Π ΠΎΠ»Ρ Π»Π΅ΠΉΠΊΠ΅ΠΌΠΈΡΠΈΠ½Π³ΠΈΠ±ΠΈΡΡΡΡΠ΅Π³ΠΎ ΡΠ°ΠΊΡΠΎΡΠ° Π² ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ ΡΠΎΡΡΠ° ΡΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΈ Π·Π°ΡΠΎΠ΄ΡΡΠ΅ΠΉ ΠΌΡΡΠΈ Π² ΠΊΡΠ»ΡΡΡΡΠ΅
ΠΠΈΡΡΠ΅ΡΡΠ°ΡΠΈΡ
ΠΠΌΠ±ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠ΅ ΡΡΠ²ΠΎΠ»ΠΎΠ²ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ (ΠΠ‘Π) ΡΠ²Π»ΡΡΡΡΡ Π²Π°ΠΆΠ½Π΅ΠΉΡΠΈΠΌ ΠΎΠ±ΡΠ΅ΠΊΡΠΎΠΌ, Π±ΠΈΠΎΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ ΠΈ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎ-Π³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΡ ΡΠ²ΠΎΠ΅ΠΉ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ Π²ΠΎΡΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΡΡ ΡΠΌΠ±ΡΠΈΠΎΠ³Π΅Π½Π΅Π· ΠΊΠ°ΠΊ in vitro, ΡΠ°ΠΊ ΠΈ in vivo (Bradley et al., 1984; Doetschman et al., 1985). ΠΠΎΡΠ»Π΅ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ Π² Π±Π»Π°ΡΡΠΎΡΠΈΡΠ»Ρ ΠΠ‘Π ΡΡΠ°ΡΡΠ²ΡΡΡ Π² ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΠΎΡΠ³Π°Π½ΠΎΠ² ΠΈ ΡΠΊΠ°Π½Π΅ΠΉ Ρ ΠΈΠΌΠ΅ΡΠ½ΠΎΠ³ΠΎ Π·Π°ΡΠΎΠ΄ΡΡΠ° (Martin, 1981). ΠΡΠΎ ΡΠ½ΠΈΠΊΠ°Π»ΡΠ½ΠΎΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²ΠΎ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
Π‘ΠΏΠΈΡΠΎΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
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