Исследование механизма действия тетраалкиаммониевого производного 6-метилурацила в синапсах дыхательной и локомоторных мышц крысы
Диссертация
Актуальность исследования. Ацетилхолинэстераза (АХЭ) — один из ключевых ферментов, обеспечивающих нормальное функционирование холинергических синапсов за счет ограничения действия ацетилхолина (АХ), освобождающегося из нервного окончания. Хорошо известно, что ингибирование этого фермента приводит к накоплению АХ в синаптической щели, вызывая при ритмической стимуляции стойкую деполяризацию… Читать ещё >
Список литературы
- Зобов В.В. Биологическая активность фосфорилированных производных 6-метилурацила / В. В. Зобов, Л. А. Березинский, B.C. Резник, В. Д. Акамсин // Хим,-фарм. журнал. -2002. -Т. 36, № 11. -С. 21−22.
- Зобов В.В. Отсроченные последствия интоксикации дафний селективным и неселективным ингибитором ацетилхолинэстеразы /В.В. Зобов, Л. А. Березинский, A.A. Аслямова, B.C. Резник // Бюлл. экспер. биол. и мед. -2005а. -Т 139, № 1. -С. 77−78.
- Кочетков М.А. Синтез избирательных ингибиторов бутирилхолинэстеразы -потенциальных антиатерогенных веществ: автореф. дис.. канд. хим. наук / М. А. Кочетков, ГосНИИОХТ. Москва, 1998. — 26 с.
- Кривой И.И. Нервно-мышечный синапс и антихолинэстеразные вещества / И. И. Кривой, В. И. Кулешов, Д. Л. Матюшин. Л.: изд-во ЛГУ им. A.A. Жданова, -1987. -238 с.
- Михельсон М.Я. Э.В. Ацетилхолин: О молекулярном механизме действия / М. Я. Михельсон, Э.В. Зеймаль. Л.: Наука, 1970. 279 с.
- Моралев С.М. Современные представления о структуре и каталитических свойствах холинэстераз позвоночных и беспозвоночных (обзор) / С. М. Моралев, Е. В. Розенгарт // Журнал эволюционной биохимии и физиологии. 1999. — Т.35,1,-С. 3−14.
- Моралев С.Н. «Каталитическая машина» холинэстераз разных животных устроена одинаково / С. Н. Моралев, Е. В. Розенгарт, A.A. Суворов // ДАН. 2001. -Т. 381, № 1.-С. 123−125
- Отчет о НИР ИОФХ им. А. Е. Арбузова КазНЦ РАН, инв. № 431. Казань, 1990. — 434 с.
- Прозоровский В.Б. Неантихолинэстеразные механизмы действия антихолинэстеразных средств / В. Б. Прозоровский, Н. В. Саватеев. -Л.: Медицина, 1976.- 160 с.
- Резник B.C. Новый класс ингибиторов холинэстераз: тетраалкиламмониевые производные 6-метилурацила и аллоксазина /B.C. Резник, К. А. Аникиенко, В. К. Курочкин, В. Д. Акамсин, И. В. Галяметдинова, Е. А. Бычихин // ДАН. 1998. -Т.362, № 1. — С.68−70.
- Федоров В.В. Особенности постсинаптических потенциалов и ионных токов в синапсах быстрых и медленных мышечных волокон крысы / В. В. Федоров // Нейрофизиология. 1980. -Т.11, № 6. — С. 627−636.
- Харкевич Д.А. Фармакология / Д. А. Харкевич. -М.: Медицина, 1980. С. 85−101.
- Холинэстеразы наземных животных и гидробионтов / Бресткин А. П. и др. -Владивосток: Тихоокеанский научно-исследовательский рыбохозяйственный центр (ТИНРО центр), 1997. -466 с.
- Яковлев В.А. Кинетика ферментативного катализа / В. А. Яковлев М.: Наука, 1965.-248 с.
- Adler М. Role of butyrylcholinesterase in canine tracheal smooth muscle function / M. Adler, M.G. Filbert // FEBS Lett. -1990. -V. 267. -P. 107−110.
- Anderson C.R. Voltage clamp analysis of acetylcholine produced end-plate current fluctuations at frog neuromuscular junction /C.R. Anderson, C.F. Stevens // J.Physiol. (London). 1973. — V.235. — P. 655−691.
- Anglister L. Acetylcholinesterase density and turnover number at frog neuromuscular junctions, with modeling of their role in synaptic function / L. Anglister, J.R. Stiles, M.M. Salpeter//Neuron. -1994. -V. 12, No.4. -P. 783−794
- Arpagaus M. Structure of the gene for human butyrylcholinesterase. Evidence for a single copy / M. Arpagaus, M. Kott, K.P. Yatsis, C.F. Bartels, B.N. La Du, O. Lockridge // Biochemistry. 1990. — V.29. — P. 124−131.
- Bacou F. Acetylcholinesterase forms in fast and slow rabbit muscle / F. Bacou, P. Vigneron, J. Massoulie // Nature. 1982. — V.296. — P.661−664.
- Barnard E.A. Cholinergic receptor molecules and cholinesterase molecules at mouse skeletal muscle junctions / E.A. Barnard, J. Wieckowsky, Т.Н. Chiu // Nature. 1971. -V. 234. — P. 207−209.
- Bon S. The dependence of Acetylcholinesterase aggregation at low ionic strength upon a polyanionic component / S. Bon, J. Cartaud, J. Massouli // Eur. J. Biochem. -1978.-V.85.-P.1−14.
- Botti S.A. A Modular Treatment of Molecular Traffic Through the Active Site of Cholinesterase / S.A. Botti, C.E. Felder, S. Lifson, J.L. Sussman, I. A Silman // Biophys J. -1999, -V. 77, N. 5. P. 2430−2450.
- Boudreau-Lariviere C. Fast and slow skeletal muscles express a common basic profile of acetylcholinesterase molecular forms / C. Boudreau-Lariviere, V. Gisiger, R.N. Michel, D.A. Hubatsch, B.J. Jasmin // Am. J. Physiol. 1997. — V.272, N.l. — P. 68−76.
- Boudreau-Lariviere C. Myotubes originating from single fast and slow satellite cells display similar patterns of AChE expression / C. Boudreau-Lariviere, D. Parry, B. Jasmin // Am. J. Physiol. Regulatory Iniegrative Comp. Physiol. 2000. — V. 278.
- Bourne Y. Acetylcholinesterase inhibition by fasciculin: crystal structure of the complex/ Y. Bourne, P. Taylor, P. Marchot // Cell. -1995. -V. 83. -P. 503−512.
- Bourne Y. Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site / Y. Bourne, P. Taylor, Z. Radic, P. Marchot // EMBO J. -2003. -V 22, No. l.-P. 1−12.
- Burke R Physiological types and histochemical profiles in motor units of the cat gastrocnemius / R Burke, D Levine, P Tsairis, F Zajac // J Physiol. 1973. — V. 234: — P. 723−748.
- Changeux J.-P. Studies on the molecular mechanism of the response of the excitable membrane to cholinergic agents / J.-P. Changeux // Chem. Phys. Lip. 1972. — V. 8. — P. 355−365.
- Collins P.L. Effect of denervation on the molecular forms of acetylcholinesterase in rat diaphragm / P.L. Collins, S.G. Younkin // J Biol Chem. 1982. — V.257. — P. 1 363 813 644.
- Cresnar B. Neural regulation of muscle acetylcholinesterase is exerted on the level of its mRNA / B. Cresnar, N. Crne-Finderle, K. Breskvar, J. Sketelj // J Neurosci Res. -1994. V.38. — V.294−299.
- Dudai Y. Molecular structure of acetylcholinesterase from electric organ tissue of the electric eel / Y. Dudai, M. Herzberg, I. Silman // Proc. Natl. Acad. Sci. USA. — 1973. -V. 70.-P. 2473−2476.
- Duval N. Site-directed mutagenesis of active-site-related residues in Torpedo acetylcholinesterase / N. Duval, S. Bon, I. Silman, J. Sussman, J. Massoulie // FEBS Lett. 1992. — V. 309. — P. 421−423.
- Fahim M.A. Topographic comparison of neuromuscular junctions in mouse slow and fast twitch muscles / M.A. Fahim, J.A. Holley, N. Robbins // Neuroscience.- 1984.-V. 13.-P. 227−235.
- Ekstrom T.J. Promoter elements and transcriptional regulation of the acetylcholinesterase gene / T.J. Ekstrom, W. M. Klump, D. Getman, M. Karin, P. Taylor // DNA Cell Biol. 1993. — V.12. — P.63−72.
- Engel AG, Lambert EH, Gomez MR. A new myasthenic syndrome with end-plate acetylcholinesterase deficiency, small nerve terminals, and reduced acetylcholine release / A.G. Engel, E.H. Lambert, M.R. Gomez//Ann Neurol. 1977. — VI. -P. 315−330.
- Feng. G. Genetic analysis of collagen Q: Roles in acetylcholinesterase and butyrylcholinesterase assembly and in synaptic structure and function / G. Feng, E.
- Krejci, J. Molgo, J.M. Cunningham, J. Massouli, J.R. Sanes // J. Cell Biol. 1999. -V.144. — P.1349−1360.
- Fernandez H.L. Exercise selectively increases G4 AChE activity in fast-twitch muscle / H.L. Fernandez, J.A. Donoso // J Appl Physiol. 1988. — V.65. -P.2245−2252.
- Fernandez H.L. Physiological regulation of G4 AChe in fast-twitch muscle: effects of exercise and CGRP / H.L. Fernandez, C.A. Hodges-Savola // J Appl Physiol. 1996. -V.80. -P.357−362.
- Fernandez-Valle C. Regulation of acetylcholinesterase synthesis and assembly by muscle activity / C. Fernandez-Valle, R.L. Rotundo // J. Biol. Chem. 1989. — P. 1−7.
- Fournier M Mechanical properties of muscle units in the cat diaphragm / M. Fournier, G.C. Sieck // J Neurophysiol. 1988. — V.59: — P. 1055−1066.
- Giniatullin R.A. Desensitization shortens the high-quantal-content endplate current time course in frog muscle with intact cholinesterase / R.A. Giniatullin, M. Talantova, F. Vyskocil // J. Physiol. 1997. — P. 641−8.
- Gisiger V. Acetylcholinesterase adaptation to voluntary wheel running is proportional to the volume of activity in fast, but not slow, rat hindlimb muscles / V. Gisiger, M. Belisle, P.F. Gardiner // Eur J Neurosci. 1994. — V.6, N.5. — P.673−680.
- Gisiger V. Correlation between the acetylcholinesterase content in motor nerves and their muscles / V. Gisiger, H. Stephens // J Physiol. 1982. — V.78, N.8. — P.720−728.
- Grassi J. Molecular forms of acetylcholinesterase in bovine caudate nucleus and superior cervical ganglion: solubility properties and hydrophobic character / J. Grassi, M. Vigny, J. Massouli // J Neurochem. 1982. — V.38. — P.457−469.
- Grisaru D. Structural roles of acetylcholinesterase variants in biology and pathology / D. Grisaru, M. Sternfeld, A. Eldor, D. Glick, H. Soreq // Eur. J. Biochem. -1999. -V. 264.-P. 672−686
- Hall Z.W. Multiple forms of acetylcholinesterase and their distribution in endplate and non-endplate regions of rat diaphragm muscle/ Z.W. Hall // J Neurol. 1973. — V.4. -P.343−361.
- Harel M. Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis / M. Harel, J.L. Sussman, E. Krejci, S. Bon, P. Chanal, J. Massoulie, I. Silman // Proc. Natl. Acad. Sci. USA. 1992. — V. 89. — P. 10 821−10 831.
- Hennig R. Firing pattern of motor units in normal rats / R. Hennig, T. Lomo // Nature. 1985.-V. 214.-P. 297−299.
- Hobbiger F. Pharmacology of anticholinesterase drugs / F. Hobbiger // Handbook of exp. pharmacol. / Ed. E. Zaimis / Springer-Verlag Berlin, Heidelberg, N.Y., -1976. -v. 42. ch. 4.-P. 486−581.
- Inestrosa N.C. Association of the synaptic forms of acetylcholinesterase with extracellar matrix in cultured mouse muscle cells / N.C. Inestrosa, L. Silberstien, Z.W. Hall // Cell. 1982. — V.29. — P.71−79.
- Jasmin B.J. Regulation by exercise of the pool of G4 acetylcholinesterase characterizing fast muscles: opposite effects of running training in antagonist muscles / B.J. Jasmin, V. Gisiger // J Neurosci. 1990. — V.10. — P. 1444−1454.
- Jeffrey L. Cholinesterase inhibitors: A new class of psychotropic compounds./ L. Jeffrey, M.D. Cummings // Am. J. Psychiatry 2000. -V.157. -P. 4−15.
- Jeyarasasignam G. Nitric oxid is involved in acetylcholinesterase inhibitor-induced miopathy in rats / G. Jeyarasasignam, M. Yeluashvili, M. Quik // JPET. 2000. — V. 295. -P. 314−320.
- Johnson B.D. Differential susceptibility of diaphragm muscle fibers to neuromuscular transmission failure / B.D. Johnson, G.C.Sieck // J Appl Physiol. 1993. — V.75. — P. 341−348.
- Katz B. The binding of acetylcholine to receptors and its removal from the synaptic cleft /B. Katz, R. Miledi // J.Physiol. 1973. — V. 231. — P. 549−574.
- Katz L.S. Modulation of central muscarinic receptor binding in vivo by organophosphate paraoxon / L.S. Katz, J.K. Marquis // Toxicol.Appl. Pharmacol. 1989. -V.101.-P. 114−123.
- Karczmar A.G. Invited review: anticholinesterases: dramatic aspects of their use and misuse / A. Karczmar // Neurochem. Int. -1998. V. 32, No. 5−6. — P. 401−411.
- Kasprzak H. Recovery of acetylcholinesterase at intact neuromuscular junctions after in vivo inactivation with diisopropylfluorophoosphate / H. Kasprzak, M.M. Salpeter // J. Neurosc.- 1985.- V.5.-P.951−955.
- Koelle G.B. Cytological distribution and physiological functions of cholinesterases / G.B. Koelle // Cholinesterases and anticholinesterase agents: Handbuch der experimentallen Pharmakologie. Bd 15. Berlin: Springer, 1963. — P. 187−299.
- Koelle G.B. The histochemical differentiation of types of cholinesterases and their localizations in tissues of the cat / G.B. Koelle // J. Pharmacol, Exp. Ther. 1950. -V. 100.-P.158−179.
- Kong F. Firing properties and hypercapnic responses of single phrenic motor axons in the rat / F. Kong, A. Berger // J. Appl. Physiol. 1986. — V. 61. — P. 1999−2004.
- Lee S. Characterization of a hydrophobic, dimeric form of acetylcholinesterase from Torpedo / S. Lee, S.J. Camp, P.B. Taylor // J. Biol. Chem. 1982a. — V.257. — P. 1 230 212 309.
- Lee S. Structural characterization of the asymmetric (17 + 13) forms of acetylcholinesterase from Torpedo: Analysis of subunit composition / S. Lee, S. Heinemann, P.B. Taylor // J. Biol. Chem. 1982b. — V.257. — P. 12 283−12 291.
- Legay C. Developmental regulation of acetylcholinesterase transcripts in the mouse diaphragm: alternative splicing and localization / C. Legay, M. Huchet, J. Massoulie', J.P. Changeux // Eur J Neurosci. 1995. -V.7. -P.1803−1809.
- Legay C. Why So many forms of acetylcholinesterase? / C. Legay // Microscopy research and technique. -2000. -V. 49. P. 56−72
- Li Y. Gene structure of mammalian acetylcholinesterase. Alternative exons dictate tissue-specific expression / Y. Li, S. Camp, T.L. Rachinsky, D. Getman, P. Taylor // J. Biol. Chem. 1991. — V.266. — P.23 083−23 090.
- Li Y. Promoter elements and transcriptional control of the mouse acetylcholinesterase gene / Y. Li, S. Camp, T.L. Rachinsky, C. Bongorno, P. Taylor // J. Biol. Chem. 1993a. — V.268. — P.3563−3572.
- Li Y. Tissue-specific expression and alternate mRNA processing of the mammalian acetylcholinesterase gene / Y. Li, S. Camp, P. Taylor // The Journal of Bio. Chem. -1993b. V.268. — P.5790−5797.
- Lockridge O. Complete amino acid sequence of human serum cholinesterase /0. Lockridge, C.F. Bartles, T.A. Vaughan, C.K. Wong, S.E. Norton, L.L. Johnson // J. Biol. Chem. 1987. -V.262. — P.549−557.
- Lockridge O. Interchain disulfide bonds and subunit organization in human serum cholinesterase /0. Lockridge, H.W. Eckerson, B.N. La Du. // J. Biol. Chem. 1979. -V.254. — P.8324−8330.
- Lockridge O. Loss of the interchain disulfide peptide and dissociation of the tetramer following limited proteolysis of native human serum cholinesterase /0. Lockridge, B.N. La Du. // J. Biol. Chem. 1982. -V.257. -P.12 012−12 018.
- Lockridge O. Structure of human serum cholinesterase / O. Lockridge // BioEssays. -1988. -V.9, N.4. P.125−128.
- Lomo T. Stimulation of denervated rat soleus muscle with fast and slow activity patterns induces different expression of acetylcholinesterase molecular forms / T. Lomo, J. Massoulye, M. Vigny // J. Neurosci. 1985. — V.5. — P. 1180−1187.
- Lwebuga-Mukasa J.S. Molecular forms of acetylcholinesterase from Torpedo californica: Their relationship to synaptic membranes / J.S. Lwebuga-Mukasa, S. Lappy, P. Taylor// Biochemistry. 1976. -V.15. — P. 1425−1434.
- Mantilla C. Mechanisms underlying motor unit plasticity in the respiratory system / C. Mantilla, C. Sieck. //J. Appl. Physiol. 2003. -V. 94. — P. 1230−1241.
- Massoulie J. Molecular and cellular biology of cholinesterases / J. Massouli, L. Pessementi, S. Bon, E. Krejci, F.M. Yallette // Progress in Neurobiology. 1993.- V.41. -P. 31−91.
- Massoulie J. Recommendations for nomenclature in cholinesterases / J. Massoulie, J.L. Sussman, B.P. Doctor // Multidisciplinary approaches to Cholinesterase Functions / Eds. A. Schafferman, B. Velan. New York: Plenum Press, 1992. — p. 285−288.
- Maulet Y. Single gene encodes glycophospholipid-anchored and asymmetric acetylcholinesterase forms: Alternate coding exons contain inverted repeat sequences / Y.
- Maulet, S. Camp, G. Gibney, T.L. Rachinsky, T.J. Ekstrom, P. Taylor // Neuron. 1990.- V.4. -P.289−301.
- Mays C. Characterization of pepsin-resistant collagen-like tail subunit fragments of 18S and 14S acetylcholinesterase from Electrophoras electricus / C. Mays, T.L. Rosenberry//Biochemistry. 1981.-V.20. -P.2810−2817.
- Michel R.N. Neural regulation of acetylcholinesterase mRNAs at mammalian neuromuscvular synapses / R.N. Michel, C.Q. Vu, W. Tetzlaff, B.J. Jasmin // J Cell Biol.- 1994. V.127. -P.1061−1069.
- Miledi R. Acetylcholinesterase activity in intact and homogenized skeletal muscle in the frog / R. Miledi, P.C. Molenar, R.L. Polak // J/ Physiol. 1984. — V.349. — P.663−686.
- Moore D.H. Acetylcholinesterase-catalyzed hydrolysis of an amide / D.H. Moore, G.P. Hess // Biochemistry. 1975. — V.14, N. l 1. — P.2386−2396.
- Morrison I.E. Approaches to the study and analyses of the inhibition of enzymes by slow and tight binding inhibitors / I.E. Morrison, S.R. Stone // Comments Mol. Cell. Biophys. — 1985. — V.2. — P.347−368.
- Mover M. Effect of phasic activation on endplate potential in rat diaphragm / M. Mover, E. van Lunteren // J. Neurophystol. 1999. -V. 82. -P. 3030−3040
- Nachmansohn D. Studies on cholinesterase: I. On the specificity of the enzyme in nerve tissue. / D. Nachmansohn, M.A. Rothenberg // J. Biol. Chem. 1992. — ch.9 -P.306−309.
- Nichols J. Termination of the transmitter action/ J Nichols, A Martin, B Wallace //From neuron to brain. 1976. -v. 42. ch. 4. — C. 486−581.
- Norel X. Degradation of acetylcholine in human airways: role of butyrylcholinesterase / X. Norel, M. Angrisani, C. Labat, L. Gorenne, F. Dulmet, F. Rossi, C. Brink//Br. J. Pharmacol. -1993. -V. 108. -P. 914−919.
- Peng H.B. Acetylcholinesterase clustering at the neuromuscular junction involves perlecan and dystroglycan / H.B. Peng, H. Xie, S.G. Rossi, R.L. Rotundo // J. Cell Biol. -1999. V.145. — P.911−921.
- Peng H.B. Development of acetylcholinesterase induced by basic polypeptide-coated latex beads in cultured xenopus muscle cells / H.B. Peng, K.-X. Gao, M.-Z. Xie,
- D.-Y. Zhao // Develop. Biol. -1988. V.127. — P. 452−455.
- Pope C. Pharmacology and toxicology of cholinesterase inhibitors: uses and misuses of a common mechanism of action / C. Pope, S. Karanth, J. Liu // Environmental toxicology and pharmacology. 2005. — V. 19. — P. 433−446.
- Radic Z. Site of fasciculin interaction with acetylcholinesterase / Z. Radic, R. Duran, D.C. Vellom, Y. Li, C. Cervenansky, P. Taylor // J. Biol. Chem. 1994. — V.269. -P.11 233−11 239.
- Rakonczay Z. Heterogeneity of rat brain acetylcholinesterase: a study by gel filtration and gradient centrifugation / Z. Rakonczay, G. Vincendon, J.P. Zanetta // J Neurochem. 1981. — V.37. — P.662−669.
- Reznik V.S. New type of cholinesterase inhibitors: methylphosphonic derivatives, containing 6-methyluracil group in thioesteric radical / V.S. Reznik, V.D. Akamsin, G.I. Podzigun, L.N. Shitov, Gordybaev, E.V. Tungusova, K.A. Anikienko, E.A. Bychikhin,
- E.V. Guskova, S.P. Mamontov, Yu.L. Kruglyak // Chemistry of phosphorus compound: XI Internat. conf. Kazan, 1996. — 80 p.
- Rosenberry T.L. Acetylcholinesterase. / T.L. Rosenberry // Advances in Enzymology and Related Areas of Molecular Biology // edited by MEISTER A. / John Wiley & Sons Inc. Publishers, 1975. — Vol. 43. — P. 103−218.
- Rosenberry T.L. Structure of 18S and 14S acetylcholinesterase. Identification of collagen-like subunits that are linked by disulfide bonds to catalytic subunits / T.L. Rosenberry, J.M. Richardson // Biochem. 1977. — V.16. — P.3550−3558.
- Rossi S.G. Cell surface acetylcholinesterase molecules on multinucleated myotubes are clustered over the nucleus of origin / S.G. Rossi, R.L. Rotundo // J. Cell Biol. 1992.-V.l 19.-P.1657−1667.
- Rossi S.G. Localization of «non-extractible» acetylcholinesterase to the vertebrate neuromuscular junctions / S.G. Rossi, R.L. Rotundo // J Biol Chem. 1993. — V.268. -P.19 152—19 159.
- Rotundo R.L. Expression and localization of acetylcholinesterase at the neuromuscular junction / R.L. Rotundo // J. of Neurocytology. 2003. -V. 32. — p. 743 766.
- Rotundo R.L. Function and molecular structure of acetylcholinesterase/ R.L. Rotundo // Myology / edited by Engel A. G., Franziniarmstrong C. New York: McGraw-Hill, 1994.
- Santi D.V. Approaches to the rational design of enzyme inhibitors / D.V. Santi, G.L. Kenyon // Burger’s medicinal chemistry / Ed. M.E. Wolff. N.Y. etc.: Willey, 1980.-P. 349−391.
- Schumacher M. Primary structure of Torpedo californica acetylcholinesterase deduced from its cDNA sequence / M. Schumacher, S. Camp, Y. Maulet, M. Newton, K. MacPhee-Quigley, S.S. Taylor, T. Friedmann, P. Taylor // Nature. 1986. — V.319. -P.407−409.
- Schwarz M. Engineering of human cholinesterases explains and predicts diverse consequences of administration of various drugs and poisons / M. Schwarz, D. Glick, Y. Loewenstein, H. Soreq // Pharmacol, and Ther. 1995. — N.2. — P.283−322.
- Silver A. A histochemical investigation of cholinesterases at neuromuscular junctions in mammalian and avian muscle / A. Silver // J. Physiol. -1963. V. 169. — P. 386−393.
- Sketelj J. Influence of denervation on the molecular forms of junctional and extrajunctional acetylcholinesterase in fast and slow muscles of the rat / J. Sketelj, N. Crne-Finderle, M. Brzin // Neurochem Int. 1992. — V. 21. — P.415−421.
- Sketelj J. Neural regulation of acetylcholinesterase in skeletal muscles / J. Sketelj //BAM. 1994.-V.4.-P.281−291
- Sketelj J. Specific impulse patterns regulate acetylcholinesterase activity in skeletal muscles of rats and rabbits / J. Sketelj, E. Leisner, B. Gohlsch, D. Skorjanc, D. Pette // J Neurosci Res. 1997. — V.47, N. 1. — P.49−57.
- Sussman J.L. Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine binding protein / J.L. Sussman, M. Harel, F. Frolow // Science. -1991. V.253, N.5022. — P.872−879.
- Sussman J.L. Three-dimensional structure of acetylcholinesterase and of its complexes with anticholinesterase drugs / J.L. Sussman, M. Harel, I. Silman // Chem. Biol. Interact. 1993. — V.87. — P. 187−197.
- Taylor J.L. Conformers of acetylcholinesterase: a mechanism of allosteric control / J.L. Taylor, R.T. Mayer, C.M. Himel // Mol. Pharmacol. 1994. — V.45. — P.74−83.
- Ting A.L. Transcriptional regulation of acetylcholinesterase-associated collagen ColQ in fast- and slow-twich muscle fibers / A.L. Ting, N.L. Siow, L.W. Kong, W.K. Tsim // Chem.Bbiol. Interact. 2005. — V. 15. — P. 157−158.
- Vellom D.C. Amino acid residues controlling acetylcholinesterase and butyrylcholinesterase specificity / D.C. Vellom, Z. Radic, Y. Li, N.A. Pickering, S. Camp, P. Taylor // Biochemistry. 1993. — V.32. — P.12−17.
- Vigny M. The motor end-plate specific form of acetylcholinesterase: appearance during embryogenesis and reinnervation of rat muscle / M. Vigny, J. Koenig, F. Rieger // J Neurochem. 1976. — V.27. — P.1347−1353.
- Wood S.J. Safety factor at the neuromuscular junction / S.J. Wood, C.R. Slater // Progress in Neurobiology. 2001. — V.64. -P.393−429.
- Younkin S. Cellular localizatijn of the molecular forms of acetylcholinesterase in rat diaphragm / S. Younkin, C. Rosenstein, P. Collins, T. Rosenberry // J. Biol. Chem. -1982.-V. 257. P. 13 630−13 637.
- Zengel J.E. Membrane electrical properties and prediction of motor-unit type of medial gastrocnemius motoneurons in the cat / J. E Zengel, S. A Reid, G. W Sypert, J. B Munson // JNeurophysiol. 1985. — V. 53. -P. 1323−1344.
- Zhao Q. Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine / Q. Zhao, X.C. Tang //Eur J Pharmacol. -2002. -V. 455, N. 2−3. -P. 101−107.
- Zwart R. Competitive potentiation of acetylcholine effects on neuronal nicotinic receptors by acetylcholmesterase-inhibiting drugs / R. Zwart, R. van Kleef, C. Gotti, C.J. Srnulders, H. Vijverberg // J.Neuchem. 2000. -V. 75. -P. 2492−2500.
- Выражаю сердечную благодарность моим научным руководителям доктору биологических наук Бухараевой Элле Ахметовне и кандидату биологических наук Зобову Владимиру Васильевичу за помощь в выполнении и оформлении данной работы.