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Синтез и изучение свойств липодипептидов для самоорганизующихся систем доставки функциональных генов

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Boussif O., Gaucheron J., Santaella Hanno C., Kolbe V.J., Vierling P. Enhanced in vitro and in vivo cationic lipid-mediated gene delivery with a fluorinated glycerophosphoethanolamine helper lipid//J. Gene Med. 2001. -V. 3. — P. 109−114. Maitani Y., Igarashi S., Sato M., Hattori Y. Cationic liposome (DC-Chol/DOPE = 1:2) and a modified ethanol injection method to prepare liposomes, increased gene… Читать ещё >

Синтез и изучение свойств липодипептидов для самоорганизующихся систем доставки функциональных генов (реферат, курсовая, диплом, контрольная)

Содержание

  • СПИСОК ПРИНЯТЫХ В РАБОТЕ СОКРАЩЕНИЙ
  • ЛИТЕРАТУРНЫЙ ОБЗОР
  • Компоненты катионных липосом
  • Комплекс амфифил/ДНК
  • Средства для модификации липосом
  • Включение в липосомы векторов активного нацеливания на клетку-мишень
  • Контролируемое высвобождение содержимого липосом
  • РЕЗУЛЬТАТЫ РАБОТЫ И ИХ ОБСУЖДЕНИЕ
  • Синтез липодипептидов на основе эфиров /,-глутаминовой кислоты и /,-глутамина
  • Исследование свойств агрегатов, формируемых полученными соединениями в водной среде
  • Изучение свойств комплексов катионные липодипептиды/ДНК
  • Определение эффективности трансфекции полученных соединений
  • ВЫВОДЫ
  • ЭКСПЕРИМЕНТАЛЬНАЯ ЧАСТ

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