Анализ генов предрасположенности к развитию бронхиальной астмы в Республике Башкортостан
Диссертация
Исследование гетерогенности по частотам аллелей и генотипов полиморфного варианта -308G>A гена TNFA не обнаружило достоверных различий между контрольными группами исследуемых этнических групп (р>0,05). Учитывая отсутствие межэтнических различий по данному локусу и высокий уровень метисации населения РБ, изучено распределение частот аллелей и генотипов по полиморфному варианту -308G>A гена TNFA… Читать ещё >
Список литературы
- Аульченко Ю.С., Аксенович Т. П. Методологические подходы и стратегии картирования генов, контролирующих комплексные признаки человека // Вестник ВОГиС. 2006. — Т. 10. — № 1. — С. 189 202.
- Баранов B.C., Баранова Е. В., Иващенко Т. Э., Асеев М. В. Геном человека и гены «предрасположенности» (Введение в предиктивную медицину) СПб.: Интермедика, 2000. — 263с.
- Баранов B.C., Иващенко Т. Э., Лаврова О. В., и др. Некоторые молекулярно-генетические аспекты этиопатогенеза атопической бронхиальной астмы // Медицинская генетика. — 2008. № 10. — С. 3−13.
- Брагина Е.Ю., Фрейдин М. Б., Тен И.А., и др. Полиморфизм генов биотрансформации ксенобиотиков GSTT1, GSTM1, CYP2E1 и CYP2C19 у больных атопической бронхиальной астмой // Бюллетень СО РАМН. 2005. — № 3 (117). — С. 121−125.
- Геппе Н.А., Каганов С. Ю. Национальная программа «Бронхиальная астма у детей. Стратегия лечения- и профилактика» и ее реализация // Пульмонология. 2002. — № 1. — С. 38−42.
- Гланц С. Медико-биологическая статистика. М.: Практика, 1999. -459с.
- Глобальная стратегия лечения и профилактики бронхиальной астмы / Под ред. Чучалина А. Г. М.: Атмосфера, 2007. — 104с.
- Глотов А.С., Наседкина Т. В., Иващенко Т. Э., и др. Создание биочипа для анализа полиморфизма в генах системы биотрансформации // Молекуляр. биология. 2005. — Т. 39. — С. 403−412.
- Голденкова-Павлова И.В., Брускин С. А., Абдеев P.M., и др. Сравнительный анализ результатов фенотипирования и генотипирования по полиморфизму N-ацетилирования у человека // Генетика. 2006. — Т. 42. — № 8. — С. 1−8.
- Ю.Животовский JI.A. Популяционная биометрия. М.: Наука, 1991. — 272 с.
- П.Зайцева О. В., Лаврентьев А. В., Зайцева С. В., и др. Интерлейкин-1 альфа фактор некроза опухолей-альфа и интерферон-гамма в сыворотке крови детей больных бронхиальной астмой // Аллергология. — 2000. —1.№ 3.-С. 4−7.
- Карунас А.С., Измайлова А. Р., Загидуллин Ш. З., и др. Анализ ассоциации полиморфных вариантов генов цитокинов с бронхиальной астмой в республике Башкортостан // Цитокины и Воспаление. 2007. -Т.6.-№ 4.-С. 22−28.
- Ляхович В.В., Гавалов С. М., Вавилин В. А., и др. Полиморфизм генов ферментов биотрансформации ксенобиотиков и особенности бронхиальной астмы у детей // Пульмонология. — 2002. Т. 12. — № 2. — С. 31−38.
- Национальная программа «Бронхиальная астма у детей. Стратегия лечения и профилактика» / Под ред. Чучалина А. Г. М.: Атмосфера, 1 2008.- 108с.
- Руководство по диагностике, лечению и профилактике бронхиальной астмы / Под ред. Чучалина А. Г. М.: НТЦ-КВАН, 2005. — 51с.
- Фрейдин М.Б., Брагина Е. Ю., Огородова Л. М., и др. Полиморфизм генов глутатионтрансфераз 0х и щ (GSTT1 и GSTM1) у больных атопической бронхиальной астмой в Западно-Сибирском регионе // Молекулярная биология. 2002. — Т. 36. — № 4. — С. 1−5.
- Фрейдин М.Б., Брагина Е. Ю., Огородова JI.M., и др. Генетика атопии: современное состояние // Вестник ВОГиС. — 2006. — Т. 10. — № 3. — С. 492−503.
- Чучалин А.Г. Генетические аспекты бронхиальной астмы // Пульмонология. 1999. — Vol.9, № 4. — С. 6−10.
- Ярилин А.А. Основы иммунологии: Учебник. М.: Медицина, 1999. — 608с.
- Abdel-Rahman S.Z., El-Zein R.A., Anwar W.A., et al. A multiplex PCR procedure for polymorphic analysis of GSTM1 and GSTT1 genes in population studies // Cancer Lett. 1996. — Vol. 107. — P. 229−233.
- Adithan C., Gerard N., Vasu S., et al. Allele and genotype frequency of CYP2C19 in a Tamilian population // Br J Clin Pharmacol. 2003. — Vol. 56.-P. 331−333.
- Allabi A.C., Gala J.-L., Desager J.-P., et al. Genetic polymorphisms of CYP2C9 and CYP2C19 in the Beninese and Belgian populations // J Clin Pharmacol. 2003. — Vol. 56. — P. 653−657.
- Allen M., Heinzmann A., Noguchi E., et al. Positional cloning of a novel gene influencing asthma from chromosome 2ql4 // Nat Genet. 2003. — Vol. 35. -№ 3. — P. 258−263.
- Androutsopoulos V.P., Tsatsakis A.M., Spandidos D.A. Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention // BMC Cancer. -2009.-Vol. 9:187.
- Arend W. Interleukin 1 receptor antagonist: a new member of the interleukin 1 family // J Clin Invest. 1991. — Vol.5. — P. 1445−1451.
- Arman A., Soylu O., Yildirim A. Interleukin-1 receptor antagonist gene VNTR Polymorphism is associated with coronary artery disease // Arq Bras Cardiol. -2008. Vol. 91. -№ 5. — P. 268−273.
- Asadullah K., Sterry W., Volk H.D. Interleukin-10 Therapy Review of a New Approach // Pharmacol Rev. — 2003. — Vol.55. — P. 241−269.
- Baldini M., Lohman I.С., Halonen M., et al. A Polymorphism in the 5' flanking region of the CD14 gene is associated with circulating soluble CD 14 levels and with total serum immunoglobulin E // Am J Respir Cell Mol Biol. 1999. — Vol.20. — P. 976−983.
- Barnes K.C. Atopy and asthma genes where do we stand? // Allergy. -2000. — Vol. 55. — P. 803−817.
- Basehore M.J., Howard T.D., Lange L.A., et al. A comprehensive evaluation of IL4 variants in ethnically diverse populations: association of total serum IgE levels and asthma in white subjects // J Allergy Clin Immunol. 2004. -Vol. 114, № l.-P. 80−87.
- Ваег A.N., McAllister C.B., Wilkinson G.R., et al. Altered distribution of debrisoquine oxidation phenotypes in patients with systemic lupus erythematosus // Arthritis & Rheumatism. 1986. — V. 29. — № 7. — P. 843 850.
- Begh В., Padoan M., Moss C.T., et al. Lack of association of HLA class I genes and TNFa-308 polymorphism in toluene diisocyanate-induced asthma // Allergy. 2004. — Vol. 59. — P. 61−64.
- Beghe В., Barton S., Rorke S., et al. Polymorphisms in the interleukin-4 and interleukin-4 receptor a chain genes confer susceptibility to asthma and atopy in a Caucasian population // Clin Exp Allergy. 2003. — Vol. 33. — P. 1111−1117.
- Bell D.A., Taylor J.A., Butler M.A., et al. Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans // Carcinogenesis. 1993. -Vol. 14.-P. 1689−1692.
- Bergamaschi E., De Palma G., Mozzoni P., et al. Polymorphism of quinine-metabolizing enzymes and susceptibility to ozone-induced acute effects // Am J Respir Crit Care Med.-2001.-Vol. 163.-P. 1426−1431.
- Berndt S.I., Chatterjee N., Huang W.Y., et al. Variant in sex hormone-binding globulin gene and the risk of prostate cancer // Cancer Epidemiol Biomarkers Prev. 2007. — Vol. 16. — P. 165−168.
- Beyeler C., Armstrong M., Bird H.A., et al. Relationship between genotype for the cytochrome P450 CYP2D6 and susceptibility to ankylosing spondylitis and rheumatoid arthritis // Annals of the Rheumatic Diseases. -1996.-Vol. 55.-P. 66−68.
- Beyer K., Nickel R., Freidhoff L., et al. Association and linkage of atopic dermatitis with chromosome 13ql2−14 and 5q31−33 markers // J Invest Dermatol. 2000. — Vol. 115. — P. 906−908.
- Bhandari V. Developmental differences in the role of interleukins in hyperoxic lungs injury in animal models // Front Bios. 2002. — Vol.7:dll624−33.
- Black R.A., White J.M. ADAMs: focus on the protease domain // Curr Opin Cell Biol. 1998.-Vol. 10.-№ 5.-P. 654−659.
- Blakemore A.I., Tarlow J.K., Cork M.J., et al. Interleukin-1 receptor antagonist gene polymorphism as a disease severity factor in systemic lupus erythematosus // Arthritis Rheum. 1994. — Vol.37. — P. 1380−1385.
- Blakey J., Halapi E., Bjornsdottir U.S., et al. Contribution of ADAM33 polymorphisms to the population risk of asthma // Thorax. 2005. — Vol. 60.-P. 274−276.
- Borger P., Kauffman H.F., Postma D.S., et al. Interleukin-4 gene expression in activated human T lymphocytes is regulated by the cyclic adenosine monophosphate-dependent signaling pathway // Blood. 1996. — Vol.87. -№ 2.-P. 691−698.
- Bozina N., Bradamante V., Lovric M. Genetic polymorphism of metabolic enzymes P450 (CYP) as a susceptibility factor for drug response, toxicity, and cancer risk // Arh Hig Rada Toksikol. 2009. — Vol. 60. — № 2. — P. 217−242.
- Bozina N., Graniae P., Lalise Z., et al. Genetic Polymorphisms of Cytochromes P450: CYP2C9, CYP2C19, and CY P2D6 in Croatian Population // Croat Med J. 2003. — Vol. 44. — P. 425−428.
- Bradding P., Walls A.F. and Holgate, S.T. The role of the mast cell in the pathophysiology of asthma // J Allergy Clin Immunol. 2006. — Vol.117. -P. 1277−1284.
- Brasch-Andersen C., Tan Q., Borglum A.D., et al. Significant linkage to chromosome 12q24.32-q24.33 and identification of SFRS8 as a possible asthma susceptibility gene // Thorax. 2006. — Vol.61. — P. 874−879.
- Braun-Fahrlander C. Environmental exposure to endotoxin and other microbial products and the decreased risk of childhood atopy: evaluating developments since April 2002 // Curr Opin Allergy Clin Immunol. 2003. -Vol.3.-№ 5.-P. 325−329.
- Broide D.H., Lotz M., Cuomo A.J., et al. Cytokines in symptomatic asthma airways // J Allergy Clin Immunol. 1992. — Vol. 89, № 5. — P. 958−967.
- Brown M.A., Edwards S., Hoyle E., et al. Polymorphisms of the CYP2D6 gene increase susceptibility to ankylosing spondylitis // Human Molecular Genetics. -2000. Vol. 9.-№. 11.-P. 1563−1566.
- Brusselle G.G., Kips J.C., Tavernier J.H., et al. Attenuation of allergic airway inflammation in IL-4 deficient- mice // Clin Exp Allergy. — 1994. — Vol.24.-№ l.-p. 73−80.
- Burchard E.G., Silverman E.K., Rosenwasser L.J., et al. Association between a sequence variant in the IL-4 gene promoter and FEV (l) in asthma // Am J Respir Crit Care Med. 1999. — Vol. 160. — P. 919−922.
- Burrows В., Martinez F.D., Halonen M., et al. Association of asthma with serum IgE levels and skin-test reactivity to allergens // N Engl J Med. -1989. Vol. 320, № 5. — P. 271−277.
- Carroll W.D., Lenney W., Jones P.W., et al. Effects of glutathione S-transferase Ml, T1 and PI on lung function in asthmatic families // Clin Exp Allergy. 2005. — Vol. 35. — P. 1155−1161.
- Cascorbi I., Brockmoller J., and Roots I. A C4887A polymorphism in exon 7 of human CYP1AJ: population frequency, mutation linkages, and impact on lung cancer susceptibility // Cancer Research. 1996. — Vol. 56. — P. 4965−4969.
- Cascorbi I., Drakoulis N., Brockmoller J., et al. Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian, individuals: correlation with phenotypic activity // Am J Hum Genet. 1995. — Vol. 57. — P. 581−592.
- Castro J., Telleria J.J., Linares P., et al. Increased TNFA*2, but not TNFB*1, allele frequency in Spanish atopic patients // J Invest Allergol Clin Immunol. 2000. — Vol: 10.-P. 149−154.
- Castro-Giner F., Kogevinas M., Machler M., et al. TNFA -308G>A in two international population-based cohorts and risk of asthma // Eur Respir J. -2008. Vol.32. — № 2. — P. 350−361.
- Castro-Giner F., Kogevinas M., Imboden M., et al. Joint effect of obesity and TNFA variability on asthma: two international cohort studies // Eur Respir J.- 2009. -Vol.33. -№ 5. P. 1003−1009.
- Cembrzynska-Nowak M., Szklarz E., Inglot A.D., et al. Elevated release of tumor necrosis factor-alpha and interferon-gamma by bronchoalveolar leukocytes from patients with bronchial asthma // Am Rev Respir Dis. — 1993. Vol. 147, № 2. — P. 291−295.
- Chae S.C., Park Y.R., Oh G.J., et al. The suggestive association of eotaxin-2 and eotaxin-3 gene polymorphisms in Korean population with allergic rhinitis // Immunogenetics. 2005. — Vol. 56, № 10. — P. 760−764.
- Chagani Т., Pare P.D., Zhu S., et al. Prevalence of tumor necrosis factor-alpha and angiotensin converting enzyme polymorphisms in mild/moderate and fatal/near-fatal asthma // Am J Respir Crit Care Med. 1999. — Vol.160. -№ 1.- P. 278−282.i
- Chan I.H.S., Tang N.L.S., Leung T.F., et al. Study of gene-gene interactions for endophenotypic qauntitative traits in Chinese asthmatic children // Allergy.-2008.-Vol. 63.-P. 1031−1039.
- Chan A.T., Tranah G.J., Giovannucci E.L., et al. A prospective study of genetic polymorphisms in the cytochrome Р-450 2C9 enzyme and the risk for distal colorectal adenoma // Clin Gastroenterol Hepatol. 2004. — Vol. 2. — № 8. — P. 704−712.
- Chan-Yeung M., Malo J.L. Table of the major inducers of occupational, asthma. In: Bernstein I.L., Chan-Yeung M., Malo J.L., Bernstein D.I., eds.
- Asthma in the workplace // New York: Marcel Dekker. 1999. — P. 683 720.
- Chang T.J., Chang H., Chen P., et al. Requirement of aryl hydrocarbon receptor overexpression for CYP1B1 up-regulation and cell growth in human lung adenocarcinomas // Clin Cancer Res. 2007. — Vol. 13. — P. 3845.
- Chen J., Giovannucci E., Kelsey K., et al. A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer // Cancer Res. —i 1996.-Vol. 56.-№ 21.-P. 4862−4864.
- Chen H., Wilkins L.M., Aziz N., et al. Single nucleotide polymorphisms in the human interleukin-IB gene affect transcription according to haplotype context // Hum Mol Gen. 2006. — Vol.15. — № 4. — P. 519−529.
- Chen W., Mempel M., Schober W., et al. Gender difference, sex hormones, and immediate type hypersensitivity reactions // Allergy. 2008. — Vol. 63, № 11.-P. 1418−27.
- Cheng L., Enomoto Т., Hirota Т., et al. Polymorphisms in ADAM33 are associated with allergic rhinitis due to Japanese cedar pollen // Clin Exp Allergy.-2004.-Vol. 34.-P. 1192−1201.
- Chiang C.H., Tang Y.C., Lin M.W., et al. Association between the IL-4 promoter polymorphisms and asthma or severity of hyperresponsiveness in Taiwanese//Respirology. — 2007. — Vol. 12. — № l.-P. 42−48.
- Chung K.F. and Barnes P.J. Cytokines in asthma // Thorax. 1999. — Vol.54.-P. 825−57.
- Crofts F., Taioli E., Trachman J., et al. Functional significance of different human CYP1A1 genotypes // Carcinogenesis. 1994. — Vol. 15. — P. 29 612 963.
- CSGA. The Collaborative Study on the Genetics of Asthma. A genome-wide search for asthma susceptibility loci in ethnically diverse populations // Nat Genet. 1997. — Vol.15. — P. 389−392.
- Cui Т., Wu J., Pan S., et al. Polymorphisms in the IL-4 and IL-4R alpha. genes and allergic asthma // Clin Chem Lab Med. 2003. — Vol.41. — № 7. -P. 888−892.
- Cullup H., Middleton P.G., Duggan G. Environmental factors and not genotype influence the plasma level of interleukin-1 receptor antagonist in normal individuals // Clin Exp Immunol. 2004. — Vol. 137. -P. 351−358.
- D’amato M., Vitiani L.R., Petrelli G. et al. Association of persistent bronchial hyperresponsiveness with p2-adrenoceptor (ADRB2) haplotypes.
- A population study // Am J Respir Crit Care Med. 1998. — Vol. 158, № 6. -P. 1968−1973.
- Dale Smith C.A., Moss J.E., Gough A.C., et al. Molecular genetic analysis of the cytochrome P450-debrisoquine hydroxylase locus and association with cancer susceptibility // Environmental Health Perspectives. — 1992. -Vol. 98.-P. 107−112.
- Daniels S.E., Bhattacharrya S., James A., et al. A genome-wide search for quantitative trait loci underlying asthma // Nature. 1996. — Vol.383. — P. 247−250.
- Dewar J.C., Wilkinson J., Wheatley A., et al. The glutamine 27 beta2-adrenoceptor polymorphism is associated with elevated IgE levels in asthmatic families // J Allergy Clin Immunol. 1997. — Vol. 100. — № 2. -P. 261−265.
- DickmannL.J., Rettie A.E., Kneller M.B., et al. Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans // Mol Pharmacol. 2001. — Vol. 60. — P. 382−387.
- Dinarello C.A. The IL-1 family and inflammatory diseases // Clin Exp Rheumatol. 2002. — Vol.20. — № 5. — Suppl 27. — P. SI-S13.
- Djukanovic R., Homeyard S., Gratziou C., et al. (1997) The effect of treatment with oral corticosteroids on asthma symptoms and airwayinflammation // Am J Respir Crit Care Med. 1997. — Vol.155. — P. 826 832.
- Downie D., McFadyen M.C.E., Rooney P.H. Profiling cytochrome P450 expression in ovarion cancer: identification of prognostic markers // Clin Cancer Res. 2005. — Vol. 11, № 20. — P. 7369−7375.
- Dunham I., Sargent C.A., Trowsdale J., et al. Molecular mapping of the human major histocompatibility complex by pulsed-field gel electrophoresis // Proc Natl Acad Sci USA.- 1987. Vol.84. — № 20. — P. 7237−7241.
- Eder W., Klimecki W., Yu L., et al. Opposite effects of CD14/-260 on serum IgE levels in children raised in different environments // J Allergy Clin Immunol. 2005. — Vol.116. — P. 601−607.
- Erbek S.S., Yurtcu E., Erbek S., et al. Proinflammatory cytokine single nucleotide polymorphisms in nasal polyposis // Arch Otolaryngol Head Neck Surg. 2007. — Vol. 133. — № 7. — P. 705−709.
- Eskdale J., Gallagher G., Verweij C.L., et al. Interleukin 10 secretion in relation to human IL-10 locus haplotypes // Proc Natl Acad Sci USA. -1998. Vol.95. — P. 9465−9470.
- Evans D.M., Zhu G., Duffy D.L., et al. Major quantitative trait locus for eosinophil count is located on chromosome 2q // J Allergy Clin Immunol. -2004.-Vol.114.-P: 826−830.
- Fabbri L.M., Caramori G., Maestrelli P. Etiology of occupational asthma. In: Roth RA, ed. Comprehensive toxicology: toxicology of the. respiratory system // Cambridge: Pergamon Press. 1997. — P. 425−435.
- Flood-Page P.T., Menzies-Gow A.N., Kay A.B., et al. Eosinophil’s role remains uncertain as anti-interleukin-5 only partially depletes numbers inasthmatic airway // Am J Respir Crit Care Med. 2003a. — Vol.167. — P. 199−204.
- Franco R.F., Simoes B.P., Tone L.G., et al. The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia // Br J Haematol. 2001. — Vol. 115. — № 3. — P. 616−618.
- Franlcel W.N., Schork N.J. Who’s afraid of epistasis? // Nat Genet. 1996. -Vol. 14.-P. 371−373.
- Fryer A.A., Bianco A., Hepple M., et al. Polymorphism at the glutathione S-transferase GSTP1 locus // Am J Respir Crit Care Med. 2000. — Vol. 161.-P. 1437−1442.
- Gao P. S., Huang S.K. Genetic aspects of asthma // Panminerva medica. -2004. Vol.46. — № 2. — P. 121−134.
- Gao J., Shan G., Sun В., et al. Association between polymorphism of tumor necrosis factor a 308 gene promoter and asthma: a meta-analysis // Thorax. — 2006. — Vol. 61. — P. 466−471.
- Garte S. The role of ethnicity in cancer susceptibility gene polymorphisms: the example of CYP1A1 // Carcinogenesis. 1998. — Vol. 19. — № 8. — P. 1329−1332.
- Garte S., Gaspari L., Alexandrie A.K., et al. Metabolic gene polymorphism frequencies in control populations // Cancer Epidemiol Biomarkers Prev. — 2001.-Vol. 10.-P. 1239−1248.
- Gawronska-Szklars В., Pawlik A., Czaja-Bulsa G., et al. Genotype of N-acetyltransferase 2 (NAT2) polymorphism in children with immunoglobulin E-mediated food allergy // Clin Pharmacol Ther. 2001. — Vol. 69, № 5. P. 372−378.
- Gerhard D.S., Nguyen L.T., Zhang Z.Y., et al. A relationship between methylenetetrahydrofolate reductase variants and the development of invasive cervical cancer // Gynecol Oncol. — 2003. — Vol. 90. № 3. — P. 560−565.
- Grammatikos A.P. The genetic and environmental basis of atopic diseases // Ann Med. 2008. — Vol.40. — № 7. — P. 482−495.
- Green S.A., Turki J., Bejarano P., et al. Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells//Am J Respir Cell Mol Biol. 1995. — Vol. 13.-№ l.-P. 25−33.
- Grove J., Daly A.K., Bassendine M.F., et al. lnterleukin 10 promoter region polymorphisms and susceptibility to advanced alcoholic liver disease // Gut. 2000. — Vol.46. — P. 540−545.
- Haag M., Leusink-Muis Т., Le Bouquin R., et al. Increased expression and decreased activity of cytochrome P450 1A1 in a murine model of toluene diisocyanate-induced asthma // Arch Toxicol. — 2002. Vol. 76. — № 11.— P. 621−627.
- Hagg S., Spigset O., Dahlqvist R. Influence of gender and oral contraceptives on CYP2D6 and CYP2C19 activity in healthy volunteers // Br J Clin Pharmacol. 2001. — Vol. 51. — P. 169−173.
- Haagerup A., Bjerke Т., Schiertz P.O., et al. Asthma and atopy a total genome scan for susceptibility genes // Allergy. — 2002. — Vol.57. — № 8. — P. 680−686.
- Hahn L.W., Ritchie-M.D., and Moore J.H. Multifactor dimensionality reduction software, for detecting gene-gene and gene-environment interactions // Bionformatics. 2003. — V. 19. — № 3. — P. 376−382.
- Hakonarson H., Bjornsdottir U.S., Halapi E., et al. A major susceptibility gene for asthma maps to chromosome 14q24 // Am J Hum Genet. 2002. -Vol.71.-P. 483−491.
- Hall S.K., Perregaux D.G., Gabel C.A., et al. Correlation of polymorphic variation in the promoter region of the interleukin-1 beta gene with secretion of interleukin-1 beta protein // Arthritis Rheumatism. 2004. — Vol.50. — P. 1976−1983.
- Hamdy S.I., Hiratsuka M., Narahara K., et al. Genotype and allele frequencies of TPMT, NAT2, GST, SULT1A1 and MDR-1 in the Egyptian population // Br J Clin Pharmacol. 2003. — Vol. 55. — № 6. — P. 560−569.
- Hanene C., Jihene L., Jamel A., et al. Association of GST genes polymorphisms with asthma in Tunisian children // Mediators of Inflamm. — 2007.-Vol. 2007.
- Hansel N.N., Diette G.B. Gene expression profiling in human asthma // Proc Am Thorac Soc. 2007. — Vol 4. — P. 32−36.
- He J.Q., Chan-Yeung M., Becker A.B., et al. Genetic variants of the IL13 and IL4 genes and atopic diseases in at-risk children // Genes Immun. — 2003. Vol.4. — № 5. — P. 385−389.
- Hefler L.A., Tempfer C.B., Grimm C., et al. Estrogen-metabolizing gene polymorphisms in the assessment of breast carcinoma risk and fibroadenoma risk in Caucasian women // Cancer. 2004. — Vol. 101. — № 2. — P. 264−269.
- Hershey G.K., Friedrich M.F., Esswein L.A., et al. The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor // N Engl J Med. 1997. — Vol.337. — № 24. — P. 1720−1725.
- Hirvonen A. Genetic factors in individual responses to environmental exposures // J Occup Environ Med. 1995. — Vol. 37. — P. 37−43.
- Hobbs C.A., Cleves M.A., Lauer R.M., et al. Preferential transmission of the MTHFR 677 T allele to infants with Down syndrome: implications for a survival advantage // Am J Med Genet. 2002. — Vol. 113. — № 1. — P. 9−14.
- Hobbs K., Negri J., Klinnert M., et al. Interleukin 10 and transforming growth factor-(3 promoter polymorphisms in allergies and asthma // Am J Respir Crit Care Med. 1998. — Vol.158. — P. 1958−1962.
- Hogaboam C.M., Carpenter K.J., Schuh J.M., et al. Aspergillus and asthma—any link? // Med Mycol. 2005. — Vol.43. — Suppl 1. — P. S197-S202.
- Holgate S.T. Pathogenesis of asthma // Clin and Exp Allergy. 2008. -V.38.-P. 872−897.
- Horwood L.J., Fergusson D.M., Shannon F.T. Social and familial factors in the development of early childhood asthma // Pediatrics. 1985. -Vol.75. -№ 5. — P. 859−868.
- Holgate S.T., Yang Y., Haitchi H.M., et al. The genetics of asthma: ADAM33 as an example of a susceptibility gene // Proceedings of the American Thoracic Society. 2006. — Vol. 3. — № 5. — P. 440−443.
- Howard T.D., Postma D.S., Jongepier H., et al. Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations // J Allergy Clin Immunol. 2003. — Vol. 112. — № 4. — P. 717 722.
- Huang S.K., Mathias R.A., Ehrlich E., et al. Evidence for asthma susceptibility genes on chromosome 11 in an African-American population // Hum Genet. 2003. — Vol.113. — P. 71−75.
- Hung H.C., Chuang J., Chien Y.C., et al. Genetic polymorphisms of CYP2E1, GSTM1, and G57T7- environmental factors and risk of oral cancer // Cancer Epidemiol Biomarkers Prev. 1997. — Vol. 6. — P. 901−905.
- Humrich J.Y., Humrich J.H., Averbeck M., et al. Mature monocyte-derived dendritic cells respond more strongly to CCL19 than to CXCL12: consequences for directional migration // Immunology. — 2006. Vol. 117.— P. 238−247.
- Hurme M., Santtila S. IL-1 receptor antagonist (IL-IRa) plasma levels are coordinately regulated by both IL-IRa and IL-1 beta genes // Eur J Immunol. 1998. Vol.28. — № 8. — P. 2598−2602.
- Husemoen L.L., Toft U., Fenger M., et al. The association between atopy and factors influencing folate metabolism: is low folate status causally related to the development of atopy? // Int J Epidemiol. 2006. — Vol. 35. — № 4.-P. 954−961.
- Hytonen A.M., Lowhagen O., Arvidsson M., et al. Haplotypes of the interleukin-4 receptor a chain gene associate with susceptibility to and severity of atopic asthma // Clin Exp Allergy. 2004. — Vol. 34. — P. 15 701 575.
- Ishiguro Y. Mucosal proinflammatory cytokine production correlates with endoscopic activity of ulcerative colitis // J Gastroenterol. 1999. — Vol.34. — P. 66−74.
- Ivaschenko Т.Е., Sideleva O.G., Baranov V.S. Glutathione-S-transferase j. i and theta gene polymorphisms as new risk factors of atopic bronchial asthma // J Mol Med. 2002. — Vol. 80. — P. 39−43.
- Jang N., Stewart G., Jones G. Polymorphisms within the PHF11 gene at chromosome 13ql4 are associated with childhood atopic dermatitis // Genes and Immunity. 2005. — Vol. 6. — P. 262−264.
- Jahnke V., Matthias C., Fryer A., et al. Glutathione 5-transferase and cytochrome P450 polymorphism as risk factors for squamous cell carcinoma of the larynx // Am J Surg. 1996. — Vol. 172. — P. 671−673.
- Jourenkova N., Reinikanen M., Bouchardy C., et al. Effects of glutathione 5-transferases GSTMI and GSTT1 genotypes on lung cancer risk in smokers //Pharmacogenetics. 1997. — Vol. 7.-P. 515−518.
- Kamada F., Mashimo Y., Inoue H., et al. The GSTP1 gene is a susceptibility gene for childhood asthma and the GSTMI gene is a modifier1. of the GSTP1 gene // Int Arch Allergy Immunol. 2007. — Vol. 144, № 4. -P. 275−286.
- Kamali-Sarvestani E., Ghayomi M.A., Nekoee A. Association of TNF-alpha -308 G/A and IL-4 -589 C/T gene promoter polymorphisms with asthma susceptibility in the south of Iran // J Investig Allergol Clin Immunol. 2007. — Vol.17. — № 6. — P. 361−366.
- Kauppi P., Lindblad-Toh K., Sevon P., et al. A Second-Generation Association Study of the 5q31 Cytokine Gene Cluster and the Interleukin-4 Receptor in Asthma // Genomics. 2001. — Vol. 77. — № 1−2. — P. 35−42.
- Kay A.B. Allergy and allergic diseases. Second of two parts // N Engl J I Med. 2001. — Vol.344. — P! 109−113.
- Kay A.B. The role of eosinophils in the pathogenesis of asthma // Trends Mol Med.-2005.-Vol.11.-P.' 148r152.
- Kay A.B. The role of T lymphocytes in asthma // Ghem Immunol Allergy.- 2006. Vol.91. — P. 59−75.
- Kempkes M., Golka К., Reich S., et al. Glutathione 5-transferase GSTMI and GSTT1 null genotypes as potential risk factors for urothelial cancer of the bladder // Arch Toxicol. 1996. — Vol. 71. — P. 123−126.
- Kimura R., Nishioka Т., Soemantri A., et al. Cis-acting effect of the IL1B C-31T polymorphism on IL-1 beta mRNA expression // Genes Immun. -2004.-Vol.5.-P. 572−575.
- Kips J.C. Cytokines in asthma // Eur Respir J Suppl. 2001. — Vol.34. — P. 24s-33s.
- Khedhaier A., Hassen E., Bouaouina N., et al. Implication of xenobiotic metabolizing enzyme gene (CYP2E1, CYP2C19, CYP2D6, mEH and NAT2) polymorphisms in breast carcinoma // BMC Cancer. 2008. — 8:109.
- Kraft M., Martin R.J., Wilson, S., et al. Lymphocyte and eosinophil influx into alveolar tissue in nocturnal asthma // Am J Respir Crit Care Med. -1999.-Vol.159.-P. 228−234.
- Laitinen T. Gene mapping in asthma-related'traits // Methods Mol Biol. — 2007.-Vol. 376.-P. 213−134.
- Laitinen Т., Polvi A., Rydman P., et al. Characterization of a common susceptibility locus for asthma-related traits // Science. 2004. — Vol. 304. — P. 300−304.
- Laprise С., Sladek R., Ponton A., et al. Functional classes of bronchial mucosa genes that are differentially expressed in asthma // BMC Genomics. -2004. Vol.5:21.
- Lee E.J., Wong J.Y., Yeoh P.N., et al. Glutathione S-transferase theta (GSTT1) genetic polymorphism among Chinese, Malays and Indians in Singapore // Pharmacogenetics. 1995. — Vol. 5. — P. 332−334.
- Lee J.-Y., Park S.-W., Chang H.K., et al. A Disintegrin and Metalloproteinase 33 Protein in Patients with Asthma Relevance to Airflow Limitation // Am J Respir Crit Care Med. 2006. — Vol. 173. — P. 729−735.
- Lee S.-G., Kim B.-S., Kim J.-H., et al. Gene-gene interaction between interleukin-4 and interleukin-4 receptor a in Korean children with asthma // Clin Exp Allergy. 2004. — Vol. 34. — P. 1202−1208.
- Levine A.J., Siegmund K.D., Ervin C.M., et al. The methylenetetrahydrofolate reductase 677C~>T polymorphism and distal colorectal adenoma risk // Cancer Epidemiol Biomarkers Prev. — 2000. — Vol. 9.-№ 7.-P. 657−663.
- Lin H.J., Han C.Y., Lin B.K., et al. Ethnic distribution of slow-acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene // Pharmacogenetics. 1994. — Vol. 4. — P. 125−134.
- Lind D.L., Choudhry S., Ung N., et al. ADAM33 is not associated with asthma in Puerto Rican or Mexican populations // Am J Respir Crit Care Med.-2003.-Vol. 168.-№ 11.-P. 1312−1316.
- Litonjua A.A., Carey V.J., Burge H.A., et al. Parental history and the risk for childhood asthma. Does mother confer more risk than father? // Am J Respir Crit Care Med.- 1998.-Vol. 158, № l.-P. 176−181.
- Louis R., Leyder E., Malaise M., et al. Lack of association between adult asthma and the tumour necrosis factor a-308 polymorphism gene // Eur Respir J. 2000. — Vol. 16. — P. 604−608.
- Loza M.J., Chang B.L. Association between Q551R IL4R genetic variants and atopic asthma risk demonstrated by meta-analysis // J Allergy Clin Immunol. 2007. — Vol. 120. — № 3. — P. 578−585.
- Lyon H., Lange C., Lake S., et al. IL10 gene polymorphisms are associated with asthma phenotypes in children // Genetic Epidemiology. 2004. -Vol.26.-P. 155−165.
- Makarova S.I., Vavilin V.A., Lyakhovich V.V., et al. Allele NAT2*5 Determines Resistance to Bronchial Asthma in Children // Bulletin of Experimental Biology and Medicine. 2000 — № 6. — P. 575−577.
- Malerba G., Pignatti P.F. A review of asthma genetics: gene expression studies and recent candidates // J Appl Genet. 2005. — Vol.46. — № 1. — P. 93−104.
- Malo J.L. Future advances in work-related asthma and the impact on occupational health // Occup Med. 2005. — Vol.55. — P. 606−611.
- Mao X.Q., Kawai M., Yamashita Т., et al. Imbalance production between interleukin-1 beta (IL-1J3) and IL-1 receptor antagonist (IL-1RA) in bronchial asthma // Biochem Biophys Res Commun. 2000. — Vol.276. — P. 607−612.
- Markova S., Nakamura Т., Makimoto H. IL-lb Genotype-Related Effect of Prednisolone on IL-lb Production in Human Peripheral Blood Mononuclear Cells under Acute Inflammation // Biol Pharm Bull. 2007. — Vol.30. — № 8.-P. 1481−1487.
- Martinez F.D., Graves P.E., Baldini M., et al. Association between genetic polymorphisms of the p2-adrenoceptor and response to albuterol in childrenwith and without a history of wheezing // J Clin Invest. 1997. — Vol. 100, № 12.-P. 3184−3188.
- Martinez F.D., Wright A.L., Taussig L.M., et al. Asthma and wheezing in the first six years of life. The Group Health Medical Associates // N Engl J Med. 1995. — Vol.332. -№ 3. — P. 133−138.
- Masoli M., Fabian D., Holt S., et al. The global burden of asthma: executive summary of the GINA Dissemination Committee Report // Allergy. 2004. — Vol. 59, № 5. — P. 469−478.
- Masson L.F., Sharp L., Cotton S.C., et al. Cytochrome P-450 1A1 gene polymorphisms and risk of breast cancer: a HuGE review // Am J Epidemiol.-2005.-Vol. 161.-№ 10. P. 901−915.
- Mathew C.C. The isolation of high molecular weight eucariotic DNA // Methods in molecular biology / Ed. Walker J.M. N.Y.- Haman press, 1984. -V.2. — P.31−34.
- May D.G., Black C.M., Olsen N.J., et al. Sclerodenna is associated with differences in individual routes of drug metabolism: a study with dapsone, debrisoquine, and mephenytoin // Clin Pharmacol Ther. 1990. — Vol. 48. — P. 286−295.
- McGlynn K.A., Rosvold E.A., Lustbader E.D., et al. Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin В // Proc Natl Acad Sci USA. -1995. -Vol. 92.-P. 2384−2387.
- Mei H., Cuccaro M.L., and Martin E.R. Multifactor dimensionality reduction-phenomics: A novel method to capture genetic heterogeneity with use of phenotypic variables // The Am J Hum Gen. -2007. V. 81. — P. 1251−1261.
- Mitsuyasu H., Izuhara К., Mao X.Q., et al. Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma // Nat Genet. -1998.-Vol. 19, № 2.-P. 119−120.
- Mitsuyasu H., Yanagihara Y., Mao X.Q., et al. Cutting edge: dominant effect of Ile50Val variant of the human IL-4 receptor alpha-chain in IgE synthesis // J Immunol. 1999. — V.162. — P. 1227−1231.
- Moffatt M.F., James A., Ryan G, et al. Extended tumour necrosis factor/HLA-DR haplotypes and asthma in an Australian population sample // Thorax. 1999.-Vol.54.-P. 757−761.
- Moffatt M.F., Kabesch M., Liang L., et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma // Nature. — 2007. Vol.448. — № 715. — P. 470−473.
- Moos V., Rudwaleit M., Herzog V., et al. Association of genotypes affecting the expression of interleukin-lb or interleukin-1 receptor antagonist with osteoarthritis // Arthritis & Rheumatism. 2000. — Vol. 43. -№ 11.-P. 2417−2422.
- Muntjewerff J.W., Kahn R.S., Blom H.J., et al. Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a metaanalysis // Mol Psychiatry. 2006. — Vol. 11. — № 2. — P. 143−149.
- Nacak M., Aynacioglu A.S., Filiz A. Association between the N-acetylation genetic polymorphism and bronchial asthma // Br J Clin Pharmacol.-2002.-Vol. 54.-P. 671−674.
- Nakamura E., Megumi Y., Kobayashi Т., et al. Genetic Polymorphisms of the Interleukin-4 Receptor a Gene Are Associated with an Increasing Risk and a Poor Prognosis of Sporadic Renal Cell Carcinoma in a Japanese
- Population // Clinical Cancer Research. 2002. — Vol. 8. — P. 2620−2625. 2002.
- Nasu K., Kubota Т., Ishizaki T. Genetic analysis of CYP2C9 polymorphism in a Japanese population // Pharmacogenetics. — 1997. Vol. 7.-P. 405−409.
- Nelson H.H., Wiencke J.K., Christiani D.C., et al. Ethnic differences in the prevalence of the homozygous deleted genotype of glutathione S-transferase theta // Carcinogenesis. 1995. — Vol. 16. — P. 1243−1245.
- Nicolae D., Cox N.J., Lester L.A., et al. Fine mapping and positional candidate studies identify HLA-G as an asthma susceptibility gene on chromosome 6p21 // Am J Hum Genet. 2005. — Vol. 76. — № 2. -P. 349 357.
- Niewinski P., Orzechowska-Juzwenko K., Patkowski J., et al. Significance of CYP2D6 oxidation genotype as a risk factor in development of allergic diseases // Pol Arch Med Wevra. 2003. — Vol. 109. — № 2. — P. 137−142.
- Noguchi E., Shibasaki M., Arinami Т., et al. Evidence for linkage between asthma/atopy in childhood and chromosome 5q31-q33 in a Japanese population // Am J Respir Crit Care Med. 1997. — Vol.156. — P. 13 901 393.
- Noguchi E., Shibasaki M., Arinami Т., et al. Association of asthma and the interleukin-4 promoter gene in Japanese // Clin Exp Allergy. 1998. -Vol.28.-№ 4.-P. 449−453.
- Noguchi E., Shibasaki M., Arinami Т., et al. Lack of association of atopy/asthma and the interleukin-4 receptor alpha gene in Japanese // Clin Exp Allergy. 1999. — Vol. 29. — P. 228−233.
- Ober C., Hoffjan S. Asthma genetics 2006: the long and winding road to gene discovery // Genes Immun. 2006. — Vol. 7, № 2. — P. 95−100.
- Paine M.F., Hart H.L., Ludington S.S., et al. The human intestinal cytochrome P450 «pie» // Drug Metab Dispos. 2006. — Vol. 34. — P. 880 886.
- Panhuysen C.I.M., Xu J., Postma D.S., et al. Evidence for a major locus for bronchial hyperresponsiveness independent of the locus regulating total serum IgE levels // Am J Hum Genet. 1996. — 5: A231.
- Pillay V., Gaillard M.C., Halkas A.A. Differences in the genotypes and plasma concentrations of the interleukin-1 receptor antagonist in black and white South African asthmatics and control subjects // Cytokine. 2000. -Vol.12.-P. 819−821.
- Pociot F., Molving J., Wogensen L., et al. A TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretionin vitro // Eur J Clin Invest. 1992. — Vol.22. — P.396−402.
- Postma D.S., Koppelman G.H. Confirmation of GPRA: a putative drug target for asthma // Am J Respir Crit Care Med. 2005. — Vol. 171. — № 12. -P. 1323−1324.
- Postma D.S., Koppelman G.H., Meyers D.A. The genetics of atopy and airway hyperresponsiveness // Am J Respir Crit Care Med. 2000. -Vol.162.-P. SI 18-S123.
- Prescott S.L., Macaubas C., Holt В J., et al. Transplacental priming of the human immune system to environmental allergens: universal skewing ofIinitial T cell responses toward the Th2 cytokine profile // J Immunol. -1998. -Vol.160.-P. 4730−4737.
- Primakoff P., Myles D.G. The ADAM gene family: surface proteins with adhesion and protease activity // Trends Genet. — 2000. Vol. 16. — № 2. — P. 83−87.
- Reihsaus E., Innis M., Maclntyre N., et al. Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects // Am J Respir Cell Mol Biol. 1993. — Vol. 8, № 3. — P. 334−339.
- Rigoli L., Di Bella C., Procopio V., et al. Molecular analysis of sequence variants in the Fcepsilon receptor I beta gene and IL-4 gene promoter in Italian atopic families // Allergy. 2004. — Vol.59. — № 2. — P. 213−218.
- Ritchie M.D., Hahn L.W., Roodi N., et al. Multifactor-dimensionality1.reduction reveals high-order interactions among estrogen-metabolism genesin sporadic breast cancer // Am J HumGenet. 2001. — Vol. 69. — P. 138 147.
- Rockman M.V., Hahn M.W., Soranzo N., et al. Positive selection on a human-specific transcription factor binding site regulating IL4 expression И Curr Biol. 2003. — Vol. 13. — № 23. — P. 2118−2123.
- Roddam P.L., Rollinson S., Kane E., et al. Poor metabolizers at the cytochrome P450 2D6 and 2C19 loci are at increased risk of developing adult acute leukaemia // Pharmacogenetics. 2000. — Vol. 10. — № 7. — P. 605−615.
- Rosenwasser L.J., Borish L. Genetics of atopy and asthma: the rationale behind promoter-based candidate gene studies (IL-4 and IL-10) // Am J Respir Crit Care Med. 1997. — Vol.156. — P. SI 52-S155.
- Rosenwasser L.J., Klemm D.J., Dresback J.K., et al. Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy // Clin Exp Allergy. 1995. — Vol. 25, Suppl. 2. — P. 74−78.
- Russo C. and Polosa R. TNF-a as a promising therapeutic target in chronic asthma: a lesson from rheumatoid arthritis // Clinical Science. 2005. -Vol.109.-P.135−142.
- Qi S.Y., Riviere P.J., Trojnar J., et al. Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases //Biochem. J. -2003. Vol. 373. — P. 179−189.
- Sachse C., Smith G., Wilkie M.J., et al. A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer // Carcinogenesis. 2002. — Vol. 23. — P. 1839−1849.
- Sandford A.J., Chagani Т., Zhu S., et al. Polymorphisms in the IL4, IL4RA, and FCERIB genes and asthma severity // J Allergy Clin Immunol. -2000.-Vol. 106, № l, Pt. l.-P. 135−140.
- Santtila S., Savinainen K., Hurme M. et al. Presence of the IL-1RA allele 2 (IL-1RN*2) is Associated, with enhanced IL-1(3 Production in vitro И Scand J Immunology. 1998. — Vol. 47. — P. 195−198.
- Settin A., Zedan M., Farag M., et al. Gene polymorphisms of lL-6(-174) G/C and IL-IRa VNTR in asthmatic children // Indian J Pediatr. 2008. -Vol.75.-№ 10.-P. 1019−1023.
- Scirica C.V., Celedon J.C. Genetics of asthma: potential implications for reducing asthma disparities // Chest. 2007. — Vol. 132. — P. 770−781.
- Schedel M., Depner M., Schoen C., et al. The role of polymorphisms in ADAM33, a disintegrin and metal! oprotease 33, in childhood asthma and lung function in two German populations // Respiratory Research. 2006. -Vol. 7:91.
- Schlesselman J. Case-control studies. Design, conduct, analysis // New York, Oxford: Oxford University Press. 1982. — P.58−96.
- Scordo M.G., Aklillu E., Yasar U., et al. Genetic polymorphism of cytochrome P450 2C9 in a Caucasian and a Black African population // Br J Clin Pharmacol. 2001. — Vol. 52. — P. 447−450.
- Shin H.D., Park B.L., Kim L.H., et al. Association of tumor necrosis factor polymorphisms with asthma and serum total IgE // Hum Mol Gen. 2004. -Vol. 13. -№ 4. — P. 397−403.
- Sibbald В., Rink E. Epidemiology of seasonal and perennial rhinitis: clinical presentation and medical history // Thorax. 1991. — Vol. 46. — № 12.-P. 895−901.
- Sigurs N., Bjarnason R., Sigurbergsson F., et al. Respiratory syncytial virus bronchiolitis in infancy is an important risk factor for asthma and allergy at age 7 // Am J Respir Crit Care Med. 2000. — Vol.161. — № 5. -P. 1501−1507.
- Smit J.J., Lukacs N.W. A closer look at chemokines and their role in asthmatic responses // Eur J Pharmacol. 2006. — Vol.533. — P. 277−288.
- Smith C.A.D., Wadelius M., Gough A.C., et al. A simplified assay for the arylamine N-acetyltransferase 2 polymorphism validated by phenotyping with isoniazid // J Med Genet. 1997. — Vol. 34. — P. 758−760.
- Sousa A.R., Lane S.J., Nakhosteen J.A., et al. Expression of interleukin-1 beta (IL-1 beta) and interleukin-1 receptor antagonist (IL-lra) on asthmatic bronchial epithelium // Am J Respir Crit Care Med. 1996. — Vol.154. — p. 1061−1066.
- Sporik R., Holgate S.T., Platts-Mills T.A., et al. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study // N Engl J Med. 1990. — Vol.323. — № 8. — P. 502−507.
- Steinke J.W., Barekzi E., Hagman J., et al. Functional Analysis of -571 IL-10 Promoter Polymorphism Reveals a Repressor Element Controlled by Spll // The Journal of Immunology. 2004. — Vol.173.-P. 3215−3222.
- Strachan D.P. Hay fever, hygiene, and household size // BMJ. -1989. — Vol.299.-P. 1259−1260.
- Suzuki I., Hizawa N., Yamaguchi E., et al. Association between a C+33T polymorphism in the IL-4 promoter region and total serum IgE levels // Clin Exp Allergy. 2000. — Vol. 30. — P. 1746−1749.
- Taki F., Kondoh Y., Matsumoto K., et al. Tumor necrosis factor in sputa of patients with bronchial asthma on exacerbation // Arerugi. 1991. — Vol. 40. — № 6. — P. 643−646.
- Tahan F., Patiroglu T. Plasma soluble human leukocyte antigen G levels in asthmatic children // Int Arch Allergy Immunol. 2006. — Vol. 141. — № 3. -P. 213−216.
- Tamer L., Calikoglu M., Aras Ate§ N., et al. Relationship between N-acetyl transferase-2 gene polymorphism and risk of bronchial asthma // Tuberk Toraks.- 2006. -Vol. 54.-№ 2.-P. 137−143.
- Tarlow J.K., Blakemore A.I., Lennard A., et al. Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat // Hum Genet. 1993. — Vol.91. — P. 403−404.
- Tarlow J.K., Clay F.E., Cork M.J., et al. Severity of alopecia areata is associated with a polymorphism in the interleukin-1 receptor antagonist gene // J Invest Dermatol. 1994. — Vol.103. — P. 387−390.
- The European Community Respiratory Health Survey Group. Genes for asthma? An analysis of the European Community Respiratory Health Survey II Ami Respir Crit Care Med. 1997. — Vol.156. — P. 1773−1780.
- Thomsen S.F., Kyvik K.O., Backer V. Etiological relationships in atopy: a review of twin studies // Twin Res Hum Genet. — 2008. Vol.11. — № 2. — P. 112−120.
- Trabetti E. Homocysteine, MTHFR gene polymorphisms, and cardio-cerebrovascular risk // J Appl Genet. 2008. — Vol. 49. — № 3. — P. 267−282.
- Truyen E., Coteur L., Dilissen E. et al. (2006) Evaluation of airway inflammation by quantitative Thl/Th2 cytokine mRNA measurement in sputum of asthma patients // Thorax. 2006. — Vol. 61. — P. 202−208.
- Umland S.P., Garlisi C.G., Shah H., et al. Human ADAM33 messenger RNA expression profile and post-transcriptional regulation // Am J Respir Cell Mol Biol. 2003. — Vol. 29. — P. 571 -582.
- Van Eerdewegh P., Little R.D., Dupuis J., et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness // Nature. — 2002.-Vol. 418.-P. 426−430.
- Vercelli D. Genetics, epigenetics, and the environment: switching, buffering, releasing // J Allergy Clin Immunol. 2004. — Vol.113. — P. 381 386.
- Vijgen L., Van Gysel M., Rector A. Interleukin-1 receptor antagonist VNTR-polymorphism inflammatory bowel disease // Genes and Immunity. 2002. — Vol. 3. — P. 400−406.
- Von Gamier С., Filgueira L., Wikstrom M., et al. Anatomical locationdetermines the distribution and function of dendritic cells and other APCs in the respiratory tract // J Immunol. 2005. — Vol. 175. — P. 1609−1618.
- Wahn U., Lau S., Bergmann R., et al. Indoor allergen exposure is a risk factor for sensitization during the first three years of life 11 J Allergy Clin Immunol. 1997. — Vol.99. — (6 Pt 1). — P. 763−769.
- Walley A.J., Cookson W.O. Investigation of an interleukin-4 promoter polymorphism for associations with asthma and atopy // J Med Genet. — 1996. -Vol.33. -№ 8.-P. 689−692.
- Walraven J.M., Zang Y., Trent J.O. Structure/function evaluations of single nucleotide polymorphisms in human N-acetyltransferase 2 // Curr Drug Metab. 2008. — Vol. 9. — № 6. — P. 471−486.
- Wang S.L., Huang J., Lai M.D., et al. Detection of CYP2C9 polymorphism based on the polymerase chain reaction in Chinese // Pharmacogenetics. -1995.-Vol. 5.-P. 37−42.
- Wei' Q., Gu J., Cheng L., et al. Benzoa. pyrene diol epoxide-induced chromosomal aberrations and risk of lung cancer // Cancer Res. 1996. -Vol. 56.-P. 3975−3979.
- Weidinger S., Gieger C., Rodriguez E., et al. Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus // PLoS Genet. 2008. — Vol.4. — № 8:el000166.
- Weiss S.T., Raby B.A., Rogers A. Asthma genetics and genomics 2009 // Curr Opin Genet Dev. 2009. — Vol.19. — № 3. — P. 279−282.
- Wen A., Wang J., Feng K., et al. Effects of haplotypes in the interleukin lbeta promoter on lipopolysaccharide-induced interleukin lbeta expression // Shock. 2006. — Vol.26. — P. 25−30.
- Werner M., Herbon N., Gohlke H., et al. Asthma is associated with single-I nucleotide polymorphisms in ADAM33 // Clin Exp Allergy. 2004. — Vol.34.-P. 26−31.
- Wilson A.G., Symons J.A., McDowell T.L., et al. Effects of a polymorphism in the human tumor necrosis factor a promoter on transcriptional activation // Proc Natl Acad Sci USA. 1997. — Vol. 94. — P. 3195−3199.
- Witte J.S., Palmer L.J., O’Connor R.D., et al. Relation between tumour necrosis factor polymorphism TNFa-308 and risk of asthma // European
- Journal of Human Genetics. 2002. — Vol. 10. — P. 82−85.
- Wolf C.R., Smith C.A., Gough A.C., et al. Relationship between the debrisoquine hydroxylase polymorphism and cancer susceptibility // Carcinogenesis. 1992.-Vol. 13.- № 6. -P. 1035−1038.
- Ying S., Zhang G., Gu S., et al. How much do we know about atopicasthma: where are we now? // Cell Mol Immunol. — 2006. Vol.3. — № 5. Pr/ч 321−332.
- Yokouchi Y., Nukaga Y., Shibasaki M., et al. Significant evidence for linkage of mite-sensitive childhood asthma to chromosome 5q31—q33 near the interleukin 12 В locus by agenome-wide search in Japanese families // Genomics. -2000.-Vol.66. P. 152−160.
- Yoshinaka Т., Nishii K., Yamada K., et al. Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity // Gene. 2002. — Vol. 282. -P. 227−236.
- Yu J., Chen В., Zhang G., et al. The 677 C-→T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene in five Chinese ethnic groups // Hum Hered. 2000. — Vol. 50. — № 4. — P. 268−270.
- Zagha E., Ozaita A., Chang S.Y., et al. DPP10 modulates Kv4-mediated A-type potassium channels // J Biol Chem. 2005. — Vol. 280. — № 19. — P. 18 853−18 861.
- Zambelli-Weiner A., Ehrlich E., Stockton M.L., et al. Evaluation of the CD14/-260 polymorphism and house dust endotoxin exposure in the Barbados Asthma Genetics Study // J Allergy Clin Immunol. — 2005. — Vol.115.-P. 1203−1209.
- Zhang Z.Y., Fasco M.J., Huang L., et al. Characterization of purified human recombinant cytochrome P4501A1-Ile462 and -Val462: assessment of a role for the rare allele in carcinogenesis // Cancer Res. 1996. — Vol. 56. — № 17. — P. 3926−3933.
- Zhang Y., Leaves N.I., Anderson G.G., et al. Positional cloning of a quantitative trait locus on chromosome 13ql4 that influences immunoglobulin E levels and asthma // Nat Genet. — 2003. — Vol. 34. — № 2. -P. 181−186.