Разработка методических подходов к рациональному дизайну полиэпитопных T-клеточных антигенов
Диссертация
Iglesias et al., 2007; Tine et al., 2005; Woodberry et al., 1999). Несмотря на то, что первые работы, посвященные изучению ДНК-вакцин, кодирующих полиэпитопные антигены, показали способность конструкций, составленных в результате простого объединения эпитопов, индуцировать цитотоксический Т-клеточный ответ на все эпитопы, включенные в их состав (Thomson et al., 1995), в дальнейшем было показано… Читать ещё >
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