Π ΠΎΠ»Ρ ΠΈΠ½ΡΠ΅ΡΠ»Π΅ΠΉΠΊΠΈΠ½Π°-2 ΠΈ JAK/STAT ΡΠΈΠ³Π½Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ Π² ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ° ΠΈΠ½ΡΠ΅ΡΠ»Π΅ΠΉΠΊΠΈΠ½Π°-2 Π² Π»ΠΈΠΌΡΠΎΡΠΈΡΠ°Ρ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°
ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΠΌΠ΅ΡΡ ΡΡΠ½Π΄Π°ΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ Π΄Π»Ρ ΠΏΠΎΠ½ΠΈΠΌΠ°Π½ΠΈΡ ΠΌΠ΅Ρ Π°Π½ΠΈΠ·ΠΌΠΎΠ², ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²ΠΎΠΌ ΠΊΠΎΡΠΎΡΡΡ ΡΠΎΡΠΌΠΈΡΡΠ΅ΡΡΡ Π’-ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠΉ ΠΎΡΠ²Π΅Ρ Π½Π° Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΌΠΈΡΠΎΠ³Π΅Π½Π°. ΠΡΡΠ²Π»Π΅Π½Π½ΡΠΉ Π² ΡΠ°Π±ΠΎΡΠ΅ Π΄Π²ΡΡ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ½ΡΠΉ Ρ Π°ΡΠ°ΠΊΡΠ΅Ρ ΠΏΠΎΠ²Π΅ΡΡ Π½ΠΎΡΡΠ½ΠΎΠΉ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ CD25 ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΠ΅Ρ ΠΎ Π½Π΅ΠΎΠ±Ρ ΠΎΠ΄ΠΈΠΌΠΎΠΉ ΠΊΠΎΠΎΡΠ΄ΠΈΠ½Π°ΡΠΈΠΈ ΡΠΈΠ³Π½Π°Π»ΡΠ½ΡΡ ΠΏΡΡΠ΅ΠΉ Ρ ΡΠ°Π·Π½ΡΡ ΠΌΠ΅ΠΌΠ±ΡΠ°Π½Π½ΡΡ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠΎΠ² (Ρ Π’-ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΠΈ Ρ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ° ΠΠ-2) Π΄Π»Ρ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎ… Π§ΠΈΡΠ°ΡΡ Π΅ΡΡ >
Π‘ΠΏΠΈΡΠΎΠΊ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ
- ΠΠΈΠΊΠΎΠ»ΡΡΠΊΠΈΠΉ Π.Π., ΠΠ°ΡΠΈΠ»Π΅Π½ΠΊΠΎ Π. Π. 2000. STAT-ΠΏΡΡΡ Π²Π½ΡΡΡΠΈΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΡΠΈΠ³Π½Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ. ΠΡΡΠ½Π°Π» ΡΠ²ΠΎΠ»ΡΡΠΈΠΎΠ½Π½ΠΎΠΉ Π±ΠΈΠΎΡ ΠΈΠΌΠΈΠΈ ΠΈ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ. 36 (6): 504−508.
- Π₯Π°ΠΈΡΠΎΠ² P.M., ΠΠ³Π½Π°ΡΡΠ΅Π²Π° Π. Π., Π‘ΠΈΠ΄ΠΎΡΠΎΠ²ΠΈΡ Π. Π., «ΠΠΌΠΌΡΠ½ΠΎΠ»ΠΎΠ³ΠΈΡ», Π., ΠΠ΅Π΄ΠΈΡΠΈΠ½Π°, 2000.
- Abraham R.T., Weiss Π. 2004. Jurkat Π’ cells and development of the T-cell receptor signalling paradigm. Nat Rev Immunol. 4: 301−308.
- Acuto O., Michel F. 2003. CD28-mediated co-stimulation: a quantitative support for TCR signalling. NatRev Immunol. 3: 939−951.
- Aivazian D., Stern L.J. 2000. Phosphorylation of T cell receptor zeta is regulated by a lipid dependent folding transition. Nat Struct Biol. 7: 1023−1026.
- Akira S. 2000. Roles of STAT3 defined by tissue-specific gene targeting. Oncogene. 19 :2607−2611.
- Baker S.J., Rane SG., Reddy E.P. 2007. Hemotopoietic cytokine receptor signaling. Oncogene. 26: 6724−6737.
- Baus D., Pfitzner E. 2006. Specific function of STAT3, SOCS1, and SOCS3 in the regulation of proliferation and survival of classical Hodgkin lymphoma cells. Int J Cancer. 118 (6): 1404−1413.
- Beach D., Gonen R., Bogin Y., Reischl I.G., Yablonski D. 2007. Dual role of SLP-76 in mediating T cell receptor-induced activation of phospholipase C-gammal. J Biol Chem. 282: 2937−2946.
- Berg L.J., Finkelstein L.D., Lucas J.A., Schwartzberg P.L. 2005. Tec family kinases in T lymphocyte development and function. Annu Rev Immunol. 23: 549−600.
- Berridge M.J. 1997. Lymphocyte activation in health and disease. Crit. Rev. Immunol. 17: 155−178.
- Bhattarai N., McLinden J.H., Xiang J., Kaufman T.M., Stapleton J.T. 2012. GB virus C envelope protein E2 inhibits TCR-induced IL-2 production and alters IL-2-signaling pathways. J Immunol. 189: 2211−2216.
- Boyum A. 1968. Separation of leucocytes from blood and bone marrow. J. Clin. Lab. Invest. 21: 9−29.
- Bradford M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248−254.
- Buitenhuis M., Coffer P.J., Koenderman L. 2004. Signal transducer and activator of transcription 5 (STAT5). Int J Biochem Cell Biol. 36: 2120−2124.
- Bunting K.D. 2007. STAT5 signaling in normal and pathologic hematopoiesis. Front Biosci. 12: 2807−2820.
- Cantrell D. 1996. T cell antigen receptor signal transduction pathways. Annu Rev Immunol. 14: 259−274.
- Chung J.Y., Park Y.C., Ye H., Wu H. 2002. All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction. J Cell Sci. 115: 679−688.
- Crabtree G.R. 1989. Contingent genetic regulatory events in T lymphocyte activation. Science. 243: 355−361.
- Crabtree G.R., Clipstone N.A. 1994. Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu Rev Biochem. 63: 1045−1083.
- Darnell Jr.J.E. 1997. STATs and gene regulation. Science. 277: 1630−1635.
- Dennehy K.M., Kerstan A., Bischof A., Park J.H., Na S.Y., Hiinig T. 2003. Mitogenic signals through CD28 activate the protein kinase Ctheta-NF-kappaB pathway in primary peripheral T cells. Int Immunol. 15: 655−663.
- Dolmetsch R.E., Lewis R.S., Goodnow C.C., Healy J.I. 1997. Differential activation of transcription factors induced by Ca2+ response amplitude and duration. Nature. 386: 855−858.
- Frank D.A. 2012. Targeting STATs for cancer therapy. JAK/STAT. 1: 1−2.
- Frauwirth K.A., Thompson C.B. 2002. Activation and inhibition of lymphocytes by costimulation. J Clin Invest. 109 :295−299.
- Gaffen S.L. 2001. Signaling domains of the interleukin 2 receptor. Cytokine. 14: 63−77.
- Genot E., Cantrell D.A. 2000. Ras regulation and function in lymphocytes. Curr Opin Immunol. 12: 289−294.
- Ghoreschi K., Laurence A., O’Shea J.J. 2009. Janus kinases in immune cell signaling. Immunol. Rev. 228: 273−287.
- Gorentla B.K., Zhong X.P. 2012. Tcell Receptor Signal Transduction in T lymphocytes. J Clin Cell Immunol. 27: 5.
- Green D.R., Drain N., Pinkoski M. 2003. Activation-induced cell death in T cells. Immunol Rev. 193: 70−81.
- Green J.M., Noel P.J., Spelling A.I., Walunas T.L., Gray G.S., Bluestone J.A., Thompson C.B. 1994. Absence of B7-dependent responses in CD28-deficient mice. Immunity. 1: 501−508.
- Grinstein S., Dixon S.J. 1989. Ion transport, membrane potential, and cytoplasmic pH in lymphocytes: changes during activation. Physiol Rev. 69: 417−481.
- Haskins K., Kappler J., Marrack P. 1984. The major histocompatibility complex-restricted antigen receptor on T cells. Annu Rev Immunol. 2: 51−66.
- Hayden M.S., West A.P., Ghosh S. 2006. NF-kappaB and the immune response. Oncogene. 25 :6758−6780.
- Hayes S.M., Love P.E. 2006. Strength of signal: a fundamental mechanism for cell fate specification. Immunol Rev. 209: 170−175.
- Hoffmann A., Natoli G., Ghosh G. 2006. Transcriptional regulation via the NF-kappaB signaling module. Oncogene. 25: 6706−6716.
- Imbert V., Renauld P.R. 1999. Duration of STAT5 activation influences the response of interleukin-2 receptor alpha gene to different cytokines. Eur Cytokine Netw. 10: 71−78.
- Imboden J.B., Stobo J.D. 1985. Transmembrane signaling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol
- Gaffen S.L. 2001. Signaling domains of the interleukin 2 receptor. Cytokine. 14: 63−77.
- Genot E., Cantrell D.A. 2000. Ras regulation and function in lymphocytes. Curr Opin Immunol. 12: 289−294.
- Ghoreschi K., Laurence A., O’Shea J.J. 2009. Janus kinases in immune cell signaling. Immunol. Rev. 228: 273−287.
- Gorentla B.K., Zhong X.P. 2012. Tcell Receptor Signal Transduction in T lymphocytes. J Clin Cell Immunol. 27: 5.
- Green D.R., Droin N., Pinkoski M. 2003. Activation-induced cell death in T cells. Immunol Rev. 193: 70−81.
- Green J.M., Noel P.J., Spelling A.I., Walunas T.L., Gray G.S., Bluestone J.A., Thompson C.B. 1994. Absence of B7-dependent responses in CD28-deficient mice. Immunity. 1: 501−508.
- Grinstein S., Dixon S.J. 1989. Ion transport, membrane potential, and cytoplasmic pH in lymphocytes: changes during activation. Physiol Rev. 69: 417181.
- Haskins K., Kappler J., Marrack P. 1984. The major histocompatibility complex-restricted antigen receptor on T cells. Annu Rev Immunol. 2: 51−66.
- Hayden M.S., West A.P., Ghosh S. 2006. NF-kappaB and the immune response. Oncogene. 25: 6758−6780.
- Hayes S.M., Love P.E. 2006. Strength of signal: a fundamental mechanism for cell fate specification. Immunol Rev. 209: 170−175.
- Hoffmann A., Natoli G., Ghosh G. 2006. Transcriptional regulation via the NF-kappaB signaling module. Oncogene. 25: 6706−6716.
- Imbert V., Renauld P.R. 1999. Duration of STAT5 activation influences the response of interleukin-2 receptor alpha gene to different cytokines. Eur Cytokine Netw. 10: 71−78.
- Imboden J.B., Stobo J.D. 1985. Transmembrane signaling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositolphosphatases and releases calcium ions from intracellular stores. J Exp Med. 161: 446−456.
- Ingley E., Klinken S.P. 2006. Cross-regulation of JAK and Src kinases. Growth Factors. 24: 89−95.
- Jatiani S.S., Baker S.J., Silverman L.R., Reddy E.P. 2010. JAK/STAT Pathways in cytokine signaling and myeloproliferative disorders. Genes Cancer. 1: 979 993.
- Karin M., Hunter T. 1995. Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus. Curr Biol. 5: 747−757.
- Karitskaya I., Aksenov N., Vassilieva I., Zenin V., Marakhova I. 2010. Long-term regulation of Na, K-ATPase pump during T-cell proliferation. Eur. J. Physiol. 460: 777−789.
- Kim H.P., Imbert J., Leonard W.J. 2006. Both integrated and differential regulation of components of IL-2/IL-2 receptor system. Cytokine Growth factor Rev. 17 :350−366.
- Kim H.P., Kelly J., Leonard W.J. 2001. The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements. Immunity. 15: 159−172.
- Kim H.P., Leonard W.J. 2002. The basis for TCR-mediated regulation of the IL-2 receptor alpha chain gene: role of widely separated regulatory elements. EMBO J. 21: 3051−3059.
- Kirken R.A., Erwin R.A., Wang L., Wang Y" Rui H., Farrar W.L. 2000. Functional uncoupling of the Janus kinase 3-Stat5 pathway in malignant growth of human T cell leukemia virus type 1-transformed human T cells. J. Immunol. 165 :5097−5104.
- Kube D., Holtick U., Vockerodt M., Ahmadi T., Haier B., Behrmann I., Heinrich P.C., Diehl V., Tesch H. 2001. STAT3 is constitutively activated in Hodgkin cell lines. Blood. 98: 762−770.
- Kumagai N., Benedict S.N., Mills G.B., Gelfand E.W. 1988. Induction of competence and progression signals in human T lymphocytes by phorbol esters and calcium ionophores. J. Cell. Physiol. 137: 329−336.
- Laemmli U.K. 1970. Cleavage of Structural Proteins During the Assembly of the Head of Bacteriophage T4. Nature. 277: 680−685.
- Lenschow D.J., Herold K.C., Rhee L., Patel B., Koons A., Qin H.Y., Fuchs E., Singh B., Thompson C.B., Bluestone J.A. 1996. CD28/B7 regulation of Thl and Th2 subsets in the development of autoimmune diabetes. Immunity. 5: 285 293.
- Leonard W.J. 1996. The molecular basis of X-linked severe combined immunodeficiency: defective cytokine receptor signaling. Annu. Rev. Med. 47: 229−239.
- Leonard W.J. 2001a. Cytokines and immunodeficiency diseases. Nat Rev Immunol. 1 :200−208.
- Leonard W.J. 2001b. Role of JAK kinases and STATs in cytokin signal transduction. Int. J. Hematol. 73: 271−277.
- Leonard W.J., Depper J.M., Crabtree G.R. 1984. Molecular cloning and expression of cDNAs for the human interleukin-2 receptor. Nature. 311: 626 631.
- Leonard W.J., Imada K., Nakajima H., Puel A., Soldaini E., John S. 1999. Signaling via the IL-2 and IL-7 receptors from the membrane to the nucleus. Cold Spring Harb. Symp. Quant. Biol. 64: 417−424.
- Leonard W.J., Shores E.W., Love P.E. 1995. Role of the common cytokine receptor gamma chain in cytokine signaling and lymphoid development. Immunol Rev. 148: 97−114.
- Liao W., Lin J.-X., Leonard W.H. 2011. IL-2 Family Cytokines: New Insights into the Complex Roles of IL-2 as a Broad Regulator of T helper Cell Differentiation. Curr Opin Immunol. 23: 598−604.
- Liao W., Lin J.X., Leonard W.J. 2013. Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy. Immunity. 38: 13−25.
- Lin J., Leonard W.J. 2000a. The role of Stat5a and Stat5b in signaling by IL-2 family cytokines. Oncogene. 19: 2566−2576.
- Lin J., Weiss A. 2001. T cell receptor signalling. J. Cell Sci. 114: 243−244.
- Lin J.-X., Leonard W.J. 1997. Signaling from the IL-2 receptor to the nucleus. Cytokine and Growth Factor Reviews. 8: 313−332.
- Lin J.-X., Leonard W.J. 2000b. Cytokine receptor signaling pathways. J Allergy Clin Immunology. 105: 877−888.
- Lowry O., Rosebrough N., Farr A., Randall R. 1951. Protein measurment with the folin phenol reagent. J.Biol.Chem. 193: 265−270.
- Macian F. 2005. NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol. 5 :472−484.
- Malek T.R., Bayer A.L. 2004. Tolerance, not immunity, crucially depends on IL-2. Nat Rev Immunol. 4: 665−674.
- Marakhova I.I., Karitskaya I.A., Aksenov N.D., Zenin V.V., Vinogradova T.A. 2005. Interleukin-2-dependent regulation of Na/Kpump in human lymphocytes. FEBS Letters. 579: 2773−2780.
- Melowic H.R., Stahelin R.V., Blatner N.R., Tian W., Hayashi K., Altman A., Cho W. 2007. Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Ctheta. J Biol Chem. 282: 21 467−21 476.
- Morgan D.A., Ruscetti F.W., Gallo R. 1976. Selective in vitro growth of Tlymphocytes from normal human bone marrows. Science. 193: 1007−1008.
- Moriggl R., Sexl V., Piekorz R., Topham D., Ihle J.N. 1999b. Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells. Immunity. 11: 2252−2230.
- Moriggl R., Topham D.J., Teglund S., Sexl V., McKay C., Wang D., Hoffmeyer A., van Deursen J., Sangster M.Y., Bunting K.D. 1999a. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity. 10: 249−259.
- Nakamura Y., Russell S.M., Mess S.A. 1994. Heterodimerization of the IL-2 receptor beta and gamma chain cytoplasmic domains is required for signalling. Nature. 369: 330−333.
- Oh-Hora M., Rao A. 2008. Calcium signaling in lymphocytes. Curr Opin Immunol. 20:250−258.
- Okumura M., Thomas M.L. 1995. Regulation of immune function by protein tyrosine phosphatases. Curr Opin Immunol. 7: 312−319.
- Palacios E.A., Weiss A. 2004. Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation. Oncogene. 23: 7990−8000.
- Pearce E.L. 2010. Metabolism in T cell activation and differentiation. Curr Opin Immunol. 22: 314−320.
- Rane S.G., Reddy E.P. 2002. JAKs, STATs and Src kinases in hematopoiesis. Oncogene. 21 :3334−3358.
- Reth M. 1989. Antigen receptor tail clue. Nature. 338: 383−384.
- Robb R.J., Rusk C.M., Yodoi J., Greene W.C. 1987. Interleukin 2 binding molecule distinct from the Tac protein: analysis of its role in formation of high-affinity receptors. Proc. Nal. Acad. Sci. U S A. 84: 2002−2006.
- Rochman Y., Spolski R., Leonard W.J. 2009. New insights into the regulation of T cells by gamma© family cytokines. Nat. Rev. Immunol. 9 :480−490.
- Ross J.A., Nagy Z.S., Cheng H., Stepkowski S.M., Kirken R.A. 2007. Regulation of T cell homeostasis by JAKs and STATs. Arch. Immunol. Ther. Exp. 55 :231−245.
- Saharinen P., Takaluoma K., Silvennoinen O. 2000. Regulation of the JAK2 tyrosine kinase by its pseudokinase domain. Mol Cell Biol. 20: 3387−3395.
- Salmond R.J., Filby A., Qureshi I., Caserta S., Zamoyska R. 2009. T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance. Immunol Rev. 228: 9−22.
- Savignac M., Mellstrom B., Naranjo J.R. 2007. Calcium-dependent transcription of cytokine genes in T lymphocytes. Pflugers Arch. 454: 523−533.
- Shahinian A., Pfeffer K., Lee K.P., Kundig T.M., Kishihara K., Wakeham A., Kawai K., Ohashi P. S., Thompson C.B., Mak T.W. 1993. Differential T cell costimulatory requirements in CD28-deficient mice. Science. 261: 609−612.
- Shi M., Lin T.H., Appell K.C., Berg L.J. 2009. Cell cycle progression following naive T cell activation is independent of JAK3/common gamma-chain cytokine signals. J. Immunol. 183: 4493−4501.
- Smith-Garvin J.E., Koretzky G.A., Jordan M.S. 2009. T cell activation. Annu. Rev. Immunol. 27: 591−619.
- Stauber D.J., Debler E.W., Horton P.A., Smith K.A., Wilson I.A. 2006. Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. Proc NatlAcad Sci USA. 103: 2788−2793.
- Staudt L.M. 2010. Oncogenic activation of NF-kappaB. Cold Spring Harb Perspect Biol. 2: a000109.
- Stritesky G.L., Jameson S.C., Hogquist K.A. 2012. Selection of self-reactive T cells in the thymus. Annu Rev Immunol. 30: 95−114.
- Sudbeck E.A., Liu X.P., Narla R.K., Mahajan S., Ghosh S., Mao C., Uckun F.M. 1999. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin. Cancer Res. 5: 1569−1582.
- Takahama Y. 2006. Journey through the thymus: stromal guides for T-cell development and selection. NatRev Immunol. 6: 127−135.
- Takeda K., Harada Y., Watanabe R., Inutake Y., Ogawa S., Onuki K., Kagaya S., Tanabe K., Kishimoto H., Abe R. 2008. CD28 stimulation triggers NF-kappaB activation through the CARMAl-PKCtheta-Grb2/Gads axis. Int Immunol. 20: 1507−1515.
- Taniguchi T., Matsui H., Fujita T., Takaoka C., Kashima N., Yoshimoto R., Hamuro J. 1983. Structure and expression of a cloned cDNA for human interleukin-2. Nature. 302: 305−310.
- Tkaczuk J., Yu C.L., Baksh S., Milford E.L., Carpenter C.B., Burakoff S.J., McKay D.B. 2002. Effect of anti-IL-2Ralpha antibody on IL-2-induced JAK/STAT signaling. Am J Transplant. 2: 31−40.
- Tuosto L. 2011. NF-ΠΊΠ family of transcription factors: biochemical players of CD28 co-stimulation. Immunol Lett. 135: 1−9.
- Turner J.M., Brodsky M.H., Irving B.A., Levin S.D., Perlmutter R.M., Littman D.R. 1990. Interaction of the unique N-terminal region of tyrosine kinase p561ck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs. Cell. 60: 755−765.
- Veillette A., Bookman M.A., Horak E.M., Bolen J.B. 1988. The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p561ck. Cell. 55: 301−308.
- Wang H., Kadlecek T., Au-Yeung B.B., Goodfellow H.E., Hsu L.-Y., Freedman T.S., Weiss A. 2010. ZAP-70: an essential kinase in T-cell signaling. Cold Spring Harb Perspect Biol. 2: a002279.
- Wang L.H., Kirken R.A., Erwin R.A., Yu C.-R., Farrar W.L. 1999. JAK3, STAT, and MAPK signalling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response. J. Immunol. 162 :3897−3904.
- Wang X., Rickert M., Garcia K.C. 2005. Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. Science. 310: 1159−1163.
- Watts T.H. 2005. TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol. 23: 3−68.
- Weiss A. 1993. T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases. Cell. 73: 209−212.
- Weiss A., Imboden J., Hardy K., Manger B., Terhorst C., Stobo J. 1986. The role of the T3/antigen receptor complex in T-cell activation. Annu. Rev. Immunol. 4: 593−619.
- Weiss A., Imboden J.B. 1987. Cell surface molecules and early events involved in human T lymphocyte activation. Adv Immunol. 41: 1−38.
- Weiss A., Littman D.R. 1994. Signal transduction by lymphocyte antigen receptors. Cell. 76: 263−274.
- Weiss A., Stobo J.D. 1984. Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line. J Exp Med. 160: 1284−1299.
- Zenner G., Dirk zur Hausen J., Burn P., Mustelin T. 1995. Towards unraveling the complexity of T cell signal transduction. Bioessays. 17: 967 975.
- Zhang W., Sommers C.L., Burshtyn D.N., Stebbins C.C., DeJarnette J.B., Trible R.P., Grinberg A., Tsay H.C., Jacobs H.M., Kessler C.M., Long E.O., Love P.E., Samelson L.E. 1999. Essential role of LAT in T cell development. Immunity. 10: 323−332.
- Zhang Y., Turkson J., Carter-Su C., Smithgall T., Levitzki A., Kraker A., Krolewski J.J. Medveczky P., Jove R. 2000. Activation of Stat3 in v-Src-transformed fibroblasts requires cooperation of JAK1 kinase activity. J. Biol. Chem. 275 :24 935−24 944.
- ΠΠΏΠΈΡΠ°Π½ΡΠ΅Π²Π° Π.Π., ΠΠΈΡΡΡΠΎΠ²Π° Π. Π., ΠΠ°ΡΠ°Ρ ΠΎΠ²Π° Π. Π. Π’ΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΎΠ½Π½ΡΠ΅ ΡΠ°ΠΊΡΠΎΡΡ STAT3 ΠΈ STAT5 Π² Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ Π’ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° // 11-Ρ ΠΌΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½Π°Ρ ΠΡΡΠΈΠ½ΡΠΊΠ°Ρ ΡΠΊΠΎΠ»Π°-ΠΊΠΎΠ½ΡΠ΅ΡΠ΅Π½ΡΠΈΡ ΠΌΠΎΠ»ΠΎΠ΄ΡΡ ΡΡΠ΅Π½ΡΡ «ΠΠΈΠΎΠ»ΠΎΠ³ΠΈΡ -Π½Π°ΡΠΊΠ° XXI Π²Π΅ΠΊΠ°». Π’Π΅Π·ΠΈΡΡ Π΄ΠΎΠΊΠ»Π°Π΄ΠΎΠ². ΠΡΡΠΈΠ½ΠΎ. 2007. — Π‘.79.
- ΠΠΈΡΡΡΠΎΠ²Π° Π.Π., ΠΠΊΡΠ΅Π½ΠΎΠ² Π. Π., Π.Π. ΠΠ°ΡΠ°Ρ ΠΎΠ²Π°. Π ΠΎΠ»Ρ STAT5 Π² ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠΈ ΠΊΡΠ»ΡΡΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ Ρ ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π»Π΅ΠΉΠΊΠ΅ΠΌΠΈΠΈ Π562: Π°Π½Π°Π»ΠΈΠ· ΠΈΠ½Π³ΠΈΠ±ΠΈΡΡΡΡΠ΅Π³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ WHI-P131 // Π¦ΠΈΡΠΎΠ»ΠΎΠ³ΠΈΡ. 2010. Π’. 52, Π²ΡΠΏ. 2. — Π‘. 184−190.
- Π¨Π°ΡΡΠΎΠ²Π° Π.Π., ΠΠ΅Π½ΠΈΠ½ Π. Π., ΠΠΊΡΠ΅Π½ΠΎΠ² Π. Π., ΠΠΈΡΡΡΠΎΠ²Π° Π. Π., ΠΠ°ΡΠ°Ρ ΠΎΠ²Π° Π. Π. ΠΠΎΠ²Π΅ΡΡ Π½ΠΎΡΡΠ½Π°Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ CD25 Ρ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° Π½Π° ΡΠ°Π·Π½ΡΡ ΡΡΠ°Π΄ΠΈΡΡ Π·Π°ΠΏΡΡΠΊΠ° ΠΏΡΠΎΠ»ΠΈΡΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ°. II. ΠΠ΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΈΠ½ΡΠ΅ΡΠ»Π΅ΠΉΠΊΠΈΠ½Π°-2 // Π¦ΠΈΡΠΎΠ»ΠΎΠ³ΠΈΡ. -2011. Π’. 53, Π²ΡΠΏ. 12.-Π‘. 990−998.
- ΠΠΈΡΡΡΠΎΠ²Π° Π.Π., ΠΠ°ΡΠ°Ρ ΠΎΠ²Π° Π. Π. Π ΠΎΠ»Ρ Π±Π΅Π»ΠΊΠ° STAT5 Π² ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ° ΠΈΠ½ΡΠ΅ΡΠ»Π΅ΠΉΠΊΠΈΠ½Π°-2 ΠΏΡΠΈ Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ² ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° // II ΠΊΠΎΠ½ΡΠ΅ΡΠ΅Π½ΡΠΈΡ ΠΌΠΎΠ»ΠΎΠ΄ΡΡ ΡΡΠ΅Π½ΡΡ ΠΠ½ΡΡΠΈΡΡΡΠ° ΡΠΈΡΠΎΠ»ΠΎΠ³ΠΈΠΈ Π ΠΠ. Π‘Π°Π½ΠΊΡ-ΠΠ΅ΡΠ΅ΡΠ±ΡΡΠ³. 2012. -Π¦ΠΈΡΠΎΠ»ΠΎΠ³ΠΈΡ. Π’. 54, Π²ΡΠΏ.4. — Π‘. 348.
- ΠΠΈΡΡΡΠΎΠ²Π° Π.Π., Π¨Π°ΡΡΠΎΠ²Π° Π. Π., ΠΠ΅Π½ΠΈΠ½ Π. Π., ΠΠΊΡΠ΅Π½ΠΎΠ² Π. Π., ΠΠ°ΡΠ°Ρ ΠΎΠ²Π° Π. Π. Π ΠΎΠ»Ρ Π±Π΅Π»ΠΊΠ° STAT5 Π² ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Π°Π»ΡΡΠ°-ΡΠ΅ΠΏΠΈ ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ° ΠΈΠ½ΡΠ΅ΡΠ»Π΅ΠΉΠΊΠΈΠ½Π°-2 Π² Π»ΠΈΠΌΡΠΎΡΠΈΡΠ°Ρ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° // Π¦ΠΈΡΠΎΠ»ΠΎΠ³ΠΈΡ. 2013. Π’. 55, Π²ΡΠΏ. 6. — Π‘. 421−429.
- Π Π·Π°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅ Ρ ΠΎΡΡ Π²ΡΡΠ°Π·ΠΈΡΡ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΠ½ΠΎΡΡΡ Π ΡΠΊΠΎΠ²ΠΎΠ΄ΠΈΡΠ΅Π»Ρ ΠΡΠ΄Π΅Π»Π° Π²Π½ΡΡΡΠΈΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ ΡΠΈΠ³Π½Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΈ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ° ΠΠΈΠΊΠΎΠ»Π°Ρ ΠΠΈΠΊΠΎΠ»Π°Π΅Π²ΠΈΡΡ ΠΠΈΠΊΠΎΠ»ΡΡΠΊΠΎΠΌΡ Π·Π° ΠΏΡΠ΅Π΄ΠΎΡΡΠ°Π²Π»Π΅Π½Π½ΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ Π·Π°Π½ΠΈΠΌΠ°ΡΡΡΡ Π½Π°ΡΡΠ½ΠΎΠΉ ΡΠ°Π±ΠΎΡΠΎΠΉ ΠΈ ΡΠΎΠ·Π΄Π°Π½ΠΈΠ΅ Π΄ΡΡΠΆΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ Π°ΡΠΌΠΎΡΡΠ΅ΡΡ Π² ΡΠ°Π±ΠΎΡΠ΅ΠΌ ΠΊΠΎΠ»Π»Π΅ΠΊΡΠΈΠ²Π΅.