Определение структуры и динамических свойств комплексов дигидрофолатредуктазы человека и L.Casel с антибактериальным препаратом триметопримом
Диссертация
Проведенное исследование свидетельствует о том, что не существует одного доминирующего фактора, определяющего селективность связывания ТМП с ДГФР бактерий. Вместе с тем, эта селективность может определяться аддитивным вкладом нескольких факторов: прямыми лиганд-лигандными взаимодействиями, изменением конформации белка при связывании лигандов, образованием резонансной сети водородных связей… Читать ещё >
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