Обширные резекции печени при злокачественных опухолях (показания, особенности хирургической техники и непосредственные результаты)
Диссертация
При планировании обширной резекции печени, при наличии злокачественной опухоли, в обязательном порядке всем больным рекомендуется провести комплексное обследование функциональных резервов свободной от опухоли печеночной паренхимы. Достаточно проведение радионуклидное исследование поглотительно-выделительной функции печени с препаратом 99mTc Brom MEZIDA и определение биохимических показателей… Читать ещё >
Список литературы
- Альперович Б. И. Хирургия печени и желчных путей, 1997, Томск
- Булынин В.И., Глухов A.A., Сомляров В. В. Новый способ резекции печени с применением «струйного скальпеля ОС-1″. Новые технологии в хирург, гепатол., С-Петербург, 1995, 97−98
- Вишневский В.А., Кубышкин В. А., Чжао A.B., Икрамов Р. З. Операции на печени. Москва, 2003
- Гальперин Э. И., Дедерер Ю. М. Нестандартные ситуации при операциях на печени и желчных путях. М., Медицина, 1987, 336
- Гальперин Э.И. Актуальные вопросы резекции печени. Хирургия, 1980, № 1, с 49−57
- Гарин A.M., Базин И. С. Злокачественные опухоли пищеварительной системы. Москва, 2003
- Готье C.B., Цирюльникова О. М., Филин A.B. и др. Радикальные резекции при обширных очаговых поражениях печени. Вестн. Рос. Акад. Мед. Наук, 1997, 8−13
- Гранов A.M., Борисов А. Е. Эндоваскулярная хирургия печени. JL, Медицина, 1986, 222
- Данилов М. В., Саидов С., Гаврилин A.B., Кустов A.B. Проблема выбора хирургической тактики у б-ных при механической желтухе опухолевой этиологии. Анн. хир. гепат., 1997, 2
- Журавлев В.А. Пути снижения риска длительных окклюзий печеночно-двенадцатиперстной связки. Анн. хир. гепат., 1997, т 2 приложен, с. 38
- Журавлев В.А. Очаговые заболевания печени и гилюсные опухоли, осложненные механической желтухой. Из-во Саратовского ун-та, 1992, 205
- Журавлев В.А. Радикальные операции у „неоперабельных“ больных с очаговыми поражениями печени. Киров, 2000
- Затолокин В. Д. Анатомические долевые резекции печени. Автореф.дис. д-ра мед. наук, М., 1974
- Затолокин В.Д. — Топографическая анатомия печеночных вен в свете анатомических резекций печени. Автореф. канд. мед. наук, М., 1968
- Израелашвили М. Ш., Комов Д.В. Опухоли печени, Тбилиси, 1990, 348
- Колосов А.Е., Журавлев В. А. Рак печени и прогноз для больных. С-П.-Киров, 2002
- Манихас Г. М. Лечение первичных злокачественных новообразований печени. Автореф. дис. канд. мед. наук, 1977
- Островерхов Г. Е., Забродская В. Ф. Хирургическая анатомия печени и желчных путей. Хирургическая анатомия живота., JL, 1972, 207−384
- Петровский Б.В. ред. Хирургическая гепатология. М., Медицина, 1972, 352
- Седов А.П. Механическая желтуха опухолевого генеза. Автор, дис. д-ра мед. наук, Воронеж, 1998
- Синюкова Г. Т., Шолохов В. Н, Патютко Ю.И. и др. Возможности интраоперационного УЗИ при хирургическом лечении метастатического поражения печени. III съезд Российской ассоц. УЗ диагн. В медицине, Москва, 1999
- Таразов П.Г., Гранов Д. А., Поликарпов A.A. Чрескатетерная терапия метастазов рака желудка в печень. Вопросы онкологии, 2000, т. 46, № 2, 221−223
- Фатех-Могхадам А., Стиебер П. Рациональное использование опухолевых маркеров. Москва, 1993
- Федоров В.Д., Брусиловский М. И., Гофман A.M., Одарюк Т. С. О целесообразности комбинированных операций при метастазах рака прямой кишки в печень. Вопр. онкол., 1980, 4, 84−88
- Федоров В.Д., Вишневский В. А. — Новые технологии в предупреждении интра и послеоперационных осложнений при резекции печени. Новые технологии в хир. гепатол., С-Петербург, 1995, 148−9
- Фэгэрэшану И., Ионеску Б., Аламанто Д., Албул Е. Хирургия печени ивнутрипеченочных желчных протоков. Бухарест, 1976, 537
- Шалимов А.А. Хирургия печени и желчных протоков. Киев, 1975, 406
- Шалимов А.А., Шалимов С. А., Ничитайло М. Е., Доманский Б. В. -Хирургия печени и желчевыводящих путей. Киев, 1993
- Шапкин В. С. Резекция печени. М., Медицина, 1967, 29 930.
- Adam R., Avisar Е., Ariche A. et al. Five-Year Survival Following Hepatic Resection after Neoadjuvant Therapy for Nonresectable Colorectal (Liver) Metastases, Ann. Surg. Oncol., 2001, 8, 4, 347−353
- Baer H., Dennison A., Maddern G. Subtotal hepatectomy: a new procedure based on the inferior right hepatic vein. Br. J. Surg., 1991,78:1221−22
- Barnett C., Curley S. Ablative Techniques for Hepatocellular Carcinoma, Sem. Oncol., 2001, 28, 5, 487−498
- Beattie E. Discussion in Mc Bride C.: Cancer of the right lobe of the liver. A variety of operative procedures. Arch. Chir., 1972, 105:289
- Bergsland E. Molecular Mechanisms Undelying the Development of Hepatocellular Carcinoma, Sem. Oncol., 28, 5, 2001, 521−531
- Bismuth H Surgical anatomy and anatomical surgery of the liver., World J. Surg., 1982, 6: 3−9
- Bismuth H., Castaing D., Garden J. Major hepatic resection under total vascular exclusion. Ann. Surg., 1989, 210: 13−19
- Bismuth H., Houssin D., Castaing D. Major and minor segmentectomies „Reglees“ in liver Surgery. World J. Surg., 1982, 6: 10−24
- Bismuth H., Morino M., Sherlok D. et al Primary treatment of hepatocellular carcinoma by arterial chemoembolization. Am. J. Surg., 1992, 163,387−94
- Blumgart L., Baer H., Czerniak A., et al Extended left hepatectomy: technical aspects an evolving procedure. Br. J. Surg., 1993, 80: 903−6
- Breedis C., Young C., Hjorstjo C. The topography of the intrahepatic duct systems. Acta Anat., 1931, 11: 599
- Cady B., Mc Dermott Major hepatic resection for metachronous metastases from colon cancer. Ann Surg, 1985, 201−204
- Caprio G. Un caso de extirpacion del lobulo izquierdo del higado. Bull. Soc. Cir. Urug., Montevideo, 1931, 2:159
- Champean M., Pineau P. Voil d’abord elargie trans-hepetique du canal hepatique gauche. Mem. Acad. Chir., 1964, 90:602
- Chen D. Hepatitis C virus in chronic liver disease and HCC IN Taiwan. Princ. Takam. Symp., 1995, 25:27−32
- Chen J., Lo-G-H< Lai-K-H. et al. Primary malignant fibrous histocytoma of the liver. Gastr.-J.-Taiwan, 1995, 12/4, 316−321
- Couinaud C. Le foie. Etudes anatomiques et chirurgicales. Paris, Masson Edit, 1957
- De Brauw L., De Velde C., Bouwhuis M. Diagnostic evaluation and survival analysis of colorectal cancer patients with liver metastases. J. Surg Oncol, 1987, 34:81−6
- Dematteo R., Fong y., Jarnagin W., Blumgart L. Recent Advances in Hepatic Resection. Sem. Surg. Oncol., 2000, 19:200−208
- Ebara M., Ohto M., Shinagawa T., et al Natural history of minute hepatocellular carcinoma smaller then 3 centimeters complicating cirrhosis. Gastroenter., 1986, 90: 289−298
- Eckberg H, Tranberg K, Anderson R. et al Pattern of recurrence in liver resection for colorectal secondaries. World J. Surg, 1987, 11:541−7
- Elias D., Lasser P., Desruennes E., et al Surgical Approach to Segment I for Malignant Tumors of the Liver, SGO, 1992, 175: 17−24
- Emre S., Schwartz M., Katz E. et al Liver resection under total vascular isolation: Variations on a theme (USA). Ann. Surg., 1993, 217:15−19
- Fan S, Ng J.L., Poon R. et al Hepatectomy for hepatocellular carcinoma: the surgeon’s role in long term survival. Arch. Surg., 1999, 1347:1124 -30
- Fan S-T, Wong J. „No — touch“ surgery for hepatobiliary cancer. World Gastro-Enterol news, Spring 2000,21−23
- Fong Y, N Kemeny, Paty Ph. et al Treatment of colorectal cancer. Sem. Surg. Oncol., 1996, 12: 219−52
- Fortner J., Maclean B., Kim D., et al The seventies evolution in liver surgery for cancer. Cancer., 1981, 47: 2162−6
- Fortner J., Shiu M., Kinne D. et al Major hepatic resection using vascular isolation and hypothermic perfusion. Ann. Surg. 1974, 180:644−52
- Foucou B., Said O., Joyeux A. et al Le segment I du foie ou lobe de Spigel. Etude anamomique et interet chirurgical. J. Chir., 1983, 120:179−86
- Goldsmith N., Woodburne R. The surgical anatomy pertaining of the liver resection. SGO, 1957, 195: 310−315
- Gou Z., Li Q., He K. Diagnosis and Treatment of Hepatic Cholangiocarcinoma. Hep. Pancr. Dis. Int., 2003, 2 (1) 62−65
- Grazi G., Gallucci A., Masetti M. et al. Surgical therapy for undifferentiated sarcoms of the liver in adults, Am.-Surg., 1996, 62/11, 901−906
- Griffith K., Scheele G. Segment oriented resection of the liver. Jn. Lygidakis N., Tytgat G. (eds). Stuttgart, Thieme, 1988
- Hasegawa H., Makuuchi M., Yamazaki S. et al Central bisegmentectomy of the liver. World J. Surg., 1989, 13:186
- Heaney J., Stanton N., Halbert D. An improved technique for vascular isolation of the liver, 1966, 163: 237−241
- Hughes K., Simon R., Songhorabodi S. et al Resection on the liver for colorectal carcinoma metastases. Surg., 1988, 103−278
- Huguet C., Bona S., Nordlinger B., et al Repeat hepotic resection for primary and metastatic carcinoma of the liver. S.G.O., 1990, 171:398−402
- Jaeck D., Bachellier Ph., Oussoultzoglou E. et al. Surgical Resection of HCC. Post-operative Outcome and Long-term Results in Europe: An Overview. Liver Transpl., 2004, 10, 2, supl. 1, 58−63
- Jarnagin W. Cholangiocarcinoma of the Extrahepatic Bile Ducts. Sem. Surg. Oncol., 2000, 19:156−176
- Jwasaki Y., Okamura T., Ozaki A., et al Surgical treatment for carcinoma atthe confluence of the major hepatic ducts. S.G.O., 1986, 162: 457−464
- Kemeny N., Niedzwiecki D., Surgot B., et al Prognostic variables in patients with hepotic metastases from colorectal cancer. Cancer, 1989, 63: 742−7
- Kinoshita H., Sakai K., Hirohashi K., et al. Preoperative Portal Vein Embolization for Hepatocellular Carcinoma, W. J. Surg., 1986, 10 803−808
- Kinoshita H., Sakai K., Horihashi K., et al Preoperative portal vein embolization for hepatocellular carcinoma. World Y. Surg., 1986, 10:803−807
- Komeda T., Fukuda Y., Sando T., et al Sensitive detection of circulation hepatocellular carcinoma cells in peripheral venous blood. Cancer, 1995, 75: 2214−9
- Koo J., Fung K., Sin K, et al Recovery of malignant tumor cells from the right atrium during hepatic resection for hepatocellular carcinoma. Cancer, 1993, 52: 1952−6
- Lai E, Fan S, Lo C. et al Anterior approach for difficult right major hepatectomy. World J. Surg., 1996, 20:314−8
- Lau W. Local Ablative Therapy for Hepatocellular Carcinoma. Endoscopy, 2000, 32 (8), 644−646
- Lau W. Primary Liver Tumors, Sem. Surg. Oncol., 2000, 19:135−144
- Launois B., Jamieson G. The importance of Glisson’s capsule and its sheaths in the intrahepatic approach to resection on the liver. S.G.O., 1992, 174:7−10
- Lerut J., Gruwes J., Blumgart L. Resection of the caudate lobe of the liver. S.G.O., 1990, 171:160−162
- Liang X., Ioncareric J., Tang Z., et al Resection of hepatocellular carcinoma. J. Gastroent. Hepatol., 1991,6:77−80
- Liver cancer study group of Japan Predictive factors for long term prognosis after partial hepatectomy for patients with hepatocellular carcinoma in Japan — Cancer, 1994, 74: 2772−80
- Liver Cancer Study Group of Japan Surgery and follow-up study of primaryliver cancer in Japan. Acta.-Hep.-Jpn., 1997, 38/5, 317−330
- Lortat -Jacob J., Robert H., Henry C. Un cas d’hepatectomie droite reglee. Mem. Acad. Chir., 1952, 78:224
- Lortat-Jacob J., Robert H. Hepatectomie droite reglee, Presse Med., 1952, 60:549
- Majno P., Adam R., Bismuth H., et al Influence of preoperatuve transarterial lipoidol chemoembolization on resection and transplantation. Ann. Surg, 1997, 266:688−703
- Makuuchi M. 9-th Congress of the International Gastro-Surgical Club, 1999, Nagasaki, Japan.
- Mark S., Rosen C., Nagarney D., Taswell H., et al Perioperative blood transfusion and determinants of survival after liver resection for metastatic colorectal carcinoma. Ann. Surg., 1992 216:493−505
- Maruuchi M., Hashikura Y., Kawasaki S., et al Personal experience of right anterior segmentectomy (segment V and VIII) for hepotic malignancies. Surgery, 1993, 114, 1:52−8
- Mc Cormack P., Burt M. E., Brains M., et al Lung resection for colorectal metastases- 10-year results. Arch. Surg., 1992, 127: 1403−6
- Mc Jndoe A., et Conseller V. A report on the bilaterality of the liver. Arch. Surg., 1927, 15:589
- Mizomoto R., Suzuki H. Surgical anatomy of the hepatic hilum with special reference to the caudate lobe. World J. Surg., 1988, 12:2−10
- Mizuomoto R., Ogura Y., Akasaka Present status and problems on surgical resection for hilar carcinoma. Clin. Surg. Jpn, 1984, 39:1383−8
- Monto A., Wright T. The Epidemiology and Prevention of Hepatocellular Carcinoma, Sem. Oncol., 2001, 28, 5, 441−449
- Morzilli G., Makuuchi M. 9-th World Congress of the International Gastro-Surgical Club, 1999, Nagasaki, Japan.
- Nagino M., Nimure Y. 9-th Congress of the International Gastro-Surgical Club, 1999, Nagasaki, Japan.
- Neuhaus P., Jonas S., Bechstein W., et al Extended resections for hilar cholangiocarcinoma. Qnn. Surg, 1999, 230:808−19
- Nimura Y Surgical anatomy of the biliary ducts. In Rossi P ed Medical radiology. Berlin, Springer, 1997,21−30
- Ohtsuka M., Into H., Kimura F. et al. Extended Hepatic Resection and outcomes in Intrahepatic cholahgiocarcinoma. J. Hepat. Pancr. Surg., 2003, 10 (4), 259−264
- Okuda K., Nakashima T., Kojiro M., et al Hepatocellular carcinoma without cirrhosis in Japanese patients. Gastroenter., 1989, 97: 140−6
- Ozawa K. Nonconventional approaches to advanced liver cancer. In liver surgery approached through the mitochondria, Tokyo, Medical Tribune, 1992: 117−65
- Pichlmayer R., Grosse H., Hauss J., et al Thechnique and preliminary results of extracorporeal liver surgery. Br. J. Surg, 1990, 77:21
- Portolani N., Tiberio G., Bonardelli S. et al Arterial chemoembolization in hepatocellular carcinoma suitable for resective surgery. Hep-Gastroenter., 1996, 12, 43: 1566−74
- Quattlebaum J. Massive resection of the liver. Ann. Surg., 1953, 137:787
- Raab R., Nussbaum K., Werner U., et al Liver metastases in breast carcinoma. Results of partial liver resection. Chirurg, 1996, 67 (3): 234−7
- Reeves M., De Matteo R. Genes ahd Viruses in Hepatobiliary Neoplasia, Sem. Surg. Oncol., 2000, 19:84−93
- Ringe B. 9-th Congress of the International Gastro-Surgical Club, 1999, Nagasaki, Japan
- Roh M. Hepatic resection for colorectal liver metastases. Hem./oncol. Clin North Amer., 1989, 1,3: 171−81
- Sakamoto E., Nimura Y., Hagakawa N., et al The pattern of infiltration at the proximal border of hilor bile duct carcinoma. Ann. Surg., 1998, 227:40 511
- Sakon M. 9-th Word Congress of the International Gastro-Surgical Club, 1999, Nagosori, Japan.
- Scheele J., Stangl R., Altendor-Hofmann Q. et al Jndicafors of prognosis after hepatic resection for colorectal secondaries. Surgery, 1991, 110: 13−29
- Shimazu M., Finar P., Marshall R., Cooper E., et al Factors affecting survival in patients presenting with synchronous hepotic metastases from colorectal cancer. Br.J. Surg., 1985, 72:373−77
- Smith J., Fortner J., Burt M. Resection of hepatic and pulmonary metastases from colorectal cancer. Surg. Oncol, 1992, 1:399−404
- Soyer P., Bluemke D., Riopel M. Hepatic leiomyosarcoma. Eur.-J.-Radiol., 1995, 19/3, 177−182
- Starzl T., Bell L., Beart R., et al Hepatic trisegmentectomy and other liver resections. S.G.O., 1975, 141:429
- Starzl T., Jwatsuki S., Shaw R. et al Left hepatic trisegmentectomy. S.G.O., 1982, 155:21−77
- Starzl T., Koep L., Weil R., et al Right trisegmentectomy for hepatic neoplasms. S.G.O., 1980, 150: 208−214
- Stephenson K., Steinberg S., Hughes K., et al Pereoperative blood transfusions are associated with decreased time to recurrence and decreased survival after resection of colorectal liver metastasis. Ann. Surg. 1988, 208: 679−87
- Stone H., Long W., Smith R. et al Physiological considerations in major hepatic resections. Am. J. Surg., 1969, 117:78
- Sugarbaker P., Ottow R., Qugust D. Surgical therapy of metastases. Liver metastases. Basic aspects, detection and management, 1984, Boston, p. 197
- Takayama T., Nakatsuka T., Shimada K. Et al Hepato-Gastr., 1995, 4, 42:415−17
- Tanaka H., Tsukuma H., Yamano H. et al. Hepatitis C virus 1 b (II) infection and development of chronic hepatitis, liver cirrhosis and HCC: a case-control study in Lapan. J. Epidemiol., 1998, 8 (4), 244−249
- Tang L-U., Yu G-Q., Xin-Da Zhou. Evolution of Surgery in the treatment ofhepatocellular carcinoma from the 1950s to the 1990s. Sem. Surg. Oncol., 1993, 9: 293−297
- Ton That Tung La vascularisation veineuse du foie et ses applications aux resections hepatiques. These Hanoi, 1939
- Ton That Tung, Ton That Bach Bilan d’une experience de la chirurgie d’exerese hepatique pour cancer. A propos de 941 hepatecmtomies. Chirurgie, 1983, 109: 27−30
- Tong That Tung Les resections majeures et mineures du foie. Paris, Masson, 1979
- Van Halteren H, van Geel A., Hart A., et al Pulmonery resection fir metastases of colorectal origin. Chest, 1995, 107:1526−31
- Wagner J, Adson M., Van Heerden G., et al The natural histiry of hepotic metastases from colorectal cancer. Ann. Surg., 1984, 199:502
- Wangensteen O. Cancer of the esophagus and stomach. Proc. 3-rd Nat. Cancer Conf., Pp. 94−97, Philadelphia, 1951
- Weinbzen K., Adam Q., Blumgart L., et al Qpparent extrahepotic invasion by metastatic tumors in the liver. Clin. Radiol., 1987, 38: 357−62
- Wood C., Gillis C., Blumgart L. A retrospective study of the natural history of patients with liver metastases from colorectal cancer. Clin. Oncol, 1976, 2:285
- Wu C-C., Ho W-L., Lin M-Ch., et al Hepatic resection for bilobar multicentric hepatocellular carcinoma: is it justified? Surgery, 1998, 123:27 077
- Yough D., Donohue J., Trastek V., et al Resection of hepatic and pulmonary metastases inpatients with colorectal cancer. Br. J. Surg., 1994, 81:94−96
- Yu Y-Q., Xin-Da Zhou, Z-Y. Tang et al Experience with resection of segment VIII of liver for hepatocellular carcinoma — Seminar in Surg. Oncol., 1993,9:305−8
- Dickson R.B., Lippman ME. Molecular Basis of breast cancer. Molecular Basis of cancer, Second edition: 313 342.
- Современная клиническая диагностика. Методика. Под редакцией Херрингтона С, Макги Д. 1999 г.
- Руководство по иммуногистохимической диагностике опухолей человека. Под редакцией Петрова С. В., Райхлина Н. Т. 2000 г.
- Kohn ЕС, Liotta LA. Metastasis and angiogenesis: Molecular Dissection and Novel Application. Molecular Basis of cancer, Second edition:163. 171.
- Folkman J. Tumor angiogenesis. Therapeutic implications. N Engl. Med 285- 1182- 1186, 1971
- Fidler IJ. Modelation of the organ microenviroment for treatment of cancer metastasis. J. Nat. Cancer Inst 1996- 87: 1588−92
- Kerbel R.S. Inhibition of tumor angiogenesis as a strangy to circumvent acquired resistance to anti-cancer therapeutic agents. BioEssaya 1991- 13:31−6
- Rak J., Filmus J, Kerbel R.S. Reciprocal paracrine interactions between tumour cells and endothelial cells: theangiogenesis progression» hypotensis. Eur J Cancer 1996: 32A 2438−50.
- Luzzi K. J., MacDonald I. C., Schmidt E.E. Dormancy of Solitary Cells After Successful Extravasation and Limited Survival of
- Early Micrometastases. American Journal ofPatology. 153: 865−873, 1998.
- Naumov G., MacDonald I., Weinmeister P. Persistence of Solitary Mammary Carcinoma Cells in a Secondary Site. A Possible Contributor to Dormancy. Cancer Research 62, 2162- 2168, 1, 2002
- Gebauer G. Fehm Т., Merkle E et al. Epithelial Cells in Bone Marrow of Breast Cancer Patients at time of Primary Surgery: Clinical Outcome uring Long-Term Follow-Up. J. Clin. Oncology, 2001, 16, 3669−3674
- Gerber В., Krause A., Muller et al. Simultaneus Immunohistochemical Detection of Tumor Cells in Lymph Nodes and Bone Marrow Aspirates in Breast Cancer and its Correlation With Other Prognostic Factors. J.
- Clinical Oncology 2001, 19, 960−971.
- Diel IJ., Kaufmann M, Goerner R et al. Detection of tumor cells in bone marrow of patients with primary breast cancer. A prognostic factor for distant metastasis. J. Clin. Oncol. 10(10): 1534−1539, 1992.
- Kirk SJ, Cooper GG, Hoper M et al. The prognostic significance of marrow micrometastases in wimen with early breast cancer. European Journal Surcical Oncology 1990- 16- 481−485.
- Braun S. et al. ErbB2 overexpression on occult metastatic cells in bone marrow predicts poor clinical outcome of stage I-III breast cancer patients. Cancer Res. 2001, 1, vol 61, 1890−1895.
- Крохина OB, Летягин ВПб Тупицын HH и соавт. Рак молочной железы. Микромктастазы в костный мозг. Вестник Онкологического научного центра РАМН им. Н, Н, Блохина 3, 2002, стр. 15−20.
- Racila Е. et al. Detectionand characterization of carcinoma cells in the lood. Proc. Natl. Acad. Sci. USA, 1998, 14, 4589−45−94.
- Wiedswang G et al. Detection of isolated tumor cells in bone marrow is an independent prognostic factor in breast cancer. J. Clin. Oncol. 21(18): 3469−3478, 2003
- Kvalheim G et al. Minimal residual disease in breast cancer. Cancer and Metastasis Reviews 18. 101−108, 1999.
- Pantel et al. Detection and clinical relevance of micrometastatic cancer cellss. Current Opinion in oncology 2000, 12, 95−101
- Franke WW et al. Diversity of cytokeratins: differentiation specific expression of cytoceratin polypeptides in epithelial cells and tissues. J. Mol Biol 1981, 153, 933−959
- Moll R et al. The catalog of human Cytokeratins: patterns of expression in normal epitelia, tumors and cultured cells. Cell. 1982, nov. 31. 11−24
- Winter S et al. Differences in polipetide composition of cytokeratin filaments, including tonofilaments, from different epithelial tissues and cells. Eur. J. Cell. Biol. 1980, 22, 371
- Schoefeld A et al. The detection of micrometastasis in the Periferial
- Blood and Bone Marrow of patients with Breast cancer Using Immunohistochemistry and reserve Transcriptase Polymerase Chain Reation for Keratin 19. Eur J. Cancer, 33, 6, 854−861,1997
- Smith B et al. Response of Circulating Tumor Cells to Systemic Therapy in Patients With Metastatic Breast Cancer: Comparison of Quantative Polimerase Chain Reaction and Immunocytochemical Techniques. J. Clin. Oncol., 2000, 7, 1432−39
- Aerts J et al. A real time quantitative reverse transcriptase chain reaction (RT-PCR) to detect breast carcinomacells in peripherial blood. Annals of Oncology 12. 39−46,2001
- Slade MJ et al. Quantative polymerase chain reaction for the detection of micrometastases in patients with breast cancer. J. Clin. Oncol 17. 870- 879,1999
- Smith B. et al. Detection of melanoma cells in peripherial blood by means of reverse transcriptase and polymerse chain reaction. Lancet 1991, 338, 1227−1229
- Jung Y et al. Clinical Significance of Bone Marrow Micrometastasis Detected By Nested RTPCR for Keratin -19 in Breast Cancer Patients.
- Weits J et al. Detection of disseminated colorectal cancer cells in lymph nodes, blood and marrow, clin Cancer Res 1999, Jul 5, 1830−1836
- Schleiermacher G et al. Increased Risk of Systemic Relapses Associated With Bone Micrometastasis and Circulating Tumor Cells in Localized Ewing Tumor. J. Clin Oncol 2003. 21, 85−91
- Vogel I. et al. Detection and prognostic impact of disseminateed tumor cells in pancreatic carcinoma. Pancreatology 2002, 2, 79−88
- Pantel K. et al. Immunocytochemical Detection of isolated tumor cells in bone marrow of patients with untreated stage C prostate cancer. Eur. J. Cancer 1995, 31 A, 10, 1627−1632
- Palmieri G et al. Prognostic Value of circulating melanoma cells21,5,2003,767−773
- Sehouli J. et al. Prognostic significance of epithelial cells in the blood of patients with gynecologicl malignancies. Anticancer Res. 2003, sep-okt. 23(5b) 4133−40
- Weitz J. et al. Detection of Hemotogenic Tumor Cell Dissemination in Patients Undergoing Resection of Liver Metastases of Colorectal Cancer. Ann Surg., v- 232 July, 2000, 66−72