Структурная организация и особенности экспрессии генов CPLX2 и MAP1B, активно функционирующих в мозге человека
Диссертация
Изучение структурно-функциональных свойств генов и особенностей регуляции их экспрессии относится к числу наиболее актуальных направлений современной молекулярной биологии. К настоящему моменту определены полные нуклеотидные последовательности геномов нескольких сотен различных биологических объектов, включая человека. В связи с этим чрезвычайно важную роль стали играть компьютерные методы… Читать ещё >
Список литературы
- Буякова О.И., Баринова Е. И., Дергунова Л. В., Хаспеков Г. Л., Чивилев И. В., Лимборская СА. Выделение и анализ мозгоспецифических последовательностей из библиотек кДНК разных отделов мозга человека // Генетика. 1992. Т. 28. № 5. С. 40−6.
- Копанцев Е.П., Нестерова Т. Д., Бородин A.M., Закиян С. М. Создание картирующей панели гибридных клеток человек-грызун // Генетика. 1993. Т.29. № 9. С. 1440−1451.
- Маниатис Т., Фрич Э., Сэмбрук Дж. Молекулярное клонирование. Москва. Мир. 1984.
- Патрушев Л.И. Экспрессия генов. Москва. Наука. 2000.
- Свердлов Е.Д. Очерки современной молекулярной генетики по курсу лекций для студентов биологического факультета МГУ. Очерк 6. Генная терапия и медицина XXI века. Молекул, генет., микробиол., вирусол. 1996. № 4. С. 3.
- Сингер М., Берг П. Гены и геномы. Москва. Мир. 1998.
- Спирин А.С. Биосинтез белка: регуляция на уровне трансляции // Соросовский образовательный журнал. 2000. Т. 6. № 5. С. 2−7.
- Adams M.D., Soares M.B., Kerlavage A.R., Fields C., Venter J.C. Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library // Nature Genet. 1993. V. 4(4). P. 373−80.
- Aguilera G., Volpi S., Rabadan-Diehl C. Transcriptional and post-transcriptional mechanisms regulating the rat pituitary vasopressin Vlb receptor gene // J Mol Endocrinol. 2003. V. 30(2). P. 99−108. Review.
- Akashi M., Hachiya M., Koeffler H.P., Suzuki G. Irradiation increases levels of GM-CSF through RNA stabilization which requires an AU-rich region in cancer cells // Biochem Biophys Res Commun. 1992. V.189(2). P. 986−93.
- Akashi M., Shaw G., Hachiya M., Elstner E., Suzuki G., Koeffler P. Number and location of AUUUA motifs: role in regulating transiently expressed RNAs // Blood. 1994. V. 83(11). P. 3182−7.
- Arranz V., Kress M., Ernoult-Lange M. The gene encoding the MOK-2 zinc-finger protein: characterization of its promoter and negative regulation by mouse Alu type-2 repetitive elements // Gene. 1994. V. 149(2). P. 293−8.
- Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and function // Cell. 2004. V. 116(2). P. 281−97. Review.
- Bashirullah A., Cooperstock R.L., Lipshitz H.D. Spatial and temporal control of RNA stability// Proc Natl Acad Sci USA. 2001. V. 98(13). P. 7025−8. Review.
- Beckmann S.L., Chikaraishi D.M., Deeb S.S., Sueoka N. Sequence complexity of nuclear and cytoplasmic ribonucleic acids from clonal neurotumor cell lines and brain sections of the rat // Biochemistry. 1981. V. 20(9). P. 2684−92.
- Bender T.P., Kuehl W.M. Murine myb protooncogene mRNA: cDNA sequence and evidence for 5' heterogeneity // Proc Natl Acad Sci USA. 1986. V. 83(10). P. 3204−8.
- Benekli M., Baer M.R., Baumann H., Wetzler M. Signal transducer and activator of transcription proteins in leukemias // Blood. 2003. V. 101(8). P. 2940−54. Review.
- Bergsten S.E., Gavis E.R. Role for mRNA localization in translational activation but not spatial restriction of nanos RNA // Development. 1999. V. 26(4). P. 659−69.
- Birnboim H.C., Doly J. A rapid alkaline extraction procedure for screening recombinant plasmid DNA // Nucleic Acids Res. 1979. V. 7(6). P. 513−23.
- Brewer G. // An A+U-rich element RNA-binding factor regulates c-myc mRNA stability in vitro. Mol Cell Biol. 1991 May-l l (5):2460−6.
- Brown C.S., Goodwin P.C., Sorger P.K. Image metrics in the statistical analysis of DNA microarray data // Proc Natl Acad Sci USA. 2001. V. 98(16). P. 8944−9.
- Buck L., Stein R., Palazzolo M., Anderson D.J., Axel R. Gene expression and the diversity of identified neurons // Cold Spring Harb Symp Quant Biol. 1983. V. 48. P. 485−92.
- Budowle В., Chakraborty R., Giusti A.M., Eisenberg A.J., Allen R.C. Analysis of the VNTR locus D1S80 by the PCR followed by high-resolution PAGE // Am J Hum Genet. 1991. V. 48(1). P. 137−44.
- Chamizo C., Rubio J.M., Moreno J., Alvar J. Semi-quantitative analysis of multiple cytokines in canine peripheral blood mononuclear cells by a single tube RT-PCR // Vet Immunol Immunopathol. 2001. V. 83(3−4). P. 191−202.
- Chappell S.A., Edelman G.M., Mauro V.P. Biochemical and functional analysis of a 9-nt RNA sequence that affects translation efficiency in eukaryotic cells // Proc Natl Acad Sci USA. 2004. V. 101(26). P. 9590−4.
- Chen C.Y., Shyu A.B. AU-rich elements: characterization and importance in mRNA degradation // Trends Biochem Sci. 1995. V. 20(11). P. 465−70. Review.
- Chen Y., Kamat V., Dougherty E.R., Bittner M.L., Meltzer P. S., Trent J.M. Ratio statistics of gene expression levels and applications to microarray data analysis // Bioinformatics. 2002. V. 18(9). P. 1207−15.
- Chen C.Z., Li L., Lodish H.F., Bartel D.P. MicroRNAs modulate hematopoietic lineage differentiation. Science. 2004. V. 303(5654). P. 83−6.
- Chikaraishi D.M. Complexity of cytoplasmic polyadenylated and nonpolyadenylated rat brain ribonucleic acids //Biochemistry. 1979. V. 18(15). P. 3249−56.
- Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction//Anal Biochem. 1987. V. 162(1). P. 156−9.
- Clark A.R., Docherty K. Negative regulation of transcription in eukaryotes // Biochem J. 1993. V. 296. P. 521−41.
- Сок S.J., Morrison A.R. The 3'-untranslated region of murine cyclooxygenase-2 contains multiple regulatory elements that alter message stability and translational efficiency // J Biol Chem. 2001. V. 276(25). P. 23 179−85.
- Colantuoni C., Purcell A.E., Bouton C.M., Pevsner J. High throughput analysis of gene expression in the human brain // J Neurosci Res. 2000. V. 59(1). P. 1−10. Review.
- Costessi L., Devescovi G., Baralle F.E., Muro A.F. Brain-specific promoter and polyadenylation sites of the beta-adducin pre-mRNA generate an unusually long 3'-UTR //Nucleic Acids Res. 2006. V. 34(1). P. 243−53.
- Cottage A.J., Edwards Y.J., Elgar G. API genes in Fugu indicate a divergent transcriptional control to that of mammals // Mamm Genome. 2003. V. 14(8). P. 514−25.
- Creancier L., Mercier P., Prats A.C., Morello D. C-myc Internal ribosome entry site activity is developmentally controlled and subjected to a strong translational repression in adult transgenic mice // Mol Cell Biol. 2001. V. 21(5). P. 1833−40.
- Crosio C., Boyl P.P., Loreni F., Pierandrei-Amaldi P., Amaldi F. La protein has a positive effect on the translation of TOP mRNAs in vivo // Nucleic Acids Res. 2000. V. 28(15). P. 2927−34.
- Dahanukar A., Wharton R.P. The Nanos gradient in Drosophila embryos is generated by translational regulation // Genes Dev. 1996. V. 10(20). P. 2610−20.
- Datson N. A., van der Perk-de Jong J., van den Berg M.P., de Kloet E.R., Vreugdenhil E. MicroSAGE: a modified procedure for serial analysis of gene expression in limited amounts of tissue// Nucleic Acids Res. 1999. V. 27(5). P. 1300−7.
- Denli A.M., Tops B.J., Plasterk R.H., Ketting R.F., Hannon G.J. Processing of primary microRNAs by the Microprocessor complex // Nature. 2004. V. 432. P. 231−235.
- Dupays L., Mazurais D., Rucker-Martin C., Calmels Т., Bernot D., Cronier L., Malassine A., Gros D., Theveniau-Ruissy M. Genomic organization and alternative transcripts of the human Connexin40 gene // Gene. 2003. V. 305(1). P. 79−90.
- Duret L., Mouchiroud D., Gautier C. Statistical analysis of vertebrate sequences reveals that long genes are scarce in GC-rich isochors // J Mol Evol. 1995. V. 40(3). P. 308−17.
- Duthie S.M., Taylor P.L., Anderson L., Cook J., Eidne K.A. Cloning and functional characterization of the human TRH receptor // Mol. Cell Endocrinol. 1993. V. 95(1−2). P. 11−5.
- Eastwood S.L., Harrison P.J. Hippocampal synaptic pathology in schizophrenia, bipolar disorder and major depression: a study of complexin mRNAs // Mol Psychiatry. 2000. V. 5(4). P. 425−32.
- Ebihara M., Ohba H., Kikuchi M., Yoshikawa T. Structural characterization and promoter analysis of human potassium channel Kv8.1 (KCNV1) gene // Gene. 2004. V. 325. P.89−96.
- Eckhart L., Kittel C., Gawlas S., Gruber F., Mildner M., Jilma В., Tschachler E. Identification of a novel exon encoding the amino-terminus of the predominant caspase-5 variants // Biochem Biophys Res Commun. 2006. V. 348(2). P. 682−8.
- Edwardson J.M., Wang C.T., Gong В., Wyttenbach A., Bai J., Jackson M.B., Chapman E.R., Morton A J. Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II //J Biol Chem. 2003. V. 278(33). P. 30 849−53.
- Engels B.M., Hutvagner G. Principles and effects of microRNA-mediated post-transcriptional gene regulation// Oncogene. 2006. V. 25(46). P. 6163−9.
- Ernoult-Lange M., Kress M., Hamer D. A gene that encodes a protein consisting solely of zinc finger domains is preferentially expressed in transformed mouse cells // Mol Cell Biol. 1990. V. 10(1). P. 418−21.
- Fedorova L.V., Dizadex I., Fedorov A.N., Ryskov A.P. In silico analysis of the restriction fragments length distribution in the human genome // Genetika. 2001. V. 37(4). P. 456−66.
- Fernandez J., Yaman I., Mishra R., Merrick W.C., Snider M.D., Lamers W.H., Hatzoglou M. Internal ribosome entry site-mediated translation of a mammalian mRNA is regulated by amino acid availability// J Biol Chem. 2001. V. 276(15). P. 12 285−91.
- Fernandez-Miragall O., Martinez-Salas E. Structural organization of a viral IRES depends on the integrity of the GNRA motif// RNA. 2003. V. 9(11). P. 1333−44.
- Ferrandon D., Elphick L., Nusslein-Volhard C., St Johnston D. Staufen protein associates with the 3'UTR of bicoid mRNA to form particles that move in a microtubule-dependent manner//Cell. 1994. V. 79(7). P. 1221−32.
- Freeman W., Morton AJ. Differential messenger RNA expression of complexins in mouse brain // Brain Res Bull. 2004. V. 63(1). P. 33−44.
- Friday R.P., Pietropaolo S.L., Profozich J., Trucco M., Pietropaolo M. Alternative core promoters regulate tissue-specific transcription from the autoimmune diabetes-related ICA1 (ICA69) gene locus // J. Biol. Chem. 2003. V. 278(2). P. 853−63.
- Gallouzi I.E., Brennan C.M., Stenberg M.G., Swanson M.S., Eversole A., Maizels N., Steitz J.A. HuR binding to cytoplasmic mRNA is perturbed by heat shock // Proc Natl Acad Sci USA. 2000. V. 97(7). P. 3073−8.
- Gamberi C., Peterson D.S., He L., Gottlieb E. An anterior function for the Drosophila posterior determinant Pumilio//Development. 2002. V. 129(11). P. 2699−710.
- Geek P., Medveczky M.M., Chou C.S., Brown A., Cus J., Medveczky P.G. Herpesvirus saimiri small RNA and interleukin-4 mRNA AUUUA repeats compete for sequence-specific factors including a novel 70K protein // J Gen Virol. 1994. V. 75. P. 2293−301.
- Gill R.W., Hodgman T.C., Littler C.B., Oxer M.D., Montgomery D.S., Taylor S., Sanseau P. A new dynamic tool to perform assembly of expressed sequence tags (ESTs) // Comput Appl Biosci. 1997. V. 13(4). P. 453−7.
- Gill R.W., Sanseau P. Rapid in silico cloning of genes using expressed sequence tags (ESTs) // Biotechnol Annu Rev. 2000. V. 5. P. 25−44. Review.
- Gillis P., Malter J.S. The adenosine-uridine binding factor recognizes the AU-rich elements of cytokine, Iymphokine, and oncogene mRNAs // J Biol Chem. 1991. V. 266(5). P. 3172−7.
- Ginsberg S.D., Hemby S.E., Lee V.M., Eberwine J.H., Trojanowski J.Q. Expression profile of transcripts in Alzheimer’s disease tangle-bearing CA1 neurons // Ann Neurol.2000. V. 48(1). P. 77−87.
- Glynn D., Bortnick R.A., Morton A.J. Complexin II is essential for normal neurological function in mice // Hum Mol Genet. 2003. V. 12(19). P. 2431−48.
- Good P.J. A conserved family of elav-like genes in vertebrates // Proc Natl Acad Sci U S A. 1995. V. 92(10). P. 4557−61.
- Gong M., Cowan K.H., Gudas J., Moscow J.A. Isolation and characterization of genomic sequences involved in the regulation of the human reduced folate carrier gene (RFC1) // Gene. 1999. V. 233(1−2). P. 21−31.
- Gordon-Weeks P.R., Fischer I. MAP1B expression and microtubule stability in growing and regenerating axons // Microsc Res Tech. 2000. V. 48(2). P. 63−74. Review.
- Gosden R.G. Oogenesis as a foundation for embryogenesis // Mol Cell Endocrinol. 2002. V. 186(2). P. 149−53. Review.
- Grabowski P.J., Black D.L. Alternative RNA splicing in the nervous system // Prog Neurobiol. 2001. V. 65(3). P. 289−308. Review.
- Gray N.K., Wickens M. Control of translation initiation in animals // Annu Rev Cell Dev Biol. 1998. V. 14. P. 399−458. Review.
- Gregory R.I., Chendrimada T.P., Shiekhattar R. MicroRNA biogenesis: isolation and characterization of the microprocessor complex // Methods Mol Biol. 2006. V. 342. P. 33−47. Review.
- Groisman I., Huang Y.S., Mendez R., Cao Q., Richter J.D. Translational control of embryonic cell division by CPEB and maskin // Cold Spring Harb Symp Quant Biol.2001. V. 66. P. 345−51. Review.
- Guigo R., Knudsen S., Drake N., Smith T. Prediction of gene structure // J Mol Biol. 1992. V. 226(1). P. 141−57.
- Hamilton T.L., Stoneley M., Spriggs K.A., Bushell M. TOPs and their regulation // Biochem Soc Trans. 2006. V. 34(1). P. 12−6.
- Hammarback J.A., Obar R.A., Hughes S.M., Vallee R.B. MAP1B is encoded as a polyprotein that is processed to form a complex N-terminal microtubule-binding domain //Neuron. 1991. V. 7(1). P. 129−39.
- Harrison P.M., Arosio P. The ferritins: molecular properties, iron storage function and cellular regulation // Biochim Biophys Acta. 1996. V. 1275(3). P, 161−203. Review.
- Henics Т., Sanfridson A., Hamilton B.J., Nagy E., Rigby W.F. Enhanced stability of interleukin-2 mRNA in MLA 144 cells. Possible role of cytoplasmic AU-rich sequence-binding proteins // J Biol Chem. 1994. V. 269(7). P. 5377−83.
- Holcik M., Sonenberg N., Korneluk R.G. Internal ribosome initiation of translation and the control of cell death // Trends Genet. 2000. V. 16(10). P. 469−73.
- Hollams E.M., Giles K.M., Thomson A.M., Leedman PJ. MRNA stability and the control of gene expression: implications for human disease // Neurochem Res. 2002. V. 27(10). P. 957−80.
- Hong Y.K., Ontiveros S.D., Strauss W.M. A revision of the human XIST gene organization and structural comparison with mouse Xist // Mamm Genome. 2000. V. 11(3). P. 220−4.
- Huggett J., Dheda K., Bustin S., Zumla A. Real-time RT-PCR normalisation- strategies and considerations // Genes Immun. 2005. V. 6(4). P. 279−84.
- Hutvagner G., McLachlan J., Pasquinelli A.E., Balint E., Tuschl Т., Zamore P.D. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA // Science. 2001. V. 293(5531). P. 834−8.
- Iacono M., Mignone F., Pesole G. uAUG and uORFs in human and rodent 5'-untranslated mRNAs // Gene. 2005. V. 349. P. 97−105.
- Ishizuka Т., Saisu H., Odani S., Abe T. Synaphin: a protein associated with the docking/fusion complex in presynaptic terminals // Biochem Biophys Res Commun. 1995. V. 213(3). P. 1107−14.
- Ishizuka Т., Saisu H., Odani S., Kumanishi Т., Abe T. Distinct regional distribution in the brain of messenger RNAs for the two isoforms of synaphin associated with the docking/fusion complex //Neuroscience. 1999. V. 88(1). P. 295−306.
- Ishizuka Т., Saisu H., Suzuki Т., Kirino Y., Abe T. Molecular cloning of synaphins/complexins, cytosolic proteins involved in transmitter release, in the electric organ of an electric ray (Narke japonica) // Neurosci Lett. 1997. V. 232(2). P. 107−10.
- Ish-Horowicz D., Burke J.F. Rapid and efficient cosmid cloning // Nucleic Acids Res. 1981. V. 9(13). P. 2989−98.
- Itakura M., Misawa H., Sekiguchi M., Takahashi S., Takahashi M. Transfection analysis of functional roles of complexin I and II in the exocytosis of two different types of secretory vesicles // Biochem Biophys Res Commun. 1999. V. 265(3). P. 691−6.
- Jansen R.P. mRNA localization: message on the move // Nat Rev Mol Cell Biol. 2001. V. 2(4). P. 247−56. Review.
- Jensen L.E., Whitehead A.S. The 3' untranslated region of the membrane-bound IL-1R accessory protein mRNA confers tissue-specific destabilization // J Immunol. 2004. V. 173(10). P. 6248−58.
- Jin X., Turcott E., Englehardt S., Mize G.J., Morris D.R. The two upstream open reading frames of oncogene mdm2 have different translational regulatory properties // J Biol Chem. 2003. V. 278(28). P. 25 716−21.
- Joseph R., Dou D., Tsang W. Molecular cloning of a novel mRNA (neuronatin) that is highly expressed in neonatal mammalian brain // Biochem Biophys Res Commun. 1994. V. 201(3). P. 1227−34.
- Kaplan B.B., Schachter B.S., Osterburg H.H., de Vellis J.S., Finch C.E. Sequence complexity of polyadenylated RNA obtained from rat brain regions and cultured rat cells of neural origin // Biochemistry. 1978. V. 17. P. 5516−24.
- Kikuchi Т., Ichikawa M., Arai J., Tateiwa H., Fu L., Higuchi K., Yoshimura N. Molecular cloning and characterization of a new neuron-specific homologue of rat polypyrimidine tract binding protein // J Biochem (Tokyo). 2000. V.128(5). P. 811−21.
- Kim H.Y., Gladyshev V.N. Alternative first exon splicing regulates subcellular distribution of methionine sulfoxide reductases // BMC Mol Biol. 2006.V. 7. P. 11.
- Kim S.H., Shim K.S., Lubec G. Human brain nascent polypeptide-associated complex alpha subunit is decreased in patients with Alzheimer’s disease and Down syndrome // J Investig Med. 2002. V. 50(4). P. 293−301.
- Kim S.Y., Chao W., Choi S.Y., Volsky D.J. Cloning and characterization of the 3'-untranslated region of the human excitatory amino acid transporter 2 transcript // J Neurochem. 2003. V. 86(6). P. 1458−67.
- Kim Y.U., Rus H.G., Fisher S.N., Pitha P.M., Shin M.L. Binding of a protein to an AU-rich domain of tumour necrosis factor alpha mRNA as a 35 kDa complex and its regulation in primary rat astrocytes // Biochem J. 1996. V. 316. P. 455−60.
- Kohler S.A., Henderson B.R., Kuhn L.C. Succinate dehydrogenase b mRNA of Drosophila melanogaster has a functional iron-responsive element in its 5-untranslated region // J Biol Chem. 1995. V. 270(51). P. 30 781−6.
- Kojima M., Morozumi Т., Onishi A., Mitsuhashi T. Structure of the pig sterol 14alpha-demethylase (CYP51) gene and its expression in the testis and other tissues // J Biochem (Tokyo). 2000. V. 127(5). P. 805−11.
- Kotite L., Zhang L.H., Yu Z., Burlingame A.L., Havel R.J. Human apoC-IV: isolation, characterization, and immunochemical quantification in plasma and plasma lipoproteins // J Lipid Res. 2003. V. 44(7). P. 1387−94.
- Kozak M. An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
- Nucleic Acids Res. 1987. V. 15(20). P. 8125−48. Review.
- Kozak M. Context effects and inefficient initiation at non-AUG codons in eucaryotic cell-free translation systems // Mol. Cell. Biol. 1989. V. 9. P. 5073−80.
- Kozak M. Initiation of translation in prokaryotes and eukaryotes // Gene. 1999. V. 234(2). P. 187−208. Review.
- Kozak M. Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes // Cell. 1986. V. 44. P. 283−92.
- Kozak M. The scanning model for translation: an update // J Cell Biol. 1989. V. 108(2). P. 229−41. Review.
- Kuersten S., Goodwin E.B. The power of the 3' UTR: translational control and development // Nat Rev Genet. 2003. V. 4(8). P. 626−37. Review.
- Kutschera W., Zauner W., Wiche G., Propst F. The mouse and rat MAP1B genes: genomic organization and alternative transcription // Genomics. 1998. V. 49(3). P. 4306.
- Lachance P.E., Chaudhuri A. Microarray analysis of developmental plasticity in monkey primary visual cortex // J Neurochem. 2004. V. 88(6). P. 1455−69.
- Lai E.C., Burks C., Posakony J.W. The К box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts // Development. 1998. V. 125(20). P. 4077−88.
- Lai E.C., Posakony J.W. The Bearded box, a novel 3' UTR sequence motif, mediates negative post-transcriptional regulation of Bearded and Enhancer of split Complex gene expression//Development. 1997. V. 124(23). P. 4847−56.
- Lai E.C., Tarn В., Rubin G.M. Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs // Genes Dev. 2005. V. 19(9). P. 1067−80.
- Lantz V., Schedl P. Multiple cis-acting targeting sequences are required for orb mRNA localization during Drosophila oogenesis // Mol Cell Biol. 1994. V. 14(4). P. 2235−42.
- Le S.Y., Maizel J.V. A common RNA structural motif involved in the internal initiation of translation of cellular mRNAs // Nucleic Acids Res. 1997. V. 25(2). P. 362−69.
- Lee C.J., Chan W.I., Scotting P.J. CIC, a gene involved in cerebellar development and ErbB signaling, is significantly expressed in medulloblastomas // J Neurooncol. 2005. V. 73(2). P. 101−8.
- Lee J., Park E.H., Couture G., Harvey I., Garneau P., Pelletier J. An upstream open reading frame impedes translation of the huntingtin gene // Nucleic Acids Res. 2002. V. 30(23). P. 5110−9.
- Leibold E.A. and Guo B. Iron-dependent regulation of ferritin and transferrin receptor expression by iron responsive element binding protein // Annu Rev Nutr. 1992. V. 12. P. 345−68. Review.
- Leviten M.W., Posakony J.W. Gain-of-function alleles of Bearded interfere with alternative cell fate decisions in Drosophila adult sensory organ development // Dev Biol. 1996. V. 176(2). P. 264−83.
- Levy A.P., Levy N.S., Goldberg M.A. Post-transcriptional regulation of vascular endothelial growth factor by hypoxia // J Biol Chem. 1996. V. 271(5). P. 2746−53.
- Liang P., Pardee A. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction // Science. 1992. V. 257(5072). P. 967−71.
- Lien, L.L., Feener С.A., Fischbach N and Kunkel L.M. Cloning of human microtubule-associated protein IB and the identification of a related gene on chromosome 15 // Genomics. 1994. V. 22(2). P. 273−80.
- Lipshitz H.D., Smibert C.A. Mechanisms of RNA localization and translational regulation // Curr Opin Genet Dev. 2000. V. 10(5). P. 476−88. Review.
- Liu D., Fischer I. Isolation and sequencing of the 5' end of the rat microtubule-associated protein (MAPlB)-encoding cDNA // Gene. 1996. V. 171(2). P. 307−8.
- Liu D., Fischer I. Two alternative promoters direct neuron-specific expression of the rat microtubule-associated protein IB gene // J Neurosci. 1996. V. 16(16). P. 5026−36.
- Lo D., Hilbush В., Sutcliffe J.G. TOGA analysis of gene expression to accelerate target development//Eur J PharmSci. 2001. V. 14(3). P. 191−6.
- Locatelli F., Magnani E., Vighi C., Lanzanova C., Coraggio I. Inhibitory effect of myb7 uORF on downstream gene expression in homologous (rice) and heterologous (tobacco) systems // Plant Mol Biol. 2002. V. 48(3). P. 309−18.
- Lopez de Heredia M., Jansen R.P. mRNA localization and the cytoskeleton // Curr Opin Cell Biol. 2004. V. 16(1). P. 80−5. Review.
- Macdonald P.M., Kerr K., Smith J.L., Leask A. RNA regulatory element BLE1 directs the early steps of bicoid mRNA localization // Development. 1993. V. 118(4). P. 123 343.
- Mandel S., Weinreb O., Youdim M.B. Using cDNA microarray to assess Parkinson’s disease models and the effects of neuroprotective drugs // Trends Pharmacol Sci. 2003. V. 24(4). P. 184−91. Review.
- Mann S.S., Hammarback J.A. Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP IB // J Biol Chem. 1994. V. 269(15). P. 11 492−7.
- Martinez-Salas E., Ramos R., Lafuente E., Lopez de Quinto S. Functional interactions in internal translation initiation directed by viral and cellular IRES elements // J Gen Virol. 2001. V. 82. P. 973−84. Review.
- Mazumder В., Seshadri V., Fox P.L. Translational control by the З'-UTR: the ends specify the means // Trends Biochem Sci. 2003. V. 28(2). P. 91−8. Review.
- McClelland M., Mathieu-Daude F., Welsh J. RNA fingerprinting and differential display using arbitrarily primed PCR//Trends Genet. 1995. V. 11. P. 242−6.
- McMahon H.T., Missler M., Li C., Sudhof T.C. Complexins: cytosolic proteins that regulate SNAP receptor function // Cell. 1995. V. 83(1). P. 111−9.
- Mei В., Li C., Dong S., Jiang C.H., Wang H., Hu Y. Distinct gene expression profiles in hippocampus and amygdala after fear conditioning // Brain Res Bull. 2005. V. 67(1−2). P. 1−12.
- Meijer H.A., Thomas A.A. Control of eukaryotic protein synthesis by upstream open reading frames in the 5'-untranslated region of an mRNA // Biochem J. 2002. V. 367. P. 1−11. Review.
- Meixner A., Wiche G., Propst F. Analysis of the mouse MAP1B gene identifies a highly conserved 4.3 kb 3'-untranslated region and provides evidence against the proposed structure of DBI-1 cDNA // Biochim Biophys Acta. 1999. V. 1445(3). P. 345−50.
- Mendez R., Richter J.D. Translational control by CPEB: a means to the end // Nat Rev Mol Cell Biol. 2001. V. 2(7). P. 521−9. Review.
- Meric F., Searfoss A.M., Wormington M., Wolffe A.P. Masking and unmasking maternal mRNA. The role of polyadenylation, transcription, splicing, and nuclear history // J Biol Chem. 1996. V. 271(48). P. 30 804−10.
- Meyuhas O. Synthesis of the translational apparatus is regulated at the translational level // Eur J Biochem. 2000. V. 267(21). P. 6321−30. Review.
- Mignone F., Gissi C., Liuni S., Pesole G. Untranslated regions of mRNAs // Genome Biol. 2002. V. 3(3). Review.
- Milanesi L., D’Angelo D., Rogozin I.B. GeneBuilder: interactive in silico prediction of gene structure//Bioinformatics. 1999. V. 15(7−8). P. 612−21.
- Milner R.J. and Sutcliffe J.G. Gene expression in rat brain // Nucleic Acids Res. 1983. V. 11(16). P. 5497−520.
- Milner R.J., Bloom F.E., Sutcliffe J.G. Brain-specific genes: strategies and issues // Curr Top Dev Biol. 1987. V. 21. P. 117−50. Review.
- Mirnick К., Middleton F.A., Marquez A., Lewis D.A., Levitt P. Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex // Neuron. 2000. V. 28(1). P. 53−67.
- Missler M., Sudhof T.C. Neurexins: three genes and 1001 products // Trends Genet. 1998. V. 14(1). P. 20−6. Review.
- Muller W.E., Slor H., Pfeifer K., Huhn P., Век A., Orsulic S., Ushijima H., Schroder H.C. Association of AUUUA-binding protein with A+U-rich mRNA during nucleo-cytoplasmic transport // J Mol Biol. 1992. V. 226(3). P. 721−33.
- Murphy L.D., Herzog C.E., Rudick J.B., Fojo A.T., Bates S.E. Use of the polymerase chain reaction in the quantitation of mdr-1 gene expression // Biochemistry. 1990. V. 29(45). P. 10 351−6.
- Musunuru K. Cell-specific RNA-binding proteins in human disease // Trends Cardiovasc Med. 2003. V. 13(5). P.188−95.
- Myer V.I., Fan X.N., Steitz J.A. Identification of Hur as a protein implicated in AUUUA-mediated mRNA decay// EMBO J. 1997. V. 16(8). P. 2130−9.
- Nagy E. and Rigby W.F. Glyceraldehyde-3-phosphate dehydrogenase selectively binds AU-rich RNA in the NAD (+)-binding region (Rossmann fold) // J. Biol. Chem. 1995. V. 270(6). P. 2755−63.
- Narayanan C.S., Fujimoto J., Geras-Raaka E., Gershengorn M.C. Regulation by thyrotropin-releasing hormone (TRH) of TRH receptor mRNA degradation in rat pituitary GH3 cell // J. Biol. Chem. 1992. V. 267(24). P. 17 296−303.
- Nave A., Kashi Y., Soller M. Minisatellite and microsatellite length variation at a complex bovine VNTR locus // Anim Genet. 1997. V. 28(1). P. 52−4.
- Noble M., Lewis S.A., Cowan N.J. The microtubule binding domain of microtubule-associated protein MAP1B contains a repeated sequence motif unrelated to that of MAP2 and tau // J Cell Biol. 1989. V. 109. P. 3367−76.
- Noh S.J., Lee K., Paik H., Hur C.G. TISA: Tissue-specific Alternative Splicing in Human and Mouse Genes // DNA Res. 2006. V. 13(5). P. 229−43
- Okano H., Imai Т., Okabe M. Musashi: a translational regulator of cell fate // J Cell Sci. 2002. V. 115. P. 1355−9. Review.
- Ostareck D.H., Ostareck-Lederer A., Shatsky I.N., Hentze M.W. Lipoxygenase mRNA silencing in erythroid differentiation: The 3'UTR regulatory complex controls 60S ribosomal subunit joining// Cell. 2001. V. 104(2). P. 281−90.
- Ostareck-Lederer A., Ostareck D.H. Control of mRNA translation and stability in haematopoietic cells: the function of hnRNPs К and E1/E2 // Biol Cell. 2004. V. 96(6). P. 407−11. Review.
- Ouchi Y., Kubota Y., Ito C. Serial analysis of gene expression in methamphetamine-and phencyclidine-treated rodent cerebral cortices: are there common mechanisms? // Ann N Y Acad Sci. 2004. V. 1025. P. 57−61.
- Pabst S., Hazzard J.W., Antonin W., Sudhof T.C., Jahn R., Rizo J., Fasshauer D. Selective interaction of complexin with the neuronal SNARE complex. Determination of the binding regions // J Biol Chem. 2000. V. 275(26). P. 19 808−18.
- Pandey A., Lewitter F. Nucleotide sequence databases: a gold mine for biologists // Trends Biochem Sci. 1999. V. 24(7). P. 276−80.
- Pelletier J., Kaplan G., Racaniello V.R., Sonenberg N. Cap-independent translation of poliovirus mRNA is conferred by sequence elements within the 5' noncoding region // Cell Biol. 1988. V. 8(3). P. 1103−12.
- Peng S.S., Chen C.Y., Shyu A.B. Functional characterization of a non-AUUUA AU-rich element from the c-jun proto-oncogene mRNA: evidence for a novel class of AU-rich elements //Mol Cell Biol. 1996. V. 16(4). P. 1490−9.
- Pesole G., Bernardi G., Saccone C. Isochore specificity of AUG initiator context of human genes // FEBS Lett. 1999. V. 464(1−2). P. 60−2.
- Pesole G., Mignone F., Gissi C., Grillo G., Licciulli F., Liuni S. Structural and functional features of eukaryotic mRNA untranslated regions // Gene. 2001. V. 276(1−2). P. 73−81. Review.
- Petrik J. Diagnostic applications of microarrays // Transfus Med. 2006. V. 16(4). P. 23 347. Review.
- Plant M.H., Laneuville 0. Characterization of a novel transcript of prostaglandin endoperoxide H synthase 1 with a tissue-specific profile of expression // Biochem J. 1999. V. 344. P. 677−85.
- Pongrac J., Middleton F.A., Lewis D.A., Levitt P., Mimics K. Gene expression profiling with DNA microarrays: advancing our understanding of psychiatric disorders // Neurochem Res. 2002. V. 27(10). P. 1049−63. Review.
- Reimann I., Huth A., Thiele H., Thiele B.J. Suppression of 15-lipoxygenase synthesis by hnRNP El is dependent on repetitive nature of LOX mRNA З'-UTR control element DICE // J Mol Biol. 2002. V. 315(5). P. 965−74.
- Rhyner T.A., Biguet N.F., Berrard S., Borbely A.A., Mallet J. An efficient approach for the selective isolation of specific transcripts from complex brain mRNA populations // J Neurosci Res. 1986. V. 16(1). P. 167−81.
- Richardson D.R. and Ponka P. The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells // Biochim. Biophys. Acta. 1997. V. 1331(1). P. 1−40.
- Rieger P.T. The role of oncology nurses in gene therapy // Lancet Oncol. 2001. V. 2(4). P. 233−8.
- Roberts G.C., Smith C.W. Alternative splicing: combinatorial output from the genome // Curr Opin Chem Biol. 2002. V. 6(3). P. 375−83.
- Rogozin I.B., Kochetov A.V., Kondrashov F.A., Koonin E.V., Milanesi L. Presence of ATG triplets in 5' untranslated regions of eukaryotic cDNAs correlates with a 'weak' context of the start codon // Bioinformatics. 2001. V. 17(10). P. 890−900.
- Rougvie A.E. Control of developmental timing in animals // Nat Rev Genet. 2001. V. 2(9). P. 690−701. Review.
- Ryan M., Starkey M., Faull R., Emson P., Bahn S. Indexing-based differential display -studies on post-mortem Alzheimer’s brains // Brain Res Mol Brain Res. 2001. V. 88(1−2). P. 199−202.
- Sartorius L.J., Nagappan G., Lipska B.K., Lu В., Sei Y., Ren-Patterson R., Li Z., Weinberger D.R., Harrison P.J. Alternative splicing of human metabotropic glutamate receptor 3 // J Neurochem. 2006. V. 96(4). P. 1139−48.
- Shao Y., Ismail-Beigi F. Different Na, K-ATPase mRNA (betal) species exhibit unique translational efficiencies // Arch Biochem Biophys. 2001. V. 390(1). P. 78−86.
- Shilling P.D., Kelsoe J.R. Functional genomics approaches to understanding brain disorders // Pharmacogenomics. 2002. V. 3(1). P. 31−45. Review.
- Schuur E.R., McPherson L.A., Yang G.P., Weigel RJ. Genomic structure of the promoters of the human estrogen receptor-alpha gene demonstrate changes in chromatin structure induced by AP2gamma// J Biol Chem. 2001. V. 276(18). P. 15 519−26.
- Siu I.M., Lai A., Blankenship J.R., Aldosari N., Riggins GJ. c-Myc promoter activation in medulloblastoma // Cancer Res. 2003. V. 63(16). P. 4773−6.
- Slack F.J., Basson M., Liu Z., Ambros V., Horvitz H.R., Ruvkun G. The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor// Mol Cell. 2000. V. 5(4). P. 659−69.
- Smale S.T. Core promoters: active contributors to combinatorial gene regulation // Genes Dev. 2001. V. 15(19). P. 2503−8. Review.
- Stayner S.K., Cunliffe H.E., Ward T.A., Eccles M.R. Cloning and characterization of the human PAX2 promoter // J Biol Chem. 1998. V. 273(39). P. 25 472−9.
- Stein I., Itin A., Einat P., Skaliter R., Grossman Z., Keshet E. Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia //Mol Cell Biol. 1998. V. 18(6). P. 3112−9.
- Stone D.M., Nikolics K. Tissue- and age-specific expression patterns of alternatively spliced agrin mRNA transcripts in embryonic rat suggest novel developmental roles // J Neurosci. 1995. V. 15(10). P. 6767−78.
- Stutz A., Conne В., Huarte J., Gubler P., Volkel V., Flandin P., Vassalli J.D. Masking, unmasking, and regulated polyadenylation cooperate in the translational control of a dormant mRNA in mouse oocytes // Genes Dev. 1998. V. 12(16). P. 2535−48.
- Sutcliffe J.G. mRNA in the mammalian central nervous system // Annu Rev Neurosci. 1988. V. 11. P. 157−98. Review.
- Sutcliffe J.G. Open-system approaches to gene expression in the CNS // J Neurosci. 2001. V. 21(21). P. 8306−9. Review.
- Sweeney R., Fan Q., Yao M.C. Antisense ribosomes: rRNA as a vehicle for antisense RNAs // Proc Natl Acad Sci USA. 1996. V. 93(16). P. 8518−23.
- Takahashi Y. Gene expression in cells of the central nervous system // Prog Neurobiol. 1992. V. 38(6). P. 523−69. Review.
- Takahashi S., Ujihara H., Huang G.Z., Yagyu K.I., Sanbo M., Kaba H, Yagi T. Reduced hippocampal LTP in mice lacking a presynaptic protein: complexin II // Eur J Neurosci. 1999. V. 11(7). P. 2359−66.
- Theil E.C. and Eisenstein R.S. Combintorial mRNA regulation: iron regulatory proteins and iso-iron-responsive elements (Iso-IREs) // J. Biol. Chem. 2000. V. 275(52). P. 40 659−62.
- Thiele B.J., Berger M., Huth A., Reimann I., Schwarz K., Thiele H. Tissue-specific translational regulation of alternative rabbit 15-lipoxygenase mRNAs differing in their 3'-untranslated regions // Nucleic Acids Res. 1999. V. 27(8). P. 1828−36.
- Thomson A.M., Rogers J.T., Leedman P.J. Iron regulatory proteins, iron-responsive elements and ferritin mRNA translation // Int. J. Biochem. Cell Biol. 1999. V. 31(10). P. 1139−52. Review.
- Thyagarajan A., Szaro B.G. Phylogenetically conserved binding of specific К homology domain proteins to the 3'-untranslated region of the vertebrate middle neurofilament mRNA // J Biol Chem. 2004. V. 279(48). P. 49 680−8.
- Timchenko N.A., Welm A.L., Lu X., Timchenko L.T. CUG repeat binding protein (CUGBP1) interacts with the 5' region of C/EBPbeta mRNA and regulates translation of C/EBPbeta isoforms // Nucleic Acids Res. 1999. V. 27(22). P. 4517−25.
- Tranque P., Ни M.C., Edelman G.M., Mauro V.P. rRNA complementarity within mRNAs: a possible basis for mRNA-ribosome interactions and translational control // Proc Natl Acad Sci USA. 1998. V. 95(21). P. 12 238−43.
- Vagner S., Galy В., Pyronnet S. Irresistible IRES. Attracting the translation machinery to internal ribosome entry sites // EMBO Rep. 2001. V. 2(10). P. 893−8. Review.
- Van der Velden A.W., Thomas A.A. The role of the 5' untranslated region of an mRNA in translation regulation during development // Int J Biochem Cell Biol. 1999. V. 31(1). P. 87−106. Review.
- Vandecandelaere A., Pedrotti В., Utton M.A., Calvert R.A., Bayley P.M. Differences in the regulation of microtubule dynamics by micro tubule-associated proteins MAP IB and MAP2 // Cell Motil Cytoskeleton. 1996. V. 35(2). P. 134−46.
- Velculescu V.E., Vogelstein В., Kinzler K.W. Analysing uncharted transcriptomes with SAGE // Trends Genet. 2000. V. 16. P. 423−5.
- Velculescu V.E., Zhang L., Vogelstein В., Kinzler K.W. Serial analysis of gene expression // Science. 1995. V. 270(5235). P. 484−7.
- Walter M.A., Spillett D.J., Thomas P., Weissenbach J., Goodfellow P.N. A method for constructing radiation hybrid maps of whole genomes // Nat Genet. 1994. V. 7(1). P. 228.
- Whitney L.W., Becker K.G., Tresser N.J., Caballero-Ramos C.I., Munson P.J., Prabhu V.V., Trent J.M., McFarland H.F., Biddison W.E. Analysis of gene expression in mutiple sclerosis lesions using cDNA microarrays // Ann Neurol. 1999. V. 46(3). P. 425−8.
- Wickens M., Bernstein D.S., Kimble J., Parker R. A PUF family portrait: 3'UTR regulation as a way of life // Trends Genet. 2002. V. 18(3). P. 150−7. Review.
- Wilkie G., Dickson K.S., Gray N.K. Regulation of mRNA translation by 5'- and 3'-UTR-binding factors // Trends Biochem Sci. 2003. V. 28(4). P. 182−8. Review.
- Wilson K.E., Ryan M.M., Prime J.E., Pashby D.P., Orange P.R., O’Beirne G., Whateley J.G., Bahn S., Morris C.M. Functional genomics and proteomics: application in neurosciences // J Neurol Neurosurg Psychiatry. 2004. V. 75(4). P. 529−38. Review.
- Wilson Т., Treisman R. Removal of poly (A) and consequent degradation of c-fos mRNA facilitated by 3' AU-rich sequences // Nature. 1988. V. 336(6197). P. 396−9.
- Wood T.L., Frantz G.D., Menkes J.H., Tobin A.J. Regional distribution of messenger RNAs in postmortem human brain // J Neurosci Res. 1986. V. 16(1). P. 311−24.
- Wormington M. Unmasking the role of the 3' UTR in the cytoplasmic polyadenylation and translational regulation of maternal mRNAs // Bioessays. 1994. V. 16(8). P. 533−5. Review.
- Wyse B.D., Linas S.L., Thekkumkara T. J, Functional role of a novel cis-acting element (GAGA box) in human type-1 angiotensin II receptor gene transcription // J Mol Endocrinol. 2000. V. 25(1). P. 97−108.
- Yamada N., Yamaya M., Okinaga S., Nakayama K., Sekizawa K., Shibahara S., Sasaki H. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema // Am J Hum Genet. 2000. V. 66(1). P. 187−95.
- Zauner W., Kratz J., Staunton J., Feick P., Wiche G. Identification of two distinct microtubule binding domains on recombinant rat MAP IB // Eur J Cell Biol. 1992. V. 57(1). P. 66−74.
- Хочу выразить глубокую благодарность заведующей Отделом молекулярных основ генетики человека, профессору Светлане Андреевне Лимборской за предоставленную возможность выполнения научной работы и мудрое руководство.
- Отдельное спасибо хочу сказать доктору биологических наук Петру Андреевичу Сломинскому и кандидату биологических наук Ирине Владыченской за все ценные советы и замечания, сделанные ими в ходе работы, готовность в любую минуту оказать помощь.
- Сердечное спасибо Обориной М. В., Дмитриевой В. Г., Ставчанскому В. В. за их неоспоримый вклад в проведенные исследования, а также всем сотрудникам Отдела за доброжелательное отношение и понимание.