Влияние флавоноидов на каналообразующую активность токсинов и антимикробных агентов в липидных бислоях
Диссертация
Модификация флавоноидами каналообразующей активности сирингомицина Е и цекропина, А является результатом изменения дипольного потенциала, вызванного адсорбцией флавоноидов на мембране. Непосредственное взаимодействие 5- (7-) и 4'-гидроксилированных флавоноидов с сенсором напряжения а-гемолизинового канала ответственно за изменение его потенциал-чувствительности. В случае макролидных полиеновых… Читать ещё >
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