Полиферментные системы для получения модифицированных нуклеозидов
Диссертация
Для достижения высокого уровня экспрессии генов, чья транскрипция регулируется промотор-операторной системой, индукция биосинтеза должна быть осуществлена только после накопления большого числа клеток в культуре. При использовании системы с Т7-РНК-полимеразой, синтез которой находится под контролем /ас-оператора (в клетках Е. coli BL21(DE3)), нежелательную конститутивную транскрипцию в клетках… Читать ещё >
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