Сравнение механизмов протекторного действия L-глутаминовой кислоты и гексапептида TGENHR на TNF-индуцированную гибель клеток линии HL-60
Диссертация
Терапевтическое применение TNF-a в качестве противоопухолевого агента осложнено из-за его общей высокой токсичности, связанной с широким спектром биологических активностей этого цитокина. Поэтому одним из подходов к использованию этого цитокина для лечения злокачественных новообразований является поиск агентов, которые снижали бы его токсическое действие, но позволяли бы сохранить его… Читать ещё >
Список литературы
- Sordet О., Bettaieb A., Bruey J. M., Eymin В., Droin N., Ivarsson M., Garrido C., Solary E. Selective inhibition of apoptosis by TPA-induced differentiation of U937 leukemic cells. Cell. Death. Differ. 1999. V.6. P.351−361.
- Vondracek J., Sheard M. A., Krejci P., Minksova K., Hofmanova J., Kozubik A. Modulation of death receptor-mediated apoptosis in differentiating human myeloid leukemia IIL-60 cells. Jour. Leuk. Biol. 2001. V.69. P.794−802.
- Locksley R.M., Killeen N. and Lenardo M.J. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell. 2001. V.104 P. 487−501.
- Tuzuner E., Liu L., Shimada M., Yilmaz E., Glanemann M., Settmacher U., Langrehr J.M., Jonas S., Neuhaus P., Nussler A.K. Heme oxygenase-1 protects human hepatocytes in vitro against warm and cold hypoxia. J. Hepatol. 2004. V 41. P.764−72.
- Kriegler M., Perez C., DeFay K. et al. A novel form of TNF/cachectin is acell surface cytotoxic transmembrane protein: ramifications for the complex hysiology of TNF. Cell 1988. V. 53. P. 45−53.
- Tang P., Hung M.C. and Klostergaard J. Human pro-tumor necrosis factor is a homotrimer. Biochemistry. 1996. V. 35. P. 8216−8222.
- Black R.A., Rauch C.T., Kozlosky C.J. et al. A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells. Nature. 1997. V. 385 P. 729−733.
- Bazan J.F. Emerging families of cytokines and receptors. Curr. Biol. 1993. V. 3 P. 603−606.
- Locksley R.M., Killeen N. and Lenardo M.J. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell. 2001. V. 104 P. 487−501.
- Naismith J.H. and Sprang S.R. Modularity in the TNF-receptor family. Trends Biochem. Sci. 1998. V. 23 P. 74−79.
- Banner D.W., D’Arcy A., Janes W. et al. Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation. Cell 1993. V. 73 P. 431−445.
- Chan F.K., Chun H.J., Zheng L. et al. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. Science. 2000 V. 288 P. 2351−2354.
- Grell M., Douni E., Wajant II. et al. The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Cell. 1995.V. 83. P.793−802.
- Grell M., Wajant H., Zimmermann G. and Scheurich P. The type 1 receptor (CD 120a) is the high-affinity receptor for soluble tumor necrosis factor. Proc. Natl. Acad. Sci. USA. 1998. V. 95. P. 570−575.
- Wallach D., Engelmann H., Nophar Y. et al. Soluble and cell surface receptors for tumor necrosis factor. Agents Actions Suppl. 1991. V. 35. P. 51−57.
- Taylor P.С. Anti-tumor necrosis factor therapies. Curr. Opin. Rheumatol. 2001. V. 13 P. 164−169.
- Solomon K.A., Pesti N., Wu G. and Newton R.C. Cutting edge: a dominant negative form of TNF-alpha converting enzyme inhibits proTNF and TNFRII secretion. J. Immunol. 1999. V. 163 P. 4105—4108.
- McDermott M.F., Aksentijevich I., Galon J. et al. Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. Cell 1999. V. 97 P. 133−144.
- Tartaglia L.A., Ayres T.M., Wong G.H. and Goeddel D.V. A novel domain within the 55kd TNF receptor signals cell death. Cell 1993. V. 74 P. 845−853.
- Schulze-Osthoff K., Ferrari D., Los M. et al. Apoptosis signaling by death receptors. Eur. J. Biochem. 1998 V. 254 P. 439−459.
- Mannel D.N. and Echtenacher B. TNF in the inflammatory response. Chem. Immunol. 2000 V. 74 P. 141−161.
- Beutler В., Greenwald D., Hulmes J.D. et al. Identity of tumour necrosis factor and the macrophage-secreted factor cachectin. Nature 1985 V. 316 P. 552−554.
- Probert L., Akassoglou K., Pasparakis M. et al. Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha. Proc. Natl. Acad. Sci. USA. 1995 V. 92 P. 11 294−11 298.
- Fontaine V., Mohand-Said S., Hanoteau N. et al. Neurodegenerative and neuroprotective effects of tumor necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2. J. Neurosci. 2002 V. 22 P. 216.
- Kontoyiannis D., Pasparakis M., Pizarro T.T. et al. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 1999 V. 10 P. 387−398.
- Yamada Y., Kirillova I., Peschon J.J. and Fausto N. Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor. Proc. Natl. Acad. Sci. USA. 1997 V. 94 P. 1441−1446.
- Bradham C.A., Plumpe J., Manns M.P. et al. Mechanisms of hepatic toxicity. I. TNF-induced liver injury. Am. J. Physiol. 1998 V. 275 P. G387-G392.
- Taylor P.C., Peters A.M., Paleolog E. et al. Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis. Arthritis Rheum. 2000 V. 43 P. 387.
- Blam ME, Stein RB and Liehtenstein GR (2001) Integrating anti-tumor necrosis factor therapy in inflammatory bowel disease: current and future perspectives. Am. J. Gastroenterol. 96:1977−1997
- Chaplin DD and Fu Y Cytokine regulation of secondary lymphoid organ development. Curr. Opin. Immunol. 1998. V. 10 P. 289−297.
- Ruddle N.H. Lymphoid neo-organogenesis: lymphotoxin’s role in inflammation and development. Immunol. Res. 1999. V. 19 P. 119−125.
- Marino M.W., Dunn A., Grail D. et al. Characterization of tumor necrosis factor-deficient mice. Proc. Natl. Acad. Sci. USA. 1997 V. 94 P. 8093−8098.
- Flynn J.L., Goldstein M.M., Chan J. et al. Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity 1995 V. 2 P. 561−572.
- Rothe J., Mackay F., Bluethmann H. et al. Phenotypic analysis of TNFR1 -deficient mice and characterization of TNFR1-deficient fibroblasts in vitro. Circ. Shock. 1994 V. 44 P. 51−56.
- Vieira L.Q., Goldschmidt M., Nashleanas M. et al. Mice lacking the TNF receptor p55 fail to resolve lesions caused by infection with Leishmania major, but control parasite replication. J. Immunol. 1996 V. 157 P. 827−835.
- Deckert-Schluter M., Bluethmann II, Rang A. et al. Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75), in murine toxoplasmosis. J. Immunol. 1998 V.160 P. 3427−3436.
- Camelo S., Lafage M. and Lafon M. Absence of the p55 Kd TNF-alpha receptor promotes survival in rabies virus acute encephalitis. J. Neurovirol. 2000 V. 6 P. 507−518.
- Zhao Y.X., Lajoie G., Zhang II. et al. Tumor necrosis factor receptor p55- deficient mice respond to acute Yersinia enterocolitica infection with less apoptosis and more effective host resistance. Infect. Immun. 2000 V. 68. P. 1243−1251.
- Lucas R., Juillard P., Decoster E. et al. Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane- bound TNF in experimental cerebral malaria. Eur. J. Immunol. 1997 V. 27 P. 1719−1725.
- Kollias G., Douni E., Kassiotis G. and Kontoyiannis D. On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease. Immunol. Rev. 1999 V. 169 P. 175−194.
- Wagner Т.Е., Huseby E.S. and Huseby J.S. Exacerbation of Mycobacterium tuberculosis enteritis masquerading as Crohn’s disease after treatment with a tumor necrosis factor-alpha inhibitor. Am. J. Med. 2002 V. 112 P. 67−69.
- Old L.J. Tumor necrosis factor. Sci. Am. 1988 V. 258 P. 59−75.
- Sugarman B.J., Aggarwal B.B., Hass P.E. et al. Recombinant human tumor necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro. Science 1985 V. 230 P. 943−945.
- Eggermont A.M. and ten Hagen T.L. Isolated limb perfusion for extremity soft-tissue sarcomas, in-transit metastases, and other unresectable tumors: credits, debits, and future perspectives. Curr. Oncol. Rep. 2001 V. 3 P. 359−367.
- Ruegg C., Yilmaz A. and Bieler G. et al. Evidence for the involvement of endothelial cell integrin alphaVbeta3 in the disruption of the tumor vasculature induced by TNF and IFN-gamma. Nat. Med. 1998 V. 4: P. 40814.
- Baud V. and Karin M. Signal transduction by tumor necrosis factor and its relatives. Trends Cell Biol. 2001 V. 11 P. 372−377. .r
- Verma I.M., Stevenson J.K., Schwarz E.M. et al. Rel/NF-kappa B/I kappa В family: intimate tales of association and dissociation. Genes Dev. 1995 V. 9 P. 2723−2735.
- Perkins N.D. The Rel/NF-kappa В family: friend and foe. Trends Biochem. Sci. 2000 V. 25 P. 434−440.
- Mercurio F., Zhu II., Murray B.W. et al. IKK-1 and IKK-2: cytokineactivated IkappaB kinases essential for NF- kappaB activation. Science 1997 V. 278 P. 860−866.
- DiDonato J.A., Hayakawa M., Rothwarf D.M. et al. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature 1997 V. 388 P. 548−554.
- Zandi E., Rothwarf D.M., Delhase M. et al. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell 1997 V. 91 P. 243−252.
- Yamaoka S., Courtois G., Bessia C. et al. Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation. Cell 1998 V. 93 P. 1231−1240.
- Rothwarf D.M., Zandi E., Natoli G. and Karin M. IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature 1998 V. 395 P. 297−300.
- Mercurio F., Murray B.W., Shevchenko A. et al. IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex. Mol. Cell Biol. 1999 V. 19 P. 1526−1538.
- Chen G., Cao P. and Goeddel D.V. TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. Mol. Cell 2002 V. 9 P. 401−410.
- Rudolph D., Yeh W.C., Wakeham A. et al. Severe liver degeneration and lack of NFkappaB activation in NEMO/IKKgamma-deficient mice. Genes Dev. 2000 V. 14 P. 854 862.
- Schmidt-Supprian M., Bloch W., Courtois G. et al. NEMO/IKK gammadeficient mice model incontinentia pigmenti. Mol. Cell 2000 V. 5 P. 981−992.
- Makris C., Godfrey V.L., Krahn-Senftleben G. et al. Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-Iinked disorder incontinentia pigmenti. Mol. Cell 2000 V. 5 P. 969−979.
- Tanaka M., Fuentes M.E., Yamaguchi K. et al. Embryonic lethality, liver degeneration, and impaired NF-kappa В activation in IKK-beta-deficient mice. Immunity 1999 V. 10 P. 421−429.
- Li Q., Van Antwerp D., Mercurio F. et al. Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. Science 1999 V. 284 P. 321−325.
- Takeda K., Takeuchi O., Tsujimura T. et al. Limb and skin abnormalities in mice lacking IKKalpha. Science 1999 V. 284 P. 313−316.
- Hu Y., Baud V., Delhase M. et al. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science 1999 V. 284 P. 316−320.
- Li Q., Lu Q., Hwang J.Y. et al. IKK 1-deficient mice exhibit abnormal development of skin and skeleton. Genes Dev. 1999 V. 13 P. 1322−1328.
- Senftleben U., Cao Y., Xiao G. et al. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa В signaling pathway. Science 2001 V. 293 P. 1495— 1499.
- Xiao G., Cvijic M.E., Fong A. et al. Retroviral oncoprotein Tax induces processing of NF-kappaB2/pl00 in T cells: evidence for the involvement of IKKalpha. EMBO J. 2001 V. 20 P.6805−6815.
- Li Q., Estepa G., Memet S. et al. Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation. Genes Dev. 2000 V. 14 P. 1729−1733.
- Pomerantz J.L. and Baltimore D. NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. EMBO J. 1999 V. 18 P. 6694−6704.
- Bonnard M., Mirtsos C., Suzuki S. et al. Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription. EMBO J. 2000 V. 19 P. 4976−4985.
- Tojima Y., Fujimoto A., Delhase M. et al. NAK is an IkappaB kinaseactivating kinase. Nature 2000 V. 404 P. 778−782.
- Peters R.T., Liao S.M. and Maniatis T. IKKepsilon is part of a novel PMAinducible IkappaB kinase complex. Mol. Cell 2000 V. 5 P. 513−522.
- Jiang Y., Woronicz J.D., Liu W. and Goeddel D.V. Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. Science 1999 V. 283 P. 543−546.
- Hsu H., Xiong J. and Goeddel D.V. The TNF receptor 1-associated protein TRADD signals cell death and NF- kappa В activation. Cell 1995 V. 81 P. 495−504.
- Hsu H., Huang J., Shu H.B. et al. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor- 1 signaling complex. Immunity 1996 V. 4 P. 387−396.
- Wajant H., Henkler F., Scheurich P. The TNF-receptor-associated factor family. Scaffold molecules for cytokine receptors, kinases and their regulators. Cell Signal. 2001 V. 13 P. 389−400.
- Hsu II., Shu H.B., Pan M.G. and Goeddel D.V. TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 1996 V. 84 P. 299−308.
- Devin A., Cook A., Lin Y. et al. The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation. Immunity 2000 V. 12 P. 41929.
- Zhang S.Q., Kovalenko A., Cantarella G. and Wallach D. Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation. Immunity 2000 V. 12 P. 301−311.
- Devin A., Lin Y., Yamaoka S. et al. The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2- dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF. Mol. Cell Biol. 2001 V. 21 P. 3986−3994.
- Ting A.T., Pimentel-Muinos F.X. and Seed B. RIP mediates tumor necrosis factor receptor 1 activation of NF-kappaB but not Fas/APO-1- initiated apoptosis. EMBO J. 1996 V.15 P. 6189−6196.
- Yang J., Lin Y., Guo Z. et al. The essential role of MEKK3 in TNF induced NF-kappa В activation. Nat. Immunol. 2001 V. 2 P. 620−624.
- Baud V., Liu Z.G., Bennett B. et al. Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKKactivation and target gene induction via an amino-terminal effector domain. Genes Dev. 1999 V. 13 P. 12 971 308.
- Kim J.W., Joe C.O. and Choi E.J. Role of receptor-interacting protein in tumor necrosis factor-alpha-dependent MEKK1 activation. J. Biol. Chem. 2001 V. 276 P. 2 706 427 070.
- Xia Y., Makris C., Su B. et al. MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factorinduced cell migration. Proc. Natl. Acad. Sci. USA 2000 V. 97 P. 5243−5248. i
- Yujiri Т., Ware M., Widmann C. et al. MEK kinase 1 gene disruption alters cell migration and c-Jun NH2- terminal kinase regulation but does not cause a measurable defect in NF- kappa В activation. Proc. Natl. Acad. Sci. USA 2000 V. 97 P. 7272−7277.
- Sanz L., Diaz-Meco M.T., Nakano II. and Moscat J. The atypical PKC interacting protein p62 channels NF-kappaB activation by the IL1-TRAF6 pathway. EMBO J. 2000 V. 19 P.1576−1586.
- Leitges M., Sanz L., Martin P. et al. Targeted disruption of the zeta PKC gene results in the impairment of the NF-kappaB pathway. Mol. Cell 2001 V. 8 P. 771−780.
- Anrather J., Csizmadia V., Soares M.P. and Winkler H. Regulation of NF kappaB Rel A phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells. J. Biol. Chem. 1999 V. 274 P. 13 594−13 603.
- Zhong H., SuYang H., Erdjument-Bromage H. et al. The transcriptional activity of NF-kappaB is regulated by the IkappaB- associated PKAc subunit through a cyclic AMP-independent mechanism. Cell 1997 V. 89 P. 413−424.
- Lallena M.J., Diaz-Meco M.T., Bren G. et al. Activation of IkappaB kinase beta by protein kinase С isoforms. Mol. Cell Biol. 1999 V. 19 P. 2180−2188.
- Sanz L., Sanchez P., Lallena M.J. et al. The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. EMBO J. 1999 V. 18 P. 3044−3053.
- Wang D., Westerheide S.D., Hanson J.L. and Baldwin A.S. Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II. J. Biol. Chem. 2000 V. 275 P. 32 592−32 597.
- Ozes O.N., Mayo L.D., Gustin J.A. et al. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 1999 V. 401 P. 82−85.
- Romashkova J.A. and Makarov S.S. NF-kappaB is a target of АКТ in antiapoptotic PDGF signalling. Nature 1999 V. 401 P. 86−90.
- Hanna A.N., Chan E.Y., Xu J. et al. A novel pathway for tumor necrosis factor-alpha and ceramide signaling involving sequential activation of tyrosine kinase, p21(ras), and phosphatidylinositol 3-kinase. J. Biol. Chem. 1999 V. 274 P. 12 722−12 729.
- Kim B.C., Lee M.N., Kim J.Y. et al. Roles of phosphatidylinositol 3-kinase and Rac in the nuclear signaling by tumor necrosis factor-alpha in rat-2 fibroblasts. J. Biol. Chem. 1999 V. 274 P. 24 372−24 377.
- Reddy S.A., Huang J.H. and Liao W.S. Phosphatidylinositol 3-kinase as a mediator of TNF-induced NF-kappa В activation. J. Immunol. 2000 V. 164 P. 1355−1363.
- Pastorino J.G., Tafani M. and Farber J.L. Tumor necrosis factor induces phosphorylation and translocation of BAD through a phosphatidylinositide-3-ОН kinase-dependent pathway. J. Biol. Chem. 1999 V. 274 P. 19 411−19 416.
- Osawa Y., Banno Y., Nagaki M. et al. TNF-alpha-induced sphingosine 1- phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. J. Immunol. 2001 V. 167 P. 173−180.
- Mayo M.W., Madrid L.V., Westerheide S.D. et al. PTEN blocks tumor necrosis factor-induced NF-kappa B-dependent transcription by inhibiting the transactivation potential of the p65 subunit. J. Biol. Chem. 2002 V. 277 P. 11 116−11 125.
- Gustin J.A., Maehama Т., Dixon J.E. and Donner D.B. The PTEN tumor suppressor protein inhibits tumor necrosis factor- induced nuclear factor kappa В activity. J. Biol. Chem. 2001 V. 276 27 740−27 744
- Burkle A. Poly (APD-ribosyl)ation, a DNA damage-driven protein modification and regulator of genomic instability. Cancer Lett. 2001 V. 163 P. 1−5.
- Oliver F.J., Menissier-de Murcia J., Nacci C. et al. Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice. EMBO J. 1999 V. 18 P. 4446−4454.
- Hassa P.O. and Hottiger M.O. A role of poly (ADP-ribose) polymerase in NF-kappa В transcriptional activation. Biol. Chem. 1999 V. 380 P. 953−959.
- Hassa P.O., Covic M., Hasan S. et al. The enzymatic and DNA binding activity of PARP-1 are not required for NF-kappa В coactivator function. J. Biol. Chem. 2001 V. 276 P.45 588−45 597.
- Chang W.J. and Alvarez-Gonzalez R. The sequence-specific DNA binding of NF-kappa В is reversibly regulated by the automodification reaction of poly (ADP-ribose) polymerase 1. J. Biol. Chem. 2001 V. 276 P. 47 664−47 670.
- Ullrich O., Diestel A., Eyupoglu I.Y., Nitsch R. Regulation of microglial expression of integrins by poly (ADP-ribose) polymerase-1. Nat. Cell Biol. 2001 V. 3 P. 1035−1042.
- Le Page C., Sanceau J., Drapier J.C., Wietzerbin J. Inhibitors of ADP-ribosylation impair inducible nitric oxide synthase gene transcription through inhibition of NF kappa В activation. Biochem. Biophys. Res. Commun. 1998 V. 243 P. 451−457.
- Kameoka M., Ota K., Tetsuka T. et al. Evidence for regulation of NF-kappaB by poly (ADP-ribose) polymerase. Biochem. J. 2000 V. 346 P. 641−649.
- На Н.С., Hester L.D., Snyder S.H. Poly (ADP-ribose) polymerase-1 dependence of stress-induced transcription factors and associated gene expression in glia. Proc. Natl. Acad. Sci. USA 2002. V. 99 P. 3270−3275.
- Hoeflich K.P., Luo J., Rubie E.A. et al. Requirement for glycogensynthase kinase-3beta in cell survival and NF- kappaB activation. Nature 2000 V. 406 P. 86−90.
- Higuchi M. and Aggarwal B.B. TNF induces internalization of the p60 receptor and shedding of the p80 receptor. J. Immunol. 1994 V. 152 P. 3550−3558.
- Mosselmans R., Hepburn A., Dumont J.E. et al. Endocytic pathway of recombinant murine tumor necrosis factor in L-929 cells. J. Immunol. 1988 V. 141 P. 3096−3100.
- Schutze S., Machleidt Т., Adam D. et al. Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling. J. Biol. Chem. 1999 V. 274 P. 10 203−10 212.
- Beg A.A., Sha W.C., Bronson R.T. and Baltimore D. Constitutive NF-kappa В activation, enhanced granulopoiesis, and neonatal lethality in I kappa В alpha-deficient mice. Genes Dev. 1995 V. 9 P. 2736−2746.
- Sarma V., Lin Z., Clark L. et al. Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis. J. Biol. Chem. 1995 V. 270 P.12 343−12 346.
- Song H.Y., Rothe M. and Goeddel D.V. The tumor necrosis factorinducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF kappaB activation. Proc. Natl. Acad. Sci. USA 1996 V. 93 P. 6721−6725.
- Lee E.G., Boone D.L., Chai S. et al. Failure to regulate TNF-induced NFkappaB and cell death responses in A20-deficient mice. Science 2000 V. 289 P. 2350−2354.
- Zetoune F.S., Murthy A.R., Shao Z. et al. A20 inhibits NF-kappa В activation downstream of multiple МарЗ kinases and interacts with the I kappa В signalosome. Cytokine 2001 V. 15 P. 282−298.
- Jaattela M., Mouritzen H., Elling F. and Bastholm L. A20 zinc finger protein inhibits TNF and IL1 signaling. J. Immunol. 1996 V. 156(3) P. 1166−73.
- Micheau 0., and Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 2003 V. 114(2) P. 181−90.
- Poyet J.L., Srinivasula S.M., Lin J.H., Fernandes-Alnemri Т., Yamaoka S., Tsichlis P.N., and Alnemri E.S. Activation of the Ikappa В kinases by RIP via IKKgamma /NEMO-mediated oligomerization J. Biol. Chem. 2000. V. 275(48) P. 37 966−77.
- Irmler M., Thome M., Hahne M., Schneider P., Hofmann K., Steiner V., Bodmer J.L., Schroter M., Burns K., Mattmann C. et al. Inhibition of death receptor signals by cellular FLIP. Nature 1997 V. 388 P. 190−195.
- Wang C.Y., Mayo M.W., Korneluk R.G., Goeddel D.V., and Baldwin A.S., Jr. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAPl and C-IAP2 to suppress caspase-8 activation Science 1998 V. 281 P. 1680−1683.
- Tang G., Minemoto Y., Dibling В., Purcell N.H., Li Z., Karin M. and Lin A. Inhibition of JNK activation through NF-kappaB target genes. Nature 2001 V. 414 P. 313 317.
- Deng Y., Ren X., Yang L., Lin Y., and Wu X. A JNK-dependent pathway is required for TNF alpha-induced apoptosis. 2003. V. 115 P. 61−70.
- De Smaele E., Zazzeroni F., Papa S., Nguyen D.U., Jin R., Jones J., Cong R., and Franzoso G. Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling Nature 2001 V. 414 P. 308−313.
- Amanullah A., Azam N., Balliet A., Hollander, C., Hoffman В., Fornace, A., and Liebermann, D. Cell signalling: cell survival and a Gadd45-factor deficiency. Nature 2003 V. 424 P. 741.
- Lee E.G., Boone D.L., Chai S., Libby S.L., Chien, M., Lodolce, J.P., and Ma, A. Failure to regulate TNF-induced NF-kappa В and cell death responses in A20-deficient mice Science 2000 V.289 P. 2350−2354.
- Bubici C., Papa S., Pham C.G., Zazzeroni F., Franzoso G. The NF-kappaB-mediated control of ROS and JNK signaling. Histol Histopathol. 2006 V. 21 P. 69−80.
- Zheng L., Fisher G., Miller R.E., Peschon J., Lynch D.H., and Lenardo M.J. Induction of apoptosis in mature T cells by tumour necrosis factor. Nature 1995 V. 377 P. 348−351.
- Chan F.K., and Lenardo M.J. A crucial role for p80 TNF-R2 in amplifying p60 TNF-R1 apoptosis signals in T lymphocytes. Eur. J. Immunol. 2000 V. 30 P. 652−660.
- Li X., Yang Y., and Ashwell J.D. TNF-RII and c-IAPl mediate ubiquitination and degradation of TRAF2. Nature 2002 V. 416 P. 345−347.
- Weber C.K., Liptay S., Wirth Т., Adler G., Schmid R.M. Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta. Gastroenterology. 2000 V. 119(5) P. 1209−1218. *
- Munro S. Lipid rafts: elusive or illusive? Cell 2003 V. 115(4)P. 377−388.
- Dykstra M., Cherukuri A., Sohn H.W., Tzeng S.J. and Pierce S.K. Location is everything: lipid rafts and immune cell signaling. Ann. Rev. Immunol. 2003. V. 21. P. 457−481.
- Legler D.F., Micheau O., Doucey M.A., Tschopp J. and Bron C. Recruitment of TNF receptor 1 to lipid rafts is essential for TNF alpha-mediated NF-kappaB activation. Immunity 2003. V. 18. P. 655−664.
- Doan J.E., Windmiller D.A. and Riches D.W. Differential regulation of TNF-R1 signaling: lipid raft dependency of p42mapk/erk2 activation, but not NF-kappaB activation. J. Immunol. 2004. V. 172 P. 7654−7660.
- Algeciras-Schimnich A., Shen L., Barnhart B.C., Murmann A.E., Burkhardt J.K. and Peter M.E. Molecular ordering of the initial signaling events of CD95. Mol. Cell. Biol. 2002. V. 22. P. 207−220.
- Muppidi J.R. and Siegel R.M. Ligand-independent redistribution of Fas (CD95) into lipid rafts mediates clonotypic T cell death. Nat. Immunol. 2004. V. 5. P. 182−189.
- Scaffidi C., Fulda S., Srinivasan A., Friesen C., Li F., Tomaselli K.J., Debatin K.M., Krammer P.H. and Peter M.E. Two CD95 (APO-l/Fas) signaling pathways. EMBO J. 1998. V. 17. P. 1675−1687.
- Siegel R.M., Frederiksen J.K., Zacharias D.A., Chan F.K., Johnson M., Lynch D., Tsien R.Y. and Lenardo M.J. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations.Science. 2000. V. 288. P. 2354−2357.
- Hueber A.O., Bernard A.M., Herincs Z., Couzinet A. and He H.T. An essential role for membrane rafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytes. EMBO Rep. 2002. V. 3. P. 190−196.
- Wyllie A.H. Apoptosis and carcinogenesis. Eur J Cell Biol 2004 V. 73(3) P. 189−197.
- Denecker G., Vercammen D., Declercq W., Vandenabeele P. Apoptotic and necrotic cell death induced by death domain receptors Cell Mol. Life Sci 2001V. 58(3) P. 356−370.
- Spinivasula S.M., Ahmad M., Fernandes-Alnemri Т., Alnemri E.S. Autoactivation of procaspase-9 by Apaf-1 -mediated oligomerization. Mol.Cell. 1998. V. 1(7). P. 949−957.
- Muzio M., Stockwell B.R., Stennicke H.R., Salvesen G.S., Dixit V.M. An induced proximity model for caspase-8 activation. JBC. 1998. V. 273(5). P. 2926−2930.
- Duan H" Dixit V. RAIDD is a new 'death' adaptor molecule. Nature. 1997 V. 385(6611). P. 86−89.
- Hsu H., Xiong J., Goeddel D.V. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa В activation. Cell 1995 V. 81(4) P. 495−504.
- Denecker G., Vercammen D., Declercq W., Vandenabeele P. Cell Mol Life Sci. 2001 V. 58(3) P. 356−370.
- Vercammen D., Brouckaert G., Denecker G., Vandecraen M., Declercq W., Fiers W., Vandenabeele P. Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways. J Exp Med 1998 V. 188(5) P. 919−930.
- Kinloch R.A., Treherne J.M., Furness L.M., Hajimohamadreza I. The pharmacology of apoptosis. Trends Pharmacol Sci. 1999 V. 20(1) P. 35−42.
- Schotte P., Declercq W., Vanhuffel S., Vandenabeele P., Beyaert R. Non-specific effects of methyl ketone peptide inhibitors of caspases. FEBS Lett 1999 V. 442(1) P. 117 121.
- Kuida K., Haydar T.F., Kuan C.Y., Gu Y., Taya C., Karasuyama H., Su M., Rakic P., Flavell R.A. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 1998 V. 94(3) P. 325−337.
- Kuida K., Zheng T. S, Na S.Q., Kuan C.Y., Yang D., Karasuyama H., Rakic P., Flavell R.A. Nature 1996 V. 384 P. 368−372.
- Kuida K., Lippke J.A., Ku G., Harding M.W., Livingston D.J., Su M., Flavell R.A. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 1995 V. 267 P. 2000−2003.
- Zheng T.S., Hunot S., Kuida K., Flavell R.A. Caspase knockouts: matters of life and death. Cell. Death. Differ. 1999 V. 6 (11) P. 1043−1053.
- Vandenabeele P., Declercq W., Beyaert R., Fiers W. Two tumour necrosis factor receptors: structure and function. Trends. Cell. Biol. 1995 V. 5. (10) P. 392−399. ,
- Lin Y., Devin A., Rodriguez Y., Liu Z.G. Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis Genes. Dev. 1999. V.13 (19). P. 2514−26.
- Pimentel-Muinos F.X., Seed В. Regulated commitment of TNF receptor signaling: a molecular switch for death or activation Immunity 1999 V. 1(6) P. 783−793.
- Kelliher M.A., Grimm S., Ishida Y" Kuo F., Stanger B.Z., Leder P. The death domain kinase RIP mediates the TNF-induced NF-kappaB signal. Immunity 1998 V. 8(3) P. 297−303.
- Cohen G.M. Caspases: the executioners of apoptosis Biochem. J. 1997 V. 326 (Pt 1) P. 1−16.
- Chao D.T., Korsmeyer S.J. BCL-2 family: regulators of cell death. Ann. Rev. Immunol. 1998 V. 16 P. 395- 419.
- Screaton G., Xu X.N. T cell life and death signalling via TNF-receptor family members. Curr. Opin. Immunol. 2000 V. 12(3) P. 316−322.
- Rich Т., Allen R.L., Wyllie A.H. Defying death after DNA damage. Nature 2000 V. 407 P. 777−783.
- Kerr J., Wyllie A.II., Currie A.R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 1972.V. 6(4) P. 239−257.
- Johnson D.E. Programmed cell death regulation: basic mechanisms and therapeutic opportunities. Leukemia 2000 V. 14(8) P. 1340−1344.
- Utz P.J., Anderson P. Life and death decisions: regulation of apoptosis by proteolysis of signaling molecules. Cell Death. Differ. 2000 V. 7(7) P. 589−602.
- Squier M., Cohen J.J. Cell-mediated cytotoxic mechanisms. Cell. Death. Differ. 1996 V. 3 P. 275 -283.
- Pornares М.1., Samali A., Orrenius S. Cleavage of the calpain inhibitor, calpastatin, during apoptosis. Cell. Death. Differ. 1998 V. 5 P. 1028−1033.
- Hajnoczky G., Csordas G., Madesh M., Pacher P. Control of apoptosis by IP (3) and ryanodine receptor driven calcium signals. Cell Calcium. 2000 V. 28 P. 349−363.
- Diaz F., Bourguignon L.Y. Selective down-regulation of IP (3)receptor subtypes by caspases and calpain during TNF alpha -induced apoptosis of human T-lymphoma cells Cell.Calcium. 2000V. 27 P. 315−328.
- James S.Y., Williams M.A., Newland A.C., Colston K.W. Leukemia cell differentiation: cellular and molecular interactions of retinoids and vitamin D. Gen Pharmacol. 1999 V. 32(1) P. 143−154.
- Brackman D., Lund-Johansen F., Aarskog D. Expression of cell surface antigens during the differentiation of HL-60 cells induced by 1,25-dihydroxyvitamin D3, retinoic acid and DMSO. Leuk. Res. 1995 V. 19, P. 57−64.
- Tohyama К., Shiga S., Fujimoto H., Hamaguchi Y., Ichiyama S. Automated analysis of differentiation-induced leukemic cells during all-trans retinoic Acid therapy of acute promyelocytic leukemia. Arch. Pathol. Lab. Med., 2003 V. 127 P. e4-e8.
- Steinman R.A. and Tweardy D. J Granulocyte colony-stimulating factor receptor mRNA upregulation is an immediate early marker of myeloid differentiation and exhibits dysfunctional regulation in leukemic cells. Blood. 1994 V. 183 P. 119−127.
- Squinto S.P., Doucet J.P., Block A.L., Morrow S.L., Davenport W.D. Jr. Induction of macrophage-like differentiation of HL-60 leukemia cells by tumor necrosis factor-alpha: potential role of fos expression. Mol Endocrinol. 1989 V. 3(2) P. 409−419.
- Bertagnolo V., Marchisio M., Capitani S., Neri L. M. Intranuclear translocation of phospholipase C-beta2 during HL-60 myeloid differentiation. Biochem. Biophys. Res. Commun. 1997 V. 235 P. 831−837.
- Marchisio M., Bertagnolo V., Colamussi M. L., Capitani S., Neri L. M. Phosphatidylinositol 3-kinase in IIL60 nuclei is bound to the nuclear matrix and increases during granulocytic differentiaton. Biochem. Biophys. Res. Commun. 1998 V. 253 P. 346 351.
- Bertagnolo V., Neri L. M., Marchisio M., Mischiati C., Capitani S. Phosphoinositide 3-kinase activity is essential for all-trans-retinoic acid-induced granulocytic differentiation of HL-60 cells. Cancer Res. 1999 V. 59 P. 542−546.
- Bertagnolo V., Brugnoli F., Marchisio M., Celeghini C., Carini C., Capitani S. Association of PI 3-K with tyrosine phosphorylated Vav is essential for its activity in neutrophil-like maturation of myeloid cells, Cell. Signal. 2004 V. 16 P. 423- 433.
- Beyaert R., Heyninck K., Devalck D., Boeykens F., Vanroy F., Fiers W. Enhancement of tumor necrosis factor cytotoxicity by lithium chloride is associated with increased inositol phosphate accumulation. J Immunol. 1993 V. 151(1) P. 291−300.
- Yorek M.A., Dunlap J.A., Thomas M.J., Cammarata P.R., Zhou C., Lowe W.L. Effect of TNF-alpha on SMIT mRNA levels and myo-inositol accumulation in cultured endothelial cells. Am. J. Physiol. Cell. Physiol. 1998 V. 43. P. 58−71.
- Williams M. A., Newland A. C. and Kelsey S.M. Monocyte-mediated killing of human leukaemia is enhanced by administration of granulocyte-macrophage colony stimulating factor following chemotherapy. Br. J. Hematol. 1997 V. 98 P. 960−968.
- Witsell A. L., and Schook L. B. Tumor necrosis factor alpha is an autocrine growth regulator during macrophage differentiation. Proc. Natl. Acad. Sci. U. S. A. 1992 V. 89 P. 4754−4758.
- Hachiya M., Shimizu S., Osawa Y., Akashi M. Endogenous production of tumour necrosis factor is required for manganese superoxide dismutase expression by irradiation in the human monocytic cell line THP-1. Biochem J. 1997 V. 328 P. 615−623.
- Zyad A., Benard J., Tursz Т., Clarke R., Chouaib S. Resistance to TNF-alpha and adriamycin in the human breast cancer MCF-7 cell line: relationship to MDR1, MnSOD, and TNF gene expression. Cancer Res. 1994 V. 54 P. 825−831.
- Rogers R.J., Monnier J.M., and Nick H.S. Tumor necrosis factor-alpha selectively induces MnSOD expression via mitochondria-to-nucleus signaling, whereas interleukin lbeta utilizes an alternative pathway. J. Biol. Chem. 2001 V. 276 P. 20 419−20 427.
- Ketley N.J., Allen P.D., Kelsey S.M., Newland A.C. Mechanisms of resistance to apoptosis in human AML blasts: the role of differentiation-induced perturbations of cell-cycle checkpoints. Leukemia 2000 V. 14 P. 620−628.
- Laskin D.L., Sirak A.A., Laskin J.D. Differentiation of HL-60 myeloid leukaemia cells is associated with a transient block in the G2 phase of the cell cycle. Cell Prolif. 1991 V. 24, P.341−353.
- Vermeulen L., Wilde G. D., Notebaert S., Berghe W. V., Haegeman G. Regulation of the transcriptional activity of the nuclear factor-kappaB p65 subunit. Biochemical Pharmacology. 2002. V.64. P. 963−970.
- Wolf B.B., Green D.R. Suicidal tendencies: apoptotic cell death by caspase family proteinases. J. Biol. Chem. (1999 V. 274 P. 20 049−20 052.
- Arora A. S., Jones B. J., Patel Т. C. Bronk S. F., Gores G. J. Ceramide induces hepatocyte cell death through disruption of mitochondrial function in the rat Hepatology. 1997. V. 25(4). P. 958−963.
- Quillet-Mary A., Jaffrezou J. P., Mansat V., Bordier C., Naval J. Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis. J. Biol. Chem. 1997. V. 272. P. 21 388−21 395.
- Ghafourifar P., Klein S. D., Schucht O., Schenk U., Pruschy M., Rocha S., Richter C. Ceramide induces cytochrome с release from isolated mitochondria. Importance of mitochondrial redox state J. Biol. Chem. 1999. V. 274. P. 6080−6084.
- Hengartner M. O. The biochemistry of apoptosis. Nature. 2000. V. 407. P. 770−776.
- Y.A. Hannun. Functions of ceramide in coordinating cellular responses to stressi
- Science. 1996. V.274. P. 1855−1859.
- Yuan H., Williams S.D., Adachi S., Oltersdorf Т., Gottlieb R.A. Cytochrome с dissociation and release from mitochondria by truncated Bid and ceramide. Mitochondrion. 2003. V. 2(4). P. 237−244.
- Thannickal V.J. and Fanburg B.L. Reactive oxygen species in cell signaling Am. J. Physiol. Lung. Cell. Mol. Physiol. 2000 V. 279 P. 1005−1028.