Динамика взаимодействия некоторых антимикробных пептидов с биомембранами
Диссертация
Молекула зервамицина II в отличие от аламетицина сохраняет спиральную структуру в воде (в течение не менее 10нс). В нативном зервамицине и зервамицине с заменой Aib-Gly в 7-ом и 9-ом положениях не наблюдается высокоамплитудных шарнирных движений изгибающих спираль. Однако ZrvII-gly9 в метаноле компактизуется за счет изгиба в области Gly9 за счет реорганизации водородных связей. В воде подобных… Читать ещё >
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