Окислительное расщепление ДНК аренами и их олигонуклеотидными конъюгатами в присутствии ионов Cu (II)
Диссертация
Впервые проведена сайт-направленная модификация двуцепочечной ДНК в составе реконструированной нуклеосомной цепи алкилирующим производным гомопиримидинового олигонуклеотида. Показано, что наличие гистонового октамера не препятствует образованию триплекса олигонуклеотид-двуцепочечная ДНК и эффективному направленному алкилированию ДНК в составе такого комплекса (степень модификации до 48… Читать ещё >
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