotides recreate Drosophila fushi tarazu zebra-stripe expression. // Genes Dev. 1991. V.5. P.855−867.
- Travers A. An engine for nucleosome remodeling. / / Cell. 1999.V. 96. P. 311−314.
- Tripoulas N.A., Hersperger E., La Jeunesse D. and Shearn A. Molecular genetic analysis of the Drosophila melanogaster gene absent, small or homeotic discs 1 (ash1). // Genetics. 1994. V. 137. P. 1027−1038.
- Tsai C. and Gergen P. Pair-rule expression of the Drosophila fushi tarazu gene: a nuclear receptor response element mediates the opposing regulatory effects of runt and hairy. II Development. 1995. V. 121. P.453- 462.
- Tsukiyama T., Becker P.B. and Wu C. ATP-dependent nucleosome disruption at a heat-shock promotor mediated by binding of GAGA transcription factor. // Nature. 1994. V.367. P.525−532.
- Tsukiyama T., Daniel C., Tamkun J., and Wu C. ISWI, a member of the SWI2/SNF2 ATPase family, encodes the 140 kDa subunit of the nucleosome remodeling factor. // Cell. 1995. V.83. P. 1021−1026.
- Tsukiyama T. and Wu C. Purification and Properties of an ATP-dependent nucleosome remodeling factor. // Cell.1995. V.83. P.1011−1020.
- Tsukiyama T. and Wu C. Chromatin remodeling and transcription. // Curr. Opin. Genet. Dev. 1997. V.7. P. 182−191.
- Ura K., Kurumizaka H., Dimitrov S., Almouzni G. and Wolffe A.P. Histone acetylation: influence on transcription, nucleosome mobility and positioning, and linker histone-dependent transcriptional repression. // EMBO J.1997.V.16. P.2096−2107.
- Urness L.D. and Thummel C.S. Molecular analysis of a steroid-induced regulatory hierarchy: the Drosophila E74A protein directly regulate L71−6 transcription. // EMBO J.1995.V.14. P.6239−6246.
- Varga-Weizs P.D. and Becker P.B. Chromatin-remodeling factors: machines that regulate? / / Cur. Opin. Cell Biol. 1998. V. 10. P. 346−353.
- Varga-Weizs P.D., Blank T.A. and Becker P.B. Energy-dependent chromatin accessibility and nucleosome mobility in a cell-free system. // EMBO J. 1995. V.14. P.2209−2216.
- Varga-Weisz P.D., Wi! m M. and Bonte E. et al. Chromatin-remodeling factor CHRAC contains the ATPases ISWI and topoisomerase II. // Nature. 1997. V.388. P.598−602.
- Vinsent A., 0'Connel P., Gray M. and Rosbash M. Drosophila maternal and embryo mRNAs transcribed from a single transcription unit use alternate combinations of exons. // EMBO J. 1984V.3. P.1003−1013.
- Wakimoto B.T. Beyond the nucleosome: epigenetic aspects of position-effect variegation in Drosophila. II Cell 1998. V.93. P.321−324.
- Wall G., Varga-Weisz P.D., Sandaltzopoulos R. and Becker P.B. Chromatin remodeling by GAGA factor and heat shock factor at the hypersensitive Drosophila hsp26 promoter in vitro. II EMBO J. 1995. V.14. P. 1727−1736.
- Wallrath L.L. Unfolding the mysteries of heterochromatin. // Curr.Opin.Genet. Devel.1998. V.8. P. 147−153.
- Wallrath L.L. and Elgin S.C.R. Position effect variegation in Drosophila is associated with an altered chromatin structure. 11 Genes Dev. 1995. V.9. P.1263−1277.
- Walter J., Dever C.A. and Biggin M.D. Two homeo domain proteins bind with similar specificity to a wide range of DNA sites in Drosophila embryos. // Genes Dev. 1994. V.8. P. 1678−1692.
- Warrick J.M., Paulson H.L., Gray-Board G.L. et al. Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila. / / Cell. 1998. V.93. P.939−949
- Weber U., Siegel V. and Mlodzik M. pipsqueak encodes a novel nuclear protein required downstream of seven-up for the development of photoreceptors R3 and R4. // EMBO J. 1995. V.14. P.6247−6257.
- Weber J.A., Taxman D.J., Lu Q. and Gilmour D.S. Molecular architecture of the hsp70 promoter after deletion of the TATA box or the upstream regulation region. // Mol.Cell. Biol. 1997. V.17. P.3799−3808.
- Wilkins R.C. and Lis J.T. Dynamics of potentiation and activation: GAGA factor and its role in heat shock gene regulation. // Nucl. Acids Res. 1997. V.25. P.3963−3968.
- Wilkins R.C. and Lis J.T. GAGA factor binding to DNA via single trinucleotide sequence element. // Nucl. Acids Res. 1998. V.26. P.2672−2678.
- Wilkins R.C. and Lis J.T. DNA distortion and multimerization: novel functions of the glutamine-rich domain of GAGA factor. // J. Mol.Biol. 1999. V.285. P.515−525.
- Wolff R. A and Hull R. A rapid and easy method for DNA recovery from agarose gels using Wizard minicolumns. II Trends Genet. 1996. V.12. P.339−340.
- Wolffe A.P.and Pruss D. Targeting chromatin disruption: Transcription regulators that acetylate histones. // Cell. 1996. V.84. P.817−819.
- Xiong W.-C. and Montell C. tramtrack is a transcriptional repressor required for cell fate determitation in the Drosophila eye. // Genes Dev. 1993. V.7. P. 1085−1096.
- Yarfitz S., Provost N.M. and Hurley J.B. Cloning of a Drosophila melanogaster guanine nucleotide regulatory protein beta-subunit gene and characterization of its expression during development. // Proc.Natl.Acad.Sci.U S A. 1988. V.8. P.7134−7138.
- Zhang M.Q. Identification of human core-promoters in silico. II Genome Res. 1998. V.8. P.319−326.
- Zharkikh A., Rzhetsky A., Morozov P. et al. VOSTORG: package of microcomputer programs for sequence analysis and phylogenetic trees construction. / /Gene. 1991 .V. 101 .P.251 -254.
- Zink D. and Paro R. Drosophila polycomb-group regulated chromatin inhibits the accessibility of trans-activator to its target DNA. // EMBO J. 1995. V.14. P.5660−5671.