Эпигенетическая характеристика индуцированных плюрипотентных стволовых клеток человека
Диссертация
С первого эксперимента по прямому репрограммированию прошло около пяти лет. За это время было проведено множество работ, посвященных повышению эффективности репрограммирования, варьированию состава ТФ и методов их введения, а также типов клеток, используемых для экспериментов. Также были предприняты многочисленные попытки использовать полученные iPS клетки в качестве модельной системы для поиска… Читать ещё >
Список литературы
- Aasen T, Raya A, Barrero MJ, Garreta E, Consiglio A, Gonzalez F, et al. Efficient and rapid generation of induced pluripotent stem cells from human keratino- cytes. Nat Biotechnol 2008−26:1276−84.
- Akao, Y., Nakagawa, Y., Naoe, T., 2006. let-7 microRNA functions as a potential growth, suppressor in human colon cancer cells. Biol Pharm Bull 29(5), 903−6.
- Aoi, T., Yae, K., Nakagawa, M., Ichisaka, T., Okita, K., Takahashi, K., Chiba, T., Yamanaka, S., 2008. Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science 321(5889), 699−702.
- Araki R, Jincho Y, Hoki Y, Nakamura M, Tamura C, Ando S, Kasama Y, Abe M., 2010. Conversion of ancestral fibroblasts to induced* pluripotent stem cells. Stem Cells. 2010 Feb-28(2):213−20.
- Barski, A., Cuddapah, S., Cui, K., Roh, T.Y., Schones, D.E., Wang, Z., Wei, G., Chepelev, I., Zhao, K., 2007. High-resolution profiling of histone methylations in the human genome. Cell 129(4), 823−37.
- Baudino TA, McKay C, Pendeville-Samain H, Nilsson JA, Maclean KH, White EL, Davis AC, Ihle JN, Cleveland JL., 2002. c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes Dev. 2002 Oct l-16(19):2530−43.
- Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, et al. A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006- 125:315−26
- Bhutani, N., Brady, J.J., Damian, M., Sacco, A., Corbel, S.Y., Blau, H.M., 2010. Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature 463(7284), 1042−7.
- Bleiloch R, Venere M, Yen J, Ramalho-Santos M. Generation of induced pluripotent stem cells in the absence of drug selection. Cell Stem Cell 2007- 1:245- 7.
- Boiani M, Scholer HR., 2005. Regulatory networks in embryo-derived pluripotent stem cells. Nat Rev Mol Cell Biol. 2005 Nov-6(ll):872−84. Review.
- Borowiak M, Melton DA., 2009. How to make beta cells? Curr Opin Cell Biol. 2009 Dec-21(6):727−32. Epub 2009 Sep 24. Review.
- Brambrink, T., Foreman, R., Wei stead, G.G., Lengner, C.J., Wernig, M., Suh, H., Jaenisch, R., 2008. Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell 2(2), 151−9.
- Brandenberger, R., Khrebtukova, I., Thies, R.S., Miura, T., Jingli, C., Puri, R., Vasicek, T., Lebkowski, J., Rao, M., 2004. Mpss profiling of human embryonic stem cells. BMC Dev Biol. 4, 10 (2004).
- Buchholz, D.E., Hikita, S.T., Rowland, T.J., Friedrich, A.M., Hinman, C.R., Johnson, L.V., Clegg, D.O., 2009. Derivation of functional retinal pigmented epithelium from induced pluripotent stem cells. Stem Cells 27(10), 2427−34.
- Carey, B.W., Markoulaki, S., Beard, C., Hanna, J., Jaeniseh, R., 2010. Single-gene transgenic mouse strains for reprogramming adult somatic cells. Nat Methods 7(1), 56−9.
- Cedar, H., Bergman, Y., 2009. Linking DNA methylation and histone modification: patterns and paradigms. Nat Rev Genet. 10(5), 295−304.
- Chambers I, Colby D, Robertson M, Nichols J, Lee S, Tweedie S, Smith A., 2003. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell. 2003 May 30−113(5):643−55.
- Chang TC, Yu D, Lee YS, Wentzel EA, Arking DE, West KM, Dang CV, Thomas-Tikhonenko A, Mendell JT., 2007. Widespread microRNA repression by Myc contributes to tumorigenesis. Nat Genet. 2008 Jan-40(l):43−50. Epub 2007 Dec 9.
- Chen, Y., Li, X., Eswarakumar, V.P., Seger, R., Lonai, P., 2000. Fibroblast growth factor (FGF) signaling through" PI 3-kinase and Akt/PKB is required for embryo id body differentiation. Oncogene 19(33), 3750−6.
- Cowan CA, Klimanskaya I, McMahon J, Atienza J, Witmyer J, Zucker JP, Wang S, Morton CC, McMahon AP, Powers D, Melton DA, 2004. Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med. 2004 Mar 25- 350(13): 1353−6.
- Dang CV, O’Donnell KA, Zeller KI, Nguyen T, Osthus RC, Li F., 2006. The c-Myc target gene network. Semin Cancer Biol. 2006 Aug-16(4):253−64. Epub 2006 Jul 25.
- Dang, D. T., Pevsner, J., & Yang, V. W., 2000. The biology of the mammalian Kruppel-like family of transcription factors. International Journal of Biochemistry and Cell Biology, 32, 1103−1121. doi: 10.1016/S1357−2725(00)00059−5.
- Davis AC, Wims M, Spotts GD, Hann SR, Bradley A., 1993. A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes Dev. 1993 Apr-7(4):671−82.
- De Felici, M., Farini, D., Dolci, S., 2009. In or out sternness: comparing growth factor signalling in mouse embryonic stem cells and primordial germ cells. Curr Stem Cell Res Ther. 4(2), 87−97.
- Deaton AM, Bird A., 2011. CpG islands and the regulation of transcription. Genes Dev. 2011 May 15−25(10):1010−22. Review.
- Deb-Rinker, P., Ly, D., Jezierski, A., Sikorska, M., Walker, P.R., 2005. Sequential DNA methylation of the Nanog and Oct-4 upstream regions in human NT2 cells during neuronal differentiation. J Biol Chem. 280(8), 6257−60.
- Doi, A., Park, I.H., Wen, B., Murakami, P., Aryee, M.J., Irizarry, R., Herb, B., Ladd-Acosta,
- Duinsbergen, D., Eriksson, M., 't Hoen, P.A., Frisen, J., Mikkers, H., 2008. Induced pluripotency with endogenous and inducible genes. Exp Cell Res. 314(17), 3255−63.
- Efroni, S., Duttagupta, R., Cheng, J., Dehghani, H., Hoeppner, D.J., Dash, C., Bazett-Jones,
- D.P., Le Grice, S., McKay, R.D., Buetow, K.H., Gingeras, T.R., Misteli, T., Meshorer, E., 2008. Global transcription in pluripotent embryonic stem cells. Cell Stem Cell 2(5), 437−47.
- Eminli, S., Utikal, J., Arnold, K., Jaenisch, R., Hochedlinger, K., 2008. Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression. Stem Cells 26(10), 2467−74.
- Evans, M.J., Kaufman, M.H., 1981. Establishment in culture of pluripotential cells from mouse embryos. Nature 292(5819), 154−6.
- Evans, P.M., Zhang, W., Chen, X., Yang, J., Bhakat, K.K., Liu, C., 2007. Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation. J Biol Chem. 282(47), 33 994−4002.
- Ghosh, Z., Wilson, K.D., Wu, Y., Hu, S., Quertermous, T., Wu, J.C., 2010. Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells. PLoS One 5(2), e8975.
- Gidekel, S., Bergman, Y., 2002. A unique developmental pattern of Oct-¾ DNA methylation is controlled by a cis-demodification element. J Biol Chem. 277(37), 34 521−30.
- Greber, B., Lehrach, H., Adjaye, J., 2007. Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal. BMC Dev Biol. 7, 46.
- Guenther, G., Arauz, A., 2010. Cerebral venous thrombosis: a diagnostic and treatment update. Neurologia. [Epub ahead of print] Spanish.
- Hajkova, P., Jeffries, S.J., Lee, C., Miller, N., Jackson, S.P., Surani, M.A., 2010. Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway. Science 329(5987), 78−82.
- Han J, Sachdev PS, Sidhu KS., 2010. A combined epigenetic and non-genetic approach for reprogramming human somatic cells. PLoS One. 2010 Aug 19−5(8):el2297.
- Ho, L., Jothi, R., Rouan, J.L., Cui, K., Zhao, K., Crabtree, G.R., 2009a. An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network. Proc Natl Acad Sci USA. 106(13), 5187−91.
- Hochedlinger K, Plath K., 2009. Epigenetic reprogramming and induced pluripotency. Development. 2009 Feb-136(4):509−23. Review.
- Huangfu, D., Maehr, R., Guo, W., Eijkelenboom, A., Snitow, M., Chen, A.E., Melton, D.A., 2008a. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol. 26(7), 795−7.
- Huangfu, D., Osafune, K., Maehr, R., Guo, W., Eijkelenboom, A., Chen, S., Muhlestein, W., Melton, D.A., 2008b. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol. 26(11), 1269−75.
- Humphrey, R.K., Beattie, G.M., Lopez, A.D., Bucay, N., King, C.C., Firpo, M.T., RoseJohn, S., Hayek, A., 2004. Maintenance of pluripotency in human embryonic stem cells is STAT3 independent. Stem Cells 22(4), 522−30.
- Kaji, K., Norrby, K., Paca, A., Mileikovsky, M., Mohseni, P., Woltjen, K., 2009. Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature 458(7239), 771−5.
- Kang, L., Wang, J., Zhang, Y., Kou, Z, Gao, S., 2009. iPS cells can support full-term development of tetraploid blastocyst-complemented embryos. Cell Stem Cell 5(2), 135−8.
- Kim, J., Chu, J., Shen, X., Wang, J., Orkin, S.H., 2008a. An extended transcriptional network for pluripotency of embryonic stem cells. Cell 132(6), 1049−61.
- Kim, J.B., Zaehres, H., Arauzo-Bravo, M.J., Scholer, H.R., 2009. Generation of induced pluripotent stem cells from neural stem cells. Nat Protoc. 4(10), 1464−70.
- Knoepfler, P. S., 2008. Why myc? An unexpected ingredient in the stem cell cocktail. Cell Stem Cell 2(1), 18−21.
- Lagarkova MA, Volchkov PY, Lyakisheva AV, Philonenko ES, Kiselev SL, 2006. Diverse epigenetic profile of novel human embryonic stem cell lines. Cell Cycle- 5:416−20.
- Lagarkova MA, Volchkov PY, Philonenko ES, Pfannkuchc K, Prokhorovich MA, Zabotina T, Kiselev SL, 2008a. CD30 is a marker of undifferentiated human embry- onic stem cells rather than a biomarker of transformed hESCs. Cell Cycle- 7:3610−2.
- Lagarkova MA, Volchkov PY, Philonenko ES, Kiselev SL, 2008b. Efficient differentiation of hESCs into endothelial cells in vitro is secured by epigenetic changes. Cell Cycle- 7:2929−35.
- Lebofsky R, Walter JC., 2007. New Myc-anisms for DNA replication and tumorigenesis? Cancer Cell. 2007 Aug- 12(2): 102−3.
- Levenstein, M.E., Ludwig, T.E., Xu, R.H., Llanas, R.A., VanDenHeuvel-Kramer, K., Manning, D., Thomson, J.A., 2006. Basic fibroblast growth factor support of human embryonic stem cell self-renewal. Stem Cells 24(3), 568−74.
- Liang J, Wan M, Zhang Y, Gu P, Xin H, Jung SY, Qin J, Wong J, Cooney AJ, Liu D, Songyang Z., 2008. Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nat Cell Biol. 2008 Jun-10(6):731−9. Epub 2008 May 4.
- Liu, L., Luo, G.Z., Yang, W., Zhao, X., Zheng, Q., Lv, Z., Li, W., Wu, H.J., Wang, L., Wang, X.J., Zhou, Q., 2010. Activation of the imprinted Dlkl-Dio3 region correlates with pluripotency levels of mouse stem cells. J Biol Chem. 285(25), 19 483−90.
- Loh, Y.H., Zhang, W., Chen, X., George, J., Ng, H.H., 2007. Jmjdla and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Genes Dev. 21(20):2545−57.
- Ludwig TE, Levenstein ME, Jones JM, Berggren WT, Mitchen ER, Frane JL, Crandall LJ, Daigh CA, Conard KR, Piekarczyk MS. Lianas RA, Thomson JA, 2006. Derivation of human embryonic stem cells in defined conditions. Nat Biotcchnol. 24(2): 185−7.
- Maherali N, Sridharan. R, Xie W, Utikal J, Eminli S, Arnold K, Hochedlinger K, 2007. Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution- Cell Stem Cell- 1:55−70.
- Maherali, N., Ahfeldt, T., Rigamonti, A., Utikal, J, Cowan, C., Hochedlinger, K., 2008. A high-efficiency system for the generation and study of human induced pluripotent stem cells. Cell Stem Cell 3(3), 340−5.
- Marchetto, M.C., Yeo, G.W., Kainohana, O., Marsala, M., Gage, F.H., Muotri, A.R., 2009. Transcriptional signature and memory retention of human-induced pluripotent stem cells. PLoS One 4(9), e7076.
- Matoba, R., Niwa, H., Masui, S., Ohtsuka, S., Carter, M.G., Sharov, A.A., Ко, M.S., 2006. Dissecting Oct¾-regulated gene networks in embryonic stem cells by expression profiling. PLoS One 1, e26.
- Mattout, A., Meshorer, E., 2010. Chromatin plasticity and genome organization in pluripotent embryonic stem cells. Curr Opin Cell Biol. 22(3), 334−41.
- McConnell BB, Ghaleb AM, Nandan MO, Yang VW, 2007. The diverse functions of Kruppel-like factors 4 and 5 in epithelial biology and pathobiology. Bioessays. 2007 Jun-29(6):549−57. Review. Erratum in: Bioessays. 2007 Sep-29(9):946.
- Mikkola, M., Olsson, C., Palgi, J., Ustinov, J., Palomaki, Т., Horelli-Kuitunen, N., Knuutila, S., Lundin, K., Otonkoski, Т., Tuuri, Т., 2006. Distinct differentiation characteristics of individual human embryonic stem cell lines. BMC Dev Biol. 6, 40.
- Niwa, H., Burdon, T., Chambers, I., Smith, A., 1998. Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev. 12(13), 2048−60.
- Okita, K., Ichisaka, T., Yamanaka, S., 2007. Generation of germline-competent induced pluripotent stem’cells.Nature 448(7151), 313−7.
- Okita, K., Nakagawa, M., Hyenjong, H., Ichisaka, T., Yamanaka, S., 2008. Generation of mouse induced pluripotent stem cells without viral vectors. Science 322(5903), 949−53.
- Pan, G., Tian, S., Nie, J., Yang, C., Ruotti, V., Wei, H., Jonsdottir, G.A., Stewart, R., Thomson, J.A., 2007. Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells. Cell Stem Cell 1(3), 299−312.
- Park, S.H., Park, S.H., Kook, M.C., Kim, E.Y., Park, S., Lim, J.H., 2004. Ultrastructure of human embryonic stem cells and spontaneous and retinoic acid-induced differentiating cells. Ultrastruct Pathol. 28(4), 229−38.
- Patel JH, Loboda AP, Showe MK, Showe LC, McMahon SB., 2004. Analysis of genomic targets reveals complex functions of MYC. Nat Rev Cancer. 2004 Jul-4(7):562−8.
- Pfannkuche K, Fatima A, Gupta MK, Dieterich R, Hescheler J., 2010. Initial colony morphology-based selection for iPS cells derived from adult fibroblasts is substantially improved by temporaryUTFl-based selection: PEoS One. 2010 Mar8−5(3):e9580.
- Popp, C., Dean, W., Feng, S., Cokus, S.J., Andrews, S., Pellegrini, M., Jacobsen, S.E., Rcik, W., 2010. Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature 463(7284), 1101−5.
- Prigione A, Adjaye J., 2010. Modulation of mitochondrial biogenesis and bioenergetic metabolism upon in vitro and in vivo differentiation of human ES and iPS cells. Int J Dev Biol. 2010−54(11−12): 1729−41.
- Reik, W., Dean, W., Walter, J., 2001. Epigenetic reprogramming in mammalian development. Science 293(5532), 1089−93.
- Richards, M., Tan, S., Fong, C.Y., Biswas, A., Chan, W.K., Bongso, A., 2003. Comparative evaluation of various human feeders for prolonged undifferentiated growth of human embryonic stem cells. Stem Cells 21, 546−56.
- Richards, M., Tan, S.P., Tan, J.H., Chan, W.K., Bongso, A., 2004. The transcriptome profile of human embryonic stem cells as defined by SAGE Stem Cells 22, 51−64.
- Santos, A.P., Abranches, R., Stoger, E., Beven, A., Viegas, W., Shaw, P.J., 2002. The architecture of interphase chromosomes and gene positioning are altered by changes in DNA methylation and histone acetylation. J Cell Sci. 115, 4597−605.
- Scheper W, Copray S., 2009. The molecular mechanism of induced pluripotency: a two-stage switch. Stem Cell Rev. 2009 Sep-5(3):204−23. Epub 2009 Jun 24.
- Scholer, H.R., Hatzopoulos, A.K., Balling, R., Suzuki, N., Grass, P., 1989. A family of octamer-specific proteins present during mouse embryogenesis: evidence for germline-specific expression of an Oct factor. EMBO J. 8(9), 2543−50.
- Shi, Y., Desponts, C., Do, J.T., Hahm, H.S., Scholer, H.R., Ding, S., 2008. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 3(5), 568−74.
- Shields JM, Christy RJ, Yang VW., 1996. Identification and characterization of a gene encoding a gut-enriched Kriippel-like factor expressed during growth arrest. J Biol Chem. 1996 Aug 16−271(33):20 009−17.
- Simonsson, S., Gurdon, J., 2004. DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei. Nat Cell Biol. 6(10), 984−90-
- Singhal, N., Graumann, J., Wu, G., Arauzo-Bravo, M.J., Han, D.W., Greber, B., Gentile, L., Mann, M., Scholer, H.R., 2010. Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming. Cell 141(6), 943−55.
- Smith, A.G., Hooper, M.L., 1987. Buffalo rat liver cells produce a diffusible activity which inhibits the differentiation of murine embryonal carcinoma and embryonic stem cells. Dev Biol. 121(1), 1−9.
- Smyth GK, 2004. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol. 2004−3:Article3. Epub 2004 Feb 12.
- Sridharan, R., Tchieu, J., Mason, M.J., Yachechko, R., Kuoy, E., Horvath, S., Zhou, Q., Plath, K., 2009. Role of the murine reprogramming factors in the induction of pluripotency. Cell 136(2), 364−77.
- Stadtfcld, M., Apostolou, E., Akutsu, H., Fukuda, A., Follett, P., Natesan, S., Kono, T., Shioda, T., Hochcdlinger, K., 2010. Aberrant silencing of imprinted genes on chromosome 12qFl in mouse induced pluripotent stem cells. Nature 465(7295), 175−81.
- Stadtfcld, M., Brcnnand, K., Hochedlinger, K., 2008a. Reprogramming of pancreatic beta cells into induccd pluripotent stem cells. Curr Biol. 18(12), 890−4.
- Stadtfcld, M., Hochedlinger, K., 2010. Induced pluripotency: history, mechanisms, and applications. Genes Dev. 24(20), 2239−63.
- Stadtfeld, M., Nagaya, M., Utikal, J., Weir, G., Hochedlinger, K., 2008b. Induced pluripotent stem cells generated without viral integration. Science 322(5903), 945−9.
- Sumi, T., Fujimoto, Y., Nakatsuji, N., Suemori, H., 2004. STAT3 is dispensable for maintenance of self-renewal in nonhuman primate embryonic stem cells. Stem Cells 22(5), 861−72.
- Szutorisz, H., Dillon, N., 2005. The epigenetic basis for embryonic stem cell pluripotency. Bioessays. 27(12), 1286−93.
- Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S, 2007. Induction of pluripotent stem cells from adult human fibroblasts by defined fac- tors. Cell- 131:861−72.
- Takahashi, K., Yamanaka, S., 2006. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126(4), 663−76.
- Thomson, J.A., Itskovitz-Eldor, J., Shapiro, S.S., Waknitz, M.A., Swiergiel, J.J., Marshall, V.S., Jones, J.M., 1998. Embryonic stem cell lines derived from human blastocysts. Science 282(5391), 1145−7.
- Utikal, J., Maherali, N., Kulalert, W., Hochedlinger, K., 2009. Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells. J Cell Sci. 122, 3502−10.
- Vallier, L., Alexander, M., Pedersen- R.A., 2005. Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells. J Cell Sci. 118, 4 495 509.
- Viswanathan, S.R., Daley, G.Q., Gregory, R.I., 2008. Selective blockade of microRNA processing by Lin28. Science 320(5872), 97−100.
- Wang, J., Rao, S., Chu, J., Shen, X., Levasseur, D.N., Theunissen, T.W., Orkin, S.H., 2006. A protein interaction network for pluripotency of embryonic stem cells. Nature 444(7117), 364−8.
- Wei D, Kanai M, Huang S, Xie K., 2006. Emerging role of KLF4 in human gastrointestinal cancer. Carcinogenesis. 2006 Jan-27(l):23−31.Epub 2005 Oct 11. Review.
- Wernig M, Meissner A, Foreman R, Brambrink T, Ku M, Hochedlinger K, 2007. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 2007- 448:318−24.
- Wernig, M., Lengner, C.J., Hanna, J., Lodato, M.A., Steine, E., Foreman, R., Staerk, J., Markoulaki, S., Jaenisch, R., 2008. A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat Biotechnol. 26(8), 916−24.
- Wilson, K.D., Venkatasubrahmanyam, S., Jia, F., Sun, N., Butte, A.J., Wu, J.C., 2009. MicroRNA profiling of human-induced pluripotent stem cells. Stem Cells Dev. 18(5), 749−58.
- Wu, Q., Chen, X., Zhang, J., Loh, Y.H., Low, T.Y., Zhang, W., Zhang, W., Sze, S.K., Lim, B., Ng, H.H., 2006. Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells. J BioLChem. 281(34), 24 090−4.
- Xiao, L., Yuan, X., Sharkis, S.J., 2006. Activin A maintains self-renewal and regulates fibroblast growth factor, Wnt, and-bone morphogenic protein pathways in human embryonic stem cells. Stem Cells 24(6), 1476−86.
- Xu, R.H., Peck, R.M., Li, D.S., Feng, X., Ludwig, T., Thomson, J.A., 2005. Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells. Nat Methods 2(3), 185−90.
- Yakubov, E., Rechavi, G., Rozenblatt, S., Givol, D., 2010- Reprogramming of human- fibroblasts to pluripotent stem cells using' mRNA of four transcription, factors. Biochem Biophys Res Commun. 394(1), 189−93.
- Yang, J., Chai, L., Fowles, T.C., Alipio, Z., Xu, D., Fink, L.M., Ward, D.C., Ma, Y., 2008. Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells. Proc Natl Acad Sci USA. 105(50), 19 756−61.
- Yeo S, Jeong S, Kim J, Han JS, Han YM, Kang YK. Characterization of DNA methylation change in stem cell marker genes during differentiation of human embryonic stem cells. Biochem Biophys Res Commun 2007- 359:536−42.
- Ying, Q.L., Nichols, J., Chambers, I., Smith, A., 2003. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 115(3), 281−92.
- Yoshida Y, Yamanaka S., 2010. Recent stem cell advances: induced pluripotent stem cells for disease modeling and stem cell-based regeneration. Circulation. 2010 Jul 6−122(l):80−7. Review.
- Yuan H, Corbi N, Basilico C, Dailey L., 1995. Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev. 1995 Nov l-9(21):2635−45.
- Yusa, K., Rad, R., Takeda, J., Bradley, A., 2009. Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon. Nat Methods 6(5), 363−9.
- Zeng, X., Miura, T., Luo, Y., Bhattacharya, B., Condie, B., Chen, J., Ginis, I., Lyons, I., Mejido, J., Puri, R.K., Rao, M.S., Freed, W.J., 2004. Properties of pluripotent human embryonic stem cells BG01 and BG02. Stem Cells 22(3), 292−312.
- Zhao XD, Han X, Chew JL, Liu J, Chiu KP, Choo A, et al. Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells. Cell Stem Cell 2007- 1:286−98.
- Zhou, W., Freed, C.R., 2009. Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cells. Stem Cells 27(11), 2667−74.