Морфофункциональные изменения органов иммунной системы при конканавалин А-индуцированном гепатите
Диссертация
Поскольку нельзя исключить возможность продукции ИЛ-2 в организме мышей через 18 часов после введения Кон А, аналогично тому, что происходит в культуре, мы исследовали содержание ИЛ-2 в монокультурах спленоцитов Кон А-стимулированных мышей. Однако нам не удалось обнаружить ИЛ-2 в этих культурах, а при стимуляции спленоцитов, полученных после введения Кон А, не зафиксировано достоверного… Читать ещё >
Список литературы
- Абдумуратова Д.А. Морфогенез и иммунологическая характеристика лимфатических узлов плода человека. //Дисс. канд. м. н. М. — 1990. — 193 с.
- Агеев А.К. Гистопатология вилочковой железы человека. — Л.: Медицина, 1973. 175 с.
- Вепхвадзе Л.К. Изменение плоидности гепатоцитов крыс в течение суток в контроле и после частичной гепатэктомии. // Известия АН ГССР, серия биологическая. 1984. — т. 10. — N4. — с.274−278.
- Гринцевич И.И. Функциональная морфология тимуса при антигенных и неантигенных воздействиях на организм. //Дисс. доктора мед. наук. — Л. — 1989.
- Зайратьянц О.В. Патология вилочковой железы и аутоиммунные болезни. //Дисс. доктора мед. наук. М. — 1992.
- Ерофеева Л.М. Тимус крыс в условиях воздействия на организм диметилсульфата. //Дисс. канд. м.н. — М. 1993. — 216 с.
- Имре Барта. Селезёнка. //Из-во акад. наук Венгрии. — Будапешт. — 1976. — 264 с.
- Коваленко Н.Я. Функциональный элемент печени в норме и патологии. Обзор. .Патол. физиол. и эксперим. терапия. 1984. вып. 1 — с. 83−88.
- Ляшенко А.А., Уваров В. Ю. К вопросу о систематизации цитокинов. // Усп. совр. биол. -2001. т.121. —N6. — с.589−603.
- П.Онищенко Г. Г., Шахгильдян И. В. Парентеральные вирусные гепатиты — актуальная проблема здравоохранения России. //Гепатит В, С, D и Gпроблемы изучения, диагностики, лечения и профилактики. М., — 1997. -с. 164−166.
- Романова Л.К. Регуляция восстановительных процессов. М.: Изд-во Моск. ун-та. — 1984. — 209 с.
- Сапин М.Р., Харин Г. М., Вавилов В. И. Цитоконструкция вилочковой железы у половозрелых обезьян. // Архив АГЭ. 1977. — т.72 — № 1. — с.32−36
- Сапин М.Р., Юрина П. А., Этинген Л. Е. Лимфатический узел. М. -Медицина — 1978.-271 с.
- Серов В.В., Апросина З. Г., Крель П. Е. и соавт. Хронический вирусный' гепатит одна из наиболее важных проблем современной медицины. //Архив патологии. — 2004. — т.66. — 6. — с.6−11.
- Ткачук М.Г. Морфологические изменения вилочковой железы под влиянием дозированных физических нагрузок в возрастном аспекте. // Автореф. дис. канд. биол. наук — 1985. 16 с.
- Хлыстова З.С. Становление иммуногенеза плода человека. //М., Медицина. 1987.
- Фукс Б.Б., Малайцев В. В., Богданова И. М. Отсутствие генерализованной иммуносупрессии у мышей С57В1/6 при прогрессивном росте сингепной Т-лимфомы EL-4 и легочной карциномы Льюиса 3LL. // Бюлл. экспер. биол. и мед. 1986. — т. С1. — пб. — с.725−728.
- Arcaro KF, Wang J, Otis CN, Zuckerman BM. Beta-galactosidase and alpha-mannosidase inhibit formation of multicellular nodules in breast cancer cell cultures. //Anticancer Res. 2004. — v.24. — n.l. — p. 139−144.
- Arya S., Gilbert E., Hong R., Bloodworth B. The Thymus. //In: Endocrine pathology, general and surgical/Ed. J.Bloodworth. N.Y. — 1982. — 2 ed. — p.767−833.
- Askari F, Dick R., Mao M., Brewer G. Tetrathiomolybdate Therapy Protect Against Concanavalin A and Carbon Tetrachloride Hepatic Damage in Mice. //Exp. Biol, and Med. 2004. — v. 229. — p.857−863.
- Baenzinger J.U., Fiete D. Structural determinants of Concanavalin A specificity for oligosaccharides. //J. Biol. Chem. 1979. — v.254 — p.2400−2407.
- Barbosa Т., Arruda S., Cavada B. et all. //Mem. Inst. Oswaldo Cruz. 2001. -v.95. n.5. — p.673−678.
- Batey RG, Cao Q, Could B. Lymphocyte-mediated liver injury in alcohol-related hepatitis. //Alcohol. 2002. — v.27. — N1. — p. 37−41.
- Batey RG., Wang J. Molecular pathogenesis of T lymphocyte-induced liver injury in alcoholic hepatitis. //Front. Biosci. 2002. — v.l. — n.7 — p. dl662−1675.
- Becker J.W., Reeke G.N., Cunningham R.A., Edelman G.M. New avidence on the location of the saccharide-binding site of Concanavalin A. //Nature. 1976. — v.259. — p.406−409.
- Becker J., Reeke G., Wang, J., Cunningham В., and Edelman, G. The Covalent and Three-Dimensional Structure of Concanavalin A. III. Structure of the Monomer and its Interaction with Metals and Saccharides. // J. Biol. Chem. -1975. v.250. — p.1513.
- Ben-Bassat H. and Goldblum N. Concanavalin A Receptors on the Surface Membrane of Lymphocytes from Patients with Hodgkin’s Disease and Other Malignant Lymphomas. //Proc. Natl. Acad. Sci. USA. 1975. — v.72. — p. 1046.
- Besedovsky H., Rey A., Sorkin E. Immunoregulation by neuroendocrine mechanisms. //In: Neuroimmunology. Ed. P. Beham, F.Spreafice. — N.Y., 1984- 12-p. 445−450.
- Berzins K. and Blomberg F. Identification of Concanavalin A-Binding Plasma Membrane Antigens of Rat Liver. //FEBS Lett. 1975. — v.54. — p. 139.
- Beyer C. and Bowers W. Periodate and Concanavalin A Induce Blast Transformation of Rat Lymphocytes by an Indirect Mechanism, //Proc. Natl. Acad. Sci. USA. 1975. — v.72. — p.3590.
- Black C.D., Kroczek R.A., Barbet J., et al. Induction of IL-2 receptor expression in vivo: response of Concanavalin A. //Cell Immunol. 1988. -v.lll.- p.420−432.
- Bockman D.E. Fine structure of normal human thymus from children and adults. //RES J. Reticuloendothel. Soc. — 1977. — v.22. — № 6. — p.36.
- Boenisch T. and Norgaard-Pedersen B. Carcinoembryonic Antigen (CEA) of Human Tissue Extracts: Partial Characterization of Two Variants Separated by Affinity Chromatography on Concanavalin A. //Clin. Chim. Acta. 1975. -v.60. — p.51.
- Bonder C., Ajuebor M., Zbytnuik L. et al. Essential Role for Neutrophil Recruitment to the Liver in Concanavalin A-Induced Hepatitis. // J. of Immunol. 2004. — v. 172 -Nl. — p.45−53.
- Brattain M. Jones C., Pittman J. and Pretlow T. The Purification of Carcinoembryonic Antigen by Glutaraldehyde Cross-Linked Concanavalin A //Biochem. Biophys. Res. Commun. 1975. — v.65. — p.63.
- Brunson K. and Watson D. Concanavalin A Preparation with Activities Related to Bacterial Lipopolysaccharide. //J. Immunol. 1975. — v. 115. -p.599.
- Chikamori K., Araki Т., Yamada M. Pattern analysis of geterogenous distribution succinate dehydrogenase in single rat hepatic loubules. //Cell and Mol. Biol. 1985 — V.31.-N3.- p.217−222.
- Clark A. and Denborough M. The Interaction of Concanavalin A with Blood-Group-Substance Glycoproteins from Human Secretions. //Biochem. J. — 1971. -v.121.-p. 811.
- Cunningham В., Wang J., Waxdal M. and Edelman G. The Covalent and Three-Dimensional Structure of Concanavalin A. II. Amino Acid Sequence of Cyanogen Bromide Fragment F3. //J. Biol. Chem. 1975. — v.250. — p. 1503.
- DePetris S. Concanavalin A Receptors, Immunoglobulins, and О Antigen of the Lymphocyte Surface. Interactions with Concanavalin A and with Cytoplasmic Structures. //J. Cell. Biol. 1975. — v.65. — p. 123.
- Dourov N. Thymus Atrophy and Immune Deficient in Malnutrition. //The Human Thymus/Eddition H. Muller-Hermellink. -Berlin Springer Verlag. -1986 -p.127−150.
- Dutton R.W. Inhibitory and stimulatory effects of Concanavalina A on the responce of mouse spleen cells to antiden. // J. Exp. Med. 1973. — v. 138. -p.1496.
- Ekstedt R.D., Merdian D.G. Effect of Concanavalin A treatment of the allogenic responce of mice to challenge with P815 mastocytoma: Interleukin 2 treatment reverses Concanavalin A supression. // Cell Immunol. 1984. — v.85.- p.447.
- Ellis J.A., Demartini J.C. Ovine Concanavalin A-induced supressor cells: generation, assay, age related effects and re-evaluation of mechanism of supression. //Immunol. 1985. — v.54. — p.353−362.
- Farr A.G., Bruyn P. Macrophage-lymphocyte clusters in lymph nodes: possible substrate for cellular interactions in the immune response. //Amer. J. Anat. -1975. v. 144. — № 2. — p. 209−232.
- Gantner F., Leist M., Lohse A.W. et al. Concanavalin A-induced T-cell-mediated hepatic injury in mice: the role of tumor necrosis factor. //Hepatology.- 1995.-v.21.- p.190−198.
- Hentze H., Ganter F., Kolb S., Wendel A. Depletion of Hepatic Glutathione Prevents Death Receptor-Dependent Apoptotic and Necrotic Liver Injury in mice. //Am. J. of Pathology. 2000. — v. 156. — N6. — p.2045−2056.
- Hasegawa A., Cheng X., Kajino K. et al. Fas-disabling small exocyclic peptide mimetics limit apoptosis by an unexpective mechanism. //PNAS. 2004. -v.101. — n.17. -p.6599−6604.
- Hershkoviz R., Bruck R., Aeed H. et al. Treatment of concanavalin A-induced hepatitis in mice with low molecular weight heparin. //J. Hepatol. 1999. — v.31. — n.5. — p.834−840.
- Huet C. and Bernadac A. Dynamic State of Concanavalin A. Receptor Interactions on Fibroblast Surfaces. //Biochim. Biophys. Acta. — 1975. — v.394. — p.605.
- Inbar M. and Sachs L. Structural Difference in Sites on the Surface Membrane of Normal and Transformed Cells. //Nature. 1969. — v.223. — p.710.
- Janossy G., Bofill M., Tredosiewicz L. et al. Cellular differentiation of lymphoid subpopulations and their microinviron.//The Human Thymus/Ed.H.Muller-Hermellink. Berlin, ect.: Spriger Verlag. — 1986. -p.89−127.
- Kato M, Ikeda N., Matsushita E, Kaneko S, Kobayashi K. Involvement of IL-10, an anti-inflammatory cytokine in murine liver injury induced by Concanavalin A. //Hepatol. Res. 2001. — v.20. — N2. — p.232−243.
- Katzen H. and Soderman D. Interaction of Concanavalin Binding Sites on Concanavalin A-Agarose with Receptors on Adipocytes Studies by Buoyant Density Method. //Biochem. 1975. — v. 14. — p.2293.
- Kimura K, Ando K, Ohnishi H, Ishikawa T, Kakumu S, Takemura M, Muto Y, Moriwaki H. Immunopathogenesis of hepatic fibrosis in chronic liver induced by repeatedly administered concanavalin A. //Int. Immunology. 1999. — N9. p. 1491−1500.
- Kornfeld R. and Ferris C. Interaction of Immunoglobulin Glycopeptides with Concanavalin A.//J. Biol. Chem. 1975. — v.250. — p.2614.
- Kristin H. The human thymus in desease with particular emphysis on thymus and thymoma. // The thymus gland. 1981. — London: Acad. Press. — p.85- 111.
- Ksontini R. et all. Disparate Role for TNF-a and Fas Ligand in Concanavalin A-Induced Hepetitis. //J. Immunol. 1998. — v. 160. -p.4082−4089.
- Kubota J. and Kanatani H. Concanavalin A: Its Action in Inducing Oocyte Maturation-Inducing Substance in Starfish Follicle Cells. //Science. 1975. -v.187. — p.654.
- Langweiler M. I., Cockerell G.L. Generation of Concanavalin A-induced supressor cell in the cat. // Int. arch allergy appl. immunol. 1982. — v.69. -p.148−153.
- Lasarte JJ, Sarobe P, Boya P et al. A recombinant adenovirus encoding hepatitis С virus core and El proteins protects mice against cytokine-induced liver damage. //Hepatology. 2003. — v.37. — n.2. — p.461−470.
- Ma X., Qiu DK., Li EL, Peng YS, Chen XY. Effect of T-cell vaccination in murine experimental autuimmune hepatitis. //Zhonghua Gan Zang Bing Za Zhi. 2004. — v. 1. — p.44−46.
- Martin J. Neuroendocrine regulation of immune response. //In: Neuroimmunology. /Ed. P. Beham, F.Spreafico. N.Y. — 1984. — 12. — p.443−444
- Massaguer A, Perez-Del-Pulgar S., Engel P. et al. Concanavalin A-induced injury is severely impaired in mice deficient in P-selectin. //J. Leukoc. Biol. — 2004. v.72. — N2. — p.262−270.
- Mathers D. and Usherwood P. Concanavalin A Blocks Desensitization of Glutamate Receptors on Insect Muscle Fibres. //Nature. 1976. — v.259. -p.409.
- McKenzie G, Sawyer W. and Nichol L. The Molecular Weight and Stability of Concanavalin A. // Biochim. Biophys. Acta. 1972. — v.263. — p.283.
- Mizuhara H., O’Neill E., Seki N., Ogawa T. et al. T cell activation-associated hepatic injury: mediation by tunor necrosis factors and protection by interleukin 6. //J. Exp. Med. 1994. — v. 179. — p. 1529−1537.
- Mizuhara H, Uno M, Seki N et al. Critical involvement of interferon gamma in the pathogenesis of T-cell activation-associated hepatitis and regulatory mechanisms of IL-6 for the manifestation of hepatitis. //Hepatology. -1996. -N6. p.1608−1615.
- Moscona A. Embryonic and Neoplastic Cell Surfaces: Availability of Receptors for Concanavalin A and Wheat Germ Agglutinin. //Science. — 1971. -v.171.-p.905.
- Nadler L.M., Strachenko P., Hardy R. et al. Characterization of human B-cell specific antigen (B2) distinct from B1 //J. immunol. 1981. — v. 126. — p. 1941−1947.
- Nel A.E., Wooten M.W., Galbraith R.M. Molecular signalin mechnisms in T-lymphocyte activation pathway: a review and future prospects. //Clin, immunol. and immunopathol. 1987. — v.44. -N2. -p. 167−186.
- Nicholson G. Topography of Membrane Concanavalin A Sites Modified by Proteolysis. //Nature New Biol. 1972. — v.239. — p. 193.
- Nicoletti F., Beltrami В., Raschi E. et al. Protection from concanavalin A (ConA)-induced T-cell-depended hepatic lesions and modulation of cytokine release in mice by sodium fusidate. //Clin. Exp. Immunol. 1997. — v. l 10. -N3.-479−484.
- Ogawa M., Mori Y., Mori T. et al. Adoptive transfer of Experimental autoimmune hepetitis in mice — cellular interactin between donor and recipient mice. //Clin, exper. Immunol. 1988. — v.- 73. — n.2. — 276−282.
- Okamoto Т., Nakano Y., Asakura W. et al. Expression of Cytokine mRNA in Extrahepatic Organs in a Mouse Concanavalin A-Hepatitis Model. //Jpn. J. Pharmacol. 1998. — v.77. — p.219−225.
- Packman K., Packman U., Penning R. Allocation of the suppressive activity of normal peripheral blood lymphocytes induced by diffusion. // Cell Immunol. -1985. -v.94.-N1 -p.21−31.
- Pommier G., Ripert G., Azoulay R. and Depieds R. Effect of Concanavalin A on Membrane-Bound Enzymes from Mouse Lymphocytes. //Biochim. Biophys. Acta. 1975.- v.389. — p.483.
- Radaeva S., Sun R., Pan H., Hong F., Gao B. Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. //Hepatology. 2004. — v.39. — n.5. -p. 1332−1342.
- Reeke G., Becker J., and Edelman G. The Covalent and Three-Dimensional Structure of Concanavalin A. IV. Atomic Coordinates, Hydrogen Bonding, and Quaternary Structure. //J. Biol. Chem. 1975. — v.250. — p. 1525−1529.
- Roth R., Cassel D., Maddux B. and Goldfine J. Regulatin of insulin receptor kinase activity by insulin mimickers and an insulin antagonist. //Biochem. Biophys. Res. Commun. 1983. — v. l 15. — p.245−252.
- Saito Т., Okumura A., Watanabe H. et al. Increase in Hepatic NKT Cells in Leucocyte Cell-Derived Chemotaxin 2-Defient Mice Contributes to Severe Concanavalin I-Induced Hepatitis. //J. Immunol. 2004. — v. 173. — p.579−585.
- Sass G., Heinlein S., Agli A., Bang R. et al. Cytokine expressin in three model of experimental hepatitis. //Cytokine. 2002. — v. 19. — n.3. — p. l 12−120.
- Sharon N. and Lis H. Lectins: Cell-Agglutinating and Sugar Specific Proteins. //Science.- 1972.-v. 177- p.949.
- Shoham J., Inbar M. and Sachs L. Differential Toxicity on Normal and Transformed Cells in vitro and Inhibition of Tumour Development in vivo by Concanavalin A. //Nature. 1970. — v.227. — p. 1244.
- Simon H., Wenzelides K., Guski H., Kranz D. Zur regeneration der leberparenchym und sinusoidazellen nach teilhepatektomie. // Zbl. allg. Pathol, und Patol. Anat. — 1985. — Bd. 130.-Nl. — p.57−62.
- Smith E. and Goldstein 1. Protein-Carbohydrate Interaction. V. Further Inhibition Studies Directed Toward Defining the Stererochemical Requirements of the Reactive Sites of Concanavalin A. //Arch. Biochem. Biophys. 1967. -v.121. — p.88.
- Smith W. G., Usinger W.R., Splitter G.A. Bovine Con A induced suppressor cell: generation, macrophage requirement and possible mechanisms of regulatory action. // J. Immunol. 1981. — v.43. — p.91−97.
- Streetz K., Wustefeld Т., Klein C. at al. Lack of gpl30 expression in hepatocytes promotes liver injury. //Gastroenterology. 2003. — v. 125. — p.532.
- Sumner J., and Howell, S. The Identification of the Hemagglutinin of the Jack Bean with Concanavalin A. //J Appl. Bacteriol. 1936. — v.32, p.227.
- Sun R., Tian Z., Kulkami S. and Gao B. IL-6 Orevents T Cell-Mediated Llepatitis via Inhibition of NICT Cells in CD4+ T Cell- and STAT3-Dependent Manners. //J. Immunol. 2004. — v. 172. — p.5648−5655.
- Suntucci L., Fiorucci S., Cammilleri F. ey al. Galectin-1 exerts immunomodulatory and protective effects on concanavalin A-induced hepatitia in mice. //Hepatology. 2000. — v.31. — n.2. — p.399−406.
- Surh C.D. and Sprend J. Homeostasis T cell proliferation: how far can T cells be activated to self-ligands? //J. Exp. med. 2002. — v. 192. — f9.
- Tiegs G., Hentschei J., Wendel A. A T cell-dependent experimental liver injury in mice inducible by Concanavalin A. //J. Clin. Invest. 1992. — v.90. — p. 196−203.
- Toyabe S., Seki S., Iiai T. et al. Requirement of IL-4 and liver NK1f T cells for Concanavalin A-induced hepatitis injury in mice. Hi. Immunol. 1997. -v.159. — p.1537.
- Toyoshima S., Iwata M., Osawa T. Kinetics of lymphocyte stimulation by Concanavalin A. // Nature. 1976. — v. 264. — p.447−449.
- Trautwein C., Rakemann Т., Malek N. ey al. Concanavalin A-induced Injury Triggers Hepatocyte Proliferation. //J. Clin. Invest. 1998. — v.101. -n.9. — p. 1960−1969.
- Tsutsui H, Adachi K., Seki E., Nakanishi K. Cytokine-induced inflamatory liver injures. //Curr. Mol. Med. 2003. — v.3. — n.6. — p.545−559.
- Wang J., Cunningham В., Waxdal M. and Edelman G. The Covalent and Three Dimensional Structure of Concanavalin A. I. Amino Acid Sequence of Cyanogen Bromide Fragments F1 and F2. //J. Biol. Chem. 1975., v.250. — p. 1490.
- Wang J., Zhao Y., Xu Q. Astibin prevents concanavalin A-inducecl liver injury by reducing TNF-alfa production and T lynphocytes adhesion. //J. Pharm. Pharmacol. 2204. — v.56. — n.4. — p.495−502.
- Xiang M., Zaccone P., Marco D. et al. Prevention by rolipram of concanavalin A-induced T-cell-dependent hepatitis in mice. //Eur. J. Pharmacol. 1999.- v.367.- n.2−3. — p.399−404.
- Yamanaka A., Hamano S., Miyazaki Y. et al. Hyperproduction of proinflammatory cytokines by WSX-1 -dificient NKT cells in concanavalin A-induced hepatitis. //J. Immunol. 2004. — v. 172. — n.6. — p.3590−3596.