Механизмы антипролиферативного действия ингибиторов деацетилаз гистонов на эмбриональные стволовые клетки мыши
Диссертация
Активность деацетилаз гистонов (HDAC) может быть связана как с поддержанием автономной пролиферации, так и трансформированного фенотипа, поскольку репрессия некоторых негативных регуляторов пролиферации и индукторов дифференцировки происходит с участием этих ферментов (Dokmanovic, Marks, 2005). Есть данные, позволяющие предполагать, что активность HDAC необходима для пролиферации ранних… Читать ещё >
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- Хочу выразить признательность Татьяне Витальевне Кисляковой, моему первому руководителю в Институте цитологии.
- Я благодарен за советы и помощь Павлу Грудинкину, Глебу Турчиновичу, большое спасибо за проведение протока с CFSE сотруднику фирмы АлкорБио Георгию Александрову.
- Огромное спасибо моим близким за всяческую поддержку и помощь в правке диссертации.