Биохимические аспекты индукции дифференцировки и апоптоза клеток линии К562
Диссертация
В связи с вышеизложенным необходимо указать, что некоторые аспекты работы требуют дальнейшего изучения. Используемые в исследовании химические реагенты имеют в большинстве случаев различное химическое строение, что обуславливает различие внутриклеточных мишеней действия дифференцирующих агентов и неоднотипность путей их метаболизма. Последние, как известно, приводят к появлению целого ряда… Читать ещё >
Список литературы
- Абелев Г. И. а-Фетопротеин: взгляд в биологию развития и природу опухолей // Соросовский образовательный журнал. 1998. -№ 9. — С. 8−13.
- Алесенко A.B., Соловьёв A.C. и др. Роль продуктов сфингомиелинового цикла в развитии апоптоза, индуцированного через рецепторы Fas и фактора некроза опухоли-а// Известия АН. Серия биологическая. 1998. — № 2.
- Анисимов А.Г., Болотников И. А. Интерлейкин-2 и стауроспорин отменяют ингибирование неспецифической цитотоксичности спленоцитов крыс высокими дозами форболмиристатацетата // Бюл. эксперим. биологии и медицины. 1996. — Т. 122, № 10. — С. 394−398.
- Обработка синхронизированных клеток К562 тетрафторалюминатом не модулирует флуорисценцию бромистого этидия и 4', 6-диамидино-2-фенилиндола при связывании с нуклеотидной ДНК // Цитология. 1999а. — Т. 41,№ 8.-С. 680−684.
- Анисимов А.Г., Волкова Т. О., Чекмасова A.A. и др. Химически индуцированная дифференцировка клеток опухолевых линий // Онтогенез. -2002.-Т. 33, № 5.-С. 325−341.
- Анисимов А. Г, Чекмасова A.A., Волкова Т. О. и др. Обработка клеток К562 тимидином на фоне дексаметазона повышает чувствительность опухолевых клеток к литическому действию лейкоцитами человека // Цитология. 2001. -Т. 43, № 1.-С. 76−81.
- Белоусов Ю. Б, Моисеев B.C., Лепахин В. К. Клиническая фармакология и фармакотерапия. Руководство для врачей: 2-е изд., исп. и доп. 1997. -Москва. — Универсум Паблишинг.
- Бычков М.Б. Топотекан ингибитор топоизомеразы I — новый противоопухолевый препарат // Современная онкология. — 1999. — Т. 1, № 1.
- И.Волкова Т. О., Малышева И. Е, Немова H.H. Влияние форбол-12 миристат-13-ацетата на модуляцию апоптоза в эритролейкемических клетках человека К562 при обработке рядом химических реагентов // Цитология. 2003. — Т. 45, № 9. -С. 859.
- Волкова Т.О., Малышева И.Е, Немова H.H. Сравнительный анализ дифференцирующего и апоптогенного действий цитидина, тимидина и гуанозина на клетки эритромиелолейкозной линии человека К562 // Вопр. мед. химии. 2002. — Т. 48, № 6. — С. 586−593.
- Волкова Т.О., Малышева И.Е, Немова H.H. Форбол-12 миристат-13-ацетат ингибирует апоптоз в эритролейкемических клетках К562, индуцированный рядом нуклеозидов // Онтогенез. 2005. — Т. 36, № 1. — С. 18−25.
- Волкова Т.О., Немова H.H. Молекулярные механизмы апоптоза лейкозной клетки. 2006. — М.: Наука. — 205 с.
- Гунин А.Г. Гистология в таблицах и схемах. 2005. — М.: Медицинское информационное агентство. — 192 с.
- Гуторов С.Л., Семенов H.H., Загрекова Е. И. Новые лекарства в лечении солидных опухолей // РМЖ. 2001. — Т. 9, № 22.
- Епифанова О.И. Лекции о клеточном цикле. 1997. — М.: КМК scientific press. -144 с.
- Ефимцева Е.В., Михайлов С. Н. Дисахаридные нуклеозиды // Успехи химии. -2004. Т. 73, № 4. — С. 435−448.
- Иванов С.Д. Пострадиационные реакции ДНК нуклеотидов лейкоцитов крови: детектирование, закономерности, диагностическое и прогностическое значение: Автореф. д-ра биол. наук. 1992. — СПб. — 40 с.
- Иммунология: в 3-х т. / под редю У. Пола. 1989. — М.: Мир. — Т. 3. — 360 с.
- Клиническая онкогематология: Руководство для врачей. 2001. — М.: Медицина. — 576 с.
- Комов В.П., Шведова В. Н. Биохимия: учеб. для студентов вузов, обуч. по напр. 655 500 (биотехнология). 2004. — М.: Дрофа. — 639 с.
- Копнин Б.П. Механизмы действия онкогенов и опухолевых супрессоров: Ключ к пониманию базовых механизмов канцерогенеза // Биохимия. 2000. — Т. 65, № 1.-С. 5−33.
- Копнин Б.П. Неопластическая клетка: основные свойства и механизмы их возникновения // Практ. Онкология. 2002. — Т. 3, № 4. — С. 235−239.
- Куцый М.П., Кузнецова Е. А., Газиев А. И. Участие протеаз в апоптозе // Биохимия. 1999.-Т. 64, № 2. — С. 453−466.
- Лушников У.Ф., Абросимов А. Ю. Гибель клетки (апоптоз). 2001. — М.: Медицина. -192 с.
- Марри Р., Греннер Д., Мейес П., Родуэлл В. Биохимия человека. 1993. — М.: Мир.-Т. 2.-415 с.
- Машковский М.Д. Лекарственные средства. В двух томах. 1998. — Харьков: Торсинг. — Т. 2. — 592с.
- Менткевич Г. Л. Достижения и проблемы лекарственного лечения детей с онкогематологическими заболеваниями // Материалы Второй ежегодной Российской онкологической конференции «Современные тенденции развития лекарственной терапии опухолей». Москва. — 1998.
- Михайлов А.Т. Эмбриональные индукторы. 1988. — М.: Наука. — 216 с.
- Михайлопуло И.А. Химия, стереохимия и биохимия дезоксифторпроизводных Л-пентофураноз: некоторые наблюдения и перспективы // Наука и инновации. -2004, — № 7.- С. 24−35.
- Поддубная И.В. Реальность и перспективы лекарственной терапии неходжкинских лимфом // Современная онкология. 1999. — Т. 1, № 1.
- Преображенская М.Н. Перспективы создания новых противоопухолевых антибиотиков // Биоорган, химия. 1998. — Т. 24. — С. 644−662.
- Регистр лекарственных средств России РЛС Энциклопедия лекарств: энциклопедия. 2006. — Вып. 15. — М.: РЛС 2007. — 1488 с.
- Робинсон М.В., Труфакин В. А. Апоптоз клеток иммунной системы // Успехи соврем, биологии. 1991. — Т. 111, № 2. — С. 246−259.
- Рукавицын О. А., Поп В. П. Хронические лейкозы: монография. 2004. — М.: Бином. — 240 с.
- Руководство по химиотерапии опухолевых заболеваний. 2005. — М.: Практическая медицина. — 704 с.
- Рыжов С.В., Новиков В. В. Молекулярные механизмы апоптотических процессов // Рос. биотерапевт, журн. 2002. — Т. 1, № 3. — С. 27−33.
- Сейц И.Ф., Князев П. Г. Молекулярная онкология: руководство для врачей. -1986. JL: медицина. — 352 с.
- Семененя И.Н. Естественные киллерные клетки (ЕКК) как звено в иммунной системе организма // Иммунология. 1994. — № 4. — С. 4−6.
- Сорокин A.M., Чекнёв С. Б., Кузнецов В. П. Иммуномодулирующая активность отечественных медицинских природных препаратов интерферона // Иммунология. 1991. — № 1. — С. 17−20.
- Харченко В.П., Кузьмин И. В. Рак лёгкого. Фундаментальные проблемы и клинические перспективы. Руководство для врачей. М.: Наука. — 1994.
- Химиотерапия опухолевых заболеваний. Руководство под ред. Н. И. Переводчиковой. 2000. — М.
- Цикл лекций по детской онкологии. 2001.-Т. 2 (ст. 38). — С. 163−175.
- Эллиот В., Эллиот Д. Биохимия и молекулярная биология. 1999. — М.: Мир. -372 с.
- Alemany M., Levin J. The effects of arsenic trioxide (As203) on human megakaryocyte leukemia cell lines. With a comparision of its effects on other cell lineages // Leuk. Lymphoma. 2000. — V.38 (1−2). — P. 153−163.
- Amundson S.A., Myers T.G., Fornace A.J. et al. Roles for p53 in growth arrest and apoptosis: Putting on the brakes after genotoxic stress // Oncogene. 1998. — V. 17, № 25.-P. 3287−3299.
- Anandan S.K., Ward J.S., Brokx R.D., Denny T., Bray M.R., Patel D.V., Xiao X.Y. Design and synthesis of thiazole-5-hydroxamic acids as novel histone deacetylase inhibitors // Bioorg. Med. Chem. Lett. 2007. — Epub ahead of print.
- Andersson L.C., Nilsson K., Gahmberg C.G. K562 a human erythroleukemic cell line // Intern. J. Cancer. — 1979. — V. 23. — P. 143−147.
- Andreeff M., Jiang S., Zhang X. et al. Expression of Bcl-2-related genes in normal and AML progenitors: changes induced by chemotherapy and retinoic acid // Leukemia. 1999.-V. 13 (11).-P. 1881−1892.
- Arita K., Kobuchi H., Utsumi T. et al. Mechanism of apoptosis in HL-60 cells induced by n-3 and n-6 polyunsaturated fatty acids // Biochem Pharmacol. 2001. -V. 62 (7).-P. 821−828.
- Arita K., Yamamoto Y., Takehara Y. et al. Mechanisms of enhanced apoptosis in HL-60 cells by L/F-irradiated n-3 and n-6 polyunsaturated fatty acids // Free Radic Biol Med. 2003. — V. 35 (2). — P. 189−199.
- Augenlight L.H., Bordonaro M., Heerdt B.G., Mariadason J., Velcich A. Cellular mechanisms of risk and transformation // Annals of the New York Academy of Sciences. 1999. — V. 889. — P. 20−31.
- Azuma A., Huang P., Matsuda A., Plunkett W. 2'-C-Cyano-2'-deoxy-l-/?-D-arabino-pentofuranosylcytosine: a novel anticancer nucleoside analog that causes both DNA strand breaks and G2 arrest // Mol Pharmacol. 2001a. — Vol. 59, Issue 4. — P. 725 731.
- Azuma A., Huang P., Matsuda A., Plunkett W. Cellular pharmacokinetics and pharmacodinamics of the deoxycitidine analog CNDAC II Biochem Pharmacol. -2001b. -Jun 15- 61(12).-P. 1497−1507.
- Bahram F., Wu S., Oberg F., Liischer B., Larsson L.-G. Posttranslational regulation of Myc function in response to phorbol ester/interferon-y-induced differentiation of v-Myc-transformed U-937 monoblasts // Blood. 1999. — V. 93, № 11. — P. 39 003 912.
- Baliga B.S., Mankad M., Shah A.K. et al. Mechanism of differentiation of human erythroleukemic cell line K562 by hemin // Cell Prolif. 1993. — V. 26. — P. 519−559.
- Benoist H., Madoulet C., Jardillier J.C., Desplaces A. Adriamycin induced resistance of sensitive K562 cells to natural killer lymphocyte attack // Cancer Immunol Immunother. 1985.-V. 20(2).-P. 122−128.
- Bernardi P., Brockemeier K.M., Pfeiffer D.R. Recent progress on regulation of the mitochondrial permeability transition pore: a cyclosporin-sensitive pore in the inner mitochondrial membrane//J. Bioenerg. Biomembr.- 1994.-V. 26. P. 509−517.
- Blanc-Brude O. P, Mesri M, Wall N.R. et al. Therapeutic targeting of the survivin pathway in cancer: initiation of mitochondrial apoptosis and suppression of tumor-associated angiogenesis // Clin Cancer Res. 2003. — V. 9 (7). — P. 2683−2692.
- Brewer G. Regulation of c-myc mRNA decay in vitro by a phorbol ester-inducible, ribosome-associated component in differentiating megakaryoblasts // J. Biol. Chem. 2000. — V. 275, Is. 43. — P. 33 336−33 345.
- Brown G, Choudhry M. A, Durham J, Drayson M. T, Michell R.H. Monocytically differentiating HL-60 cells proliferate rapidly before they mature // Exp Cell Res. -1999.-V. 253 (2).-P. 511−518.
- Budd R.C. Death receptors couple to both cell proliferation and apoptosis // J. Clin. Invest. 2002. — V. 109, № 4. — P. 437−442.
- Buscemi G, Carlessi L., Zannini L, Lisanti S, Fontanella E., Canevari S., Delia D. DNA Damage-Induced cell cycle regulation and function of novel Chk2 phosphoresidues // Molecular and Cellular Biology. 2006. — V. 26, № 21. — P. 7832−7845.
- Casini A., Scozzafava A., Mastrolorenzo A., Supuran C.T. Sulfonamides and Sulfonylated derivatives as anticancer agents // Current Cancer Drug Targets. 2002. — V. 2 (№ 1). — P. 55−75.
- Chang H.Y., Yang X. Proteases for cell suicide: functions and regulation of caspases // Microbiol. Mol. Biol. Rev. 2000. — V. 64, № 4. — P. 821−846.
- Charrad R.-S., Gadhoum Z., Qi J. et al. Effects of mt-CD44 monoclonal antibodies on differentiation and apoptosis of human myeloid leukemia cell lines // Blood. -2002. V. 99, № 1. — P. 290−299.
- Chegwidden W.R., Spencer I.M. Sulphonamide inhibitors of carbonic anhydrase inhibit the growth of human lymphoma cells in culture // Inflammopharmacol. -1995.-V.3.-P. 231−239.
- Cheng T., Wang Y., Dai W. Transcription factor egr-1 is involved in phorbol 12-myristate 13-acetate-induced megakaryocyte differentiation of K562 cells // J Biol Chem. 1994. — V. 269 (49). — P. 30 848−30 853.
- Chiu L.C., Wan J.M., Ooi V.E. Induction of apoptosis by dietary polyunsaturated fatty acids in human leukemic cells is not associated with DNA fragmentation // Int J Oncol. 2000. — V. 17 (4). — P. 789−796.
- Choi Y.J., Park J.W., Suh S.I., Mun K.C. et al. Arsenic trioxide-induced apoptosis in U937 cells involve generation of reactive oxigen species and inhibition of Akt II Int. J. Oncol. 2002. — V. 21. — P. 603−610.
- Chylicki K., Ehinger M., Svedberg H., Gullberg U. Characterization of the molecular mechanisms for /?55-mediated differentiation // Cell Growth & Differentiation. -2000a.- V. 11.-P. 561−571.
- Chylicki K" Ehinger M., Svedberg H., Bergh G., Olsson I., Gullberg U. p53-Mediated differentiation of the erythroleukemia cell line K562 II Cell Growth & Differentiation. 2000b. — V. 11. — P. 315−324.
- Collins S.J. The HL-60 promyelocyte leukemia cell line: proliferation, differentiation, and cellular oncogene expression // Blood. 1987. — V. 70, Is. 5. — P. 1233−1244.
- Cook P.R., Brazell I.A. Spectrofluorometric measurement of the binding of ethidium to superhelical DNA from cell nuclei // Eur. J. Biochem. 1978. — V. 84. -P. 465−477.
- Cultraro C.M., Bino T., Segal S. Function of the c-Myc antagonist Mad I during a molecular switch from proliferation to differentiation // Mol. Cell Biol. -1997.-V. 17.-P. 2353−2359.
- Dai Y., Rahmani M., Grant S. Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPKIJNK- and AT^/fa/^-dependent process // Oncogene. 2003. — V. 22 (46). -P. 7108−7122.
- Danilenko M., Wang X., Studzinski G.P. Carnosic acid and promotion of monocytic differentiation of HL60-G cells initiated by other agents // J Natl Cancer Inst. 2001. — V. 93 (16). — P. 1224−1233.
- Das B., Mondragon M.O., Tao S.-Z. et al. Preferential interaction of novel tumor surface protein (p38,5) with naive natural killer cells // J. Exp. Med. 1997. -V. 185.-P. 1735−1742.
- Dass D., Pintucci G., Stern A. MAPK-dependent expression ofp21 (WAF) and p27 (kip) in PMA-induced differentiation of HL-60IIFEBS. 2000. — V. 472, № 1. -P. 50−52.
- De Maria R., Lenti L., Malisan F. et al. Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis // Science. 1997. — V. 277. — P. 1652−1655.
- Defacque H., Sevilla C., Piquemal D., Rochette-Egly C., Marti J., Commes T. Potentiation of FD-induced monocytic leukemia cell differentiation by retinoids involves both RAR and RXR signaling pathways // Leukemia. 1997. — V. 11 (2) — P. 221−227.
- Deming P.B., Schafer Z.T., Tashker J.S. et al. Bcr-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release // Mol. Cell. Biol. 2004. — V. 24 (23). — P. 10 289−10 299.
- Dirsch V.M., Antlsperger D.S.M., Hentze H., Vollmar A.M. Ajoene, an experimental anti-leukemic drug: mechanism of cell death // Leukemia. 2002. — V. 16, № i.p. 74−83.
- Domaratskaia E.I., Bueverova E.I., Paiushina O.D., Starostin V.I. Alkylating damage by dipin of hematopoietic and stromal cells of the bone marrow // Izv Akad Nauk Ser Biol. 2005. -№ 3. — C. 267−272.
- Donehower R.C., Dees E.C., Baker S.D., Summerson L., Carducci M.A., Izumi T., Kobayashi T. A phase I study of CS-682, an oral antimetabolite, in patients with refractory solid tumors // Proc Am Soc Clin Oncol. 2000. — V. 19. — P. 196a.
- Dorsey J.F., Cunnick J.M., Mane S.M., Wu J. Regulation of the Erk2-Erkl signaling pathway and megakaryocyte differentiation of Bcr-Abl (+) K562 leukemic cells by Gab2 II Blood. 2002. — V. 99, № 4. — P. 1388−1397.
- Doyle B.T., O’Neill A.J., Newsholme P. et al. The loss of IAP expression during HL-60 cell differentiation is caspase-independent // J. Leukoc. Biol. 2002. -V. 71.-P. 247−254.
- Drexler H.G., MacLeod R.A. Leukemia-lymphoma cell lines as model systems for hematopoietic research // Ann. Med. 2003. — V.35 (6). — P. 404−412.
- Earnshaw W.C., Martins L.M., Kaufmann S.H. Mammalian caspases: structure, activation, substrates, and functions during apoptosis // Annu Rev Biochem. 1999. — V. 68. — P. 383−424.
- Estey E. Treatment of refractory AML // Leukemia. 1996. — V. 10. — P. 932 936.
- Fantappie O., Solazzo M., Lasagna N., Platini F., Tessitore L., Mazzanti R. P-glycoprotein mediates celecoxib-induced apoptosis in multiple drug-resistant cell lines // Cancer Res. 2007. — V.67 (10). — P. 4915−4923.
- Fernandez M.G., Troiano L., Moretti L. et al. Early changes in intramitochondrial cardiolipin distribution during apoptosis // Cell Growth & Differentiation. 2002. — V. 13. — P. 449−455.
- Ferri K.F., Kroemer G. Control of apoptotic DNA degradation // Nat. Cell Biol. 2000. — V.2. — P. 63−64.
- Fisherman J.S., Osborn B.L., Chun H.G. Choloroquinoxaline sulfonamide: a sulfanilamide antitumor agent entering clinical trials // Invest. New Drugs. 1993. -V. 11.-P. 1−9.
- Franklin C.C., Kraft A.S. Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells // J Biol Chem. 1997. — V. 272 (27). -P. 16 917−16 923.
- Franklin C.C., Kraft A.S. Constitutively active MAP kinase kinase (MEK1) stimulates SAP kinase and c-Jun transcriptional activity in U937 human leukemic cells // Oncogene. 1995. — V. 11 (11). — P. 2365−2374.
- Gao N., Dai Y., Rahmani M. et al. Contribution of disruption of the nuclear factor-^ pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol // Molecular Pharmacology. 2004. — V. 66. -P. 956−963.
- Garson D., Dokhelar M.C., Vainchenker W. et al. Protective effects of differentiation inducers on natural killer sensitivity of K562 cells: Analysis at a single-cell level // Cell Immunol. 1983. — V. 78. — P. 400−406.
- Gery S., Park D.J., Vuong P.T. et al. RTP801 is a novel retinoic acid-responsive gene associated with myeloid differentiation // Exp Hematol. 2007. — V. 35 (4).-P. 572−578.
- Gillis R.C., Daley B.J., Enderson B.L. et al. Inhibition of 5-lipoxygenase induces cell death in anti-inflammatory fatty acid-treated HL-60 cells // JPEN J Parenter Enteral Nutr. 2004. — V. 28 (5). — P. 308−314.
- Gillis R.C., Daley B.J., Enderson B.L., Karlstad M.D. Eicosapentaenoic acid and gamma-linolenic acid induce apoptosis in HL-60 cells // J Surg Res. 2002. — V. 107(1).-P. 145−153.
- Gillis R.C., Daley B.J., Enderson B.L., Kestler D.P., Karlstad M.D. Regulation of apoptosis in eicosapentaenoic acid-treated HL-60 cells // J Surg Res. 2007. — V. 137 (1). -P. 141−150.
- Golden M., Demsey R.A., Mier J.W. et al. The effect of differentiation inducers on the sensitivity of two myeloid cell lines to natural killer (NK) cellmediated lysis // Intern. J. Immunopharmacol. 1983. — V. 5. — P. 411−419.
- Granick S. The induction in vitro of the synthesis of delta-aminolevulinic acid synthetase in chemical porphyria: a response to certain drugs, sex hormones, and foreign chemicals// J Biol Chem.- 1966. V. 241 (6).-P. 1359−1375.
- Green D.R., Reed J.C. Mitochondria and apoptosis // Science. -1998. V. 281.-P. 1309−1312.
- Gulbins E., Jekle A., Ferlinz K. et al. Physiology of apoptosis // Am. J. Physiol. Renal Physiol. -2000. V. 279. — P. 605−615.
- Gumina G., Song G.Y., Chu C.K. ?-Nucleosides as chemotherapeutic agents // FEMS Microbiol Lett. 2001. — Aug 7- 202(1). — P. 9−15.
- Gwaltney S.L.II, Imade H.M., Li Q., Gehrke L., Credo R.B., Warner R.B., Le J.Y., Kovar P., Frost D., Ng S.C., Sham H.L. Antimitotic Agents // Bioorg. Med. Chem. Lett.-2001.-V. 11.-P. 1671−1673.
- Hanaoka K., Suzuki M., Kobayashi T., Tanzawa F., Tanaka K., Shibayama T., Miura S., Ikeda T., Iwabuchi H., Nakagawa A., Mitsuhashi Y., Hisaoka M., Kaneko
- M., Tomida A., Wataya Y., Nomura T., Sasaki T., Matsuda A., Tsuruo T., Kurakata S. Antitumor activity and novel DNA-self-strand-breaking mechanism of CNDAC and its iW-palmitoyl derivative (CS-682) II Int J Cancer. 1999. — Jul 19- 82(2). — P. 226−236.
- Hass R., Giesse G., Meyer G. et al. Differentiation and retrodifferentiation of U937 cells: reversible induction and suppression of intermediate filament protein synthesis // Eur. J. Cell Biol. 1990. — V. 51. — P. 265−271.
- Henriksson M., Luscher B. Proteins of the Myc network: Essential regulators of cell growth and differentiation // Adv Cancer Res. 1996. — V. 68. — P. 109.
- Herberman R.B. Cancer immunotherapy with natural killer cells // Semin Oncol. 2002. — V. 3 (7). — P. 27−30.
- Herrera R., Hubbell S., Decker S., Petruzzelli L. A role for the MEK/MAPK pathway in PA?4-induced cell cycle arrest: modulation of megakaryocyte differentiation of K562 cells // Exp Cell Res. 1998. — V. 238 (2). — P. 407−414.
- Horton M.A., Cedar S.H., Maryanka D. et al. Multiple differentiation programs in K562 erythroleukemia cells and their regulation // Progr. Clin. Biol. Res. 1983.-V.134.-P. 305−322.
- Horvat-Switzer R. D., Thompson A.A. Stromal contact inhibits effects of phorbol esters but does not inhibit staurosporine induced megakaryocyte differentiation in K562 cells // Blood (ASH Annual Meeting Abstracts). 2005. — V. 106.-Abstract 4315.
- Hosmane R.S. Ring-expanded («Fat») nucleosides as broad-spectrum anticancer and antiviral agents // Curr. Top Med Chem. 2002. — Oct- 2(10). — P. 1093−1109.
- Houghton P.J., Houghton J.A. Antitumor diarylsulfonylureas: novel agents with unfulfilled promise // Invest. New Drugs. 1996. -V. 14. — P. 271−280.
- Hu J.H., Stamatoyannopoulos G., Song C.-Z. Regulation of globin gene expression and erythroid differentiation by Sp/KLF factors // Blood (ASH Annual Meeting Abstracts). 2005. — V. 106. — Abstract 4241.
- Hu W.H., Johnson H., Shu H.B. Activation of NF-kappaB by FADD, Casper, and caspase-8 // J. Biol. Chem. 2000. — V. 275. — P. 10 838−10 844.
- Huang D.-Y., Kuo Y.-Y., Lai J.-S., Suzuki Y., Sugano S., Chang Z.-F. GATA-1 and NF-y cooperate to mediate erythroid-specific transcription of Gfi-IB gene // Nucleic Acids Research. 2004. — V. 32 (13). — P. 3935−3946.
- Huang H.-f., Chen Y.-z., Wu Y. Mitochondria-dependent apoptosis induced by a novel amphipathic photochemotherapeutic agent ZnPcS2P2 in HL-60 cells // Acta Pharmacologica Sinica. 2005. — V. 26 (9). — P. 1138−1144.
- Huang M., Wang Y., Collins M., Mitchell B.S., Graves L.M. All 1126 induces differentiation of human myeloid leukemia K562 cells by depletion of intracellular CTP pools // Molecular Pharmacology. 2002. — V. 62, Is. 3. — P. 463 472.
- Huang P., Plunkett W. Fludarabine- and gemcitabine-induced apoptosis: Incorporation of analogs into DNA is a critical event // Cancer Chemother Pharmacol. -1995. V. 36. — P. 181−188.
- Huang P., Chubb S., Hertel L.W., Grindey G.B., Plunkett W. Action of 2', 2'-difluorodeoxycytidine on DNA synthesis // Cancer Res. 1991. — V. 51. — P. 61 106 117.
- Ikezoe T., Chen S.S., Heber D., Taguchi H., Koeffler H.P. Baicalin is a major component of PC-SPES which inhibits the proliferation of human cancer cells via apoptosis and cell cycle arrest // Prostate. 2001. — V. 49 (4). — P. 285−292.
- Ito Y., Pandey P., Sporn M.B. et al. A novel triterpenoid CDDO induced apoptosis and differentiation of human osteosarcoma cells by caspase-8 dependent mechanism//Mol. Pharmacol. -2001.- V. 59.-P. 1094−1099.
- Iwatani M., Ikegami K., Kremenska Y., Hattori N., Tanaka S., Yagi S., Shiota K. Dimethyl sulfoxide has an impact on epigenetic profile in mouse embryoid body // Stem Cells. 2006. — V. 24 (11). — P. 2549−2556.
- Jack M.T., Woo R.A., Hirao A. et al. Chk2 is dispensable for /?53-mediated (//-arrest but is required for a latent /755-mediated apoptotic response // PNAS. -2002. V. 99, № 15. — P. 9825−9829.
- Jack M.T., Woo R.A., Motoyama N. et al. DNA-dependent protein kinase and checkpoint kinase 2 synergistically activate a latent population of p53 upon DNA damage // J. Biol. Chem. 2004. — V. 279 (15). — P. 15 269−15 273.
- Jackon A., Werner N. Preparation, staining, and analysis by cytometry of peripheral blood leukocytes // Manual of clinical laboratory immunology. 1986. -3rd ed. Wash. (D.C.): Amer. Soc. For Microbiology. — P. 226−235.
- Jacquel A., Herrant M., Legros L., Belhacene N., Luciano F., Pages G., Hofman P., Auberger P. Imatinib induces mitochondria-dependent apoptosis of the
- Bcr-Abl positive K562 cell line and its differentiation towards the erythroid lineage // FASEB J. 2003. — V. 17 (14). — P. 2160−2162.
- James S.Y., Williams M.A., Kelsey S.M., Newland A.C., Colston K.W. The role of vitamin D derivatives and retinoids in the differentiation of human leukaemia cells // Biochem Pharmacol. 1997. — V. 54 (5). — P. 625−634.
- Jensen M.R., Factor V.M., Thorgeirsson S.S. Regulation of cyclin G/ during murine hepatic regeneration following Dipin-induced DNA damage // Hepatology. -1998.-V. 28 (2).-P. 537−546.
- Ji Y., Studzinski G.P. Retinoblastoma protein and CCAAT/qnhancer-binding protein beta are required for 1,25-dihydroxyvitamin Dj-induced monocytic differentiation of HL-60 cells // Cancer Res. 2004. — V. 64 (1). — P. 370−377.
- Joe Y.S., Jeong J.-H., Yang S. et al. ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis // J. Biol. Chem. 2006. — V. 281, Is. 39. — P. 28 764−28 771.
- Johnson V.L., Ko S.C., Holmstrom T.H. et al. Effector caspases are dispensable for the early nuclear morphological changes during chemical-induced apoptosis // J Cell Sci. 2000. — V. 113 (17). — P. 2941−2953.
- Kanda H., Takatori S., Matsuda A., Sasaki T., Tanaka M., Fukushima M., Wataya Y. Cytotoxic mechanisms of new antitumor nucleoside analogues, 3'-ethynylcytidine (ECyd) and 3'-ethynyluridine (EUrd) II Nucleic Acids Symp Ser. -1997.-V. 37.-P. 137−138.
- Kang C.D., Han C.S., Kim K.W., Do I.R., Kim C.M., Kim S.H., Lee E.Y., Chung B.S. Activation of NF-kappaB mediates the PM4-induced differentiation of K562 cells // Cancer Lett. 1998. — V. 132 (1−2). — P. 99−106.
- Kang C. D, Lee B. K, Kim K.W., Kim C. M, Kim S.H., Chung B.S. Signaling mechanism of PMA-induced differentiation of K562 cells // Biochem Biophys Res Commun. 1996. — V. 221 (1). — P. 95−100.
- Kaye S.B. New antimetabolites in cancer chemotherapy and their clinical impact//Br J Cancer.- 1998.-V. 78 (Suppl 3). P. 1−7.
- Kim H. J, Mun J. Y, Chun Y.J. et al.ox-dependent apoptosis induced by ceramide in HL-60 cells // FEBS Lett. 2001a. — V. 505 (2). — P. 264−268.
- Kim S. S, Chae H. S, Bach J.H. et al. p53 Mediates ceramide-induced apoptosis in SKN-SH cells // Oncogene. 2002. — V. 21 (13). 2020−2028.
- Kim Y.-J, Park H.-J, Yoon S.-H, Kim M.-J, Leem K.-H, Chung J.-H, Kim H.-K. Anticancer effects of oligomeric proanthocyanidins on human colorectal cancer cell line, SNU-C4 II World J Gastroenterol. 2005. — V. 11 (30). — P. 46 744 678.
- King R.F.G., Broun S.B. The mechanism of catabolism. A study of hem breakdown in spleen microsomal fraction and in a model system by 018 labeling and in a model substitution//Biochem. J., 1978. V. 174. -N. l.-P. 103−109.
- Ко L.J., Prive C. p53: puzzle and paradigm // Genes Develop. 1996. — V. 10, № 9.-P. 1054−1072.
- Koeffler H.P., Golde D.W. Human myeloid leukemia cell lines: a review // Blood. 1980. — V. 56 (3). — P. 344−350.
- Koehler L., Hass R., Wessel K. et al. Altered arachidonic acid metabolism during differentiation of the human monoblastoid cell line U937 II Biochim. Biophys. Acta. 1990.-V. 1042.-P. 395−403.
- Kohgo S., Horie H., Ohrui H. Synthesis of 4'-C-ethynyl-beta-?>-arabino- and 4'-C-ethynyl-2'-deoxy-beta-D-ribo-pentofuranosyl pyrimidines, and their biological evaluation // Biosci Biotechnol Biochem. 1999. — Jun 63(6). — P. 1146−1149.
- Kovalenko T.A., Kharitonchik L.A., Rogozhina O.G., Vrzhesinskaia O.A., Kodentsova V.M., Stroev E.A., Seleznev N.G. The effect of ftalazol on the body allowance in rats of B-group vitamins // Eksp. Klin.Farmakol. 1999. — V. 62 (1). -P. 48−49.
- Kremenetskaya O.S., Logacheva N.P., Baryshnikov A.Y., Chumakov P.M., Kopnin B.P. Distinct effects of various p53 mutants on differentiation and viability of human K562 leukemia cells // Oncol Res. 1997. — V. 9 (4). — V. 155−166.
- Krishna R., Mayer L.D. Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs // Eur J Pharm Sci. 2000. — V. 11 (4). — P. 265−283.
- Kuo H.C., Kuo W.H., Lee Y.J., Wang C.J., Tseng T.H. Enhancement of caffeic acid phenethyl ester on all-trans retinoic acid-induced differentiation in human leukemia HL-60 cells // Toxicol Appl Pharmacol. 2006. — V. 216 (1). — P. 80−88.
- Laskay T., Kiessling R. Interferon and butyrate treatment leads to a decreased sensitivity of NK target cells to lysis by homologous but not by heterologous effector cells // Nat. Immun. Cell Growth Regul. 1986. — V. 5. — P. 211−220.
- Leary J.F., Ohlsson-Wilhelm B.M., Giuliano R. et al. Multipotent human hematopoietic cell line K562: Lineage-specific constitutive and inducible antigens // Leuk. Res.-1987.-V. 11 (9).-P. 807−815.
- Lee C.H., Yun H.J., Kang H.S. Kim H.D. ERK/MAPKpathway is required for changes of cyclin D1 and B1 during phorbol 12-myristate 13-acetate-induced differentiation of K562 cells // IUBMB Life. 1999. — V. 48 (6). — P. 585−591.
- Levade T., Jaffrezou J.P. Signaling sphingomyelinases: which, where, how and why? // Biochim. Biophys. Acta. 1999. — V. 1438. — P. 1−17.
- Lotem J., Sachs L. Control of apoptosis in hematopoiesis and leukemia by cytokines, tumor suppressor and oncogenes // Leukemia. 1996. — V. 10. — P.925−931.
- Lozzio C.B., Lozzio B.B. Human chronic myelogenous leukemia cell with positive Philadelphia chromosome // Blood. 1975. — V. 45. — P. 321−334.
- Luisi-DeLuca C., Mitchell T., Spriggs D., Kufe D.W. Induction of terminal differentiation in human K562 erythroleukemia cells by arabinofuranosylcytosine // J Clin Invest. 1984. — V. 74 (3). — P. 821−827.
- Maanen M.J., Smeets C.J., Beijnen J.H. Chemistry, pharmacology and pharmacokinetics of A^A^A^-triethylenethiophosphoramide (thioTEPA) // Cancer Treat Rev. 2000. — V. 26 (4). — P. 257−268.
- Mahdavi M., Yazdanparast R. Gnidilatimonoein from Daphne mucronata induces differentiation and apoptosis in leukemia cell lines // Arch Pharm Res. -2007.-V. 30 (2).-P. 177−181.
- Marcinkowska E., Garay E., Gocek E., Chrobak A., Wang X., Studzinski G.P. Regulation of C/EBPbeta isoforms by MAPK pathways in HL-60 cells induced todifferentiate by 1,25-dihydroxyvitamin D3 II Exp Cell Res. 2006. — V. 312 (11). -P. 2054−2065.
- Marzo I., Perez-Galan P., Giraldo P., Rubio-Felix D., Anel A., Naval J. Cladribine induces apoptosis in human leukaemia cells by caspase-dependent and -independent pathways acting on mitochondria // Biochem J. 2001. — Nov 1- 359 (Pt 3).-P. 537−546.
- Matsuda A., Nakajima Y., Azuma A., Tanaka M., Sasaki T. 2'-C-cyano-2'-deoxy-l-/?-D-arabinofuranosyl-cytosine (CNDAC): design of a potential mechanism-based DNA-strand-breaking antineoplastic nucleoside // J Med Chem. 1991a. — V. 34.-P. 2917−2919.
- Matsuda A., Sasaki T. Antitumor activity of sugar-modified cytosine nucleosides // Cancer Sci. 2004. — Feb 95(2). — P. 105−111.
- Matsuda A., Azuma A. 2'-C-Cyano-2'-deoxy-l-beta-.?>-arabinofuranosylcytosine (CNDAC): A mechanism-based DNA-strand-breaking antitumor nucleoside // Nucleosides Nucleotides. 1995. — V. 14. — P. 461−471.
- McGahon A., Bissonnette R., Schmitt M. et al. BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell // Blood. 1994. — V. 83 (12), Is. 5-P. 1179−1187.
- McGee M.M., Hyland E., Campiani G. et al. Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1,5-benzoxazepine, PBOX-6IIFEBS Lett. 2002. — V. 515 (1−3). — P. 66−70.
- McGuckin C.P., Forraz N., Liu W.M. Diaminofluorene stain detects erythroid differentiation in immature haemopoietic cells treated with EPO, IL-3, SCF,
- TGFbetal, MIP-1 alpha and INF gamma II Eur. J. Haematol. 2003. — V. 70. — P. 106−114.
- Meinhardt G., Eppinger E., Sehmidmaier R. Effects of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells // Anticancer Drugs. 2002. — V. 13, № 7. — P. 725−733.
- Mengubas K., Riordan F.A., Hoffbrand A.V. et al. Co-ordinated downregulation of bcl-2 and bax expression during granulocytic and macrophage-like differentiation of the HL-60 promyelocytic leukemia cell line // FEBS Lett. -1996.-V. 394.-P. 356−360.
- Mese H., Sasaki A., Nakayama S. et al. The role of caspase family protease, caspase-3 on cisplatin-induced apoptosis in cisplatin-resistant A431 cell line // Cancer Chemother Pharmacol. 2000. — V. 46 (3). — P. 241−245.
- Mignone R.G., Weber E.T. Potent inhibition of cell proliferation in the hippocampal dentate gyrus of mice by the chemotherapeutic drug thioTEPA II Brain Res. 2006. — V. 1111 (1). — P. 26−29.
- Miranda M.B., McGuire T.F., Johnson D.E. Importance of MEK-ll-2 signaling in monocytic and granulocytic differentiation of myeloid cell lines // Leukemia. 2002. — V. 16 (4). — P. 683−692.
- Mlejnek P., Kuglik P. Induction of apoptosis in HL-60 cells by N (6)-benzyladenosine // J Cell Biochem. 2000. — V. 77 (1). — P. 6−17.
- Moon N.-S., Di Stefano L., Dyson N. A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbfl mutant cells to ?2F-dependent apoptosis // Molecular and Cellular Biology. 2006. — V. 26, № 20 — P. 7601−7615.
- Moosavi M.A., Yazdanparast R., Sanati M.H. et al. 3-Hydrogenkwadaphnin targets inosine 5'-monophosphate dehydrogenase and triggers post-Gy arrest apoptosis in human leukemia cell lines // Int J Biochem Cell Biol. 2005a. — V. 37 (11).-P. 2366−2379.
- Moosavi M.A., Yazdanparast R., Sanati M.H. et al. The cytotoxic and antiproliferative effects of 3-hydrogenkwadaphnin in K562 and jurkat cells is reduced by guanosine // J Biochem Mol Biol. 2005b. — V. 38 (4). — P. 391−398.
- Munoz-Alonso M.J., Acosta J.C., Richard C., Delgado M.D., Sedivy J., Leon Lp21Cipl andp27Kipl induce distinct cell cycle effects and differentiation programs in myeloid leukemia cells // J. Biol. Chem. 2005. — V. 280, Is. 18. — P. 18 120−18 129.
- Murata D., Endo Y., Obata T., Sakamoto K., Syouji Y., Kadohira M., Matsuda A., Sasaki T. A crucial role of uridine/cytidine kinase 2 in antitumor activity of 3'-ethynyl nucleosides // Drug Metab Dispos. 2004. — Oct 32(10). — P. 1178−1182.
- Nagano A., Kakutani T., Matumoto Y., Ebara Y., Kanja K., Kankawa S., Wataya Y. The molecular mechanisms of 5-fluoro-2'-deoxyuridine induced cell death //Nucleic Acids Symp Ser. 1997. — V. 37. — P. 135−136.
- Nagata S. Apoptotic DNA fragmentation // Exp. Cell Res. 2000. — V. 256. -P. 12−18.
- Namavati U.B., Pawliezak R., Doniger J., Gladwin M.T. et al. Oxidant-induced cell death in respiratory epithelial cells is due to DNA damage and loss of ATP II Exp. Lung. Res. 2002. — V. 28 (2). — P. 591−607.
- Nisselbaum J.S., Green S.A. A simple ultramicromethod for determination of pyridine nucleotides in tissue // Anal. Biochem. 1969. — V. 27. — P. 212−217.
- Nurse P. Universal control mechanism regulating onset of A/-phase // Nature (Lond). 1990. — V. 344. — P. 503−508.
- Obata T., Endo Y., Murata D., Sakamoto K., Sasaki T. The molecular targets of antitumor 2'-deoxycytidine analogues // Curr Drug Targets. 2003. — May 4(4). -P. 305−313.
- Obata T., Endo Y., Tanaka M., Uchida H., Matsuda A., Sasaki T. Deletion mutants of human deoxycytidine kinase mRNA in cells resistant to antitumor cytosine nucleosides // Jpn J Cancer Res. 2001. — Jul- 92(7). — P. 793−798.
- Oberg F., Botling J., Nilsson K. Functional antagonism between vitamin D3 and retinoic acid in the regulation of CD 14 and CD23 expression during monocytic differentiation of U937 cells // J. Immunol. 1993. — V. 150. — P. 3487−3492.
- Ochiai E. Aromatic amino N-oxides. 1967. — Amsterdam: Elsevier. — 450 p.
- Ohlsson-Wilhelm B.M., Farley B.A., Kosciolek B., La Bella S., Rowley P.T. K562 human erythroleukemia cell variants resistant to growth inhibition by butyrate have deficient histone acetylation // Am. J. Hum. Genet. 1984. — V. 36 (6). — P. 1225−1238.
- Osawa M., Yamaguchi T., Nakamura Y., Kaneko S., Onodera M., Sawada K.i., Jegalian A., Wu H., Nakauchi H., Iwama A. Erythroid expansion mediated by the Gfl-IB zinc finger protein: role in normal hematopoiesis // Blood. 2002. — V. 100, № 8.-P. 2769−2777.
- Osborn M.T., Berry A., Ruberu M. S., Ning B., Bell L.M., Chambers T.C. Phorbol ester induced MDR1 expression in K562 cells occurs independently of mitogen-activated protein kinase signaling pathways // Oncogene. 1999. — V. 18 (42).-P. 5756−5764.
- Osti F., Corradini F.G., Hanau S., Matteuzzi M., Gambari R. Human leukemia K562 cells: induction to erythroid differentiation by guanine, guanosine and guanine nucleotides // Haematologica. 1997. — V. 82 (4). — P. 395−401.
- Otani M., Yoshida S., Yoshioka-Hiramoto A. et al. The dNTP imbalance death // Nucleic Acids Symp Ser. 1991. — V. 25. — P. 111−112.
- Owa T., Nagasu T. Novel sulphonamide derivatives for the treatment of cancer // Exp. Opin. Ther. Patents. 2000. — V. 10. — P. 1725−1740.
- Owa T., Yoshino H., Okauchi T., Yoshimatsu K., Ozawa Y., Sugi N.H., Nagasu T., Koyanagi N., Kitoh K. Discovery of novel antitumor sulfonamides targeting G, phase of the cell cycle // J. Med. Chem. 1999. — V. 42. — P. 3789−3799.
- Palozza P., Serini S., Torsello A. et al. Mechanism of activation of caspase cascade during beta-carotene-induced apoptosis in human tumor cells // Nutr Cancer. -2003. -V. 47(1).-P. 76−87.
- Pandey P., Nakazawa A., Ito Y. et al. Requirement for caspase activation in monocytic differentiation of myeloid leukemia cells // Ibid. 2000. — V. 19. — P. 3941−3947.
- Park B., Fikring S., Smitkwick B. Infection and nitroblue-tetrazolium reduction by neurophils // Lancet. 1988. — V. 2. — P. 532−534.
- Park J.-I., Choi H.-S., Jeong J.-S., Han J.-Y., Kim I.-H. Involvement of p38 kinase in hydroxyurea-induced differentiation of K562 cells // Cell Growth & Differentiation. 2001. — V. 12. — P. 481−486.
- Park M.T., Kang J.A., Choi J.A. et al. Phytosphingosine induces apoptotic cell death via caspase 8 activation and Bax translocation in human cancer cells // Clin Cancer Res. 2003. — V. 9 (2). — P. 878−885.
- Perkins C.L., Fang G" Kim C.N., Bhalla K.N. The role of Apaf-1, caspase-9, and bid proteins in etoposide- or paclitaxel-induced mitochondrial events during apoptosis // Cancer Res. 2000a. — V. 60 (6). — P. 1645−1653.
- Perkins C., Kim C.N., Fang G. et al. Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-Xi II Blood. 2000b. — V. 95 (3). — P. 1014−1022.
- Perkins C., Kim C.N., Fang G., Bhalla K.N. Overexpression of Apaf-1 promotes apoptosis of untreated and paclitaxel- or etoposide-treated HL-60 cells // Cancer Res. 1998. — V. 58 (20). — P. 4561−4566.
- Petrosillo G., Ruggiero F.M., Paradies G. Role of reactive oxygen species and cardiolipin in the release cytochrome c from mitochondria // The FASEB Journal. -2003.-V. 17.-P. 2202−2208.
- Pinkoski M.J., Brunner T., Green D.R. et al. Fas and Fas ligand in gut and liver // Am. J. Physiol. Gastrointest. 2000. — V. 278. — P. 354−366.
- Piwocka K., Vejda S., Cotter T.G. et al. Bcr-Abl reduces endoplasmic reticulum releasable calcium levels by a 5c/-2-independent mechanism and inhibits calcium-dependent apoptotic signaling // Blood. -2006. V. 107 (10). — P. 40 034 010,
- Plo I., Liao Z.Y., Barcelo J.M. et al. Association oiXRCCl and tyrosyl DNA phosphodiesterase (Tdpl) for the repair of topoisomerase /-mediated DNA lesions // DNA Repair (Amst). 2003. — V. 2. — P. 1087−1100.
- Podack E.R., Kupfer A. T-cell effector functions: mechanisms for delivery of cytotoxicity and help // Annu. Rev. Cell Biol. 1991. — V. 7. — P. 479−504.
- Powers J.T., Hong S.K., Mayhew C.N. et al. E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis // Molecular Cancer Research. 2004. — V. 2. — P. 203−214.
- Prado I.B., Laudanna A.A., Carneiro C.R. Susceptibility of colorectal-carcinoma cells to natural-killer-mediated lysis: Relationship to CEA expression and degree of differentiation // Intern. J. Cancer. 1995. — V.61. — P. 854−860.
- Prados J., Melguizo C., Marchai J.A., Velez C., Alvarez L., Aranega A. Therapeutic differentiation in a human rhabdomyosarcoma cell line selected for resistance to actinomycin D // Int J Cancer. 1998. — V. 75 (3). — P. 379−383.
- Pusapati R.V., Rounbehler R.J., Hong S. et al. ATM promotes apoptosis and suppresses tumorigenesis in response to Myc II PNAS. -2006. V. 103 (5). — P. 1446- 1451.
- Queva C., Hurlin P.J., Foley K.P., Eisenman R.N. Sequential expression of the MAD family of transcriptional repressors during differentiation and development // Oncogene. 1998. — Feb 26- 16 (8). — P. 967−977.
- Queva C., McArthur G.A., Ramos L.S., Eisenman R.N. Dwarfism and dysregulated proliferation in mice overexpressing the MYC antagonist MAD1 II Cell Growth & Differentiation. 1999. — V. 10. — P. 785−796.
- Racke F.K., Wang D., Zaidi Z., Kelley J., Visvader J, Soh J.W., Goldfarb A.N. A potential role for protein kinase C-epsilon in regulating megakaryocyte lineage commitment // Ibid. 2001. — V. 276, № 1. — P. 522−528.
- Rae J.M., Soukhova N.V., Flockhart D.A., Desta Z. Triethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: implications for cyclophosphamide metabolism // Drug Metab Dispos. 2002. — V. 30 (5).-P. 525−530.
- Ragg S.J., Kaga S., Berg K.A. et al. The mitogen-activated protein kinase pathway inhibits ceramide-induced terminal differentiation of a human monoblastic leukemia cell line, U937// J Immunol.- 1998,-V. 161 (3).-P. 1390−1398.
- Rathmell J.C., Thomson C.B. The central effectors of cell death in the immune system // Annu. Rev. Immunol. 1999. — V. 17. — P. 781−828.
- Regulus P., Duroux B., Bayle P.A., Favier A., Cadet J., Ravanat J.L. Oxidation of the sugar moiety of DNA by ionizing radiation or bleomycin could induce the formation of a cluster DNA lesion // Proc Natl Acad Sci USA.- 2007. -Epub ahead of print.
- Reynolds E.C., Harris A.W., Finch L.R. Deoxyribonucleoside triphosphate pools and differential thymidine sensitivities of cultured mouse lymphoma and myeloma cells // Biochim. biophys. acta. 1979. — V. 561. — P. 110−123.
- Richter C., Schweizer M., Cossarizza A. et al. Control of apoptosis by the cellular A TP level // FEBS Lett. 1996. — V. 378, № 2. — P. 107−110.
- Richter T., Schwab M., Eichelbaum M., Zanger U.M. Inhibition of human CYP2B6 by AfA^A^-triethylenethiophosphoramide is irreversible and mechanism-based // Biochem Pharmacol. 2005. — V. 69 (3). — P. 517−524.
- Robert G.H., White E., Phillips E.S., Lillycrop K.A. The expression of the developmentally regulated proto-oncogene Pax-3 is modulated by N-Myc II J. Biol. Chem. 2002. — V. 277, Is. 38. — P. 34 815−34 825.
- Robertson K.A., Hill D.P., Xu Y. et al. Downregulation of apurinic/apyrimidinic endonuclease expression is associated with the induction of apoptosis in differentiating myeloid leukemia cells // Cell Growth Differ. 1997. -V. 8 (4).-P. 443−449.
- Rogoff H.A., Pickering M.T., Frame F.M. et al. Apoptosis associated with deregulated E2 °F activity is dependent on E2F1 and AtmlNbsllChk2 II Molecular and Cellular Biology. 2004. — V. 24, № 7. — P. 2968−2977.
- Rupinder S.K., Gurpreet A.K., Manjeet S. Cell suicide and caspases // Vascul. Pharmacol. 2007. — V. 46 (6). — P. 383−393.
- Saunders L.R., Verdin E. Ornithine decarboxylase activity in tumor cell lines correlates with sensitivity to cell death induced by histone deacetylase inhibitors // Mol Cancer Ther. 2006. — V. 5. — P. 2777−2785.
- Saven A., Piro L. D. 2-Chlorodeoxyadenosine: a newer purine analog active in the treatment of indolent lymphoid malignancies // Ann Intern Med. 1994. — V. 120.-P. 784−791.
- Scaffidi C., Fulda S., Srinivasan A., Friesen C., Li F., Tomaselli K.J., Debatin K.-M., Krammer P.H., Peter M.E. Two CD95 (APO-llFas) signaling pathways // EMBO J. 1998. -V. 17.-P. 1675−1687.
- Scozzafava A., Owa T., Mastrolorenzo A., Supuran C.T. Anticancer and antiviral sulfonamides // Curr Med Chem. 2003. — Jun- 10(11). — P. 925−953.
- Scozzafava A., Mastrolorenzo A., Supuran C.T. Arylsulfonyl-A^V-diethyl-dithiocarbamates: a novel class of antitumor agents // Bioorg. Med. Chem. Lett. -2000.-V. 10.-P. 1887−1891.
- Scozzafava A., Mastrolorenzo A., Supuran C. T. Arylsulfonyl-iV, Af-dialkyl-dithiocarbamates as tumor cell growth inhibitors: novel agents targeting-tubulin // J. Enz. Inhib. 2001. — V. 16. — P. 55−64.
- Shelly C., Petruzzelli L., Herrera R. PMA-induced phenotypic changes in K562 cells: MAPK-dependent and -independent events // Leukemia. 1998. — V. 12. -P. 1951−1961.
- Shoemaker R.H. The NCI-60 human tumor cell line anticancer drug screen // Nature Reviews. Cancer. 2006. — V. 6 (10). — P. 813−823.
- Simonova V.S., Samusenko A.V., Filippova N.A., Tevyashova A.N., Lyniv L.S., Kulik G.I., Chekhun V.F., Shtil A.A. Olivomycin induces tumor cell apoptosis and suppresses/?55-induced transcription // Bull Exp Biol Med. 2005. — V. 139 (4). -P. 455−459.
- Smith H.J., Nicholls P.J., Simons C" Le Lain R. Inhibitors of steroidogenesis for the treatment of hormone-dependent cancers//Exp. Opin. Ther. Patents. 2001. -V. 11.-P. 789−824.
- Solazzo M., Fantappie O., Lasagna N., Sassoli C., Nosi D., Mazzanti R. P-gp localization in mitochondria and its functional characterization in multiple drug-resistant cell lines // Exp Cell Res. 2006. — V.312 (20). — P. 4070−4078.
- Stennicke H.R., Salvesen G.S. Caspases: enemies within // Biochim. Biophys. Acta. 2000. — V. 1477. — P. 299−306.
- Storkus W.J., Dawson J.R. 5-cell sensitivity to natural killing: Correlation with target cell stage of differentiation state of activation // J. Immunol. 1986. — V. 136.-P. 1542−1547.
- Studzinski G.P., Rathod B., Wang Q.M. et al. Uncoupling of cell cycle arrest from the expression of monocytic differentiation markers in HL-60 cell variants // Exp Cell Res. 1997. — V. 232 (2). — P. 376−387.
- Subhashini J., Mahipal S.V., Reddy M.C. et al. Molecular mechanisms in C-phycocyanin induced apoptosis in human chronic myeloid leukemia cell line-.K5<52 // Biochem Pharmacol. 2004. — V. 68 (3). — P. 453−462.
- Sugiura M., Fram R., Munroe D" Kufe D. DNA strand scission and ADP-ribosyltransferase activity during murine erythroleukemia cell differentiation // Dev. Biol. -1984.-V. 104 (2).-P.484−488.
- Sundstrom C., Nilsson K. Establishment and characterization of a human histiocytic lymphoma cell line (U9S7) II International Journal of Cancer. 1976. — V. 17, Is. 5.-P. 565−577.
- Supuran C.T., Scozzafava A. Carbonic anhydrase inhibitors // Curr. Med. Chem. Immunol., Endoc. Metab. Agents. 2001. — V. 1. — P. 61 -97.
- Supuran C.T., Casini A., Scozzafava A. Protease inhibitors of the sulfonamide type: anticancer, antiinflammatory, and antiviral agents // Med Res Rev. 2003. -Sep- 23(5).-P. 535−558.
- Svingen P.A., Loegering D., Rodriquez J. et al. Components of the cell death machine and drug sensitivity of the national cancer institute cell line panel // Clinical Cancer Research. 2004. — V. 10. — P. 6807−6820.
- Sylvester P.W., Shah S. Intracellular mechanisms mediating tocotrienol-induced apoptosis in neoplastic mammary epithelial cells // Asia Pac J Clin Nutr. -2005.-V. 14 (4).-P. 366−373.
- Tanaka M., Matsuda A., Terao T., Sasaki T. Antitumor activity of a novel nucleoside, 2' -C-cyano-2' -deoxy-1 -beta-D-arabinofuranosylcytos ine (CNDA C) against murine and human tumor // Cancer Lett. 1992. — May 30- 64(1). — P. 67−74.
- Tanaka M., Tabata S., Matsuda A., Fukushima M., Eshima K., Sasaki T. Antitumor effect and mechanism of a novel multifunctional nucleoside, 3'-ethynylnucleoside, on human cancers // Gan To Kagaku Ryoho. 1997. — Feb- 24(4). -P. 476−482.
- Terui Y., Furukawa Y., Kikuchi J. et al. Bcl-x is a regulatory factor of apoptosis and differentiation in megakaryocyte lineage cells // Exp. Hematol. -1998.-V. 26.-P. 236−244.
- Tiwari K.N., Fowler A.S., Secrist J.A. 3rd Synthesis and biological activity of 2'-deoxy-4'-thio-pyrazolo3,4-d.pyrimidine nucleosides // Nucleosides Nucleotides Nucleic Acids. 2005. — V. 24(5−7). — P. 911−914.
- Tong B., Grimes H.L., Yang T.-Y., Bear S. E., Qin Z., Du K., El-Deiry W.S., Tsichlis P.N. The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation // Mol Cell Biol. 1998. — V. 18, № 5. — P. 2462−2473.
- Torrano V., Chernukhin I., Docquier F., D’Arcy V., Leon J., Klenova E., Delgado M.D. CTCF regulates growth and erythroid differentiation of human myeloid leukemia cells // J. Biol. Chem. 2005. — V. 280, Is. 30. — P. 28 152−28 161.
- Tsuruo T., Iida H., Tsukagoshi S. et al. Overcoming of vincristine resistance in F388 leukemia in vivo and in vitro through enchanced cytotoxicity of vincristine and vinblastine by verapamil//Cancer. 1981.-V. 41.-P. 1967−1972.
- Uchikubo Y, Hasegawa T, Mitani S, Kim H. S, Wataya Y. Mechanisms of cell death induced by 5-fluoro-2'-deoxyuridine (FUdR) necrosis or apoptosis after treated with FudR II Nucleic Acids Res Suppl. 2002. — V. 2. — P. 245−246.
- Ueda N, Tsukahara N, Watanabe T. ER-34 410, a structurally novel sulfonamide as a potential and injectable antitumor agent // Proc. Am. Assoc. Cancer Res. 1995. — V. 36. — Abstract 2290.
- Vrana J. A, Saunders A.M., Chellappan S.P. et al. Divergent effects of bryostatin 1 and phorbol myristate acetate on cell cycle arrest and maturation in human myelomonocytic leukemia cells (U937) II Differentiation. 1998b. — V. 63 (l).-P. 33−42.
- Walczak H" Krammer P.H. The CD95 (APO-l/Fas) and the TRAIL (.APO-2L) apoptosis systems // Exp. Cell Res. 2000. — V. 256. — P. 58−66.
- Wang Q., Fan S., Eastman A., Worland P.J., Sausville E.A., O’Connor P.M. UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53 IIJ Nat Cancer Inst. 1996. — Jul 17- 88(14). — P. 956−965.
- Wang Q., Salman H., Danilenko M., Studzinski G.P. Cooperation between antioxidants and 1,25-dihydroxyvitamin D3 in induction of leukemia HL-60 cell differentiation through the JNKIAP-l/Egr-1 pathway // J Cell Physiol. 2005. — V. 204 (3). — P. 964−974.
- Wang Q., Wang X., Studzinski G.P. Jun iV-terminal kinase pathway enhances signaling of monocytic differentiation of human leukemia cells induced by 1,25-dihydroxyvitamin D3IIJ Cell Biochem. 2003a. — V. 89 (6). — P. 1087−1101.
- Wang S., Wang Z" Grant S. Bryostatin 1 and UCN-01 potentiate 1 -fi-D-arabinofuranosylcytosine-induced apoptosis in human myeloid leukemia cells through disparate mechanisms // Molecular pharmacology. 2003b. — V. 63, Is. 1. -P. 232−242.
- Wang X., Studzinski G.P. Activation of extracellular signal-regulated kinases (ERKs) defines the first phase of 1,25-dihydroxyvitamin Dj-induced differentiation of HL-60 cells // J Cell Biochem. 2001a. — V. 80 (4). — P. 471−482.
- Wang X., Studzinski G.P. Inhibition of p38MAP kinase potentiates the JNKISAPK pathway and AP-1 activity in monocytic but not in macrophage or granulocytic differentiation oi HL-60 cells // J Cell Biochem. 2001b. -V. 82 (1). -P. 68−77.
- Wang X., Wang T.T., White J.H., Studzinski G.P. Induction of kinase suppressor of Ras-1 (KSR-1) gene by l-a-25-dihidroxyvitamin D3 in human leukemia
- HL-60 cells through a vitamin D response element in the 5'-flanking region // Oncogene. 2006b. — V. 25(53). — P. 7078−7085.
- Wang X.H., He S.Y., Zhang Y., Xu J, Feng Q., Li L., Mi L., Chen Z.N. DMSO arrested hybridoma cells for enchanced antibody production // Sheng Wu Gong Cheng Xue Bao. 2004. — V. 20 (4). — P. 568−571.
- Wang Z., Wang S., Dai Y. et al. Bryostatin 1 increases 1-beta-D-arabinofuranosylcytosine-induced cytochrome c release and apoptosis in human leukemia cells ectopically expressing Bcl-XL H J Pharmacol Exp Ther. 2002. — V. 301 (2).-P. 568−577.
- Wataya Y., Futagami M., Naito T., Uchikubo Y., Yokogawa T., Takenaka K., Kim H.S., Matsuda A., Fukushima M., Kitade Y. Anticancer molecular mechanism of 3'-ethynylcytidine (ECyd) II Nucleic Acids Res Suppl. 2001. — V. 1. — P. 233 234.
- Wataya Y., Hwang H., Nakazawa T. et al. Molecular mechanism of cell death induced dNTP pool imbalance // Nucleic Acids Symp Ser. 1993. — V. 29. — P. 109 110.
- Werkmeister J.A., Pross H.F., Roder J.C. Modulation of K562 cells with sodium butyrate. Assotiation of impared NK susceptibility with sialic acid and analysis of other parameters // Intern. J. Cancer. 1983. — V. 32. — P. 71−78.
- Whittaker M., Floyd C.D., Brown P., Gearing A.J.H. Design and therapeutic application of matrix metalloproteinase inhibitors // Chem. Rev. 1999. — V. 99. — P. 2735−2776.
- Witt 0., Sand K., Pekrun A. Butyrate-induced erythroid differentiation of human K562 leukemia cells involves inhibition of ERK and activation of p38 MAP kinase pathways // Blood. 2000. — V. 95, № 7. — P. 2391−2396.
- Woessmann W., Mivechi N.F. Role of ERK activation in growth and erythroid differentiation of K562 cells // Exp. Cell Res. 2001. — V. 264 (2). — P. 193−200.
- Wolf B.B., Green D.R. Suicidal tendencies: apoptotic cell death by caspase family proteinases // J. Biol. Chem. 1999. — V. 274, № 29. — P. 20 049−20 052.
- Wolf D., Rotter V. Major deletions in the gene encoding the p53 tumor antigen cause lack ofp53 expression in HL-60 cells // Proc. Natl. Acad. Sci. USA. -1985.-V. 82 (3).-P. 790−794.
- Wong W.W.-L., MacDonald S., Langler R.F., Penn L.Z. Novel synthetic organosulfur compounds induce apoptosis of human leukemic cells // Anticancer Res. 2000. — V. 20. — P. 1367−1374.
- Wu J., Suzuki H., Akhand A. A et al. Modes of activation of mitogen-activated protein kinases and their roles in cepharanthine-induced apoptosis in human leukemia cells // Cell Signal. -2002b. V. 14 (6). — P. 509−515.
- Wu J., Suzuki H., Zhou Y.W. et al. Cepharanthine activates caspases and induces apoptosis in Jurkat and K562 human leukemia cell lines // J Cell Biochem. -2001.-V. 82 (2).-P. 200−214.
- Wu X., Chen J. Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis // J. Biol. Chem. 2003. — V. 278, Is. 38. -P. 36 163−36 168.
- Yamamoto S., Tamai H., Ishisaka R., Kanno T., Arita K., Kobuchi H., Utsumi K. Mechanism of alpha-tocopheryl succinate-induced apoptosis of promyelocytic leukemia cells // Free Radic Res. 2000. — V. 33 (4). — P. 407−418.
- Yang S., Jeong J.-H., Brown A.L. et al. Promyelocytic leukemia activates Chk2 by mediating Chk2 autophosphorylation // J. Biol. Chem. 2006. — V. 281, Is. 36.-P. 26 645−26 654.
- Yao C., Works K., Austin G.E. Role of transcription factor HBP1 in human leukaemic cell proliferation, apoptosis and differentiation // Blood (ASH Annual Meeting Abstracts). 2004. — V. 104. — Abstract 3556.
- Yazdanparast R., Moosavi M.A., Mahdavi M. et al. 3-Hydrogenkwadaphnin from Dendrostellera lessertii induces differentiation and apoptosis in HL-60 cells // PlantaMed.-2005.- V. 71 (12).-P. 1112−1117.
- Yoshimatsu K., Yamaguchi A., Yoshino H., Koyanagi N., Kitoh K. Mechanism of action of E7010, an orally active sulfonamide antitumor agent: inhibition of mitosis by binding to the colchicine site of tubulin // Cancer Res. -1997.-V. 57.-P. 3208−3213.
- Yoshioka A., Tanaka S., Hiraoka O., Koyama Y., Hirota Y., Wataya Y. The mechanism of dNTP-unbalanced cell death induced by 5-fluorouracil and its derivatives//Nucleic Acids Symp Ser. 1985. — V.16. -P. 245−248.
- Yu C., Krystal G., Dent P. et al. Flavopiridol potentiates STI571 -induced mitochondrial damage and apoptosis in BCR-ABL-positive human leukemia cells // Clin Cancer Res. 2002a. — V. 8 (9). — P. 2976−2984.
- Yu C., Rahmani M., Almenara J. et al. Histone deacetylase inhibitors promote 5T/57/-mediated apoptosis in 577 577-sensitive and -resistant Bcr/Abt human myeloid leukemia cells // Cancer Res. 2003a. — V. 63 (9). — P. 2118−2126.
- Yu C., Rahmani M., Conrad D. et al. The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abt cells sensitive and resistant to STI571II Blood. 2003b. — V. 102 (10). — P. 3765−3774.
- Yuksel S., Saydam G., Uslu R. et al. Arsenic trioxide and methylprednisolone use different signal transduction pathway in leukemic differentiation // Leuk. Res. -2002.-V. 26.-P. 391−398.
- Zhang J.-W., Peng H., Du Z.-W. Identification, characterization of a novel zinc finger protein (HZF1) gene and its roles in erythroid and megakaryocyte differentiation II Blood (ASH Annual Meeting Abstracts). 2005. — V. 106. -Abstract 4237.
- Zhang L., Insel P.A. The pro-apoptotic protein Bim is a convergence point for cAMPIprote’m kinase A- and glucocorticoid-promoted apoptosis of lymphoid cells // J. Biol. Chem. 2004. — V. 279, Is. 20. — P. 20 858−20 865.
- Zhang M., Endo Y., Sasaki T. Determinants in chemosensitivity of oncogene-transformed NIH3T3 cells to 2'-C-cyano-2'-deoxy-l-beta-D-arabino-pentofuranosylcytosine 11 Int J Oncol. 1999. — Mar- 14(3). — P. 543−549.
- ZhaoY., Tan J., Zhuang L. et al. Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bimll PNAS.-2005.-V. 102, № 44.-P. 16 090−16 095.