Иммунологическая характеристика и клиническое значение опухолевых клеток, циркулирующих в периферической крови больных распространенным раком молочной железы
Диссертация
Впервые установлена частота обнаружения (41,3%) и охарактеризован субпопуляционный состав циркулирующих опухолевых клеток в периферической крови больных местно-распространенным и диссеминированным раком молочной железы. Показано, что циркулирующие в периферической крови опухолевые клетки гетерогенны по экспрессии молекул главного комплекса гистосовместимости II класса (HLA-DR) и рецептора CD95… Читать ещё >
Список литературы
- Богатырев В.Н. Изучение содержания ДНК и РНК в клетках опухоли методом лазерной проточной цитофлуорометрии и иммунологических показателей у больных с новообразованиями молочных желез. Диссертация канд. мед. Наук. Москва, 1983 г.
- Вартапетян А. Полимеразная цепная реакция. Молекулярная биология. Вып.4, 926−936, 1991 г.
- Гарин A.M. Адъювантная и неоадъювантная химиотерапия. Противоопухолевая химиотерапия. Справочник под редакцией Н. И. Переводчиковой. стр. 176−177, 1996 г.
- Давыдов М.И., Аксель Е. М. Статистика злокачественных новообразований в России и странах СНГ в 2004г. Вестник РОНЦ им. Н. Н. Блохина РАМН, т. 17, № 3 (прил.1) 2006.
- Давыдов М.И., Демидов Л. В., Поляков Б. И. Основы современной онкологии, Москва 2002, стр. 21−24.
- Дейчман Г. И. Иммунологический надзор организма и отбор опухолевых клеток в процессе роста и прогрессии опухолей. Глава IX. 4 в издании Канцерогенез под редакцией Заридзе Д. Г. Москва. 2000.
- Крохина О.В., Летягин В. П., Тупицын Н. Н. и соавторы. Рак молочной железы. Микрометастазы в костный мозг. Вестник Российского Онкологического Научного Центра РАМН имени Н. Н. Блохина. стр. 15−20, 3/2002.
- Летягин В.П., Паниченко А. В., Крохина О. В. и др. Иммуноморфологическое стадирование рака молочной железы. Вестник Российского Онкологического Научного Центра РАМН имени Н. Н. Блохина. 2001 № 3ю С. 44−47.
- Луговская С.А., Почтарь М. Е., Тупицын Н. Н. Иммунофенотипирование в диагностике гемобластозов. Москва 2005.
- Лушпикое Е.Ф., Амбросимов А. Ю. Гибель клетки (апоптоз). Москва, 2001 г.
- Моисеенко В.М. «Естественная история «роста рака молочной железы. «Практическая онкология: избранные лекции» под редакцией С. А. Тюляндина и В. М. Моисеенко. 2004. Стр. 22.
- Моисеенко В.М., Семиглазов В. Ф., Тюляндин С. А. Современное лекарственное лечение местно-распространенного и метастатического рака молочной железы. 1997. Стр. 11−25.
- Перадзе М. Бесцитокиновая мобилизация стволовых гемопоэтических клеток у больных раком молочной э/селезы. Автореферат диссертации на соискание ученой степени кандидата медицинских наук. 2004.
- Петров С. В., Райхлин Н. Т. Руководство по иммуногистохимической диагностике опухолей человека. 2000.
- Семиглазов В.Ф. Адъювантная химиотерапия рака молочной железы. Материалы IV Российской Онкологической Конференции. 2000 г, стр. 35 -40.
- Семиглазов В.Ф. Меняющаяся роль хирургического и системного лечения операбельного рака молочной железы. Материалы VI Российской Онкологической Конференции. 2002 г, стр. 10−12.
- Семиглазов В.Ф., Нургазиев К. Ш., Арзуманов А. С. и соавторы. Опухоли молочной железы (лечение и профилактика). Алматы, 2001. — 345с.
- Ставровская А.А. Механизмы лекарственной устойчивости опухолевых клеток. Глава XII.2. в издании Канцерогенез под редакцией ЗаридзеД.Г. Москва. 2000.
- Талаева Ш. Ж., Швецова Г. Н., Тулеуов А. Е. Апоптоз, опосредованный системой Fas-FasL (глава 8 в издании Рак молочнойжелезы под редакцией Н. Е. Кушлинского, С. М. Портного, К. П. Лактионова, Москва 2005).
- Тупицын Н.Н. Иммунофенотип рака молочной железы (глава 2 в издании Рак молочной железы под редакцией Н. Е. Куишинского, С. М. Портного, К. П. Лактионова, Москва 2005.
- Тюляндин С.А. Системная терапия операбельного рака молочной железы. «Практическая онкология: избранные лекции» под редакцией С. А. Тюляндина иВ.М. Моисеенко. 2004. Стр. 73−83.
- Херрингтон С, Макги Д. Современная клиническая диагностика. Методы. 1999.
- Aerts J, Wynendaele W, Paridaens et al. A real-time quantitative reverse transcriptase polymerase chain reaction (RT-PCR) to detect breast carcinoma cells in peripheral blood. Annals of Oncology 12: 39−46, 2001.
- Baselga J., Tripathy D., Mendelsohn J. et al Phase II study of weekly intravenous recombinant humanized anti-pl85Her2 monoclonal antibody in patients with Her2/neu-over- expressing metastatic breast cancer. J. Clin. Oncol., 14: 737−744, 1996.
- Berger U, Bettelheim R, Mansi JL et al. The relationship between micrometastasis in the bone marrow, histopathologic features of the primary tumor in breast cancer and prognosis. Am J Clin Pathol 90, 1−6, 1994.
- Braun S, Kentenich C, Janni W et al. Lack of effect of adjuvant chemotherapy on the elimination of single dormant tumor cells in bone marrow of high-risk breast cancer patients. J Clin Oncol 2000, 18, 80−86.
- Braun S, Pantel К et al. Prognostic significance of micrometastatic bone marrow involvement. Breast Cancer Res. Treat. — 1998 — Nov.- 52 (1/3)-P. 201−216.
- Brown S. A pooled analysis of bone marrow micrometastasis in breast cancer. New England Journal of Medicine, 2005 Aug 25- 353(8) :793−802.
- Braun S., Cevatli S., Assemi C. et al. Comparative analysis of Micrometastasis to the Bone marrow and Lymph Nodes of Node-Negative Breast Cancer Patients Receiving No Adjuvant therapy. J Clin Oncol, Vol 19, No5 (March 1), 2001: pp 1468−1475.
- Braun S., Schlimok G., Heumos I. et al. erbB2 Overexpression on Occult Metastatic Cells in Bone Marrow Predicts Poor Clinical Outcome of Stage I-III Breast Cancer Patients. Cancer Research 61, 1890−1895, March 1, 2001.
- Coombes RC, Berger U. Easton D et al. Prognostic significance of micrometastasis in Bone Marrow of patients with Primary Breast Cancer. Natl Cancer Inst Monogr 1986,1, 51−53.
- Conha A., Cabrera Т., Ruiz-Cabello F., Garrido F. Can the HLA phenotype be used as a prognostic factor in breast carcinomas. //Int. J. Cancer. -1991. -V.6. -P. 146−154.
- Conha A., Ruiz-Cabello F., Cabrera T. et al. Different patterns of HLA-DR antigen expression in normal epithelium, hyperplastic and neoplastic malignant lesions of the breast. //Eur. J. Immunogenet. //1995. -V.22, N4. -P.299−310.
- Cote RJ, Rosen PP, lesser ML et al. Prediction of early relapse in patients with operable Breast Cancer by the detection of occult Bone Marrow Micrometastasis. J. Clin. Oncol. 1991,9,1749−1756-
- Cristofanilli M., Budd G., Ellis M. et al. Circulating tumor cells, Disease Progression, and Survival in Metastatic Breast Cancer. New England Journal of Medicine. Vol. 351: 781−791 August 2004.
- De Vita VT, Hellman S, Rosenberg SA. Cancer. Principles and Practice of Oncology. 6th Edition.
- Dickson RB, Lippman ME Molecular Basis of breast cancer. Molecular Basis of cancer, Second edition: 313−342.
- Diel I J, Kaufmann M, Costa SD, Holle R, Minckwitz GV et al. Micrometastatic breast cancer cells in bone marrow at primary surgery: prognostic value in comparison with nodal status. JNCO 88: 1652−1658, 1997.
- Diel IJ, Kaufmann M, Goerner R et al, Detection of tumor cells in bone marrow ofpatients with primary breast cancer. A prognostic factor for distant metastasis. J. Clin. Oncol. 10(10): 1534−1539, 1992.
- Diel I J, Solomayer E, Costa S et al. Reduction in new metastases in breast cancer with adjuvant clodronat treatment. N Engl. J. Med 1998- 339: 357−363.
- Ditsch N, Mayer B, Rolle M, Untch M. Estrogen receptor expression profile of disseminated epithelial tumor cells in bone marrow of breast cancer patients. Recent Results Cancer Res. 2003−162:141−7.
- Fehm Т., Sagalowsky A., CliffordE. et al. Cytogenetic Evidence That Circulating Epithelial Cells in Patients with Carcinoma Are Malignant. Clinical Cancer Research Vol. 8, 2073−2084, July 2002
- Fidler IJ. Modulation of the organ microenvironment for treatment of cancer metastasis. J Natl Cancer Inst 1996- 87:1588−92.
- Fisher B, Osborn K, Margolese R et al. Neoplasms of the breast. // Cancer medicine. 3d edition./Ed. By J. Holland et al. 1993. P. 1706−1774.
- FolkmanJ: Tumor angiogenesis. Therapeutic implications. N Engl J Med 285:1182−1186, 1971
- Franke W. W, Schiller D.L., Moll R., Winter S., Schmid E. Et al. Diversity of cytokeratins: differentiation specific expression of cytokeratin polypeptides in epithelial cells and tissues. J.Mol. Biol. — 1981 #153 — P. 933−959.
- Funke I, Schraut W. Meta-analyses of studies on bone marrow micrometastasis: an independent prognostic impact remains to be substantiated. //J. Clin. Oncol. 1998 16, № 2 — 557−566.
- Funke I., Fries S., Rolle M et al. Comparative analyses of bone marrow micrometastases in breast and gastric cancer. // Int. J. Cancer — 1996-March, 15- Vol.65 № 6-P. 755−761.
- Gafforio JJ, Serrano MJ, Sanches-Rovira P et all. Detection of breast cancer cells in the peripheral blood is positively correlated with estrogen-receptor status and predicts for poor prognosis. Int J Cancer 2003 Dec 20- 107 (6): 984−90.
- Gebauer G, Fehm T, Merkle E et al. Epithelial Cells in Bone Marrow of Breast Cancer Patients at time of Primary Surgery: Clinical
- Outcome During Long-Term Follow-Up. J. Clin. Oncol 2001, 16, 36 693 674
- Gerber В., Krause A., Muller et al. Simultaneus Immunohistochemical Detection of Tumor Cells in Lymph Nodes and Bone Marrow Aspirates in Breast Cancer and Its Correlation With Other Prognostic Factors. J. Clin. Oncol. 2001, 19, 960−971.
- Ghossein R., Bhattacharya S., Rosai J. Molecular Detection of Micrometastases and Circulating Tumor Cells in Solid Tumors. Clinical Cancer Research Vol. 5, 1950−1960, August 1999.
- Guba M., Cernaianu G., Koehl G. A Primary Tumor Promotes Dormancy of Solitary Tumor Cells before Inhibiting Angiogenesis. Cancer Research 61, 5575−5579, July 15, 2001.
- Harbeck N, Untch M, Pache L et al. Tumor cell detection in the bone marrow of breast cancer patients at primary therapy: results of a 3-year median follow up.. Br J Cancer 69: 566−571, 1994.
- Ikeda N, Miyoshi Y, Motomura К et al. Prognostic significance of occult bone marrow micrometastases of breast cancer detected by quantitative polymerase chain reaction for cytokeratin 19 mRNA. Jpn J Cancer Res. 2000 Sep-91 (9) :918−24.
- Jung Y, Lee K, Kim H et al. Clinical Significance of Bone Marrow Micrometastasis Detected by Nested RT-PCR for Keratin-19 in Breast Cancer Patients. Japanese Journal of Clinical Oncology 33:167−172, 2003
- Kerbel R.S. Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents. BioEssaya 1991- 13:31−6.
- Kirk SJ, Cooper GG, Hoper M et al. The prognostic significance of marrow micrometastases in women with early breast cancer. European Journal Surgical Oncology 1990- 16: 481−485.
- Klein С A, Blankenstein TJ, Schmidt-Kittler О et al. Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer. Lancet 2002 Aug 31- 360 (9334): 683−9
- Kohn EC, Liotta LA Metastasis and Angiogenesis: Molecular Dissection and Novel Application. Molecular Basis of cancer, Second edition: 163−171.
- Kraeft S., Sutherland R., Gravelin L. et al. Detection and Analysis of Cancer Cells in Blood and Bone Marrow Using a Rare Event Imaging System. Clinical Cancer Research Vol. 6, 434−442, February 2000.
- Kvalheim G., Naume В., Nesland J. et al. Minimal residual disease in breast cancer. Cancer and Metastasis Reviews 18: 101−108, 1999.
- Litle VR, Lockett SJ, Palavicini MG. Genotype/phenotype analyses of low frequency tumor cells using computerized image microscopy. Cytometry 1996- 23:244−349.
- Luzzi K. J., MacDonald I. C., Schmidt E. E. Dormancy of Solitary Cells after Successful Extravasation and Limited Survival of Early Micrometastases. American Journal of Pathology. 153:865−873, 1998.
- Manhani AR, Manhani R, Soares et al. CK-19 expression by RTPCR in the peripheral blood of breast cancer patients correlates with response to chemotherapy. // Breast Cancer Res. Treat. — 2001 — Apr. Vol.66-M3-P.249−254.
- Mansi Jl, Easton D, Berger U, et al. Bone Marrow Micrometastasis in Primary Breast Cancer: prognostic significance after 6 years follow-up. Eur. J. Cancer 1991, 27, 1552−1555
- Mansi Jl. Outcome of primary-breast-cancer patients with micrometastases: a long-term follow-up study. Lancet 1999- 354:195−200.
- Menard S, Squicciarini P, Luini A et al. Immunodetection of bone marrow micrometastases in breast carcinoma patients and its correlation with primary tumor prognostic features. Br J Cancer 69: 1126−1129, 1994.
- Molino A., Pelosi G., Micciolo R. et al. Bone marrow micrometastases in breast cancer patients. Breast Cancer Research and Treatment 58, 123−130, 1999.
- Moll R., Franke W.W., Schiller D.L. The catalog of human Cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. //Cell. 1982-Nov. Vol. 31-P. 11−24.
- Momburg F., Moldenhauer G., Hammerling G.J., Moller P. Immunohistochemical study of the expression of a Mr 34 000 human epithelium specific surface glycoprotein in normal and malignant tissues. Cancer Res. 1987. V.47. P.2883−2891.
- Mori, Datta Y., Adams P., Drobyski W. Sensitive detection of occult breast cancer by reverse-transcriptase polymerase chain reaction. J Clin Oncol. 1994 Mar- 12 (3):475−82.
- Muller P., Weckerman D., Riethmuller G et al. Detection of genetic alterations in micrometastatic cells in bone marrow of cancer patients by fluorescence in situ hybridization. Cancer Genet Cytigenet 1996- 88: 8−16.
- Naumov G., MacDonald I., Weinmeister P. Persistence of Solitary Mammary Carcinoma Cells in a Secondary Site. A Possible Contributor to Dormancy. Cancer Research 62, 2162−2168, April 1, 2002.
- Offner S., Schmaus W., Witter K. et al. p53 gene mutations are not required for early dissemination of cancer cells. PNAS Vol.96, Issue 12, 6942−6946, 1999.
- Palmieri G, Ascierto P, Perrone F et al. Prognostic Value of Circulating Melanoma Cells Detected by Reverse Transcriptase-Polymerase Chain Reaction. J. Clin. Oncol, Vol 21, Issue 5 (March), 2003: 767−773
- Pantel K, Aignher C, Kollermann J et al Immunocytochemical Detection of isolated tumour cells in bone marrow ofpatients with untreatedstage С prostatic cancer. Eur. J. Cancer. 1995 — Vol. 31A — 10-P. 16 271 632.
- Pantel K, Schlimock G, Braun S et al. Differential expression of proliferation-associated molecules in individual micrometastatic carcinoma cells. J.Natl. Cancer Inst.-1993- Vol. 85-P. 1419−1424 95
- Pantel K. Detection and clinical relevance of micrometastatic cancer cells. Current Opinion in oncology 2000- 12:95−101.
- Pantel K., Cote R., Fodstad J. Detection and Clinical Importance of Micrometastatic Disease. Journal of the National Cancer Institute, Vol. 91, No. 13, 1113−1124, July 7, 1999.
- Pantel K., Schlimok G., Kutter D. Frequent down-regulation of major histocompatibility class I antigen expression on individual micrometastatic carcinoma cells. Cancer Research, Vol 51, Issue 17 47 124 715.
- Racila E., Euhus D., Weiss A.J. et al. Detection and characterization of carcinoma cells in the blood. Proc. Natl. Acad. Sci. USA, 1998 April 14- 4589−45−94.
- Rak J, Filmus J, Kerbel RS. Reciprocal paracrine interactions between tumour cells and endothelial cells: the «angiogenesis progression» hypothesis. Eur J Cancer 1996- 32A: 2438−50.
- Redding WN, Monaghan P, Imrie SF, et al. Detection of micrometastasis in patients with primary breast cancer. Lancet 1983, 2, 1271−1274. J
- Salvadori B, Squicciarini P, Rovini D et al. Use of monoclonal antibody MBrl to detect micrometastases in bone marrow specimens of breast cancer patients. Eur J Cancer 26 (8): 865−867, 1990
- Schindlbeck C, Janni W, Schaffer P et al. Tumor biology of primary breast cancer and minimal residual disease. Acta Med Austriaca 2002- 29 Suppl 59: 27−31
- Schleiermacher G., Peter M., Oberlin O. et al. Increased Risk of Systemic Relapses Associated With Bone Marrow Micrometastasis and Circulating Tumor Cells in Localized Ewing Tumor. J. Clin. Oncol. 2003, 21:85−91.
- Sehouli J, Konsgen D, Nimpsch R et al. Prognostic significance of epithelial cells in the blood of patients with gynecological malignancies. Anticancer Res. 2003 Sep-Oct- 23(5b): 4133−40.
- Slade MJ, Smith BM, Sinnet HD et al. Quantative polymerase chain reaction for the detection of micrometastases in patients with breast cancer. J. Clin. Oncol. 17: 870−879, 1999.
- Smith B, Selby P, Southgate J et al. Detection of melanoma cells in peripheral blood by means of reverse transcriptase and polymerase chain reaction. Lancet- 1991. Vol.338. P. 1227−1229.
- Solomayer EF, Diel I J, Meyberg GC et al. Prognostic relevance of cathepsin D detection in micrometastatic cells in the bone marrow of patients with primary breast cancer. Breast Cancer Res Treat 1998 May- 49 (2): 145−54.
- Stathopoulou A, Vlachonikolis D, Mavroudis D et al. Molecular detection of Cytokeratin-19-Positive Cells in the Peripheral Blood of Patients With Operable Breast Cancer: Evaluation of Their Prognostic Significance. J. Clin. Oncol. 2002,16, 3404−3412
- Thurm H, Ebel S, Kentenich et al. Rare expression of epithelial cell adhesion molecule on residual micrometastatic breast cancer cells after adjuvant chemotherapy. Clin Cancer Res. 2003 Jul- 9 (7):2598−604.
- Triparaneni G., Smith B.M., Singh A. et al. Monitoring minimal residual disease during adjuvant therapy in breast cancer (4 year follow-up). Annual meeting summaries, 2003
- Uhr JW, Scheuermann RH, Street NE, Vitetta ES. Cancer dormancy: opportunities for new therapeutic approaches. Nat Med. 1997 May-3 (5):505−9.
- Vogel I, Kalthojf H, Henne-Bruns D, Kremer B. Detection and prognostic impact of disseminated tumor cells in pancreatic carcinoma. Pancreatology 2002- 2 (2): 79−88
- Wells C.A., Heryet A., Brochier J. et al. The immunocytochemical detection of axillary micrometastases in breast cancer. Br. J. Cancer. 1984. V50. P. 193−197.
- Weitz J, Kienle P, Magener A, Koch M et al. Detection of disseminated colorectal cancer cells in lymph nodes, blood and bone marrow. Clin Cancer Res 1999 Jul- 5 (7): 1830−1836
- Wiedswang G., Borgen E., Karesen R et al. Detection of isolated tumor cells in bone marrow is an independent prognostic factor in breast cancer. J. Clin. Oncol. 21(18): 3469−3478, 2003.
- Winter S., Jarasch E.D., Schmid E» Franke WW, Denk H. Differences in polypeptide composition of cytokeratin filaments, including tonofilaments, from different epithelial tissues and cells. //Eur. J. Cell Biol. -1980 -#22- P.371.0 /ЬО
- Wong N.S., Kahn H.J., Zhang L. et al. Prognostic significance of circulating tumour cells enumerated after filtration enrichment in early and metastatic breast cancer patients.// Breast Cancer Res Treat. 2006 Mar 16
- Xenidis N, Vlachonikolis I., Mavroudis D et al. Peripheral Blood circulating cytokeratin-19 mRNA-positive cells after the completion of adjuvant chemotherapy in patients with operable breast cancer. Annals of Oncology 14: 849−855, 2003.
- Zhang J, Shen KW, Liu G et al. Antigenic profiles of disseminated breast tumor cells and microenvironment in bone marrow. Eur J Surg Oncol 2003 Mar- 29 (2): 121−126
- Zia A, Schildberg FW, Funke I et al. MHC class I negative phenotype of disseminated tumor cells in bone marrow is associated with poor survival in ROMO breast cancer patients. Int J Cancer 2001 Aug 15- 93 (4): 566−70.