Π Π΅Π³ΡΠ»ΡΡΠΈΡ RAL-Π·Π°Π²ΠΈΡΠΈΠΌΡΡ ΡΠΈΠ³Π½Π°Π»ΡΠ½ΡΡ ΠΏΡΡΠ΅ΠΉ Π² ΠΊΠ°Π½ΡΠ΅ΡΠΎΠ³Π΅Π½Π΅Π·Π΅: ΡΠ±ΠΈΠΊΠ²ΠΈΡΠΈΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ RalA ΠΈ RalB
ΠΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΡ
Π Π΄Π°Π½Π½ΠΎΠΉ ΡΠ°Π±ΠΎΡΠ΅ Π±ΡΠ» Π²ΠΏΠ΅ΡΠ²ΡΠ΅ ΠΏΡΠΎΠ΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΠΎΠ²Π°Π½ ΡΠ°ΠΊΡ ΡΠ±ΠΈΠΊΠ²ΠΈΡΠΈΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π±Π΅Π»ΠΊΠΎΠ² RalA ΠΈ RalBΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π΄Π°Π½Π½Π°Ρ ΠΌΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΈΡ Π½Π΅ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠΈΠ³Π½Π°Π»ΠΎΠΌ ΠΏΡΠΎΡΠ΅Π°ΡΠΎΠΌΠ½ΠΎΠΉ Π΄Π΅Π³ΡΠ°Π΄Π°ΡΠΈΠΈ. Π£Π±ΠΈΠΊΠ²ΠΈΡΠΈΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ RalA Π½Π°ΠΉΠ΄Π΅Π½ΠΎ Π²ΠΎ Π²ΡΠ΅Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π½ΡΡ Π»ΠΈΠ½ΠΈΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈ Π³ΡΡΠ·ΡΠ½ΠΎΠ² ΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ, ΡΠ°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, ΡΠ½ΠΈΠ²Π΅ΡΡΠ°Π»ΡΠ½ΡΠΌ Π΄Π»Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΡΠΈΠΏΠΎΠ² ΠΊΠ»Π΅ΡΠΎΠΊ. Π Ρ ΠΎΠ΄Π΅ ΡΠ°Π±ΠΎΡΡ ΡΠΎΠ·Π΄Π°Π½ΠΎ Π±ΠΎΠ»Π΅Π΅ 60 Π½ΠΎΠ²ΡΡ Π³Π΅Π½Π½ΡΡ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΎΠ², ΠΊΠΎΡΠΎΡΡΠ΅ ΠΌΠΎΠ³ΡΡ Π±ΡΡΡ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
Π‘ΠΏΠΈΡΠΎΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
- Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 100 (2000).
- Bogenrieder T, Herlyn M. Axis of evil: molecular mechanisms of cancer metastasis. Oncogene 22 (2003).
- Hahn WC, Weinberg RA. Rules for making human tumor cells. N Engl J Med 347 (2002).
- Bos JL. ras oncogenes in human cancer: a review. Cancer Res 49 (1989).
- Schubbert S, Shannon K, Bollag G. Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer 7 (2007).
- Land H, Parada LF, Weinberg RA. Cellular oncogenes and multistep carcinogenesis. Science 222 (1983).
- Shih TY, Weeks MO, Young HA, Scholnick EM. Identification of a sarcoma virus-coded phosphoprotein in nonproducer cells transformed by Kirsten or Harvey murine sarcoma virus. Virology 96 (1979).
- DeFeo D, Gonda MA, Young HA, Chang EH, Lowy DR, Scolnick EM, Ellis RW. Analysis of two divergent rat genomic clones homologous to the transforming gene of Harvey murine sarcoma virus. Proc Natl AcadSciUSA 78(1981).
- Ellis RW, DeFeo D, Furth ME, Scolnick EM. Mouse cells contain two distinct ras gene mRNA species that can be translated into a p21 one protein. Mol Cell Biol 2 (1982).
- Chang EH, Gonda MA, Ellis RW, Scolnick EM, Lowy DR. Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses. Proc Natl Acad Sci USA 79 (1982).
- Wennerberg K, Rossman KL, Der CJ. The Ras superfamily at a glance. J Cell Sci 118 (2005).
- Colicelli J. Human RAS superfamily proteins and related GTPases. Sci STKE 2004 (2004).
- Mor A, Philips MR. Compartmentalized Ras/MAPK signaling. Anna Rev Immunol 24 (2006).
- Karnoub AE, Weinberg RA. Ras oncogenes: split personalities. Nat Rev Mol Cell Biol 9 (2008).
- Buday L, Downward J. Many faces of Ras activation. Biochim Biophys Acta 1786 (2008).
- Bos JL. All in the family? New insights and questions regarding interconnectivity of Ras, Rapl and Ral. EMBO J17 (1998).
- Rodriguez-Viciana P, McCormick F. Characterization of interactions between ras family GTPases and their effectors. Methods Enzymol 407 (2006).
- Vojtek AB, Hollenberg SM, Cooper JA. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74 (1993).
- Zhang XF, Settleman J, Kyriakis JM, Takeuchi-Suzuki E, Elledge SJ, Marshall MS, Bruder JT, Rapp UR, Avruch J. Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature 364 (1993).
- Leicht DT, Balan V, Kaplun A, Singh-Gupta V, Kaplun L, Dobson M, Tzivion G. Raf kinases: function, regulation and role in human cancer. Biochim Biophys Acta 1773 (2007).
- Leicht DT, Balan V, Kaplun A, Singh-Gupta V, Kaplun L, Dobson M, Tzivion G. Raf kinases: function, regulation and role in human cancer. Biochim Biophys Acta 1773 (2007).
- McFarlin DR, Lindstrom MJ, Gould MN. Affinity with Raf is sufficient for Ras to efficiently induce rat mammary carcinomas. Carcinogenesis 24 (2003).
- Yuan TL, Cantley LC. PI3K pathway alterations in cancer: variations on a theme. Oncogene 27 (2008).
- Franke TF. PI3K/Akt: getting it right matters. Oncogene 27 (2008).
- Zhao L, Vogt PK. Class I PI3K in oncogenic cellular transformation. Oncogene 27 (2008).
- Rodriguez-Viciana P, Warne PH, Dhand R, Vanhaesebroeck B, Gout I, Fry MJ, Waterfleld MD, Downward J. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature 370 (1994).
- Campbell PM, Singh A, Williams FJ, Frantz K, Ulkii AS, Kelley GG, Der CJ. Genetic and pharmacologic dissection of Ras effector utilization in oncogenesis. Methods Enzymol 407 (2006).
- Albright CF, Giddings BW, Liu J, Vito M, Weinberg RA. Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase. EMBO J12 (1993).
- Hofer F, Fields S, Schneider C, Martin GS. Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator. Proc Natl Acad Sci U SA91 (1994).
- Spaargaren M, Bischoff JR. Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap. Proc Natl Acad Sci USA 91 (1994).32,33,34,35,36,37,38,39,40,41,42.43,44,45,46,47.
- Kikuchi A, Demo SD, Ye ZH, Chen YW, Williams LT. ralGDS family members interact with the effector loop of ras p21. Mol Cell Biol 14 (1994).
- Ferro E, Magrini D, Guazzi P, Fischer TH, Pistolesi S, Pogni R, White GC, Trabalzini L. G-protein binding features and regulation of the RalGDS family member, RGL2. Biochem J 415 (2008).
- Xu J, Shi S, Matsumoto N, Noda M, Kitayama H. Identification of Rgl3 as a potential binding partner for Rap-family small G-proteins and profilin II. Cell Signal 19 (2007).
- D Adamo DR, Novick S, Kahn JM, Leonardi P, Pellicer A. rsc: a novel oncogene with structural and functional homology with the gene family of exchange factors for Rai. Oncogene 14 (1997).
- Bunney TD, Katan M. Phospholipase C epsilon: linking second messengers and small GTPases. Trends Cell Biol 16 (2006).
- Boettner B, Govek EE, Cross J, Van Aelst L. The junctional multidomain protein AF-6 is a binding partner of the RaplA GTPase and associates with the actin cytoskeletal regulator profilin. Proc Natl AcadSciU SA97 (2000).
- Han L, Colicelli J. A human protein selected for interference with Ras function interacts directly with Ras and competes with Rafl. Mol Cell Biol 15 (1995).
- Shivakumar L, Minna J, Sakamaki T, Pestell R, White MA. The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation. Mol Cell Biol 22 (2002).
- Vavvas D, Li X, Avruch J, Zhang XF. Identification of Norel as a potential Ras effector. J Biol Chem 273 (1998).
- Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J. The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Norel. Oncogene 21 (2002).
- Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and pl6INK4a. Cell 88 (1997).
- Kendall SD, Adam SJ, Counter CM. Genetically engineered human cancer models utilizing mammalian transgene expression. Cell Cycle 5 (2006).
- Hamad NM, Elconin JH, Karnoub AE, Bai W, Rich JN, Abraham RT, Der CJ, Counter CM. Distinct requirements for Ras oncogenesis in human versus mouse cells. Genes Dev 16 (2002).
- Rangarajan A, Hong SJ, Gifford A, Weinberg RA. Species- and cell type-specific requirements for cellular transformation. Cancer Cell 6 (2004).
- Khokhlatchev A, Rabizadeh S, Xavier R, Nedwidek M, Chen T, Zhang XF, Seed B, Avruch J. Identification of a novel Ras-regulated proapoptotic pathway. CurrBiol 12 (2002).
- Quilliam LA. Specificity and expression of RalGPS as RalGEFs.
- Methods Enzymol 407 (2006).
- Chardin P, Tavitian A. The ral gene: a new ras related gene isolated by the use of a synthetic probe. EMBO J 5 (1986).
- Nakashima S, Morinaka K, Koyama S, Ikeda M, Kishida M, Okawa K, Iwamatsu A, Kishida S, Kikuchi A. Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors. EMBO J18 (1999).
- Tian X, Rusanescu G, Hou W, Schaffhausen B, Feig LA. PDK1 mediates growth factor-induced RaLGEF activation by a kinase-independent mechanism. EMBO J 21 (2002).
- Ramocki MB, White MA, Konieczny SF, Taparowsky EJ. A role for RalGDS and a novel Ras effector in the Ras-mediated inhibition of skeletal myogenesis. J Biol Chem 273 (1998).
- Feig LA, Urano T, Cantor S. Evidence for a Ras/Ral signaling cascade. Trends Biochem Sci 21 (1996).
- Bhattacharya M, Anborgh PH, Babwah AV, Dale LB, Dobransky T, Benovic JL, Feldman RD, Verdi JM, Rylett RJ, Ferguson SS. Beta-arrestins regulate a RalGDS Ral effector pathway that mediates cytoskeletal reorganization. Nat Cell Biol 4 (2002).
- Clough RR, Sidhu RS, Bhullar RP. Calmodulin binds RalA and RalB and is required for the tlirombin-induced activation of Ral in human platelets. J Biol Chem 277 (2002).
- Wang KL, Khan MT, Roufogalis BD. Identification and characterization of a calmodulin-binding domain in Ral-A, a Ras-related GTP-binding protein purified from human erythrocyte membrane. J Biol Chem 272 (1997).
- Mirey G, Balakireva M, L’Hoste S, Rosse C, Voegeling S, Camonis J. A Ral guanine exchange factor-Ral pathway is conserved in Drosophila melanogaster and sheds new light on the connectivity of the Ral, Ras, and Rap pathways. Mol Cell Biol 23 (2003).
- Rusanescu G, Gotoh T, Tian X, Feig LA. Regulation of Ras signaling specificity by protein kinase C. Mol Cell Biol 21 (2001).
- Moskalenko S, Henry DO, Rosse C, Mirey G, Camonis JH, White MA. The exocyst is a Ral effector complex. Nat Cell Biol 4 (2002).
- Sugihara K, Asano S, Tanaka K, Iwamatsu A, Okawa K, Ohta Y. The exocyst complex binds the small GTPase RalA to mediate filopodia formation. Nat Cell Biol 4 (2002).
- Lipschutz JH, Mostov KE. Exocytosis: the many masters of the exocyst. CurrBiol 12 (2002).77.