Цитокинпродуцирующая функция клеток и цитокины сыворотки крови при колоректальном раке
Диссертация
Согласно современным представлениям о взаимодействии злокачественного новообразования с факторами, обеспечивающими гомеостаз организма, антигены опухолевых клеток, хотя и распознаются иммунной системой (Crimeen-Irwin В. et al., 2005; Casiano С.А. et al., 2006; Ostrand-Rosenberg S., 2008), которая, тем не менее, не осуществляет элиминацию трансформированных клеток так как, реакции, направленные… Читать ещё >
Список литературы
- Абелев, Г. И. На пути к пониманию природы рака / Г. И. Абелев, Т. Л. Эрайзер // Биохимия. — 2008. — Т. 73. — № 5. — С. 605−618.
- Автандилов, Г. Г. Медицинская морфометрия / Автандилов Г. Г. -М.: Медицина, 1990. 382 с.
- Аутеншлюс, А.И. Содержание цитокинов IL-ip, TNF-a и уровни антител к TNF-a у больных с онкологическими и воспалительными заболеваниями / А. И. Аутеншлюс, А. Н. Шкунов, Г. Г. Иванова и др. // Цитокины и воспаление. 2005. — Т. 4. — № 3. — С. 11−15.
- Аутеншлюс, А.И. Содержание цитокинов и антител к ФНО a у больных раком молочной железы и фиброаденоматозом / А. И. Аутеншлюс, Г. Г. Иванова, C.B. Сидоров и др. // Иммунология. — 2003. — № 3. — С. 140−142.
- Галактионов, В.Г. Иммунология : учебник для студентов вузов / В. Г. Галактионов. 3-е изд., перераб. и доп. — М.: Академия, 2004. — 528 с.
- Гланц, С. Медико-биологическая статистика / С. Гланц — пер. Ю. А. Данилова — под ред. Н. Е. Бузикашвили, Д. В. Самойлова М.: Практика, 1999.-459 с.
- Гранов, A.M. Канцерогенез и иммунобиология опухоли. Функциональные и клинические аспекты / A.M. Гранов, О. Е. Молчанов // Вопросы онкологии. 2008. — Т. 54. — № 4. — С. 401−409.
- Громова, А.Ю. Полиморфизм генов семейства IL-1 человека / А. Ю. Громова, А. С. Симбирцев // Цитокины и воспаление. 2005. — Т. 4. — № 2.-С. 3−12.
- Давыдов М. И. Аксель Е.М. Статистика злокачественных новообразований в России и странах СНГ в 2007 г. // Вестник Российского научного центра им. H. Н. Блохина РАМН. 2009. — Т. 20. — № 3 (прил. 1).
- Демьянов, A.B. Диагностическая ценность исследования уровней цитокинов в клинической практике / A.B. Демьянов, А. Ю. Котов, А. С. Симбирцев // Цитокины и воспаление. 2003. — Т. 2. — № 3. — С. 20−35.
- Земляной, В.П. Современные методы диагностики и оценки степени распространенности рака ободочной и прямой кишки / В. П. Земляной, Т. Н. Трофимова, C.JI. Непомнящая, Т. В. Дементьева // Практическая онкология. 2005. — Т.6. — № 2. — С. 71−80.
- Кадагидзе, З.Г. Регуляторные Т-клетки и их роль в противоопухолевом иммунном ответе / З. Г. Кадагидзе, А. И. Черткова, Е. Г. Славина // Вопросы онкологии. 2009. — Т. 55. — № 3. — С. 269−277.
- Кадагидзе, З.Г. Цитокины / З. Г. Кадагидзе // Практическая онкология. 2003. — Т. 4. — № 3. — С. 131−139.
- Кардашева, С.С. Клиническая картина, факторы риска и иммуногистохимические маркеры при пищеводе Баррета / С. С. Кардашева, A.C. Трухманов, Т. А. Демура и др. // Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2008. № 3. — С. 15−24.
- Клинышкова, Т.В. Клинико-морфологическое обоснование оптимизации лечения больных с гиперплазией эндометрия / Т. В. Клинышкова, Н. Б. Фролова, С. И. Мозговой // Российский вестник акушера-гинеколога. 2010. -№ 3. С. 16−20.
- Криволапов, Ю.А. Морфологическая диагностика лимфом / Ю. А. Криволапов, Е. Е. Леенман СПб.: КОСТА, 2006. — 208 с.
- Кузнецов, В.П. Интерфероны в каскаде цитокинов: исторический и современный аспекты / В. П. Кузнецов // Антибиотики и химиотерапия. -1998.-№ 5.-С. 28−40.
- Курганова, Е.В. Генерация в культуре in vitro и характеристика регуляторных Т-клеток человека / Е. В. Курганова, Е. А. Шевела, H.A. Тихонова и др. // Медицинская иммунология. 2008. — Т. 10. — № 2−3. — С. 109−113.
- Маев, И.В. Проблемы и перспективы неинвазивного скрининга колоректального рака / И. В. Маев, В. М. Говорун, Ю. А. Кучерявый и др. // Клиническая медицина. 2009. — № 7. — С. 10−16.
- Останин, А.А. Сравнительная оценка уровня 17 цитокинов в сыворотке и цельной крови здоровых доноров методом проточной флюориметрии / А. А. Останин, Е. Р. Черных // Цитокины и воспаление. -2005.-Т. 4.-№ 2.-С. 25−32.
- Пинегин, Б.В. Макрофаги: свойства и функции / Б. В. Пинегин, М. И. Карсонова // Иммунология. 2009. — Т. 30. — № 4. — С. 241−249.
- Рахимова, О.Ю. Колоректальный рак актуальная проблема внутренней медицины / О. Ю. Рахимова, В. Б. Александров // Клиническая медицина. — 2008. — № 3. — С. 7−12.
- Реброва, О.Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ STATISTICA / О. Ю. Реброва. М.: МедиаСфера, 2002. — 312 с.
- Симбирцев, А. С. Цитокины — новая система регуляции защитных реакций организма / А. С. Симбирцев // Цитокины и воспаление. -2002.-Т. 1. -№ 1.-С. 9−16.
- Телетаева, Г. М. Цитокины и противоопухолевый иммунитет / Г. М. Телетаева // Практическая онкология. 2007. — Т. 8. — № 4. — С. 211−218.
- Фрейдлин, И.С. Иммунная система и ее дефекты : Руководство для врачей / И. С. Фрейдлин. СПб.: НТФФ Полисан, 2000.-231 с.
- Харченко, Е.П. Канцерогенез: иммунная система и иммунотерапия / Е. П. Харченко // Иммунология. 2011. — Т. 32. — № 1. — С. 50−56.
- Чиссов, В.И. Онкология : учебник с компакт-диском / под ред. В. И. Чиссова, C. J1. Дарьяловой. М.: ГЭОТАР-Медиа, 2007. — 560 с.
- Alzoghaibi, М. Serum vascular endothelial growth factor and interleukin-6 in colorectal cancer / M. Alzoghaibi // Saudi. J. Gastroenterol. -2011.-Vol. 17. № 3. — P. 163−164.
- Amin, M.A. Interleukin-18 induces angiogenic factors in rheumatoid arthritis synovial tissue fibroblasts via distinct signaling pathways / M.A. Amin, P.J. Mansfield, A. Pakozdi et al. // Arthritis Rheum. 2007. — Vol. 56. — № 6. — P. 1787−1797.
- Antonysamy, M. A. Evidence for a role of IL-17 in organ allograft rejection: IL-17 promotes the functional differentiation of dendritic cell progenitors / M. A. Antonysamy, W. C. Fanslow, F. Fu et al. // J. Immunol. 1999. — Vol. 162.-P. 577−584.
- Apte, R.N. The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions / R.N. Apte, S. Dotan, M. Elkabets et al. // Cancer. Metastasis. Rev. 2006. — Vol. 25. — № 3. — P. 387−408.
- Arend, W.P. Biological role of interleukin 1 receptor antagonist isoforms / W.P. Arend, C.J. Guthridge // Ann. Rheum. Dis. 2000. — Vol. 59. -Suppl. l.-P. i60-i64.
- Arnold, C.N. Molecular pathogenesis of colorectal cancer: implications for molecular diagnosis / C.N. Arnold, A. Goel, H.E. Blum, C.R. Boland // Cancer. 2005. — Vol. 104. — № 10. — P. 2035−2047.
- Ashizawa, T. Study of interleukin-6 in the spread of colorectal cancer: the diagnostic significance of IL-6 / T. Ashizawa, R. Okada, Y. Suzuki et al. // Acta Med. Okayama. 2006. — Vol. 60. — № 6. — P. 325−330.
- Bachmann, M.F. Interleukin 2: from immunostimulation to immunoregulation and back again / M.F. Bachmann, A. Oxenius // EMBO Rep. -2007. Vol. 8. — № 12. — P. 1142−1148.
- Balkwill, F. Tumour necrosis factor and cancer / F. Balkwill // Nat. Rev. Cancer. 2009. — Vol. 9.-P. 361−371.
- Barksby, H.E. The expanding family of interleukin-1 cytokines and their role in destructive inflammatory disorders / H.E. Barksby, S.R. Lea, P.M. Preshaw, J.J. Taylor // Clin. Exp. Immunol. 2007. — Vol. 149. — № 2. — P. 217 225.
- Becker, C. IL-6 signaling promotes tumor growth in colorectal cancer / C. Becker, M.C. Fantini, S. Wirtz et al. // Cell Cycle. 2005. — Vol. 4. — № 2. -P. 217−220.
- Benchetrit, F. Interleukin-17 inhibits tumor cell growth by means of a T-cell-dependent mechanism / F. Benchetrit, A. Ciree, V. Vives et al. // Blood. -2002.-Vol. 99.-№ 6.-P. 2114−2121.
- Bennett, I.L. Studies on the pathogenesis of fever, II: characterization of fever producing substances from polymorphonuclear leukocytes and from the fluid of sterile exudates / I.L. Bennett, P.B. Beeson // J. Exp. Med. 1953. — Vol. 98.-№ 5.-p. 493−508.
- Benveniste, E.N. TNF-alpha- and IFN-gamma-mediated signal transduction pathways: effects on glial cell gene expression and function / E.N. Benveniste, D.J. Benos // FASEB. J. 1995. — Vol. 9.-№ 15.-P. 1577−1584.
- Bernstein, C.N. Cancer risk in patients with inflammatory bowel disease / C.N. Bernstein, J.F. Blanchard, E. Kliewer, A. Wajda // Cancer. -2001. -Vol. 91.-P. 854−862.
- Bodger, K. Gastric mucosal secretion of interleukin-10: relations to histopathology, Helicobacter pylori status, and tumour necrosis factor-alpha secretion / K. Bodger, J.I. Wyatt, R.V. Heatley // Gut. 1997. — Vol. 40. — № 6. -P. 739−744.
- Boehm, U. Cellular responses to interferon-gamma / U. Boehm, T. Klamp, M. Groot, J.C. Howard // Annu. Rev. Immunol. 1997. — Vol. 15. — P. 749−795.
- Boom, W.H. Heterogeneity of helper/inducer T lymphocytes. II. Effects of interleukin 4- and interleukin 2-producing T cell clones on resting B lymphocytes / W.H. Boom, D. Liano, A.K. Abbas // J. Exp. Med. 1988. -Vol. 167.-№ 4.-P. 1350−1363.
- Borden, E.C. Interferons at age 50: past, current and future impact on biomedicine / E.C. Borden, G.C. Sen, G. Uze et al. // Nat. Rev. Drug. Discov. -2007. Vol. 6. — № 12. — P. 975−990.
- Brat, D.J. The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis / D.J. Brat, A.C. Bellail, E.G. Van Meir // Neuro-oncol. 2005. — Vol. 7. — № 2. — P. 122−133.
- Burchill, M.A. Interleukin-2 receptor signaling in regulatory T cell development and homeostasis / M.A. Burchill, J. Yang, K.B. Vang, M.A. Farrar // Immunol. Lett. 2007. — Vol. 114.-№ 1.-P. 1−8.
- Burstein, E. Colitis and cancer: a tale of inflammatory cells and their cytokines / E. Burstein, E.R. Fearon // J. Clin. Invest. 2008. — Vol. 118. — № 2. -P. 46467.
- Cao, R. Interleukin-18 acts as an angiogenesis and tumor suppressor / R. Cao, J. Farnebo, M. Kurimoto, Y. Cao // FASEB. J. 1999. — Vol. 13. — P. 2195−2202.
- Carpentier, I. Function and regulation of tumor necrosis factor type 2 / I. Carpentier, B. Coornaert, R. Beyaert // Curr. Med. Chem. 2004. — Vol. 11. — P. 2205−2212.
- Casiano, C.A. Tumor-associated antigen arrays for the serological diagnosis of cancer / C.A. Casiano, M. Mediavilla-Varela, E.M. Tan // Mol. Cell. Proteomics. 2006. — Vol. 5. — № 10.-P. 1745−1759.
- Carswell, E.A. An endotoxin induced serum factor that causes necrosis of tumors / E.A. Carswell, L.J. Old, R.L. Kassel et al. // Proc. Natl. Acad. Sci. U. S. A. 1975. — Vol. 72. — P. 3666−3670.
- Chang, C.Y. Intratumoral delivery of IL-18 naked DNA induces T-cell activation and Thl response in a mouse hepatic cancer model / C.Y. Chang, J. Lee, E.Y. Kim et al. // BMC Cancer. 2007. — Vol. 7. — P. 87.
- Cheng, G.Z. Advances of AKT pathway in human oncogenesis and as a target for anti-cancer drug discovery / G.Z. Cheng, S. Park, S. Shu et al. // Curr. Cancer. Drug. Targets. 2008. — Vol. 8. — P.2−6.
- Chizzolini, C. Prostaglandin E2 synergistically with interleukin-23 favors human Thl7 expansion / C. Chizzolini, R. Chicheportiche, M. Alvarez et al. // Blood. 2008. — Vol. 112. — P.3696−3703.
- Cho, J.H. An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2 / J.H. Cho, O. Boyman, H.O. Kim et al. // J. Exp. Med. 2007. -Vol. 204.-№ 8.-P. 1787−1801.
- Cohen, S. Similarities of Tcell function in cellmediated immunity and antibody production / S. Cohen, P.E. Bigazzi, T. Yoshida // Cell. Immunol. 1974. -Vol. 2.-P. 150−159.
- Colon and rectum. In: American Joint Committee on Cancer. AJCC Cancer Staging Manual. 6th ed. NY, Springer, 2002. — P. 113−124.
- Crimeen-Irwin, B. Failure of immune homeostasis the consequences of under and over reactivity / B. Crimeen-Irwin, K. Scalzo, S. Gloster et al. // Curr. Drug. Targets. Immune. Endocr. Metabol. Disord. — 2005. — Vol. 5. — № 4. — P. 413−422.
- De Groote, D. Ex vivo cytokine production by whole blood cells from cancer patients / D. De Groote, Y. Gevaert, M. Lopez et al. // Cancer. Detect. Prev. 1996. — Vol. 20. -№ 3. — P. 207−213.
- De Vita, F. Elevated perioperative serum vascular endothelial growth factor levels in patients with colon carcinoma / F. De Vita, M. Orditura, E. Lieto et al. // Cancer. 2004. — Vol. 100. — P. 270−278.
- Dinarello, C.A. Blocking IL-1 in systemic inflammation. / C.A. Dinarello // J. Exp. Med. 2005. — Vol. 201. — № 9. — P. 1355−1359.
- Dinarello, C.A. Why not treat human cancer with interleukin-1 blockade? / C.A. Dinarello // Cancer Metastasis Rev. 2010. — Vol. 29. — № 2. -P. 317−329.
- Dinarello, C.A. Interleukin-18, a proinflammatory cytokine / C.A. Dinarello // Eur. Cytokine. Netw. 2000. — Vol. 11. — № 3. — P. 483−486.
- Dinarello, C.A. Targeting interleukin 18 with interleukin 18 binding protein / C.A. Dinarello // Ann. Rheum. Dis. 2000. — Vol. 59. — Suppl. 1. — P. il7-i20.
- Dinarello, C.A. Novel targets for interleukin 18 binding protein / C.A. Dinarello // Ann. Rheum. Dis. 2001. — Vol. 60. — Suppl. 3. — P. iiil8- iii24.
- Dinarello, C.A. The paradox of pro-inflammatory cytokines in cancer / C.A. Dinarello // Cancer Metastasis Rev. 2006. — Vol. 25. — P. 307−313.
- Di Vizio, D. Skp2 expression is associated with high risk and elevated Ki67 expression in gastrointestinal stromal tumours / D. Di Vizio, F. Demichelis, S. Simonetti et al. // BMC Cancer. 2008. — Vol. 8. — P. 134.
- Dummer, R. Long-term pegylated interferon-alpha and its potential in the treatment of melanoma / R. Dummer, J. Mangana // Biologies. 2009. — Vol. 3.-P. 169−182.
- Elaraj, D.M. The role of interleukin 1 in growth and metastasis of human cancer xenografts / D.M. Elaraj, D.M. Weinreich, S. Varghese et al // Clin. Cancer Res. 2006. — Vol. 12. — P. 1088−1096.
- Eldesoky, A. Clinical relevance of serum vascular endothelial growth factor and Interleukin-6 in patients with colorectal cancer / A. Eldesoky, A. Shouma, Y. Mosaad, A. Elhawary // Saudi. J. Gastroenterol. 2011. — Vol. 17. -№ 3. — P. 170−173.
- Erreni, M. Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer / M. Erreni, A. Mantovani, P. Allavena // Cancer Microenviron. 2011. -Vol. 4.-№ 2.-P. 141−154.
- Evans, C. The correlation between colorectal cancer rates of proliferation and apoptosis and systemic cytokine levels- plus their influence upon survival / C. Evans, I. Morrison, A.G. Heriot et al. // Br. J. Cancer. 2006. — Vol. 94.-№ 10.-P. 1412−1419.
- Ferrero-Miliani, L. Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1 beta generation / L. Ferrero-Miliani, O. H Nielsen, P. S Andersen, S.E. Girardin // Clin. Exp. Immunol. 2007. — Vol. 147. — P. 227−235.
- Fischer, J.R. Selective suppression of cytokine secretion in patients with small-cell lung cancer / J.R. Fischer, M. Schindel, N. Stein et al. // Ann. Oncol. 1995. — Vol. 6. — № 9. — P. 921−926.
- Frankel, B. Soluble Fas-ligand (sFasL) in human astrocytoma cyst fluid is cytotoxic to T-cells: another potential means of immune evasion / B. Frankel, S.L. Longo, G.W. Canute // J. Neurooncol. 2000. — Vol. 48. — № 1. — P. 21−26.
- Francipane, M.G. Crucial role of interleukin-4 in the survival of colon cancer stem cells / M.G. Francipane, M.P. Alea, Y. Lombardo et al. // Cancer Res. 2008. — Vol. 68. — № 11. — P. 4022−4025.
- Fyfe, G. Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy / G. Fyfe, R.I. Fisher, S.A. Rosenberg et al. // J. Clin. Oncol. 1995. — Vol. 13. — P. 688 696.
- Gerlini, G. Metastatic melanoma secreted IL-10 down-regulates CD1 molecules on dendritic cells in metastatic tumor lesions / G. Gerlini, A. Tun-Kyi, C. Dudli et al. // Am. J. Pathol. 2004. — Vol. 165. — № 6. — P. 1853−1863
- Gilli, F. Neutralizing antibodies against IFN-beta in multiple sclerosis: antagonization of IFN-beta mediated suppression of MMPs / F. Gilli, A. Bertolotto, A. Sala et al. // Brain. 2004. — Vol. 127. — № 2. — P. 259−268.
- Grutz, G. New insights into the molecular mechanism of interleukin-10-mediated immunosuppression / G. Grutz // J. Leukoc. Biol. 2005. — Vol. 77. -№ l.-P. 3−15.
- Gui, J. Effects of acupuncture on Thl, Th2 cytokines in rats of implantation failure / J. Gui, F. Xiong, J. Li, G. Huang // Evid. Based. Complement. Alternat. Med. 2012. — Vol. 2012. — P. 893 023.
- Hagemann, T. Macrophages induce invasiveness of epithelial cancer cells via NF-kappa B and JNK / T. Hagemann, J. Wilson, H. Kulbe et al. //. J. Immunol.-2005.-Vol. 175.-P. 1197−1205.
- Haggar, F.A. Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors / F.A. Haggar, R.P. Boushey // Clin. Colon. Rectal. Surg.- 2009. Vol. 22. — № 4. — P. 191−197.
- Hansen, M.B. Transfusion-related inhibition of cytokines (TRICK). Experimental transfer of neutralizing autoantibodies to interleukin-6 by plasma transfusions / M.B. Hansen, P. Galle, M. Salomo et al. // Vox Sang. 2007. — Vol. 92. -№ 3. — P. 213−223.
- Hao, N.B. Macrophages in tumor microenvironments and the progression of tumors / N.B. Hao, M.H. Lii, Y.H. Fan et al. // Clin. Dev. Immunol.- 2012. Vol. 2012. — P. 948 098.
- Hardy, R.G. ABC of colorectal cancer: molecular basis for risk factors / R.G. Hardy, S.J. Meltzer, J.A. Jankowski // BMJ. 2000. — Vol. 321. — P. 886 889.
- Hatanaka, E. Neutrophils and monocytes a spotentially important sources of proinflammatory cytokines in diabetes / E. Hatanaka, P.T. Monteagudo, M.S. Marrocos, A. Campa // Clin. Exp. Immunol. 2006. — Vol. 146. — № 3. — P. 443−447.
- He, Z. Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury / Z. He, L. Lu, C. Altmann et al. // Am. J. Physiol. Renal Physiol. 2008. — Vol. 295. — № 5. — P. F1414-F1421.
- Heriot, A.G. Reduction in cytokine production in colorectal cancer patients: association with stage and reversal by resection / A.G. Heriot, J.B. Marriott, S. Cookson et al. // Br. J. Cancer. 2000. — Vol. 82. — № 5. — P. 10 091 012.
- Hofer, T. Competition for IL-2 between Regulatory and Effector T Cells to Chisel Immune Responses / T. Hofer, O. Krichevsky, G. Altan-Bonnet // Front. Immunol. 2012. — Vol. 3. — P. 268.
- Hoffmann, P.R. Interaction between phosphatidylserine and the phosphatidylserine receptor inhibits immune responses in vivo / P.R. Hoffmann, J.A. Kench, A. Vondracek et al. // J. Immunol. 2005. — Vol. 174. — № 3. — P. 1393−1404.
- Hong, D.S. Interleukin-6 and its receptor in cancer: implications for Translational Therapeutics / D.S. Hong, L.S. Angelo, R. Kurzrock // Cancer. -2007. Vol. 110. — № 9. — P. 1911−1928.
- Honorati, M.C. Interleukin-17, a regulator of angiogenic factor release by synovial fibroblasts / M.C. Honorati, S. Neri, L. Cattini, A. Facchini // Osteoarthritis Cartilage. 2006. — Vol. 14. — P. 345−352.
- Horiuchi, T. Transmembrane TNF-a: structure, function and interaction with anti-TNF agents / T. Horiuchi, H. Mitoma, S. Harashima et al. // Rheumatology.-2010.-Vol. 49.-№ 7.-P. 1215−1228.
- Hsu, T.C. Transformation nonresponsive cells owe their resistance to lack of p65/nuclear factor-kappaB activation / T.C. Hsu, R. Nair, P. Tulsian et al. // Cancer Res.-2001.-Vol. 61.-P. 4160168.
- Huang, X. Regulation of stromal proliferation, growth arrest, differentiation and apoptosis in benign prostatic hyperplasia by TGF-(3 / X. Huang, C. Lee // Front. Biosci. 2003. — Vol. 8. — P. 740−749.
- Hyzdalova, M. The interaction of butyrate with TNF-alpha during differentiation and apoptosis of colon epithelial cells: role of NF-kappaB activation / M. Hyzdalova, J. Hofmanova, J. Pachernik et al. // Cytokine. 2008. — Vol. 44. -№ 1. — P. 33−43.
- Isaacs, A. Virus interference. I. The interferon / A. Isaacs, J. Lindenmann // Proc. R. Soc. Lond. B. Biol. Sci. 1957. — Vol. 147. — P. 258−267.
- Ishida, Y. The role of IL-18 in the modulation of matrix metalloproteinases and migration of human natural killer (NK) cells / Y. Ishida, K. Migita, Y. Izumi et al. // FEBS Lett. 2004. — Vol. 569. — № 1−3. — P. 156−160.
- Ikeda, H. The roles of IFN gamma in protection against tumor development and cancer immunoediting / H. Ikeda, L.J. Old, R.D. Schreiber // Cytokine Growth Factor Rev. 2002. — Vol. 13. — № 2. — P. 95−109.
- Ito, M. Tumor-derived TGFbeta-1 induces dendritic cell apoptosis in the sentinel lymph node / M. Ito, Y. Minamiya, H. Kawai et al. // J. Immunol. -2006.-Vol. 176.-№ 9.-P. 5637−5643.
- Iwagaki, H. Interleukin-1 receptor antagonists and other markers in colorectal cancer patients / H. Iwagaki, A. Hizuta, N. Tanaka // Scand. J. Gastroenterol. 1997. — Vol. 32. -№ 6. — P. 577−581.
- Jain, S. Prostaglandin E2 regulates tumor angiogenesis in prostate cancer / S. Jain, G. Chakraborty, R. Raja et al. // Cancer Res. 2008. — Vol. 68. -№ 19.-P. 7750−7759.
- Jeon, S.H. Mechanisms underlying TGF-(31-induced expression of VEGF and Flk-1 in mouse macrophages and their implications for angiogenesis / S.H. Jeon, B.C. Chae, H.A. Kim et al. // J. Leukocyte Biol. 2007. — Vol. 81. — P. 557−566.
- Jiang, J. Evaluation of malignancy using Ki-67, p53, EGFR and COX-2 expressions in gastrointestinal stromal tumors / J. Jiang, M.S. Jin, J. Suo et al. // World J. Gastroenterol.-2012.-Vol. 18. -№ 20. -P. 2569−2575.
- Jimenez-Sainz, M.C. Signaling pathways for monocyte chemoattractant protein 1 -mediated extracellular signal-regulated kinase activation
- M.C. Jimenez-Sainz, B. Fast, F.Jr. Mayor, A.M. Aragay // Mol. Pharmacol. -2003. Vol. 64. — № 3. — P. 773−782.
- Johnson, C. Interleukin-6 and its receptor, key players in hepatobiliary inflammation and cancer / C. Johnson, Y. Han, N. Hughart et al // Transl. Gastrointest. Cancer. 2012. — Vol. 1. — № 1. — P. 58−70.
- Johnston, D.A. TNF induction of jagged-1 in endothelial cells is NFkappaB-dependent / D.A. Johnston, B. Dong, C.C. Hughes // Gene. 2009. -Vol. 435.-P. 36−44.
- Jonasch, E. Interferon in oncological practice: review of interferon biology, clinical applications, and toxicities / E. Jonasch, F.G. Haluska // Oncologist. 2001. — Vol. 6. — P. 34−55.
- Jones, S.A. Therapeutic strategies for the clinical blockade of IL-6/gpl30 signaling / S.A. Jones, J. Scheller, S. Rose-John // J. Clin. Invest. 2011. -Vol. 121.-P. 3375−3383.
- Ju, D. W. Interleukin 18 transfection enhances antitumor immunity induced by dendritic cell-tumor cell conjugates / D. W. Ju, Q. Tao, G. Lou // Cancer Res.-2001.-Vol. 61.-P. 3735−3740.
- Jung, M.K. IL-18 enhances the migration ability of murine melanoma cells through the generation of ROI and the MAPK pathway / M.K. Jung, H.K. Song, K.E. Kim et al. // Immunol. Lett. 2006. — Vol. 107. — № 2. — P. 125−130.
- Jussila, L. Lymphatic endothelium and Kaposi’s sarcoma spindle cells detected by antibodies against the vascular endothelial growth factor receptor-3 / L. Jussila, R. Valtola, T.A. Partanen et al. // Cancer Res. 1998. — Vol. 58. — № 8. -P. 1599−1604.
- Kaler, P. Tumor associated macrophages protect colon cancer cells from TRAIL-induced apoptosis through IL-lf3- dependent stabilization of snail intumor cells / P. Kaler, V. Galea, L. Augenlicht, L. Klampfer // PLoS One. 2010. -Vol. 5.-№ 7.-P. el 1700.
- Kaler, P. The NF-kappaB/AKT-dependent Induction of Wnt Signaling in Colon Cancer Cells by Macrophages and IL-lbeta / P. Kaler, B.N. Godasi, L. Augenlicht, L. Klampfer // Cancer Microenviron. 2009. — Vol. 2. — № 1. — P. 6980.
- Kaminska, J. CRP, TNF-alpha, IL-lra, IL-6, IL-8 and IL-10 in blood serum of colorectal cancer patients / J. Kaminska, M.M. Kowalska, M.P. Nowacki et al.//Pathol. Oncol. Res. 2000. — Vol. 6.-№ l.-P. 38−41.
- Kang, J.S. Interleukin-18 increases metastasis and immune escape of stomach cancer via the downregulation of CD70 and maintenance of CD44 /J.S. Kang, S.Y. Bae, H.R. Kim et al // Carcinogenesis. 2009. — Vol. 30. — № 12. — P. 1987−1996.
- Kannanganat, S. Multiple-cytokine-producing antiviral CD4 T cells are functionally superior to single-cytokine-producing cells / S. Kannanganat, C. Ibegbu, L. Chennareddi et al. //. J. Virol. 2007. — Vol. 81. — № 16. — P. 84 688 476.
- Kawakami, K. Overexpressed cell surface interleukin-4 receptor molecules can be successfully targeted for antitumor cytotoxin therapy / K. Kawakami, M. Kawakami, R.K. Puri // Crit. Rev. Immunol. 2001. — Vol. 21. — P. 299−310.
- Kehlen, A. Interleukin-17 stimulates the expression of ІкВа mRNA and the secretion of IL-6 and IL-8 in glioblastoma cell lines / A. Kehlen, K. Thiele, D. Riemann et al. // J. Neuroimmunol. 1999. — Vol.101. — P. 1−6.
- Kim, D.K. Clinical significances of preoperative serum interleukin-6 and C-reactive protein level in operable gastric cancer / D.K. Kim, S.Y. Oh, H.C. Kwon et al. // BMC Cancer. 2009. — Vol. 9. — P. 155.
- Kim, K.E. Expression of ADAM33 is a novel regulatory mechanism in IL-18-secreted process in gastric cancer / K.E. Kim, H. Song, C. Hahm et al. // J. Immunol. 2009. — Vol. 182. — № 6. — P. 3548−3555.
- Kim, K.E. Interleukin-18 is a critical factor for vascular endothelial growth factor-enhanced migration in human gastric cancer cell lines / K.E. Kim, H. Song, T.S. Kim et al.//Oncogene. 2007. — Vol. 26.-№ 10.-P. 1468−1476.
- Kim, R. Cancer immunoediting from immune surveillance to immune escape / R. Kim, M. Emi, K. Tanabe // Immunology. 2007. — Vol. 121. — № 1. -P. 1−14.
- Kim, R. Cancer cell immune escape and tumor progression by exploitation of anti-inflammatory and pro-inflammatory responses / R. Kim, M. Emi, K. Tanabe // Cancer Biol. Ther. 2005. — Vol. 4. — № 9. — P. 924−933.
- Kim, S.H. Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18 / S.H. Kim, M. Eisenstein, L. Reznikov et al. // Proc. Natl. Acad. Sci. USA. 2000. — Vol. 97. — P. 1190−1195.
- Kioi, M. Expression and targeting of interleukin-4 receptor for primary and advanced ovarian cancer therapy / M. Kioi, S. Takahashi, M. Kawakami et al. // Cancer Res. 2005. — Vol. 65. — № 18. — P. 8388−8396.
- Konishi, N. Interleukin-1 receptor antagonist inhibits the expression of vascular endothelial growth factor in colorectal carcinoma / N. Konishi, C. Miki, T. Yoshida et al // Oncology. 2005. — Vol. 68. — P. 138−145.
- Konsti, J. Development and evaluation of a virtual microscopy application for automated assessment of Ki-67 expression in breast cancer / J. Konsti, M. Lundin, H. Joensuu et al. // BMC Clin. Pathol. 2011. — Vol. 11. — P. 3.
- Kirkegaard, H. Association of adherence to lifestyle recommendations and risk of colorectal cancer: a prospective Danish cohort study / H. Kirkegaard, N.F. Johnsen, J. Christensen, K. Frederiksen // BMJ. 2010. — Vol. 341. — P. c5504.
- Kroeger, K.M. IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway / K.M. Kroeger, B.M. Sullivan, R.M. Locksley // J. Leukoc. Biol. 2009. — Vol. 86. — № 4. — P. 769−778.
- Kuwano, K. Signal transduction pathways of apoptosis and inflammation induced by the tumor necrosis factor receptor family / K. Kuwano, N. Hara // Am. J. Respir. Cell Mol. Biol. 2000. — Vol. 22. — № 2. — P. 147−149.
- La, E. Role of intracellular interleukin-1 receptor antagonist in skin carcinogenesis / E. La, J.E. Rundhaug, S.M. Fischer // Mol. Carcinog. 2001. -Vol. 30.-№ 4.-P. 218−223.
- Lahm, H. Selective suppression of cytokine secretion in whole blood cell cultures of patients with colorectal cancer / H. Lahm, M. Schindel, L. Frikart et al. // Br. J. Cancer. 1998. — Vol. 78. -№ 8. — P. 1018−1023.
- Lamagna, C. Dual role of macrophages in tumor growth and angiogenesis / C. Lamagna, M. Aurrand-Lions, B.A. Imhof // J. Leukoc. Biol. -2006. Vol. 80. — № 4. — P. 705−713.
- Le, N.H. Tumour-stroma interactions in colorectal cancer: converging on beta-catenin activation and cancer sternness / N.H. Le, P. Franken, R. Fodde // Br. J. Cancer.-2008.-Vol. 98.-№ 12.-P. 1886−1893.
- Leach, S.T. Local and systemic interleukin-18 and interleukin-18-binding protein in children with inflammatory bowel disease / S.T. Leach, I. Messina, D.A. Lemberg et al. // Inflamm. Bowel Dis. 2008. — Vol. 14. — № 1. -P. 68−74.
- Lee, I.Y. Interleukin-4 inhibits the vascular endothelial growth factor-and basic fibroblast growth factor-induced angiogenesis in vitro / I.Y. Lee, J. Kim, E.M. Ko et al. // Mol. Cells. 2002. — Vol. 14. — P. 115−121.
- Levi-Montalcini, R. A diffusible agent of mouse sarcoma producing hyperplasia of sympathetic ganglia and hyper neurotization of viscera in the chick embryo / R. Levi-Montalcini, V. Hamburger // J. Exp. Zool. 1953. — Vol. 123. -P. 233−288.
- Lewis, A.M. Interleukin-1 and cancer progression: the emerging role of interleukin-1 receptor antagonist as a novel therapeutic agent in cancer treatment / A.M. Lewis, S. Varghese, H. Xu, H.R. Alexander // J. Transl. Med. 2006. -Vol. 4.-P. 48.
- Li, A. IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis / A. Li, S. Dubey, M.L. Varney et al. // J. Immunol. 2003. — Vol. 170. — P. 3369−3376.
- Li, X. A destructive cascade mediated by CCL2 facilitates prostate cancer growth in bone / X. Li, R. Loberg, J. Liao et al. // Cancer Res. 2009. -Vol. 69.-P. 1685−1692.
- Li, Z. Paradoxical roles of IL-4 in tumor immunity / Z. Li, L. Chen, Z. Qin // Cell Mol. Immunol. 2009. — Vol. 6. — № 6. — P. 415−422.
- Lima, L.G. Tumor-derived microvesicles modulate the establishment of metastatic melanoma in a phosphatidylserine-dependent manner / L.G. Lima, R. Chammas, R.Q. Monteiro et al. // Cancer Lett. 2009. — Vol. 283. — № 2. — P. 168 175.
- Lin, M.T. IL-6 inhibits apoptosis and retains oxidative DNA lesions in human gastric cancer AGS cells through up-regulation of anti-apoptotic gene mcl1 / M.T. Lin, C.Y. Juan, K.J. Chang et al. // Carcinogenesis. 2001. — Vol. 22. -№ 12.-P. 1947−1953.
- Lindemann, S. Activated platelets mediate inflammatory signaling by regulated interleukin lbeta synthesis / S. Lindemann, N.D. Tolley, D.A. Dixon et al. // J. Cell Biol. 2001. — Vol. 154. — P. 485−490.
- Ling, K.L. Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients / K.L. Ling, S.E. Pratap, G.J. Bates et al. // Cancer Immun. 2007. — Vol. 7. — P. 7.
- Liu, Y. Expression cloning and characterization of a human IL-10 receptor / Y. Liu, S.H. Wei, A.S. Ho et al. // J. Immunol. 1994. — Vol. 152. — P. 1821−1829.
- Loberg, R.D. CCL2 is a potent regulator of prostate cancer cell migration and proliferation / R.D. Loberg, L.L. Day, J. Harwood et al // Neoplasia. 2006. — Vol. 8. — P. 578−586.
- Lu, B. T-cell death and cancer immune tolerance / B. Lu, O.J. Finn // Cell Death Differ.-2008.-Vol. 15.-№ l.-P. 70−79.
- Lu, Y. Monocyte chemotactic protein-1 (MCP-1) acts as a paracrine and autocrine factor for prostate cancer growth and invasion / Y. Lu, Z. Cai, D.L. Galson et al. // Prostate. 2006. — Vol. 66. — № 12. — P. 1311−1318.
- Lukacher, A.E. IFN-gamma suspends the killing license of anti-tumor CTLs / A.E. Lukacher // J. Clin. Invest. 2002. — Vol. 110. — № 10. — P. 14 071 409.
- Lukaszewicz, M. Clinical significance of interleukin-6 (IL-6) as a prognostic factor of cancer disease / M. Lukaszewicz, B. Mroczko, M. Szmitkowski // Pol. Arch. Med. Wewn. 2007. — Vol. 117. — № 5−6. — P. 247−251
- Luo, D. Differential functions of tumor necrosis factor receptor 1 and 2 signaling in ischemia-mediated arteriogenesis and angiogenesis / D. Luo, Y. Luo, Y. He et al. // Am. J. Pathol. 2006. — Vol. 169. — № 5. — P. 1886−1898.
- Luppi, F. Interleukin-8 stimulates cell proliferation in non-small cell lung cancer through epidermal growth factor receptor transactivation / F. Luppi, A.M. Longo, W.I. de Boer et al. // Lung Cancer. 2007. — Vol. 56. — P. 25−33.
- Mallat, Z. Interleukin-18/interleukin-18 binding protein signaling modulates ischemia-induced neovascularization in mice hindlimb / Z. Mallat, J.S. Silvestre, S. Le Ricousse-Roussanne et al. // Circ. Res. 2002. — Vol. 91. — № 5. -P. 441−448.
- Mantovani, A. Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression / A. Mantovani, P. Allavena, A. Sica // Eur. J. Cancer. 2004. — Vol. 40. — № 11. — P. 1660−1667.
- Martins, S.F. Role of endoglin and VEGF family expression in colorectal cancer prognosis and anti-angiogenic therapies / S.F. Martins, R.M. Reis, A.M. Rodrigues et al. // World J. Clin. Oncol. 2011. — Vol. 2. — № 6. — P. 272−280.
- Mazodier, K. Severe imbalance of IL-18/IL-18BP in patients with secondary hemophagocytic syndrome / K. Mazodier, V. Marin, D. Novick et al. // Blood.-2005.-Vol. 106.-№ 10.-P. 3483−3489.
- McKenna, R.M. Antibodies to interferon-alpha in treated cancer patients: incidence and significance / R.M. McKenna, K.E. Oberg // J. Interferon Cytokine Res.- 1997.-Vol. 17.-№ 3.-P. 141−143.
- Mitsiades, C.S. The role of apoptosis-inducing receptors of the tumor necrosis factor family in thyroid cancer / C.S. Mitsiades, V. Poulaki, N. Mitsiades // J. Endocrinol. 2003. — Vol. 178. — № 2. — P. 205−216.
- Miyazaki, T. Clinical significance of plasma level of vascular endothelial growth factor-C in patients with colorectal cancer / T. Miyazaki, N. Okada, K. Ishibashi et al. // Jpn. J. Clin. Oncol. 2008. — Vol. 38. — P. 839−843.
- Mocellin, S. Interleukin-10 and the immune response against cancer: a counterpoint / S. Mocellin, F.M. Marincola, H.A. Young // J. Leukoc. Biol. 2005. -Vol. 78. -№ 5.-P. 1043−1051.
- Monti, P. The CC chemokine MCP-1/CCL2 in pancreatic cancer progression: regulation of expression and potential mechanisms of antimalignant activity / P. Monti, B.E. Leone, F. Marchesi et al. // Cancer Res. 2003. — Vol. 63. -№ 21.-P. 7451−7461.
- Mosser, D.M. Interleukin-10: new perspectives on an old cytokine / D.M. Mosser, X. Zhang // Immunol. Rev. 2008. — Vol. 226. — P. 205−218.
- Murugaiyan, G. Protumor vs antitumor functions of IL-17 / G. Murugaiyan, B. Saha // J. Immunol. 2009. — Vol. 183. — № 7. — P. 4169−4175.
- Mysliwiec, P. Combined perioperative plasma endoglin and VEGF-a assessment in colorectal cancer patients / P. Mysliwiec, K. Pawlak, A. Kuklinski, B. Kedra // Folia. Histochem. Cytobiol. 2009. — Vol. 47. — № 2. — P. 231−236.
- Naftali, T. Interleukin-18 and its binding protein in patients with inflammatory bowel disease during remission and exacerbation / T. Naftali, D. Novick, G. Gabay et al. // Isr. Med. Assoc. J. 2007. — Vol. 9. — № 7. — P. 504 508.
- Nakao, S. Infiltration of COX-2-expressing macrophages is a prerequisite for IL-1 beta-induced neovascularization and tumor growth / S. Nakao, T. Kuwano, C. Tsutsumi-Miyahara et al. // J. Clin. Invest. 2005. — Vol. 115. — № 11.-P. 2979−2991.
- Nam, J. S. Transforming growth factor P subverts the immune system into directly promoting tumor growth through interleukin-17 / J. S. Nam, M. Terabe, M. J. Kang et al. // Cancer Res. 2008. — Vol. 68. — P. 3915−3923.
- Nelms, K. The IL-4 receptor: signaling mechanisms and biologic functions / K. Nelms, A.D. Keegan, J. Zamorano et al. // Annu. Rev. Immunol. -1999.-Vol. 17.-P. 701−738.
- Nelson, B.H. IL-2, regulatory T cells, and tolerance / B.H. Nelson // J. Immunol. 2004. — Vol. 172. — № 7. — P. 3983−3988.
- Neufeld, G. Vascular endothelial growth factor (VEGF) and its receptors / G. Neufeld, T. Cohen, S. Gengrinovitch, Z. Poltorak // FASEB J. -1999.-Vol. 13.-P. 9−22.
- Neurath, M.F. IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer / M.F. Neurath, S. Finotto // Cytokine Growth Factor Rev.-2011.-Vol. 22.-№ 2.-P. 83−89.
- Novick, D. Interleukin-18 binding protein: a novel modulator of the Thl cytokine response / D. Novick, S.H. Kim, G. Fantuzzi et al. // Immunity. -1999.-Vol. 10.-P. 127−136.
- Novick, D. Interleukin-18 binding protein in the sera of patients with Wegener’s granulomatosis / D. Novick, D. Elbirt, C.A. Dinarello et al. // J. Clin. Immunol. -2009. Vol. 29. -№ 1. — P. 38−45.
- O’Boyle, G. Chemokine-mediated inflammation: Identification of a possible regulatory role for CCR2 / G. O’Boyle, J.G. Brain, J.A. Kirby, S. Ali // Mol. Immunol. 2007. — Vol. 44. — P. 1944−1953.
- Ochoa, C.E. Interleukin 6, but not T helper 2 cytokines, promotes lung carcinogenesis / C.E. Ochoa, S.G. Mirabolfathinejad, V.A. Ruiz et al. // Cancer Prev. Res.-2011.-Vol. 4. -№ 1. P. 51−64.
- O’Connor, P.M. Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease / P. M. O’Connor, T.K. Lapointe, P.L. Beck, A.G. Buret // Inflamm. Bowel Dis. 2010. — Vol. 16. — № 8. -P. 1411−1420.
- Okada, H. Gene therapy and biologic therapy with interleukin-4 / H. Okada, N. Kuwashima // Curr. Gene Ther. 2002. — Vol. 2. — P. 437−450.
- Olejniczak, K. Biological properties of interleukin 2 and its role in pathogenesis of selected diseases a review / K. Olejniczak, A. Kasprzak // Med. Sci. Monit. — 2008. — Vol. 14. — № 10. — P. RA179- RA189.
- Oliveira, S.H. The role of chemokines and chemokine receptors in eosinophil activation during inflammatory allergic reactions // S. H. Oliveira, N. W. Lukacs // Braz. J. Med. Biol. Res. 2003. — Vol. 36. — № 11. — P. 1455−1463.
- Olson, J.L. Intravitreal anakinra inhibits choroidal neovascular membrane growth in a rat model / J.L. Olson, R.J. Courtney, B. Rouhani et al // Ocul. Immunol. Inflam. 2009. — Vol. 17. — P. 195−200.
- Onishi, T. An assessment of the immunological environment based on intratumoral cytokine production in renal cell carcinoma / T. Onishi, Y. Ohishi, K. Imagawa et al. // BJU Int. 1999. — Vol. 83. — P. 488−492.
- O’Shea, J.J. Jaks and Stats as therapeutic targets / J.J. O’Shea, R. Visconti, T.P. Cheng, M. Gadina // Ann. Rheum. Dis. 2000. — Vol. 59. — P. il 15-il 18.
- Ostrand-Rosenberg, S. Immune surveillance: a balance between pro-and anti-tumor immunity / S. Ostrand-Rosenberg // Curr. Opin. Genet. Dev. -2008.-Vol. 18.-№ l.-P. 11−18.
- Ouaked, N. Regulation of the foxp3 gene by the Thl cytokines: the role of IL-27-induced STAT1 / N. Ouaked, P.Y. Mantel, C. Bassin et al. // J. Immunol. 2009. — Vol. 182. — № 2. — P. 1041−1049.
- Overwijk, W.W. Functions of gammaC cytokines in immune homeostasis: current and potential clinical applications / W.W. Overwijk, K.S. Schluns // Clin. Immunol. 2009. — Vol. 132,-№ 2.-P. 153−165.
- Page, G. Plasma cell-like morphology of Thl-cytokine-producing cells associated with the loss of CD3 expression / G. Page, A. Sattler, S. Kersten et al. // Am. J. Pathol. 2004. — Vol. 164. — № 2. — P. 409−417.
- Pan, S. Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis / S. Pan, P. An, R. Zhang et al. // Mol. Cell. Biol. 2002. — Vol. 22. — № 21. — P. 7512−7523.
- Park, S.H. Shift toward T helper 1 cytokines by type II collagen-reactive T cells in patients with rheumatoid arthritis // S.H. Park, D.J. Min, M.L. Cho et al. // Arthritis Rheum. 2001. — Vol. 44. № 3. — P. 561−569.
- Park, S. The dual effects of interleukin-18 in tumor progression / S. Park, S. Cheon, D. Cho // Cell. Mol. Immunol. 2007. — Vol. 4. — № 5. — P. 329 335.
- Pena, L.L. Immunohistochemical detection of Ki-67 and PCNA in canine mammary tumors: relationship to clinical and pathologic variables / L.L. Pena, A.I. Nieto, D. Perez-Alenza et al. // J. Vet. Diagn. Invest. 1998. — Vol. 10. — № 3. — P. 237−246.
- Phelan, J.D. Cutting edge: mechanism of enhancement of in vivo cytokine effects by anti-cytokine monoclonal antibodies / J.D. Phelan, T. Orekov, F.D. Finkelman // J. Immunol. 2008. — Vol. 180. — № 1. — P. 44−48.
- Popivanova, B.K. Blocking TNF-a in mice reduces colorectal carcinogenesis associated with chronic colitis / B.K. Popivanova, K. Kitamura, Y. Wu et al. // J. Clin. Invest. 2008. — Vol. 118. — № 2. — P. 560−570.
- Potter, J.D. Colorectal cancer: molecules and populations / J.D. Potter // J. Natl. Cancer. Inst. 1999. — Vol. 91. — № 11. — p. 916−932.
- Pradeep, A.R. Exploring the role of Thl cytokines: interleukin-17 and interleukin-18 in periodontal health and disease // A.R. Pradeep, P. Hadge, S. Chowdhry et al. // J. Oral. Sci. 2009. — Vol. 51. — № 2. — P. 261−266.
- Prokopchuk, O. Interleukin-4 enhances proliferation of human pancreatic cancer cells: evidence for autocrine and paracrine actions / O. Prokopchuk, Y. Liu, D. Henne-Bruns, M. Kornmann // Br. J. Cancer. 2005. -Vol. 92.-№ 5.-P. 921−928.
- Rajesh, V. Lalla. Expression of Vascular Endothelial Growth Factor Receptors on tumor cells in head and neck squamous cell carcinoma / V. Lalla. Rajesh, BDS, PhD et al. // Arch. Otolaryngol. Head. Neck. Surg. 2003. — Vol. 129.-Vol. 8.-P. 882−888.
- Revoltella, R.P. Natural and therapeutically-induced antibodies to cytokines / R.P. Revoltella // Biotherapy. 1998. — Vol. 10. — № 4. — P. 321−331.
- Robb, R.J. Heterogeneity of Human T-Cell Growth Factor (S) due to variable glycosylation / R.J. Robb, K. A. Smith // Mol. Immunol. 1981. — Vol. 18.-P. 1087−1094.
- Roca, H. CCL2 and interleukin-6 promote survival of human CD1 lb+ peripheral blood mononuclear cells and induce M2-type macrophage polarization / H. Roca, Z.S. Varsos, S. Sud et al // J. Biol. Chem. 2009. — Vol. 284. — P. 3 434 234 354.
- Rose-John, S. Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer / S. Rose-John, J. Scheller, G. Elson, S.A. Jones // J. Leukoc. Biol. 2006. — Vol. 80. — № 2. -P.227−236.
- Rubie, C. Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer / C. Rubie, V.O. Frick, S. Pfeil et al. // World J. Gastroenterol. 2007. — Vol. 13. — № 37. — P. 4996−5002.
- Ruddy, M.J. Functional cooperation between interleukin-17 and tumor necrosis factor-alpha is mediated by CCAAT/enhancer-binding protein familymembers / M.J. Ruddy, G.C. Wong, X.K. Liu et al. // J. Biol. Chem. 2004. — Vol. 279.-№ 4.-P. 2559−2567.
- Saha, B. Gene modulation and immunoregulatory roles of interferon gamma / B. Saha, S. Jyothi Prasanna, B. Chandrasekar, D. Nandi // Cytokine. -2010.-Vol. 50.-№ l.-P. 1−14.
- Schmidt-Weber, C. New T-helper subsets controlling the immune system and tissue cells / C. Schmidt-Weber // Immunotherapy. 2010. — Vol. 2. -№ 4. — P. 427−429.
- Schoenborn, J.R. Regulation of interferon-gamma during innate and adaptive immune responses / J.R. Schoenborn, C.B. Wilson // Adv. Immunol. -2007.-Vol. 96.-P. 41−101.
- Schroder, K. Interferon-gamma: an overview of signals, mechanisms and functions / K. Schroder, P.J. Hertzog, T. Ravasi, D.A. Hume // J. Leukoc. Biol. -2004.-Vol. 75,-№ 2.-P. 163−189.
- Schwandner, R. Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction / R. Schwandner, K. Yamaguchi, Z. Cao // J. Exp. Med. 2000. — Vol. 191. — № 7. — P. 1233−1240.
- Sen, G.C. The interferon system—a bird’s eye view of its biochemistry / G.C. Sen, P. Lengyel // J. Biol. Chem. 1992. — Vol. 267. — P. 5017−5020.
- Sethi, G. TNF: a master switch for inflammation to cancer / G. Sethi, B. Sung, B.B. Aggarwal//Front. Biosci. 2008.-Vol. 13.-P. 5094−5107.
- Shan, N.N. High-dose dexamethasone regulates interleukin-18 and interleukin-18 binding protein in idiopathic thrombocytopenic purpura / N.N. Shan, X.J. Zhu, Q. Wang et al. // Haematologica. 2009. — Vol. 94. — № 11. — P. 1603−1607.
- Shao, X.T. Expression of interleukin-18, IL-18BP, and IL-18R in serum, synovial fluid, and synovial tissue in patients with rheumatoid arthritis / X.T. Shao, L. Feng, L.J. Gu et al. // Clin. Exp. Med. 2009. — Vol. 9. — № 3. — P. 215−221.
- Sheehan, J.J. Proteolytic activation of monocyte chemoattractant protein-1 by plasmin underlies excitotoxic neurodegeneration in mice / J.J. Sheehan, C. Zhou, I. Gravanis et al. // J. Neurosci. 2007. — Vol. 27. — P. 17 381 745.
- Shime, H. Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway / H. Shime, M. Yabu, T. Akazawa et al. // J. Immunol. -2008.-Vol. 180. P.7175−7183.
- Shishodia, S. Nuclear factor-kappaB activation mediates cellular transformation, proliferation, invasion angiogenesis and metastasis of cancer / S. Shishodia, B.B. Aggarwal // Cancer Treat. Res. 2004. — Vol. 119. — P. 139−173.
- Shurin, M.R. Thl/Th2 balance in cancer, transplantation and pregnancy / M.R. Shurin, L. Lu, P. Kalinski et al. // Springer Semin. Immunopathol. 1999. — Vol. 21. — P. 339−359.
- Smith, K.A. Interleukin-2: Inception, impact, and implications / K.A. Smith // Science. 1988. — Vol. 240. — P. 1169−1176.
- Smyth, M.J. Cancer immunosurveillance and immunoediting: the roles of immunity in suppressing tumor development and shaping tumor immunogenicity / M.J. Smyth, G.P. Dunn, R.D. Schreiber // Adv. Immunol. -2006.-Vol. 90.-P. 1−50.
- Solinas, G. Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation / G. Solinas, G. Germano, A. Mantovani, P. Allavena // J. Leukoc. Biol. 2009. — Vol. 86. — № 5. — P. 1065−1073.
- Sornasse, T. Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level / T. Sornasse, P.V. Larenas, K.A. Davis et al. // J. Exp. Med. 1996. — Vol. 184. -№ 2.-P. 473−483.
- Souza-Fonseca-Guimaraes, F. NK cells in anti-bacterial innate immunity: angels or devils? / F. Souza-Fonseca-Guimaraes, M. Adib-Conquy, J.M. Cavaillon // Mol. Med. 2012. — Vol. 18. — № 1. — P. 270−285.
- Stassi, G. Control of target cell survival in thyroid autoimmunity by T helper cytokines via regulation of apoptotic proteins // G. Stassi, D. Di Liberto, M. Todaro et al // Nat. Immunol. 2000. — Vol. 1. — P. 483−488.
- Stauber, D.J. Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor / D.J. Stauber, E.W. Debler, P.A.
- Horton et al. // Proc. Natl. Acad. Sci. USA. 2006. — Vol. 103. — № 8. — P. 27 882 793.
- Stejskal, S. Isolation of granulocytes: which transcriptomedowe analyse neutrophils or eosinophils? / S. Stejskal, I. Koutna, Z. Rucka // Folia. Biol. — 2010. — Vol. 56. — № 6. — P. 252−255.
- Streicher, K.L. Activation of a nuclear factor kappaB/interleukin-1 positive feedback loop by amphiregulin in human breast cancer cells / K.L. Streicher, N.E. Willmarth, J. Garcia et al. // Mol. Cancer Res. 2007. — Vol. 5. -№ 8. -P. 847−861.
- Tayal, V. Cytokines and anti-cytokines as therapeutics- an update / V. Tayal, B.S. Kalra // Eur. J. Pharmacol. 2008. — Vol. 579. — № 1−3. — P. 1−12.
- Tedgui, A. Cytokines in atherosclerosis: pathogenic and regulatory pathways / A. Tedgui, Z. Mallat // Physiol. Rev. 2006. — Vol. 86. — № 2. — P. 515−581.
- Terme, M. IL-18 induces PD-1 -dependent immunosuppression in cancer / M. Terme, E. Ullrich, L. Aymeric et al // Cancer Res. 2011. — Vol. 71. -№ 16.-P. 5393−5399.
- Timoshanko, J.R. Leukocyte-derived interleukin-1 beta interacts with renal interleukin-1 receptor I to promote renal tumor necrosis factor and glomerular injury in murine crescentic glomerulonephritis / J.R. Timoshanko, A.R.
- Kitching, Y. Iwakura et al. // Am. J. Pathol. 2004. — Vol. 164. — № 6. — P. 19 671 977.
- To, K.F. Constitutional activation of IL-6-mediated JAK/STAT pathway through hypermethylation of SOCS-1 in human gastric cancer cell line / K.F. To, M.W. Chan, W.K. Leung et al. // Br. J. Cancer. 2004. — Vol. 91. — № 7. -P. 1335−1341.
- Todaro, M. Autocrine production of interleukin-4 and interleukin-10 is required for survival and growth of thyroid cancer cells / M. Todaro, M. Zerilli, L. Ricci-Vitiani et al. // Cancer Res. 2006. — Vol. 66. — № 3. — P. 1491−1499.
- Toge, H. Angiogenesis in renal cell carcinoma: the role of tumor-associated macrophages / H. Toge, T. Inagaki, Y. Kojimoto et al. // Int. J. Urol. -2009.-Vol. 16.-№ 10.-P. 801−807.
- Triozzi, P.L. Effects of interleukin-1 receptor antagonist on tumor stroma in experimental uveal melanoma / P.L. Triozzi, W. Aldrich, A. Singh // Invest. Ophthalmol. Vis. Sci. 2011. — Vol. 52.-№ 8.-P. 5529−5535.
- Tsujimoto, H. Roles of inflammatory cytokines in the progression of gastric cancer: friends or foes? / H. Tsujimoto, S. Ono, T. Ichikura et al. // Gastric Cancer.-2010.-Vol. 13.-№ 4.-P. 212−221.
- Ueno, T. Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer / T. Ueno, M. Toi, H. Saji // Clin. Cancer Res. 2000. — Vol. 6. — № 8 — P. 3282−3289.
- Vandenabeele, P. Two tumour necrosis factor receptors: structure and function / P. Vandenabeele, W. Declercq, R. Beyaert, W. Fiers // Trends Cell Biol. 1995. — Vol. 5 — P. 392−399.
- Vaish, V. Chemopreventive effects of NSAIDs on cytokinesand transcription factors during the early stages of colorectal cancer / V. Vaish, S.N. Sanyal // Pharmacol. Rep. 2011. — Vol. 63. — № 5. — P. 1210−1221.
- Volpe, S. CCR2 Acts as Scavenger for CCL2 during Monocyte Chemotaxis / S. Volpe, E. Cameroni, B. Moepps // PLoS One. 2012. — Vol. 7. -№ 5.-P. e37208
- Vrdoljak, E. Cancer epidemiology in Central, South and Eastern European countries / E. Vrdoljak, M.Z. Wojtukiewicz, T. Pienkowski et al. // Croat. Med. J. 2011. — Vol. 52. — № 4. — P. 478−487.
- Waldhauer, I. Tumor-associated MICA is shed by ADAM proteases / I. Waldhauer, D. Goehlsdorf, F. Gieseke et al. // Cancer Res. 2008. — Vol. 68. -№ 15.-P. 6368−6376.
- Wang, P. PUMA is directly activated by NF-kB and contributes to TNF-a-induced apoptosis / P. Wang, W. Qiu, C. Dudgeon et al. // Cell Death Differ. 2009. — Vol. 16 — № 9. — P. 1192−1202.
- Watanabe, M. Anti-cytokine autoantibodies are ubiquitous in healthy individuals / M. Watanabe, K. Uchida, K. Nakagaki et al. // FEBS Lett. 2007. -Vol. 581.-№ 10.-P. 2017−2021.
- Waterston, A.M. TNF autovaccination induces self anti-TNF antibodies and inhibits metastasis in a murine melanoma model / A.M. Waterston, F. Salway, E. Andreakos et al. // Br. J. Cancer. 2004. — Vol. 90. — № 6. — P. 1279−1284.
- Waugh, D.J. The interleukin-8 pathway in cancer / D.J. Waugh, C. Wilson // Clin. Cancer Res.-2008.-Vol. 14.-№ 21.-P. 6735−6741.
- Witkowska, A.M. On the role of sIL-2R measurements in rheumatoid arthritis and cancers / A.M. Witkowska // Mediators Inflamm. 2005. — Vol. 2005. -№ 3. — P. 121−130.
- Woerly, G. Expression of Thl and Th2 immunoregulatory cytokines by human eosinophils / G. Woerly, N. Roger, S. Loiseau, M. Capron // Int. Arch. Allergy Immunol. 1999. -Vol. 118. — № 2−4. — P. 95−97.
- Wu, Y. TNF-a/NF-KB/Snail pathway in cancer cell migration and invasion / Y. Wu, B.P. Zhou // Br. J. Cancer. 2010. — Vol. 102. № 4. — P. 639 644.
- Xu, T. Role of cytokines in promoting immune escape of FasL-expressing human colon cancer cells / T. Xu, B.C. Sun, Q. Li, X.S. Hao // World J. Gastroenterol.-2005.-Vol. 11. -№ 25. -P. 3915−3919.
- Yamane, H. Independent roles for IL-2 and GATA-3 in stimulating naive CD4+ T cells to generate a Th2-inducing cytokine environment / H. Yamane, J. Zhu, W. E. Paul // J. Exp. Med. 2005. — Vol. 202. — № 6. — P. 793 804.
- Yan, L. Therapeutic potential of cytokine and chemokine antagonists in cancer therapy / L. Yan, G.M. Anderson, M. DeWitte, M.T. Nakada // Eur. J. Cancer. 2006. — Vol. 42. — № 6. — P. 793−802.
- You, Z. Interleukin-17 receptor-like gene is a novel antiapoptotic gene highly expressed in androgen-independent prostate cancer / Z. You, X.B. Shi, G. DuRaine et al. // Cancer Res. 2006. — Vol. 66. — № 1. — P. 175−183.
- Zhang, C. Elevated IGFIR expression regulating VEGF and VEGF-C predicts lymph node metastasis in human colorectal cancer / C. Zhang, L. Hao, L. Wang et al. // BMC Cancer. 2010. — Vol. 10. — P. 184.
- Zhang, D. Association of IL-lbeta gene polymorphism with cachexia from locally advanced gastric cancer / D. Zhang, H. Zheng, Y. Zhou et al. // BMC Cancer. 2007. — Vol. 7. — P. 45.
- Zhang, J. Targeting chemokine (C-C motif) ligand 2 (CCL2) as an example of translation of cancer molecular biology to the clinic / J. Zhang, L. Patel, K.J. Pienta // Prog. Mol. Biol. Transl. Sci. 2010. — Vol. 95. — P. 31−53.
- Zhou, L. The IL-10 and IFN-gamma pathways are essential to the potent immunosuppressive activity of cultured CD8+ NKT-like cells / L. Zhou, H. Wang, X. Zhong et al. // Genome Biol. 2008. — Vol. 9. — № 7. — P. R119.
- Ziolkowska, M. High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism / M. Ziolkowska, A. Koc, G. Luszczykiewicz et al. // J. Immunol. 2000. — Vol. 164.-№ 5.-P. 2832−2838.
- Zou, W. Immunosuppressive networks in the tumour environment and their therapeutic relevance / W. Zou // Nat. Rev. Cancer. 2005. — Vol. 5 — P. 263−274.