Особенности развития эпилептического статуса и способов его купирования у крыс разного возраста на литий-пилокарпиновой модели
Диссертация
Актуальной представляется и оценка центральных функций регуляторных нейропептидов как агентов, потенциально участвующих в контроле судорожной активности мозга. Тиролиберин нашел применение в неврологии, в терапии эписиндромов, клинике детской эпилепсии. Лабораторные и клинические исследования показали особое нейроанатомическое распределение и нейрохимическую роль для тиролиберина в модуляции… Читать ещё >
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- Перечень использованных сокращений.
- BDNF Brain-derived neurotrophic factor -фактор роста нервных клеток
- ERK extracellular signal-regulated kinase — внеклеточная сигнал регулируемая киназа
- PIA L-фенилизопропиладенозин
- NMDA N-methyl d-aspartate рецептор
- PBN N- терт-бутил-альфа-фенилнитрон
- PGP P-glycoprotein — многофункциональный переносчик Р-гликопротеинаrTMS rapid transcranial magnetic stimulation — транскраниальная магнитная стимуляция
- SWD spike-wave discharges — спайк-волновые разряды
- АМРА alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate1. АМФ аденозинмонофосфат1. АТФ аденозинтрифосфат
- АЭП антиэпилептические препараты
- ГАМК у-аминомасляная кислота
- ГОМК у-оксимасляная кислота
- ДНК дезоксирибонуклеиновая кислота
- КПП крестообразный приподнятый лабиринт1. ЛП латентный период
- MPT mitochondrial permeability transition — резкое повышение внутренней мембраны митохондрий
- ПД постнатальный день развития (крысенка) ПТЗ — пентилентетразол
- ТРГ тиреотропин-рилизинг-гормон, тиролиберин
- ЦНС центральная нервная система
- ЭДТА этилендиаминтетраацетиловая кислота1. ЭКГ электрокардиограмма
- ЭС, эпистатус эпилептический статус1. ЭЭГ электроэнцефалограмма