Конструирование белок-нуклеиновых комплексов для направленного транспорта в клетки чужеродной ДНК
Диссертация
Задачей представленной работы являлось конструирование, получение и очистка рекомбинантных белков-переносчиков терапевтически значимого генетического материала в опухолевые клетки, сурперэкспресси-рующие рецепторы АФП, а также исследование их свойств. В качестве адресующего домена использовался рецепторсвязывающий домен АФП (3D). Для создания вектора-переносчика белковый лиганд (3D) был снабжен… Читать ещё >
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