Список литературы. 
Нейротропное и антигипоксическое действие нейротрофического фактора головного мозга (BDNF) in vitro и in vivo

Агрба Е.А., Мухина И. В. Пространственно-временная характеристика нейросетевой активности первичных культур гиппокампа // Вестник Нижегородского университета им. Н. И. Лобачевского. 2013. № 4 (1). С. 139−144.

Анохин К.В., Бурцев М. С., Зарайская И. Ю., Лукашев А. О., Редько В. Г. Проект «Мозг Анимата»: разработка модели адаптивного поведения на основе теории функциональных систем // 8-ая Национальная конференция по искусственному интеллекту с международным участием. М.: Физматлит. 2002. С. 781−789.

Буреш Я., Бурешова О., Хьюстон Д. Методики и основные эксперименты по изучению мозга и поведения. М., Высш. шк. 1991.-399с.

Ведунова М.В., Сахарнова Т. А., Митрошина Е. В., Мухина И. В. Антигипоксические свойства нейротрофического фактора головного мозга при моделировании гипоксии в диссоциированных культурах гиппокампа // Современные технологии в медицине. 2012. № 4. С. 17−23.

Ведунова М.В., Митрошина Е. В., Сахарнова Т. А., Бобров М. Ю., Безуглов В. В., Хаспеков Л. Г., Мухина И. В. Влияние N-арахидоноилдофамина на функционирование нейронной сети первичной культуры гиппокампа при моделировании гипоксии // Бюллетень экспериментальной биологии и медицины. 2013. 156 № 10. С. 447−451.

Гланц С. Медико-биологическая статистика. М., Практика. 1999. 462с.

Гомазков О. А. Нейротрофическая регуляция и стволовые клетки мозга. М.: Икар, 2006. 331 с.

Гомазков О.А. Cтарение мозга и нейротрофическая терапия. М.: Икар, 2011. 92 с.

Гусев Е.И., Скворцова В. И., Стаховская Л. В. Проблема инсульта в Российской Федерации: время активных совметных действий // Журнал неврологии и психиатрии. 2007. № 8. С. 4−10.

Дривотинов Б.В., Гарустович Т. К., Гарустович Л. В., Сайрам Н. Прогнозирование возникновения осложнений и ранняя диагностика осложнений ишемического инсульта // Ишемия мозга. Материалы Международного Симпозиума. СПб., 1997. С. 139−140.

Колчинская А. З. Анализ гипоксических состояний и метода их коррекции с позиции теории систем // Гипоксия. Механизмы, адаптация, коррекция. Материалы Всерос. Конференции. М. 1997. C. 59−60.

Лебедев Р.Д., Бурцев М. С. Кластеризация пачек спонтанной активности нейрональной культуры // Сб. научных трудов Всероссийской научно-технической конференции «Нейроинформатика 2010»: в 2-х частях, Ч. 1. М.: НИЯУ МИФИ, 2010. С. 296−303.

Лукьянова Л. Д. Митохондриальная дисфункция — типовой патологический процесс, молекулярный механизм гипоксии // В кн.: Проблемы гипоксии: молекулярные, физиологические и медицинские аспекты. Под ред. Лукьяновой Л. Д. и Ушакова И. Б. М.: Истоки, 2004. 590с.

Лукьянова Л.Д., Дудченко A.M., Цыбина Т. А., Германова Э. Л. Регуляторная роль митохондрий при гипоксии и их взаимодействие с транскрипционной активностью. // Вестник РАМН. 2007. № 2. С. 3−13.

Лукьянова Л.Д., Германова Э. Л., Цыбина T.A., Копаладзе Р. А., Дудченко A.M. Эффективность и механизм действия различных типов гипоксических тренировок. Возможность их оптимизации. // Патогенез. 2008. Т. 6 (№ 3). С. 32−36.

Лурье Ю. Ю. Унифицированные методы анализа вод. М.: Химия, издание 2-е исправленное. 1973. 376 с.

Методические рекомендации по экспериментальному изучению препаратов, предлагаемых для клинического изучения в качестве антигипоксических средств /под ред. Лукьяновой Л. Д. — М., 1990. — 18 с.

Мухина И.В., Казанцев В. Б., Хапеков Л. Г., Захаров Ю. Н., Ведунова М. В., Митрошина Е. В., Коротченко С. А., Корягина Е. А. Мультиэлектродные матрицы — новые возможности в исследовании пластичности нейрональной сети // Современные технологии в медицине. 2009. № 1. С. 8−15.

Никонов В.В., Павленко А. Ю. Метаболическая терапия гипоксических состояний // Журнал «Медицина неотложных состояний». 2009. 3−4 (22−23).

Новиков В.Е., Арбаева М. В., Парфенов Э. А. Влияние антигипоксанта пQ226 на поведение мышей в «открытом поле» // Психофармакология и биологическая наркология. 2005. Т. 5. вып. 3. С. 979−983.

Самойлов М.О., Семенов Д. Г., Тюлькова Е. И., Рыбникова Е. А., Ватаева Л. А., Глущенко Т. С., Строев С. А., Миллер О. Л. В кн.: Проблемы гипоксии: молекулярные, физиологические и медицинские аспекты. Под ред. Лукьяновой Л. Д. и Ушакова И. Б. М.: Истоки, 2004. 590с.

Сахарнова Т.А., Ведунова М. В., Мухина И. В. Нейротрофический фактор головного мозга (BDNF) и его роль в функционировании центральной нервной системы // Нейрохимия. Т. 24. № 4. 2012. С. 269−277.

Султанов В.С., Зарубина И. В., Шабанов П. Д. Церебропротекторные и энергостабилизирующие эффекты полиренольного препарата ропрена при ишемии головного мозга у крыс // Обзоры по клин. фармакол. и лек. терапии. 2010. Т.8(3). С. 31−47.

Худякова Н.А., Баженова Т. В. Поведенческая активность линейных и нелинейных мышей разных цветовых вариаций в тесте «Открытое поле» // Вестник Удмуртского Университета. 2012. № 2. С. 89−93.

Чеснокова Н.П., Понукалина Е. В., Бизенкова М. Н. Современные представления о патогенезе гипоксий. Классификация гипоксий и пусковые механизмы их развития // Современные наукоемкие технологии. 2006. № 5. С. 23−27.

Шахламов В.А., Сороковой В. И. Реакция клеток на гипоксию // Архив анатомии, гистологии и эмбриологии. 1983. Т.85(7). С. 12−25.

Широкова О.М., Фрумкина Л. Е., Ведунова М. В., Митрошина Е. В., Захаров Ю. Н., Хаспеков Л. Г., Мухина И. В. Морфофункциональные закономерности развития нейронных сетей диссоциированных культур гиппокампа in vitro // Журнал Современные технологии в медицине. 2013. № 2. С. 6−13.

Шляхто Е.В., Баранцевич Е. Р., Щербак Н. А., Галагудза М. М. Молекулярные механизмы формирования ишемической толерантности головного мозга. Часть 1. // Вестник РАМН. 2012. № 6. С. 42−50.

Шляхто Е.В., Баранцевич Е. Р., Щербак Н. А., Галагудза М. М. Молекулярные механизмы формирования ишемической толерантности головного мозга. Часть 2. // Вестник РАМН. 2012. № 7. С. 20−29.

Aguado T., Romero E., Monory K., Palazuelos J., Sendtner M., Marsicano G., Lutz, B., Guzman M., Galve-Roperh I. The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis // J. Biol. Chem. 2007. V. 282(33). P. 23 892−23 898.

Alderson R.F., Curtis R., Alterman A.L., Lindsay R.M., DiStefano P. S. Truncated TrkB mediates the endocytosis and release of BDNF and neurotrophin-4/5 by rat astrocytes and schwann cells in vitro // Brain Res. 2000. V. 871(2). P. 210−222.

Almeida R.D., Manadas B.J., Melo C.V., Gomes J.R., Mendes C.S., Graos M.M., Carvalho R.F., Carvalho A.P., Duarte C.B. Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways // Cell death and differentiation. 2005. V. 12(10). P. 1329−1343.

Alonso M., Vianna M.R., Depino A.M., Mello e Souza T., Pereira P., Szapiro G., Viola H., Pitossi F., Izquierdo I., Medina J.H. BDNF-triggered events in the rat hippocampus are required for both shortand long-term memory formation // Hippocampus. 2002. V. 12(4). P. 551−560.

Aptowicz C.O., Kunkler P.E., Kraig R.P. Homeostatic plasticity in hippocampal slice cultures involves changes in voltage-gated Na+ channel expression // Brain Res. 2004. 998(2): 115−163.

Araki R., Nashito I. Multicomponent analysis of near-in-frared spectra of rat heard // Adv. Exp. Med. and Biol. 1989. V.248. P. 11−20.

Arthur J.S.C., Fong A.L., Dwyer J.M., Davare M., Reese E., Obrietan K., Impey S. Mitogenand stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophins // J. Neurosci. 2004. V. 24(18). P. 4324−4332.

Balkowiec A., Kunze D.L., Katz D.M. Brain-derived neurotrophic factor acutely inhibits AMPA-mediated currents in developing sensory relay neurons // J. Neurosci. 2000. V. 20(5). P. 1904;1911.

Barbacid M. The Trk family of neurotrophin receptors // J. Neurobiol. 1994. V. 25(11). P. 1386−1403.

Barde Y.A., Edgar D., Thoenen H. Purification of a new neurotrophic factor from mammalian brain // EMBRO J. 1982. V. 1(5). P. 549−553.

Barnabe-Heider F., Miller F.D. Endogenously produced neurotrophins regulate survival and differentiation of cortical progenitors via distinct signaling pathways // J. Neurosci. 2003. V. 23(12). P. 5149−5160.

Bath K.G., Lee F.S. Variant BDNF (Val66Met) impact on brain structure and function // Cogn Affect Behav Neurosci. 2006. V. 6(1). P. 79−85.

Behar T.N., Li Y.X., Tran H.T., Ma W., Dunlap V., Scott C., Barker J.L. GABA stimulates chemotaxis and chemokinesis of embryonic cortical neurons via calcium-dependent mechanisms // J. Neurosci. 1996. V. 16(5). P. 1808−1818.

Bekinschtein P., Cammarota M., Izquierdo I., Medina J.H. BDNF and memory formation and storage // Neuroscientist. 2008. V. 14(2). P. 147−156.

Belhage B., Hansen G.H., Elster L., Schousboe A. Effects of gamma-aminobutyric acid (GABA) on synaptogenesis and synaptic function // Perspect. Dev. Neurobiol. 1998. V. 5(2−3). P. 305−322.

Bidaut-Russell M., Devane W.A., Howlett A.C. Cannabinoid receptors and modulation of cyclic AMP accumulation in the rat brain // J. Neurochem. 1990. V. 55(1). P. 21−26.

Biffo S., Offenhдuser N., Carter B.D., Barde Y.A. Selective binding and internalisation by truncated receptors restrict the availability of BDNF during development // Developmemt. 1995. V. 121(8). P. 2461−2470.

Boehler M., Wheeler B.C., Brewer G.J. Added astroglia promotes greater synapse density and higher activity in neuronal networks // Neuron Glia Biol. 2007. V. 3(2). P. 127−140.

Bonni A., Brunet A., West A.E., Datta S.B., Takasu M.A., Greenberg M.E. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent andindependent mechanisms // Science. 1999. V. 286. P. 1358−1361.

Bramham C.R., Southard T., Sarvey J.M., Herkenham M., Brady L.S. Unilateral LTP triggers bilateral increases in hippocampal neurotrophin and trk receptor mRNA expression in behaving rats: evidence for interhemispheric communication // J. Comp Neurol. 1996. V. 368(3). P. 371−382.

Brunig I., Penschuck S., Berninger B., Benson J., Fritschy J.M. BDNF reduces miniature inhibitory postsynaptic currents by rapid downregulation of GABA (A) receptor surface expression // Eur. J. Neurosci. 2001. V. 13(7). P. 1320−1328.

Caldeira M.V., Melo C.V., Pereira D.B., Carvalho R.F., Carvalho A.L., Duarte C.B. BDNF regulates the expression and traffic of NMDA receptors in cultured hippocampal neurons // Mol Cell Neurosci. 2007. V. 35(2). P. 208−219.

Casaccia-Bonnefil P., Carter B.D., Dobrowsky R.T., Chao M.V. Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75 // Nature. 1996. V. 383(6602). P. 716−719.

Castren E., Thoenen H., Lindholm D. Brain-derived neurotrophic factor messenger RNA is expressed in the septum, hypothalamus and in adrenergic brain stem nuclei of adult brain and is increased by osmotic stimulation in the paraventricular nucleus // Neurocience. 1995. V. 64(1). P. 71−80.

Castrйn E., Zafra F., Thoenen H., Lindholm D. Light regulates expression of brain-derived neurotrophic factor mRNA in rat visual cortex // Proc Natl Acad Sci USA. 1992. V. 89(20). P. 9444−9448.

Chang S.H., Poser S., Xia Z. A novel role for serum response factor in neuronal survival // J. Neurosci. 2004. V. 24(9). P. 2277−2285.

Chao M.V., Bothwell M. Neurotrophins: to cleave or not to cleave // Neuron. 2002. V. 33 (1). P. 9−12.

Chen A., Xiong L-J., Tong Y., Mao M. The neuroprotective roles of BDNF in hypoxic ischemic brain injury // Biomedical reports. 2013. V. 1. P. 167−176.

Cheng Q., Yeh H.H. Brain-derived neurotrophic factor attenuates mouse cerebellar granule cell GABA (A) receptor-mediated responses via postsynaptic mechanisms // J. Physiol. 2003. V. 548(3). P. 711−721.

Chien C. B, Pine J. Voltage-sensitive dye recording of action potentials and synaptic potentials from sympathetic microcultures // Biophys. J. 1991. V. 60(3). P. 697−711.

Choi J.S., Kim J.A., Joo C.K. Activation of MAPK and CREB by GM1 induces survival of RGCs in the retina with axotomized nerve // Invest. Ophthalmol. Vis. Sci. 2003. V. 44(4). P. 1747−1752.

Climent E., Sancho-Tello M., Miсana R., Barettino D., Guerri C. Astrocytes in culture express the full-length Trk-B receptor and respond to brain derived neurotrophic factor by changing intracellular calcium levels: effect of eyhanol exposure in rats // Neurosci Lett. 2000. V. 288(1). P. 53−56.

Croll S.D., Suri C., Compton D.L., Simmons M.V., Yancopoulos G.D., Lindsay R.M., Wiegand S.J., Rudge J.S., Scharfman H.E. Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex // Neuroscience. 1999. V. 93. P. 1491−1506.

Сunha C., Brambilla R., Tomas K.L. A simple role for BDNF in learning and mamory? // Frontiers in Molecular Neuroscience. 2010. V.3:1. doi: 10.3389/neuro.02.001.2010.

Davies P., Anderton B., Kirsch J., Konnerth A., Nitsch R., Sheetz M. First one in, last one out: thr role of gabaergic transmission in generation and degeneration // Prog. Neurobiol. 1998. V. 55(6). P. 651−658.

Dechant G., Barde Y.A. The neurotrophin receptor p75 (NTR): novel functions and implications for diseases of the nervous system // Nat Neurosci. 2002. V. 5(11). P. 1131−1136.

Demarse T.B., Wagenaar D.A., Blau A.W., Potter S.M. The neurally controlled animat: biological brains acting with simulated bodies // Auton. Robots. 2001. V. 11(3). P. 305−310.

D’Hooge R. and De Deyn P.P. Application for the Morris water maze in the study of learning and memory // Brain Res. Rev. 2001; V. 36(1). Р. 60−90.

Dias B.G., Banerjee S.B., Duman R.S., Vaidya V.A. Differential regulation of brain derived neurotrophic factor transcripts by antidepressant treatments in the adult rat brain // Neuropharmacology. 2003. V. 45 (4). P. 553−563.

Dirnagl U., Becker K., Meisel A. Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use // Lancet Neurol. 2009. V. 8(4). P. 398−412.

Downward J. PI 3-kinase, Akt and cell survival // Semin Cell Dev. Biol. 2004. V.15(2). P. 177−182.

Edelman E., Lebmann V., Brigadski T. Preand postsynaptic twists in BDNF secretion and action in synaptic plasticity // Neuropharmacology. 2014. V.76. P. 610−627. doi: 10.1016/j.neuropharm.2013.05.043.

Egan M.F., Kojima M., Callicott J.H., Goldberg T.E., Kolachana B.S., Bertolino A., Zaitsev E., Gold B., Goldman D., Dean M., Lu B., Weinberger D.R. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function // Cell. 2003. V. 112(2). P. 257−269.

Eide F.F., Vining E.R., Eide B.L., Zang K., Wang X.Y., Reichardt L.F. Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling // J. Neurosci. 1996. V. 16(10). P. 3123−3129.

Elkabes S., DiCicco-Bloom E.M., Black I.B. Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function // J. Neurosci. 1996. V. 16(8). P. 2508−2521.

Esposito D., Patel P., Stephens R.M., Perez P., Chao M.V., Kaplan D.R., Hempstead B.L. The cytoplasmic and transmembrane domains of the p75 and TrkA receptors regulate high affinity binding to nerve growth factor // J. Biol Chem. 2001. V. 276(35). P. 32 687−32 695.

Farrant M., Kaila K. The cellular, molecular and ionic basis of GABA (A) receptor signaling // Prog Brain Res. 2007. V. 160. P. 59−87.

Ferenz K.B., Gast R.E., Rose K., Finder I.E., Hasche A., Krieglstein J. Nerve growth factor and brain-derived neurotrophic factor but not granulocyte colony-stimulating factor, nimodipine and dizocilpine, require ATP for neuroprotective activity after oxygen-glucose deprivation of primary neurons // Brain Research. 2012. V. 1448. P. 20−26. doi: 10.1016/j.brainres.2012.02.016.

Ferrer I., Marнn C., Rey M.J., Ribalta T., Goutan E., Blanco R., Tolosa E., Martн E. BDNF and full-length and truncated TrkB expression in Alzheimer disease. Implications in therapeutic strategies // J. Neuropathol Exp Neurol. 1999. V.58(7). P. 729−739.

Ferrini F., De Koninck Y. Microglia control neuronal network excitability via BDNF signaling // Neural plasticity. 2013. V. 2013: 429 815. doi: 10.1155/2013/429 815.

Figurov A., Pozzo-Miller L.D., Olafsson P., Wang T., Lu B. Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus // Nature. 1996. V. 381(6584). P. 706−709.

Frade J.M., Rodriguez-Tebar A., Barde Y.A. Induction of cell death endogenous nerve growth factor through its p75 receptor // Nature. 1996. V. 383(6596). P. 166−168.

Frisen J., Verge V.M., Fried K., Risling M., Persson H., Trotter J, Hцkfelt T., Lindholm D. Characterization of glial trkB receptors: differential response to injury in the central and peripheral nervous systems // Proc Natl Acad Sci USA. 1993. V. 90(11). P. 4971−4975.

Fryer R.H., Kaplan D.R., Kromer L.F. Truncated trkB receptors on nonneuronal cells inhibit BDNF-induced neurite outgrowth in vitro // Exp Neurol. 1997. V. 148(2). P. 616−627.

Fukuda H., Yasuda H., Shimokawa S., Tamura M. The oxygen dependence of the energy state of cardiac tissue: 31P-NMR and optical measurement of myoglobin in perfused rat heart // Adv. Exp. Med. Biol. 1989. V. 248. P. 531−573.

Ganguly K., Schinder A.F., Wong S.T., Poo M. GABA itself promotes the developmental switch of neuronal GABAergic responses from excitation to inhibition // Cell. 2001. V. 105(4). P. 521−532.

Georgiev D.D., Taniura H., Kambe Y., Yoneda Y. Crosstalk between brain-derived neurotrophic factor and N-methyl-D-aspartate receptor signaling in neurons // Biomed Rev. 2008. V.19. P. 17−27.

Grande I., Fries G.R., Kunz M., Kapczinski F. The role of BDNF as a mediator of neuroplasticity in bipolar disoder // Psychiatry Investig. 2010. V. 7(4). P. 243−250.

Gross G.W., Kovalski J.M. Origins of activity patterns in self-orgaizing neuronal networks in vitro // J. Intell. Mater. Syst. Struct. 1999. V. 10. P. 558−564.

Haapasalo A., Koponen E., Hoppe E., Wong G., Castrйn E. Truncated trkB. T1 is dominant negative inhibitor of trkB. TK±mediated cell survival // Biochem Biophys Res Commun. 2001. V. 280(5). P. 1352−1358.

Haapasalo A., Sipola I., Larsson K., Akerman K.E., Stoilov P., Stamm S., Wong G., Castren E. Regulation of TRKB surface expression by brain-derived neurotrophic factor and truncated TRKB isoforms // J. Biol Chem. 2002. V. 277(45). P. 43 160−43 167.

Hall J., Thomas K.L., Everitt B.J. Rapid and selective induction of BDNF expression in the hippocampus during contextual learning // Nat Neurosci. 2000. V. 3(6). P. 533−535.

Ham M.I., Bettencourt L.M., McDaniel F.D., Gross G.W. Spontaneous coordinated activity in cultured networks: analysis of multiple ignition sites, primary circuits, and burst phase delay distributions // Journal of Computational Neuroscience. 2008. V. 24(3). P. 346−357.

Han B.N., Holtzman D.M. BDNF protects the neonatal brain from hypoxic-ischemic injury in vivo via the ERK pathway // J. Neurosci. 2000. V. 20(15). P. 5775−5781.

Hashimoto R., Takei N., Simazu K., Christ L., Lu B., Chuang D.M. Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity // Neuropharmacology. 2002. V. 43(7). P. 1173−1179.

Haydar T.F., Wang F., Schwartz M.L., Rakic P. Differential modulation of proliferation in the neocortical ventricular and subventricular zones // J. Neurosci. 2000. V. 20(15). P. 5764−5774.

Hensch T.K., Stryker M.P. Columnar architecture sculpted by GABA circuits in developing cat visual cortex // Science. 2004. V. 303(5664). P. 1678−1681.

Hetman M., Gozdz A. Role of extracellular signal regulated kinases 1 and 2 in neuronal survival // Eur. J. Biochem. 2004. V. 271. P. 2050;2055.

Hetman M., Kanning K., Cavanaugh J.E., Xia Z.G. Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signalregulated kinase and phosphatidylinositol 3-kinase // J. Biol. Chem. 1999. V. 274(32). P. 22 569−22 580.

Howells D.W., Porritt M.J., Wong J.Y., Batchelor P.E., Kalnins R., Hughes A.J., Donnan G.A. Reduced BDNF mRNA expression in the Parkinson’s disease substancia nigra // Exp Neurol. 2000. V. 166(1). P. 127−135.

Huber K.M., Sawtell N.B., Bear M.F. Brain-derived neurotrophic factor alters the synaptic modification threshold in visual cortex // Neuropharmacology. 1998. V. 37(4−5). P. 571−579.

Inglefield J.R., Mundy W.R., Meacham C.A., Shafer T.J. Identification of calcium-dependent andindependent signaling pathways involved in polychlorinated biphenyl-induced cyclic AMP-responsive elementdi-binding protein phosphorylation in developing cortical neurons // Neuroscience. 2002. V. 115(2). P. 559−573.

Irving E.A., Bamford M. Role of mitogenand stress-activated kinases in ischemic injury // J. Cereb. Blood Flow Metab. 2002. V. 22(6): 631−647.

Ishibashi H., Hihara S., Takahashi M., Heike T., Yokota T., Iriki A. Tool-use learning induces BDNF expression in a selective portion of monkey anterior parietal cortex // Brain Res Mol Brain Res. 2002. V. 102(1−2). P. 110−112.

Jain V., Baitharu I., Prasad D., Ilavazhagan G. // Enriched environment prevents hypobaric hypoxia iduced memory impairment and neurodegeneration: role of BDNF/PI3K/GSK3 В pathway coupled with CREB activation // Plos one. 2013 V.8(5): e62235. doi: 10.1371/journal.pone.62 235.

Jiang Y., Wei N., Zhu J., Lu T., Chen Z., Xu G., Liu X. Effects of brain-derived neurotrophic factor on local inflammation in experimental stroke of rat // Mediators of Inflammation. 2010. V. 2010: 372 423. P. 1−10.

Jiang Y., Wei N., Lu T., Zhu J., Xu G., Liu X. Intranasal brain-derived neurotrophic factor protects brain from ischemic insult via modelling local inflammation in rats. Neuroscience. 2011. V.172. P. 398−405.

Jones K.R., Reichardt L.F. Molecular cloning of a human gene that is a member of the nerve growth factor family // Proc. Natl. Acad. Sci. U.S.A. 1990. V. 87(20). P. 8060−8064.

Kamioka H., Jimbo Y., Charlety P.J., Kawana A. Planar electrode arrays for long-term measurement of neuronal firing in cultured cortical slices // Cellular Eng. 1997. V. 2. P. 148−153.

Khaspekov L.G., Brenz Verca M.S., Frumkina L.E., Hermann H., Marsicano G., Lutz B. Involvement of brain-derived neurotrophic factor in cannabinoid receptor-dependent protection against excitotoxicity // Eur.Neuroci. 2004. V. 19(7). P. 1691−1698.

Khazipov R., Leinekugel X., Khalilov I., Gaiarsa J.L., Ben-Ari Y. Synchronization of GABAergic interneuronal network in CA3 subfield of neonatal rat hippocampal slices // J. Physiol. 1997. V. 498(3). P. 763−772.

Kim H., Li Q., Hempstead B.L., Madri J.A. Paracrine and autocrine functions of Brain-derived neurotrophic factor (BDNF) and Nerve growth factor (NGF) in brain-derived endothelial cells // The Journal of Biological Chemistry. 2004. V.279(32). P. 33 538−33 546.

Kraig R.P., Pulsinelly W.A., Plum F. Carbonic acid buffer changes during complete brain ischemia // Am J Physiol. 1986. Vol. 250. P. 348−357.

Larsen E.C., Hatcher G.F., Adibhatla R.M. Effects of D609 on phospholipid metabolism and cell death during oxygen-glucose deprivation in PC12 cells // Neuroscience. 2007. V. 146(3). P. 946−961.

Leal G., Comprido D., Duarte C.B. BDNF-induced local protein synthesis and synaptic plasticity // Neuropharmacology. 2014. V.76. P. 639−656. doi: 10.1016/j.neuropharm.2013.04.005.

Lee F.S., Kim A.H., Khursigara G., Chao M.V. The uniqueness of being a neurotrophin receptor // Neurobiol. 2001. V. 11(3). P. 281−286.

Lee R., Kermani P., Teng K.K., Hempstead B.L. Regulation of cell survival by secreted proneurotrophins // Science. 2001. V. 294(5548). P. 1945;1948.

Leibrock J., Lottspeich F., Hohn A., Hofer M., Hengerer B., Masiakowski P., Thoenen H., Barde Y.A. Molecular cloning and expression of brain-derived neurotrophic factor // Nature. 1989. V. 341(6238). P. 149−152.

Leinekugel X., Tseeb V., Ben-Ari Y., Bregestovski P. Synaptic GABAA activation induces Ca2+ rise in pyramidal cells and interneurons from rat neonatal hippocampal slices // J. Physiol. 1995. V. 487(2). P. 319−329.

Levine S. Anoxic-ischemic encephalopathy in rats // Am J Pathol. 1960. V. 36. P. 1−17.

Li Y., Zhou W., Li X., Zeng S., Liu M., Luo Q. Characterization of synchronized bursts in cultured hippocampal neuronal networks with learning training on microelectrode arrays // Biosens Bioelectron. 2007. V. 22(12). P. 2976−2982.

Lin S.Y., Wu K., Levine E.S., Mount H.T., Suen P.C., Black I.B. BDNF acutely increases tyrosine phosphorylation of the NMDA receptor subunit 2B in cortical and hippocampal postsynaptic densities // Brain Res Mol Brain Res. 1998. V. 55(1). P. 20−27.

Lu B. Pro-region of neurotrophins: role in synaptic modulation // Neuron. 2003. V. 39(5). P. 735−738.

Luikart B.W., Nef S., Shipman T., Parada L.F. In vivo role of truncated trkb receptors during sensory ganglion neurogenesis // Neuroscience. 2003. V. 117(4). P. 847−858.

Lukyanova L.D., Dudchenko A.V., Tzybina Т.А., Germanova E.L., Tkatchuk E.N. Mitochondrial signaling in adaptation to hypoxia // Adaptation. Biol. Med. / Lukyanova L, Takeda N., Singal P.- New Delhi, Narosa P.H. 2008. V. 5. P. 245−259.

Madara J.C., Levine E.S. Presynaptic and postsynaptic NMDA receptors mediate distinct effects of brain-derived neurotrophic factor on synaptic transmission // J Neurophysiol. 2008. V. 100(6). P. 3175−3184.

Maddahi A., Edvinsson L. Cerebral ischemia induces microvascular pro-inflammatory cytokine expression via MEK/ERK pathway // Neuroinflammation. 2010. V. 7. P. 32−38.

Madhavan R., Chao Z.C., Potter S.M. Spontaneous bursts are better indicators of tetanus-induced plasticity than responses to probe stimuli // Proceeding of Second International IEEE EMBS Conference on Neural Engineering. 2006. P. 5−8.

Maisonpierre P.C., Le Beau M.M., Espinosa R., Ip N.Y., Belluscio L., de la Monte S.M., Squinto S., Furth M.E., Yancopoulos G.D. Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations // Genomics. 1991. V. 10(3). P. 558−568.

Mao M., Wang Z.L., Zhou H., Li S.F., Yu D., Hua J.P. Cellular levels of TrkB and MAPK in the neuroprotective role of BDNF for embryonic rat cortical neurons against hypoxia in vitro // Int. J. Dev. Neurosci. 2005. V. 23 (6). P. 515−521.

Markham A., Cameron I., Bains R., Franklin P., Kiss J.P., Schwendimann L., Gressens P., Spedding M. Brain-derived neurotrophic factormediated effects on mitochondrial respiratory coupling and neuroprotection share the same molecular signaling pathways // Europian Journal of Neurosci. 2012. V. 35. P. 366−374.

Markham A., Cameron I., Franklin P., Spedding M. BDNF increases rat brain mitochondrial respiratory coupling at complex I, but not complex II // Eur. J. Neurosci. 2004. V.20(5). P.1189−1196.

Martin J.L., Finsterwald C. Cooperation between BDNF and glutamate in the regulation of synaptic transmission and neuronal development // Commun Integr Biol. 2011. V. 4(1). P. 14−16.

Miyata K., Omori N., Uchino H., Yzmafuchi T., Isshiki A., Shibasaki F. Involvement of the brain-derived neurotrophic factor/TrkB pathway in neuroprotective effect of cyclosporine A in forebrain // Neuroscience. 2001. V. 105(3). P. 571−578.

Mizoguchi Y., Ishibashi H., Nabekura J. The action of BDNF on GABA (A) currents changes from potentiating to suppressing during maturation of rat hippocampal CA1 pyramidal neurons // J. Physiol. 2003. V. 548. P. 703−709.

Mizoguchi Y., Monji A., Kato T., Seki Y., Gotoh L., Horikawa H., Suzuki S.O., Iwaki T., Yonaha M., Hashioka S., Kanba S. Brain-derived neurotrophic factor induced sustained elevation of intracellular Ca2+ in rodent microglia // J. Immunol. 2009. V. 183(12). P. 7778−7786.

Mograbi B., Bocciardi R., Bourget I., Rochet N., Farahi-Far D., Juhel T., Rossi B. Glial cell line-derived neurotrophic factor-stimulated phosphatidylinositol 3-kinase and Akt activities exert opposing effects on the ERK pathway // J. Biol. Chem. 2001. V. 276(48). P. 45 307−45 319.

Murer M.G., Yan Q., Raisman-Vozari R. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer’s disease and Parkinson’s disease // Prog Neurobiol. 2001. V. 63(1). P. 71−124.

Nakazawa T., Tamai M., Mori N. Brain-derived neurotrophic factor prevents axotomized retinal ganglion cell death through MAPK and PI3K signaling pathways // Invest. Ophthalmol. Vis. Sci. 2002. V. 439(10). P. 3319−3326.

Namura S., Iihara K., Takam I.S., Kikuchi H., Matsushita K., Moskowitz M.A., Bonventre J.V., Alessandrini A. Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia // PNAS. 2001. V. 98(20). P. 11 569−11 574.

Narisawa-Saito M., Iwakura Y., Kawamura M., Araki K., Kozaki S., Takei N., Nawa H. Brain-derived neurotrophic factor regulates surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors by enhancing the N-ethylmaleimide-sensitive factor/GluR2 interaction in developing neocortical neurons // J. Biol Chem. 2002. V. 277(43). P. 40 901−40 910.

Neeper S.A., Gуmez-Pinilla F., Choi J., Cotman C. Exercise and brain neurotrophins // Nature. 1995. V. 373(6510). P. 109.

Nguyen T.L., Kim C.K., Cho J.H., Lee K.H., Ahn J.Y. Neuroprotection signaling pathway of nerve growth factor and brain-derived neurotrophic factor against staurosporine induced apoptosis in hippocampal H19−7/IGF-IR // Exp Mol Med. 2010. V. 42(8). P. 583−595.

Nong Y., Huang Y.Q., Salter M.W. NMDA receptors are movin' in // Curr Opin Neurobiol. 2004. V. 14(3). P. 353−361.

Pan L., Song X., Xiang G., Wong A., Xing W., Cheng J. First spike rank order as a reliable indicator of burst initiation and its relation with early-to-fire neurons // IEEE Trans. Biomed. Eng. 2009. V. 56(6). P. 1673−1682.

Park J.Y., Kim E.J., Kwon K.J., Jung Y.S., Moon C.H., Lee S.H., Baik E.J. Neuroprotection by fructose-1,6-bisphosphate involves ROS alterations via p38 MAPK/ERK // Brain Res. 2004. V. 1026 (2). P. 295−301.

Patapoutian A., Reichardt L.F. Trk receptors: mediators of neurotrophin action // Curr Opin Neurobiol. 2001. V. 11(3). P. 272−280.

Patterson S.L., Abel T., Deuel T.A., Martin K.C., Rose J.C., Kandel E.R. Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice // Neuron. 1996. V. 16(6). P. 1137−1145.

Patterson S.L., Grover L.M., Schwartzkroin P.A., Bothwell M. Neurotrophin expression in rat hippocampal slices: a stimulus paradigm including LTP in CA1 evokes increases in BDNF and NT-3 mRNAs // Neuron. 1992. V. 9(6). P. 1081−1088.

Phillips H.S., Hains J.M., Armanini M., Laramee G.R., Johnson S.A., Winslow J.W. BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer’s disease // Neuron. 1991. V. 7(5). P. 695−702.

Pimashkin A., Kastalskiy I., Simonov A., Koryagina E., Mukhina I., Kazantsev V. Spiking signatures of spontaneous activity bursts in hippocampal cultures // Frontiers in Computational Neuroscience. 2011. 5(46) doi: 10.3389/fncom.2011.46.

Pine J. Recording action potentials from cultured neurons with extracellular microcircuit electrodes // J. Neurosci. Methods. 1980. V. 2(1). P.19−31.

Porcher C., Hatchett C., Longbottom R.E., McAinch K., Sihra T.S., Moss S.J., Thomson A.M., Jovanovic J.N. Positive feedback regulation between gamma-aminobutyric acid type A (GABA (A)) receptor signaling and brain-derived neurotrophic factor (BDNF) release in developing neurons // J. Biol Chem. 2011. V. 286(24). P. 21 667−21 677.

Potter S.M., DeMarse T.B. A new approach to neural cell culture for long-term studies // Journal of Neuroscience Methods. 2001. V. 110. P. 17−24.

Regehr W.G., Pine J., Cohan C.S., Mischke M.D., Tank D.W. Sealing cultured neurons to embedded dish electrodes facilitates long-term stimulation and recording // J. Neurosci. Methods. 1989. V. 30(2). P. 91−106.

Roback J.D., Marsh H.N., Downen M., Palfrey H.C., Wainer B.H. BDNF-activated signal transduction in rat cortical glial cells // Eur J Neurosci. 1995. V. 7(5). P. 849−862.

Rocamora N., Welker E., Pascual M., Soriano E. Upregulation of BDNF mRNA expression in the barrel cortex of adult mice after sensory stimulation // J. Neurosci. 1996. V. 16(14). P. 4411−4419.

Rose C.R., Blum R., Kafitz K.W., Kovalchuk Y., Konnerth A. From modulator to mediator: rapid effects of BDNF on ion channels // Bioessays. 2004. V. 26(11). P. 1185−1194.

Rosental A., Goeddel D.V., Nguyen T., Martin E., Burton L.E., Shih A., Laramee G.R., Wurm F., Mason A., Nikolics K. et al. Primary structure and biological activity of human brain-derived neurotrophic factor // Endocrinology. 1991. V. 129(3). P. 1289−1294.

Roux P.P., Colicos M.A., Barker P.A., Kennedy T.E. p75 neurotrophin receptor expression is induced in apoptotic neurons after seizure // J. Neurosci. 1999. V. 19(16). P. 6887−6896.

Saarelainen T., Lukkarinen J.A., Koponen S., Grцhn O.H., Jolkkonen J., Koponen E., Haapasalo A., Alhonen L., Wong G., Koistinaho J., Kauppinen R.A., Castrйn E. Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons show increased susceptibility to cortical injury after focal cerebral ischemia // Mol Cell Neurosci. 2000. V. 16(2). P. 87−96.

Saarelainen T., Pussinen R., Koponen E., Alhonen L., Wong G., Sirviц J., Castrйn E. Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons have impaired long-term spatial memory but normal hippocampal LTP // Synapse. 2000. V. 38(1). P. 102−104.

Satoh T., Nakatsuka D., Watanabe Y., Nagata I., Kikuchi H., Namura S. Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons // Neurosci. Lett. 2000. V. 288(2). P. 163−166.

Schabitz W.R., Sommer C., Zoder W., Kiessling M., Schwaninger M., Schwab S. Intravenous brain-derived neurotrophic factor reduces infarct size and counterregulates Bax and Bcl-2 expression after temporary focal cerebral ischemia // Stroke. 2000. V. 31(9). P. 2212−2217.

Scharfman H.E. Hyperexcitability in combined entorhinal/hippocampal slices of adult rat after exposure to brain-derived neurotrophic factor // J. Neurophysiol. 1997. V. 78(2). P. 1082−1095.

Scharfman H.E., Goodman J.H., Sollas A.L. Actions of brain-derived neurotrophic factor in slices from rats with spontaneous seizures and mossy fiber sprouting in the detate gyrus // J. Neurosci. 1999. V. 19 (13). P. 5619−5631.

Scharfman H.E., Goodman J.H., Sollas A.L., Croll S.D. Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor // Exp. Neurol. 2002. V. 174. P. 201−214.

Schratt G.M., Nigh E.A., Chen W.G., Hu L., Greenberg M.E. BDNF regulates the translation of a select group of mRNAs by a mammalian target of rapamycin-phosphatidylinositol 3-kinase-dependent pathway during neuronal development // J. Neurosci. 2004. V. 24(33). P. 7366−7377.

Segal R.A. Selectivity in neurotrophin signalling: theme and variations // Annu Rev Neurosci. 2003. V. 26. P. 299−330.

Sheng M., Cummings J., Roldan L.A., Jan Y.N., Jan L.Y. Changing subunit composition of heteromeric NMDA receptors during development of rat cortex // Nature. 1994. V. 368(6467). P. 144−147.

Shi S.S., Shao S.H., Yuan B.P., Pan F., Li Z.L. Acute stress and chronic stress change brain-derived neurotrophic factor (BDNF) and tyrosine kinase-coupled receptor (TrkB) expression in both young and aged rat hippocampus // Yonsei Med J. 2010. V. 51(5). P. 661−671.

Shishkina G.T., Kalinina T.S., Berezova I.V., Bulygina V.V., Dygalo N.N. Resistance to the development of stress-induced behavioral despair in the swim test associated with elevated hippocampal Bcl-xl expression // Behav. Brain Res. 2010. V. 213(2). P. 218−224.

Smith M.L., Bendek G., Dahlgren N., Rosen I., Wieloch T., Siesjo B.K. Models for studying long-term recovery following forebrain ischemia in the rat. 2. A 2-vessel occlusion model // Acta Neurol Scand. 1984. V. 69(6). P. 385−401.

Song D.K., Choe B., Bae J.H., Park W.K., Han I.S., Ho W.K., Earm Y.E. Brain-derived neurotrophic factor rapidly potentiates synaptic transmission through NMDA, but suppresses it through non-NMDA receptors in rat hippocampal neuron // Brain Res. 1998. V. 799(1). P. 176−179.

Stegenga J., le Feber J., Rutten W.L. Changes within bursts during learning in dissociated neural networks // Engineering in Medicine and Biology Society, 2008. EMBS 2008: 30th Annual International Conference of the IEEE. P.4968−4971.

Sun X., Zhou H., Luo X., Li S., Yu D., Hua J., Mu D., Mao M., Neuroprotection of brain-derived neurotrophic factor against hypoxic injury in vitro requires activation of extracellular signal-regulated kinase and phosphatidylinositol 3-kinase // Int. J. Devl Neuroscience. 2008. V. 26. P. 363−370.

Tanaka T., Saito H., Matsuki N. Inhibition of GABAA synaptic responses by brain-derived neurotrophic factor (BDNF) in rat hippocampus // J. Neurosci. 1997. V. 17(9). P. 2959−2966.

Thomas C.A., Springer P.A., Loeb G.E., Berwald-Netter Y., Okun L.M. A miniature microelectrode array to monitor the bioelectric activity of cultured cells // Exp. Cell Res. 1972. V. 74(1). P. 61−66.

Vedunova M., Sakharnova T., Mitroshina E., Perminova M., Pimashkin A., Zakharov Yu., Dityatev A., Mukhina I. Seizure-like activity in hyaluronidase-treated dissociated hippocampal cultures // Frontiers in cellular neuroscience. 2013. V. 7(149). doi: 10.3389/fncel.2013.149.

Veit C., Genze F., Menke A., Hoeffert S., Gress T.M., Gierschik P., Giehll K. Activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase is required for glial Cell line-derived neurotrophic factor-induced migration and invasion of pancreatic carcinoma cells // Cancer Res. 2004. V. 64. P. 5291−5300.

Wagenaar D.A., Pine J., Potter S. M. An extremely rich repertoire of bursting patterns during the development of cortical cultures // BMC Neurosci. 2006. 7:11.

Walton M., Connor B., Lawlor P., Young D., Sirimanne E., Gluckman P., Cole G., Dragunow M. Neuronal death and survival in two models of hypoxic-ischemic brain damage // Brain Res. Brain Res. Rev. 1999. V. 29 (2−3). P. 137−168.

Wang Y., Cao M., Liu A., Di W., Zhao F., Tian Y., Jia J. Changes of inflammatory cytokines and neurotrophins emphasized their roles in hypoxic-ischemic brain damage // International Journal of Neuroscience. 2013. V. 123(3). P. 191−195.

Wheeler B.C., Novak J.L. Current source density estimation using microelectrode array data from the hippocampal slice preparation // IEEE Trans. Biomed. Eng. 1986. V. 33(12). P. 1204−1212.

Wiedemann F.R., Siemen D., Mawrin C., Horn T.F., Dietzmann K. The neurotrophin receptor TrkB is colocalized to mitochondrial membranes // Int. J. Biochem. Cell Biol. 2006. V.38(4). P. 610−620.

Wu X., Zhu D., Jiang X., Okagaki P., Mearow K., Zhu G., McCall S., Banaudha K., Lipsky R.H., Marini A.M. AMPA protects cultured neurons against glutamate excitotoxicity through a phosphatidylinositol 3-kinase-dependent activation in extracellular signal-regulated kinase to upregulate BDNF gene expression // J. Neurochem. 2004. V. 90(4). P. 807−818.

Xiang G., Pan L., Huang L., Yu Z., Cheng J., Xing W., ZhouY. Microelectrode array-based system for neuropharmacological applications with cortical neurons cultured in vitro // Biosens Bioelectron. 2007. V. 22(11). P. 2478−2484.

Yacoubian T.A., Lo D.C. Truncated and full-length TrkB receptors regulate distinct modes of dendritic growth // Nat Neurosci. 2000. V. 3(4). P. 342−349.

Yamada K., Nabeshima T. Brain-derived neurotrophic factor/TrkB signaling in memory processes // J. Pharmacol Sci. 2003. V. 91(4). P. 267−270.

Zaccaro M.C., Ivanisevic L., Perez P., Meakin S.O., Saragovi H.U. p75 Co-receptors regulate ligand-dependent and ligand-independent Trk receptor activation, in part by altering Trk docking subdomains // J. Biol Chem. 2001. V. 276(33). P. 31 023−31 029.

Zhang J., Geula C., Lu C., Koziel H., Hatcher L.M., Roisen F.J. Neurotrophins regulate proliferation and survival of two microglial cell lines in vitro // Exp. Neurol. 2003. V. 183(2). P. 469−481.

Zhu X., Han X., Blendy J.A., Porter B.E. Decreased CREB levels suppress epilepsy // Neurobiol Dis. 2012. V. 45(1). P. 253−263.

Zuccato C., Ciammola A., Rigamonti D., Leavitt B.R., Goffredo D., Conti L., MacDonald M.E., Friedlander R.M., Silani V., Hayden M.R., Timmusk T., Sipione S., Cattaneo E. Loss of huntingtin-mediated BDNF gene transcription in Huntington’s disease // Science. 2001. V. 293(5529). P. 493−498.