Картирование генома человека с помощью флюоресцентной in situ гибридизации: Субхромосомная локализация 137 последовательностей
Диссертация
Из 64 000−100 000 генов, содержащихся в геноме человека, в настоящее время картировано только несколько тысяч. Это связано с тем, что основная часть генов экспрессируется только в определенных тканях и на определенных этапах развития, что существенно затрудняет их поиск. Идентификация генов при тотальном клонировании и секвенировании генома также встречает определенные трудности: большая часть… Читать ещё >
Список литературы
- Билтуева Л.С., Рубцов Н. Б., Сердюкова Н. А., Воробьева Н. В., Кафтановская Е. М., Ян Фентан, Забаровскии Е.Р., Графодатскии А. С. Возможности анализа макроэволюционных преобразовании хромосом млекопитающих // Генетика, — 1997,-Т. 33(8).-с. 1094−1101.
- Графодатский А.С., Раджабли С. И. Хромосомы сельскохозяйственных и лабораторных млекопитающих//Новосибирск: Наука,-1988.- 128 с.
- Забаровский Е.Р., Домнинский Д. А., Киселев Л. Л. Физическое картирование генома человека: на пути к выработке оптимальной стратегии // Молекулярная биология, — 1994.-Т.28, N.6.- Р. 1231−1244.
- Козырев С.В. CpG островки как инструмент поиска новых генов: клонирование, анализ экспрессии, экзон-интронная структура и хромосомная локализация гена LKLF человека //Автореф. дис.канд. биол. Наук: 03.00.03. М.: ИМБ, 1999.
- Коллинз Ф. Анализ генома. Методы / Под ред. Дейвиса К., // М., Мир.- 1990.-с. 95−122.
- Маниатис Т., Фрич Э., Сэмбрук Д. Молекулярное клонирование // М.: Мир, 1984.
- Antequera F., Bird A. Number of CpG islands and genes in human and mouse // Pros. Natl. Acad. Sci USA.- 1993,-V90.- P. 11 995−11 999.
- Antequera F., Boyes J., Bird A. High levels of de novo methylation and altered chromatin structure at CpG islands in cell-lines // Cell.- 1990, — V. 62.- P. 503−514.
- Ainscough J.F., John R.M., Surani M.A. Mechanism of imprinting on mouse distal chromosome 7 // Genet. Res.- 1998, — V. 72, N.3.- P. 237−245.
- Aota S., and Ikemura T. Diversity in G+C content at the third position of codons in vertebrate genes and its cause // Nucl. Acids Res.- 1986, — V,-14, — P. 6345−6355.
- Berezney R., and Coffey D.S. Identification of a nuclear protein matrix // Biochem. Biophys. Res. Commun.- 1974,-V. 60, — P. 1410−1417.
- Bernardi G. The vertebrate genome: isochores and evolution // Mol. Biol. Evol.-1993,-V. 10,-P. 186−204.
- Bernardi G. // Isochores and the evolutionary genomics of vertebrates // Gene.-2000,-V. 241, — P. 3−17.
- Bickmore W., Sumner A. Mammalian chromosome banding an expression of genom organization // Trends Genet.-1989.- V. 5.-P. 144−148.
- Bickmore W.A., Carothers A.D. Factors affecting the timing and imprinting of replication on a mammalian chromosome // J. Cell Sci.-1995.- V. 108.- P. 28 012 809.
- Bird A. CpG islands as gene markers in the vertebrate nucleus // Trends in Genetics.-1987.-.V. 3, N.12.-P. 342−347.
- Bird A., Taggart M., Frommer M., Miller O.J., Macleod D. A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA // Cell.-1985,-V. 40, — P. 91−99.
- Boulikas T. Chromatin domains and prediction of MAR sequences // International Review of Cytology.- 1995,-V. 162А, — P. 279−388.
- Boy de la Tour E. and Laemmli U.K. The metaphase scaffold is helically folded: sister chromatids have predominantly opposite helical handedness // Cell.- 1988,-V. 55, — P. 937−944.
- Boyle A.L., Ballard S.G., Ward D.C. Differential distribution of long and short interspersed element sequences in the mouse genome: chromosome karyotyping by fluorescence in situ hybridization // Pros. Natl. Acad. Sci USA.- 1990, — V. 87,-P. 7757−7761.
- Bridger J.M., Bickmore W.A. Putting the genome on the map // Trends in Genetics.- 1998.-.V. 14, N.10.-P. 403−409.
- Britten R.J., Graham D.E., Neufeld B.R. Analisis of repeating DNA sequence by reassociation // Methods in enzymology. N.Y.I.: Acad.Press.- 1974, — V. 29.- part E.- P. 363−419.
- Burke D.T., Carle G.F., Olson M.V. Cloning of large segments of exogenous DNA into yeast by means of artificial chromosome vector // Science.- 1987, — V. 236.- P. 806−812.
- Camargo M., Cervenka. J. Patterns of chromosomal replication in synchronized lymphocytes. 1. Evaluation and application of methotrexate block // Hum. Genet.-1980.-V. 54, — P. 47−53.
- Cavalier-Smith T. Eukariote gene numbers, non-coding DNA and genom size // In: Cavalier-Smith T. (Ed.), The Evolution of Genom Size, Willey, London, 1985.-P. 69−103.
- Cedar H. DNA methyiation and gene activity. // Cell.- 1988, — V. 53, — P. 3−4.
- Chandley A.C. A model for effective pairing and recombination at meiosis based on early replicating sites (R-bands) along chromosomes // Hum. Genet.-1986, — V. 72.- P. 50−57.
- Chen T.L., Manuelidis L. SINEs and LINEs claster in distinct DNA fragments of Giemsa band size // Chromosoma.- 1989, — V. 98, N.5.- P. 309−316.
- Chumakov I.M. and 60 other authors. A YAC contig map of the human genome // Nature.- 1995,-V. 377(suppl.).- P. 175−297.
- Collins F., Weissman S. Direction cloning of DNA fragments at a large distance from an initial probe: a circularisation method // Proc. Natl. Acad. Sci. USA.-1984.-V. 81, — P. 6812−6816.
- Collins F., Drumm M., Cole J., Lockwood W., Vande Woude G., Lannuzzi M. Construction of a general human jumping library with application to cyclic fibrosis // Science.- 1987, — V. 235, — P. 1046−1049.
- Comings D.E. Mechanisms of chromosome banding and implication for chromosome structure //Annu. Rev. Genet.- 1978, — V. 12, — P. 25−46.
- Cooper D.N. Mapping the human genome // Ann. Genet.- 1994, — V. 37, — P. 101 112.
- Craig J.M., Bickmore W.A. Chromosome bands flavours to savour // BioEssays.- 1993, — V. 15, — P. 349−354.
- Craig J.M., Bickmore W.A. The distribution of CpG islands in mammalian chromosomes // Nature Genet.-1994.- V. 7, — P. 376−382.
- Cross S.H., Bird A.P. CpG islands and genes // Current Opinion in Genetics and Development.-1995.- V. 5, — P. 309−314.
- De Sario A., Geigl E., Palmieri G., D’Urso M., and Bernardi G. A compositional map of human chromosome band Xq28 // Proc. Natl. Acad. Sci. USA.- 1996.-V. 93, — P. 1298−1302.
- Dhar V., Skoultchi A.I., Schildkraut C.L. Activation and repression of a beta-globin dene in cell hybrids is accompanied by a shift in its temporal replication // Mol. Cell Biol.- 1989, — V. 9, N.8.- P. 3524−3532.
- Donev R.M., Djondjurov L.P. Macromolecular and ultrastructural of the mitotic chromosome scaffold // DNA Cell Biol.- 1999, — V. 18, N.2.- P. 97−105.
- Drouin R., Boutouil M., Fetni R., Holmquist G.P. Scott P., Richer C-L. Lemieux N. DNA replication asynchrony between the paternal and maternal alleles of imprinted genes does not straddle the R/G transition // Chromosoma.-1997.- V. 106, — P. 405−411.
- Drouin R., Holmquist G.P. Richer C-L. High-resolution replication bands compared with morphologic G- and R-bands // AdV. Hum. Genet.-1994, — V. 22.-P. 47−115.
- Drouin R., Lemieux N., Richer C-L. Analysis of DNA replication during S-phase by means of dynamic chromosome banding at high resolution // Chromosome.-1990,-V. 99, — P. 273−280.
- Drouin R., Lemieux N., Richer C-L. Chromosome condensation from prophase to late metaphase: Relationship to chromosome bands and their replication time // Cytogenet. Cell Genet.- 1991, — V57.- P. 91−99.
- Dutrillax В., Counturier J., Richer C-L., and Viegas-Peguinot E. Sequence of DNA replication in 277 R- and Q-bands of human chromosomes using a BrdU treatment //Chromosoma.-1976, — V. 58, — P. 51−61.
- Edmondson D.G., Roth S.Y. Chromatin and transcription // The FASEB Journal.-1996, — V. 10, — P. 1173−1182.
- Efstratiadis A. Parental imprinting of autosomal mammalian genes //. Curr. Opin. Genet DeV. 1994,-V. 4, — P. 265−280.
- Ehrlich M., Wang R.Y. 5-Methilcytosine in eukaryotic DNA // Science.- 1981, — V. 212(4501).- P. 1350−1357.
- Federico С., Saccone S., and Bernardi G. The gene-richest bands of human chromosomes replicate at the onset of the S-phase // Cytogenet. Cell Genet.-1998,-V. 80, — P. 83−88.
- Fields C. Adams M.D., White O., Venter J.C. How many genes in the human genome? // Nature Genet.-1994.- V. 7, — P. 345−346.
- Filipski J. Correlation between molecular clock ticking, codon usage, fidelity of DNA repair, chromosome banding and chromatin compactness in germline cell // FEBS LETTERS.-1987, — V. 217, N.2.- P. 184−186.
- Frank D., Keshet I., Shani M., Levine A., Razin A., Cedar H. Demethylation of CpG islands in embrionic cells // Nature.-1991.- V. 351.- P. 239−241.
- Gardiner K., Aissani В., and Bernardi G. A compositional map of human chromosome 21 // EMBO J.-1990.-V. 9, N.1.- P. 25−34.
- Gardiner-Garden M., and Frommer M. CpG islands in vertebrate genomes // J. Moi. Biol.-1987, — V. 196, — P. 261−282.
- Gemmill R.M., Chumakov I., Scott P., et al. A second-generation YAC contig map of human chromosome // Nature.- 1995, — V. 377, — P. 299−319/
- Giacalone J., Friedes J., and Franke U. A novel GC-rich human macrosatellite VNTR in Xq24 is differentially methylated on active and inactive X chromosomes // Nature Genetics.- 1992, — V. 1.- P. 137−143.
- Green E., Green P. Sequence-tagged site (STS) content mapping of human chromosomes: theoretical considerations and early experiences // PCR Methods Appl.-1991,-V. 1, — P. 77−90.
- Gregory P. D., Horz W. Chromatin and transcription. How transcription factors battle with a repressive chromatin environment // Eur. J. Biochem.- 1998, — V. 251, — P. 9−18.
- Hatada I., Kitagava K., Yamaoka Т., Wang X.D., Arai Y., Hashido H., Ohishi S., Masuda J., Ogata J., Mukai T. Allele-specific methylation and expression of an imprinted U2af1-rs1 (SP2) gene// Nucleic Acids Res.-1995.- V. 23.- P. 36−41.
- Hatton K.S., DharV., Brown E.H., Iqbal M.A., Stuart S., Didano V. Т., Schildkraut C.L. Replication program of active and inactive multigene families in mammalian cells // Mol. Cell Biol.- 1988- V. 8, — P. 2149−2158.
- Hilcs R., Muhlig P., and Claussen U. The nature of G-bands analyzed by chromosome stretching // Cytogenet. Cell Genet.-1997.- V. 79, — P. 162−166.
- Hino O., Testa J.R., Buetow K.H., Taguchi Т., Zhou J.Y., Bremer M., Bruzel A., Yeung R., Levan G., Levan K.K. Universal mapping probes and the origin of human chromosome 3. // Proc Natl Acad Sci.- 1993, — V. 90, — P. 730−734
- Holberg M., Johnasson. Preferential location of X-ray induced chromosome breakage in the R-bands of human chromosomes // Hereditas.- 1973, — V. 74.- P. 57−68.
- Holmquist G.P. Chromosome bands, their chromatin flavor, and their functional features//Am. J. Hum. Genet.-1992.-V. 51, — P. 17−37.
- Holmquist G.P. Role of replication time in the control of tissue-specific gene expression//Am. J. Hum. Genet- 1987,-V. 40, — P. 151−173.
- Hudson T.J., Stein L.D., Gerety S.S., Ma J., Castle A.B., Silva J., Slonim D.K., Baptista R., Kruglyak L., Xu S.H. et al. An STS-based map of the human genome //Science.- 1995,-V. 270, — P. 1945−1954.
- Ikemura Т., and Aota S. Global variation in G+C content along vertebrate genome DNA // J. Mol. Biol.-1988.- V. 203.- P. 1−13.
- Ikemura Т., Wada K., and Aota S. Giant G+C mosaic structures of the human-genome found by arrangement of GenBank human DNA sequences according to genetic positions // Genomics.-1990.- V. 8, — P. 207−216.
- ISCN An International System for Human Cytogenetic Nomenclature (ed. Harnden D.G. and Klinger H.P.) — 1985.
- Jabbari K., Caccio S., de Barros J.P. P., Desgres J., Bernardi G. Evolutionary changes in CpG and methylation level in the genome of vertebrates // Gene.-1997,-V. 205,-P. 109−118/
- Jackson D.A., Pombo A. Replicon clasters are stable units of chromosome structure: evidence that nuclear organization contributes to the efficient activation and propagation of S phase in human cells // J. Cell Biol.-1998, — V. 140, N.6.- P. 1285−1295.
- Kamakaka R.T., Thomas J.O. Chromatin structure of transcriptionally competent and repressed genes // EMBO J.- 1990, — V. 9.- P. 3997−4006.
- G., Zabarovsky E.R. Analisis of Notl linking clones isolated from human chromosome 3 specific libraries // Gene.-1999.-V. 239, — P. 259−271.
- Kokalj-Vokas N., Zagorac A., Pristovnik M., Bourgeois C., Dutrillaux B. DNA methylation of the extraembryonic tissues: an in situ study on human metaphase chromosomes//Chrom. Res.- 1998,-V. 6, — P. 161−166.
- Korenberg J.R., and Rykowski M.C. Human genome organisation. Alu, Lines, and the molecular structure of metaphase chromosome bands // Cell.- 1988.- V. 53.-P. 391−400.
- Koshland D., Strunnikov A. Mititic chromosome condensation // Annu. ReV. Cell DeV. Biol.- 1996,-V. 12, — P. 305−333.
- Kurz A., Lampel S., Nikolenko J.E., Bradi J., Benner A., Zirbel R.M., Cremer Т., Lichter P. Active and inactive genes localize preferentially in the periphery of chromosome territories // J. Cell Biol.-1996, — V. 135,-P. 1195−1202.
- Larsen F., Gundersen G., Lopez R., Prudz H. CpG islands as gene markers in the human genome//Genomics.-1992a.-V. 13, — P. 1095−1107
- Larsen F., Gundersen G. and Prudz H. Choice of enzymes for mapping based on CpG islands in the human genome//GATA.- 1992b.-V. 9(3).- P. 80−85.
- Lindsay S., Bird A.P. Use of restriction enzymes to detect potential gene sequences in mammalian DNA // Nature.- 1987, — V. 327, — P. 336−338.
- Lawrence J.В., Willnave C.A., Singer R.H. Sensitive, high-resolution chromatin and chromosome mapping in situ: presence and orientation of two closely integrated copies of EBV in a limphoma line // Cell.- 1988, — V. 52, — P.- 51 -61.
- Macleod D., Charlton J., Mullins J., Bird A.P. Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island // Genes DeV. -1994, — V. 8.- P. 2282−2292.
- Manuelidis !., Ward D.C., Chromosomal and nuclear distribution of the 1,9-kb human DNA repeat segment // Chromosoma.- 1984,-V. 91, — P. 28−38.
- Marcus M., Nielsen K., Goitein R., Gropp A. Pattern of condensation of mouse and Chinese hamster chromosomes in G2 and mitosis of 33 258 Hoechst -treated cell // Expl. Cell Res.-1979.-V. 122, — P. 191−201.
- Marsden M.P., Laemmli U.K. Metaphase chromosome structure: evidence for a radial loop model // Cell (Cambridge, Mass.).- 1979, — V. 17.* P. 849−858.
- McKusick V. A. Genomic mapping and how it has progressed // FASEB J.-1991,.- V. 26.- P. 50−64.
- Mitelman F., Mertens F., Johansson B. A breakpoint map of recurrent chromosomal rearrangements in human neoplasia // Nat Genet.- 1997, — Apr-15.-Spec No.- P.417−74
- Morton N. Parameters of human genome // Proc. Natl. Acad. Sci. USA.-1991 .V. 88, — P. 7474−7476.
- Mouchiroud D., D" Onofrio G., Aissani В., Macaya G., Gautier C., and Bernardi G. The distribution of gene in human genome // Gene.- 1991.- V. 100, — P. 181 187.
- Mouchiroud D., Bernardi G. Compositional properties of coding sequences and Mammalian phylogeny // J. Mol. Evol.- 1993,-V. 37, — P. 109−116.
- Nasir J., Maconochie M.K., and Brown S.D.M. Co-amplification of L1 line elements with localised low copy repeats in Giemsa dark bands: implications for genome organisation // Nucl. Acid Res.- 1991.- V. 19.- P. 3255−3260.
- Ng H., Bird A. DNA methylation and chromatin modification // Current Opinion in Genet. & Develop.- 1999, — V. 9, — P. 158−163.
- Nightingale K.P., Wellinger R.E., Sogo J.M., Becker P. B. Histone acetilation facilitates RNA polimerase II transcription of the Drosophila hsp26 gene in chromatin // EMBO Journal.- 1998, — V. 17, N.10.- P. 2865−2876.
- Nishioka Y., Dolan B.M., Fiorellino A., and Prado V. F. Nucleotide sequence analisis of a mouse Y chromosomal DNA fragment containing BKM and LINE elements // Genetica.- 1992, — V. 87, — P. 7−15.
- Noccala S., Noccala C. Coiled internal structure of chromonema within chromosomes suggesting hierarchical model for chromosome structure // Hereditas.- 1986, — V. 104, — P. 29−40.
- Ohnuki Y. Structure of chromosomes. I. Morphological studies of the spiral structure of human somatic chromosomes // Chromosoma.-1968.- V. 25, — P. 402 428.
- Olson M., Hood L., Cantor C., Botstein D. A common language for physical mapping of the human genome//Science.- 1989, — V. 245, — P. 1434−1435.
- Paulson J.R., and Laemmli U.K. The structure of histone-depleted metaphase chromosomes // Cell (Cambridge, Mass.).- 1977, — V. 12, — P. 817−828.
- Pinkel D., Straume Т., Gray J.W. Cytogenetic analysis using quantitative, high sensitivity, fluorescence hybridization // Proc. Natl. Acad. Sci. USA.- 1986.-V. 83.-P. 2934−2938.
- Poustka A. Construction and use of chromosome jumping libraries: // Methods in enzymology.- 1993.- V. 217, — P. 358−379.
- Poustka A. Large insert linking-clone libraries: construction and use // Methods in enzymology.- 1993, — V. 217, — P. 335−358.
- Poustka A., Pohl Т., Barlow D., Frischauf A., Lehrach H. Construction and use of chromosome jumping libraries from Notl-digested DNA // Nature.- 1987.- V. 352, — P. 353−355.
- Rattner J.B. Integrating chromosome structure with function // Chromosoma.-1992.-V. 101, — P. 259−264.
- Razin S.V., Cedar H. DNA methylation and genomic imprinting // Cell.-1994,-V. 77, — P. 473−476.
- Razin S.V., Gromova 1.1., larovaia O.V. Specificity and functional significance of DNA interaction with the nuclear matrix: new approaches to clarify the old question // International Review of Cytology.- 1995.- V. 162 В, — P. 405−448.
- Rocci A., Di Castro M., Prantera G. Effects of DAPI on human leucocytes in vitro // Cytogenet. Cell Genet.-1979.- V. 23, — P. 250−254.
- Sabeur G., Macaya G., Kadi F., Bernardi G. The isohore patterns of Mammalian genomes and their phylogenetic implications // J. Mol. Evol.-1993.- V. 37, — P. 93−108.
- Saccone S., Caccio S. Kusuda J., Andreozzi L., Bernardi G. Identification of the gene-richest bands in human chromosomes // Gene.-1996, — V. 174, — P. 85−94.
- Saccone S., Caccio S. Perani P., Andreozzi L., Rapisarda A., Motta S., Bernardi G. Compositional mapping of mouse chromosomes and identification of the gene-richest regions // Chrom. Res.- 1997, — V. 5, — P. 293−300.
- Saccone S., De Sario A., Valle G.D., and Bernardi G. The highest gene concentration in the human genome are in telomeric bands of metaphase chromosomes // Proc. Natl. Acad. Sci. USA.- 1992.-V. 89, — P. 4913−4917.
- Saccone S., De Sario A., Wiegant J., Raap A.K., Valle G.D., and Bernardi G. Correlation between isochores and chromosomal bands in the human genome // Proc. Natl. Acad. Sci. USA.- 1993.-V. 90, — P. 11 929−11 933.
- Saccone S., Federico C., Solovei I., Croquette M., Delia Valle G. and Bernardi G. Identification of the gene-richest bands in human prometaphase chromosomes // Chrom. Res.- 1999.- V. 7, — P. 379−386.
- Saitoh Y., Laemmli U. Metaphase chromosome structure: bands arise from a differential folding path of the highly AT-rich scaffold // Cell.- 1994, — V. 76, — P. 609 622.
- Sanford J., Kim B.W., Deaven L.L., Jones C., Higgins M.J., Novak N.J., Shows T.B. A human chromosome 11 Notl end clone library // Genomics.-1993.- V. 15,-P. 653−658.
- Seabright M. A rapid banding technique for human chromosomes // Lancet.-1971,-V. 11.-P. 971.
- Sternberg N. Bacteriophage P1 cloning system for the isolation, amplification, and recovery of DNA fragments as large as 100 kilobase pairs // Proc. Natl. Acad. Sci. USA.- 1990.-V. 87, — P. 103−107.
- Tazi J., Bird A. Alternative chromatin structure at CpG islands // Cell.-1990.- V. 60, — P. 909−920.
- Thiery J., Macaya G., Bernardi G. An analysis of eukaryotic genomes by density gradient centrifugation //J. Mol. Biol.- 1976,-V. 108, — P. 219−235.
- Tse C., Sera Т., Wolffe A.P., Hansen J.C. Disruption of higher-order folding by core histone acetilation dramatically enhances transcription of nucleosomal arrays by RNA polimerase III // Molecular and Cell Biology.-1998.-V. 18, N.8.- P. 4629−4638.
- Tykocinski M.L., Max E.E. CG dinucleotide clasters in MHC genes and in 5' demethylated genes // Nucleic Acids Res.-1984, — V. 12, — P. 4385−4396.
- Van Pouke M., Tornsten A., Mattheeuws M., Van Zeveren A., Peelman L.J., and Chowdhary B.P. Comparative mapping between human chromosome 3 and porcine chromosome 13 // Cytogenet Cell Genet.-1999.- V. 85, — P. 279−284.
- Vorobieva N.V., Filipenko M.L., Karpova G.G., Mertvetsov N.P. and Graphodatsky A.S. Assignment of the L32 ribosomal protein gene (RPL32) to human chromosome 3q13.3-q21 by in situ hibridization // Cytogenet. Cell Genet.-1997,-V. 77,-P. 190−191.
- Weisbrod S. Active chromatin. // Nature.- 1982, — V. 297, — P. 289−295.
- Wolfe K.H., Sharp P. M., Li W-H. Mutation rates differ among regions of the mammalian genome // Nature.- 1989, — V. 337, — P. 283−285.
- Wolffe A.P., Pruss D. Targeting chromatin disruption: transcription regulators that acetilate histones // Cell.- 1999.- V. 84.- P. 817−819.
- Wong A.K., Yee H.A., van de Sande J.H., and Rattner J.B. Distribution of CT-rich tracts is conserved in vertebrate chromosomes // Chromosoma.- 1990, — V. 99, — P. 344−351.
- Yokota H., Singer M.J., van den Engh G.J., Trask B.J. Regional difference in the compaction of chromatin in human Go/G 1 interphase nuclei // Chromosome Research.- 1997,-V. 5, — P. 157−166.
- Yunis J.J. Mid-prophase human chromosomes. The attainment of 2000 bands // Human Genet.-1981.-V. 56.-P. 239−298.
- Zabarovsky E.R., Winberg G., Klein G. The SK-diphasmids Vectors for genomic, jumping and cDNA library//Gene-1993,-V. 127,-P. 1−14.
- Zink D., Bornfleth H., Visser A., Cremer C., Cremer T. Organization of early and late replicating DNA in human chromosome territories // ExP. Cell Res.-1999.-V. 247, — P. 176−188.
- Zoubak S., Clay O., Bernardi G. The gene distribution of human genome // Gene.- 1996, — V. 174, — P. 95−102.