Изучение свойств глутаматных рецепторов АМПА-типа мозга крысы на модели эпилепсии, вызванной имплантацией кобальта
Диссертация
В Институте Мозга человека РАН под руководством проф. Дамбиновой С. А. в течение ряда лет проводятся исследования участия ионотропных рецепторов глутамата, в том числе, АМРА-рецепторов, в развитии пароксизмальных состояний головного у человека и животных. Выдвинута концепция об участии аутоиммунных процессов в развитии эпилепсии, в частности, отмечено появление аутоантител (аАТ) к субъединицам… Читать ещё >
Список литературы
- Брагина H.H., Доброхотова Т. А. Функциональные асимметрии человека / Медицина. 1988. — М.
- Вартанян Г. А., Пирогов А.А Механизмы памяти центральной нервной системы / Под. ред. Г. А. Вартаняна. 1988. — Л.
- Гранстрем O.K., Ван Рин Т., Войскил P.A., Дамбинова С. А. Аутоантитела к фрагменту АМРА/квисквалатного типа глутаматного рецептора при модельной эпилепсии у крыс // Нейрохимия 1997. — т. 14. — No 2. — С. 75−87.
- Громова Л.Г., Гранстрем ОДС-, Изыкенова Г.А., Дамбинова С. А. Особенности определения в сыворотке крови аутоантител к АМРА/квисквалатным рецепторам головного мозга человека // Нейрохимия 1997. — т. 14. — No 1. -С. 98−106.
- Дамбинова С.А. Нейрорецепторы глутамата // Наука. 1989.- Л.
- Дамбинова С.А., Беседин В. И. Выделение и очистка белков, специфически связывающих L-глутамат, из мембран головного мозга крысы // Нейрохимия. 1982.-T.l.-No.4.-С. 543−549.
- Дамбинова С.А., Беседин В. И., Городинский А. И., Маргулис М. Н., Павлова О. И. Функция глутаматных рецепторов в мембранных везикулах, протеолипосомах и гибридных клетках нейробластомы N18Tg2a // Физиологич.ж.СССР. 1984. — Т.70. — No.'7. — С. 952−960
- Andrews, P. I., Dichter, M. A., Bercovic, S. F., Newton, M. R., McNamara J. O. Plasmapheresis in Rasmussen’s encephalitis // Neurology 1996. — vol. 46 — pp. 242−246.
- Babb TL, Pretorius JK, Kupfer WR, Crandall PH. Glutamate decarboxylase-immunoreactive neurons are preserved in human epileptic hippocampus // J.Neurosci. 1989. — No 9 — pp. 2562−74.
- Bading, H., Greenberg, M.E. // Science 1991 — No 253 — pp. 912.
- Barinaga M. Antibodies linked to rare epilepsy // Science 1995 — vol. 268 -No21-pp. 362−363.
- Bekenstein J, Rempc D, Lothman E. Decrease heterosynaptic and homosynaptic paired pulse inhibition in the rat hippocampus as a chronic sequela to limbic status epilepticus //Brain Res 1993 — No 601 — pp.111−20.
- Bekenstein JW, Lothman EW. Dormancy of inhibitory interneurons in a model of• Xtemporal lobe epilepsy // Science 1993 — No 259 — pp.97−100.
- Cavazos j. E., Das I., Sutula T. p. Neuronal loss induced in limbic pathways by kindling: evidence for induction of hippocampal sclerosis by repeatit briae seizures. // The J. of Neuroscience 1994 — No 14. — Vol.5 — pp.3106−3121.
- Chapman AG, DOmuller N. Hamson BL, Baron BM, Parvez N, Meldrum BS. Anticonvulsant activity of a novel NMDA/glycine site antagonist, MDL 104, 653. against kindled and sound-induced seizures. // Eur J Pharmacol 1995 — No 274 -pp. 83−88.
- Chapman AG. Excitatory neurotransmission and antiepileptic drug development: a status report. In: Pedley TA, Meldrum BS, eds. // Recent advances in epilepsy. -1995 -Vol.6.-pp. 1−21.
- Chapman AG., Smith SE, Meldrum BS. The anticonvulsant effect of the non-NMDA antagonists. NBQX and GYKI 52 466, in mice. // Epilepsy Res 1991b -No 9-pp. 92−96.
- Coenen A.M., Drinkenburg W.H., Peeters B.W., Vossen J.M., Van Luijelaar E.L. Absence epilepsy and the level of vigilance in rats of the WAG/Rij strein. // Neurosci- Biobehav.- 1991 No 15 — 259,-263.
- Cole, A.J., Saffen, D. W., Baraban, J.M., Worley, P.F. Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation.// Nature 1989 — No 340 — pp. 474−476
- Consroe P., Picchioni A., Chin L. Audiogenic seizure susceptible rats. // Fed. Proc. 1979-No 38. — pp. 2411−2416.
- Croucher MJ, Collins JF, Meldrum BS. Anticonvulsant action of excitatory amino acid antagonists. Science 1982:216: 899−901.
- Dambinova S. A., Izykenova G. A., Burov S.V., Grigorenko E.V., Gromov S.A. The presence of autoantibodies to N-terminus domain of GluRl subunit of AMPA receptor in the blood serum of patients with epilepsy // J.Neurol.Sci. 1997 — No 152-pp. 93−97.
- Dawson G.D., Holmes О. Cobalt applied to the sensorimotor area of the cortex cerebri of the rat. // J. Physiol (Lond) 1966 — Nol85 — pp.455−470.
- Delgado-Escueta A.V., Serratosa J., Liu A., Weissbecketr K., Medina M.T., Gee M., Treiman L., Sparkes R. Progress in mapping human epilepsy genes.// Epilepsia 1994 — No35(Suppl.) — S29-S40.
- Doble, A. Excitatory amino acid receptors and neurodegeneration. // Therapie -1995 vol. 50- pp. 319−337.
- During MJ, Spencer DD. Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain. // Lancet 1993 — No 341 — pp. 1607−1610.
- Durmuller N. Craggs M, Meldrum B. The effect of the non-NMDA antagonists GYKI 52 466 and NBQX and the competitive NMDA receptor antagonist D¦ ' lis
- CPPene on the development of amygdala kindling and on amygdala-kindicd seizures. // Epilepsy Res -1994 No 17 — pp.67−74.
- Ernfors, P., Bengzon, J., Persson, H., Lindvall, O. Increase levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis. // Neuron. 1991 — No 7 — pp. 165−176.
- Ferri R., Dal Gracco S., Elia M., Musumeci S., Spada R., Stefanini M. Scalp topographic mapping’of middle-latency somatosensory evoked potentials in nornal aging and dementia. // Neurophysiol Clin 1996 — Vol. 26 — pp. 331−319.
- Fischer J., Holubar J., Malik V. A new method of producing chronic epileptogenic cortical foci in rats. // Physiologia Bohemoslovaca 1967 — Vol. 16 -pp. 272−276.
- Fisher R. S. Animal models of the epilepsies. // Brain Research Review 1989 -Vol. 14-pp. 245−278. ¦ •
- Fisher RS, Cysyk BJ, Lesser RP, Pontecorvo MJ, Ferkany JT, Schwerdt PR, Hart J, Gordon B. Dextromethorphan for treatment of complex partial seizures. // Neurology 1990 — Vol. 40 — pp.547−559.
- Frey H.H., Loscher W., Reiche R., Schultz D. Anticonvulsant potency of common antiepileptic drugs in the gerbil. // Pharmacology 1983 — Vol. 27. — pp.330−335.
- Gall, C.M., Issackson, P.J. Limbic, seizures incrase neuronal production of messenger RNA for nerve growth factor. // Science 1989 — Vol. 245 — pp. 758 761.
- Gold, S.J., Hennegrriff, M., Lynch, G., Gall, C. M. Relative concentrations and seizure-induced changes in mRNAs encoding three AMPA receptor subunits in hippocampus and cortex. // The J. of Comparative Neurology 1996 — Vol. 365 -pp. 541−555.
- Greenamyre, J.T. and Porter, R.H.P. // Neurology -1994 Vol. 44 — Suppl. 8 — S7.
- Hayashi T. A physiological study of epileptic seizures following cortical stimulation in animals and its «application to human clinics. // Jap J Physiol 1952 -No 3-pp.46−64.
- Hollmann M. // Nature -1989- Vol. 342 pp. 643.
- Hosford D.A., Crain B.J., Cao Z. Increased AMPA-sensitive quisqualate receptor binding and reduced NMDA receptor binding in epileptic human hippocampus. // JNeurosci-1991-No 11-pp.428−434.
- Houser CR. GABA neurons in seizure disorders: a review of immunocytochemical studies. // Neurochem Res -1991 Vol. 16 — pp. 295−308.
- Ikonomidou, Ch., Turski L. Exitotoxity and neurodegenerative diseases. // Current Opinion in Neurology 1995 — vol. 8 — pp. 487−497.
- Imaizuma K., Nakano T. Mutant stocks, strain El. // Mouse News Lrtter 1964 Vol. 31-p. 57.
- Isackson, P.J., Huntsman, M. M., Murray, K. D., Gall, C. M. BDNF mRNA expression is increased in a^lult rat forebrain after limbic seizures: temporal patterns of induction distinct from NGF. // Neuron. 1991 — No 6 — pp.937−948.
- Janjua NA, Itano T, Kugoh T, Hosokawa K, Nakano M, Matsui LH, HataseO. Familial increase in plasma glutamic acid in epilepsy. // Epilepsy Res 1992 -Noll-pp.37−44.
- Janjua NA, Kabuto H, Mori A. Increased plasma glutamic acid in a genetic model of epilepsy. // Neurochem Res^- 1992a Vol. 17 — pp. 293−296.
- Johnston. M. V. Developmental aspects of epileptogenesis. // Epilepsia 1996 -Vol. 37 — pp. S2-S9.
- Keinanen K., Wisden W., Sommer B., Werner P., Herb A., Verdorn T.A., Sakmann B., Seeburg P.H. A family of AMPA-selective glutamate receptors. // Science 1990 — Vol.249 — pp. 556−560.
- Kaltschmidt, C., Kaltschmidt, B. and Baeuerle, P.A. // Proc. NatL Acad. Sci. USA 1995-Vol. 92- p.9618
- Kalviainen R, Halonen T., Pitkanen A, Riekkinen PJ. Amino acid levels in the cerebrospinal fluids of newly diagnosed epileptic patients: effect of vigabartin and carmazepin monotherapies. // J Neurochem -1993 Vol. 60 — pp. 1244−1250.
- Kamphuis W, Gorier JA, Lopes da Silva F. A long-lasting decrease in the inhibitory effect of GAB A on glutamate' responses of hippocampal pyramidal neurons induced by kindling epileptogenesis. // Nenroscience 1991 — Vol.41 -pp. 425−431.
- Kamphuis W, Huisman E. Dreijer AMC, Ghijsen WEJM, Verhage M, Lopes da Silva FH. Kindling increases the K±evoked Ca2+~dependent release of endogenous GAB A in area CAI of rat hippocampus. // Brain Res 1990 — Vol. 511 -pp, 63−70.
- Kapur J, Michelson HB, Butterbaugh GG, Lothman EW. Evidence for a chronic loss of inhibition in the hippocampus after kindling: electrophysiological studies. // Epilepsy Res 1989 — No 4 — pp. 90−99.
- Khrestchatisky M., Ferhat L., Charton G., Bernard A., Polard H., Represa A., Ben-Ari Y. Molecular correlats between reactive and developmental plasticity in the rat hippocampus. J! J. of Neurobiology 1995 — Vol. 26 — No.3 — pp. 426−436.
- Koella W.P. Animal experiniental methods in the study of antiepileptic drugs. / In: H.-H. Frey and D. Janz (Eds.), Antiepileptic Drugs. Handbook of Experimental Pharmacology 1985 — Vol. 74 — Springer — Berlin — pp. 282−339.
- Kohr G, De Koninck Y. Mody 1. Properties of NMDA receptor channels in neurons acutely isolated from epileptic kindled rats. // J Neurosci 1993 — vol. 13 -pp. 3612−3627.
- Kraus JE, Yeh G-C, Bonhaus DW, Nadler JV, McNamara JO. Kindling induces the long-lasting expression of a novel population of NMDA receptors in hippocampal region CA3. // J Neurosci 1994. — Vol. 14 — pp. 4196−4205.
- Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4 // Nature. 1970. — Vol. 227. — No. 5259. — pp.680−685.
- Lee S, Miskovsky J, Williamson J, Ho wells R, Devinsky 0, Lothman E, Christakos S. Changes in glutamate receptor and proenkephalin gene expression after kindled seizures. // Mol Brain Res 1994. — Vol. 24 — p.34.
- Lerea, L. S., McNamara, J.O. Ionotropic glutamate receptor subtypes activate c-fos transcription by distinct calcium-requiring intracellular signaling pathways. // Neuron-1993 No 10 — pp. 31−41.
- Lerea, L.S., Carlson, N.G. and McNamara, J.O. // Mol Pharmacol 1995 — Vol. 47-pp.1119.
- Louvel J, Pumain R. N-methyl-D-aspartate-mediated responses in epileptic cortex in man: an in vitro study. In: Engel J. // Neurotransmitters, Seizures and Epilepsy IV. Amsterdam: Elsevier 1992 — pp.487−95.
- Lowry O.H., Rosebrogh N. J., Farr A. L., Randall R.J. Protein measurement with the Folin phenol reagent // J. Biol. Chem. 1951.- Vol. 193. — No. 1. — pp. 265 -275.
- Martin, L. J., Blackstone, C. D., D. Levey, C. D., Huganir, B. L., Price, D. L. AMPA glutamate receptor subunits are differentially distributed in rat brain. // Neuroscience 1993, — Vol. 53 — No 2 — p. 327−358.
- Maxon S.C., Fine M.D., Ginsburg B.E., Koniecki D.L. A mutant for spontaneous seizures in C57BL/1 OBg mice. // Epilepsia 1983 Vol. 24 — pp. 15−24.
- McDonald J.W., Garofalo E.A., Hood T. Altered excitatory and inhibitory amino acid receptor binding in hippocampus of patients with temporal lobe epilepsy. // Ann Neurol 1994 — Vol. 29 — pp529−541.
- Mclntyre D., Kelly M., Armstrong J. Kindling in the perirhnial cortex. // Brain Res 1993 — Vol. 615 — pp. 1−6. '
- McNamara J.O. Role of neurotransmitters in seizure mehanisms in the kindling model of epilepsy. // FASEB J 1984−43:2516−20.
- McNamara JO. Cellular and molecular basis of epilepsy. // J Neurosci 1994 -Vol. 14-pp. 3413−3422.
- Meldrum BS. The role of glulamate in epilepsy and other CNS disorders. // Neurology 1994 — Vol. 44 — Suppl 8 — S14−23.
- Meldrum BS. Neurotransmission in Epilepsy // Epilepsia 1995 — Vol. 36 -Suppl. 1 -S30−35.
- Meldrum BS. Croucher MJ, Badman G, Collins JF. Antiepileptic action of excitatory amino acid antagonists in the photosensitive baboon Papio Papio // Neurosci Lett 1983 — Vol. 39 -pp.101−104.
- Meldrum BS. Excitatory amino acids in epilepsy and potential novel therapies. // Epilepsy Res 1992 — No 2 — pp. 189−196.
- Michaelis E. K., Chittenden W. L., Johnson B.E., Galton N., Decedue C. Purification, biochemical characterization, binding activity and selectivity of glutamate binding protein from bovine brain. // J. Neurochem. 1984 — Vol.42 -No.2 — pp.397−406.
- Michaelis EK. Glutamate Neurotransmission: characteristics ofNMDA receptors in the mammalian brain // Neur. Not. Meg .- 1996 Vol. II — issue2 — pp.03−11.
- Minamoto Y, Itano T. Tokuda M, Matsui H. Janjua NA, Hosokawa K, Okada Y. Murakami TH. Negi T, Hatase 0. In vivo microdialysis of amino acid neurotransmitlers in the hippocampus in amygdaloid kindled rat. // Brain Res -1992 Vol. 573 -pp. 345−348.
- Mody I, Stanton PR, Heinemann U. Activation of N-meth-D-aspartate receptors parallels changes in cellular and synaptic properties of dentate granule cells after kindling. // J Neurophysiol 1988 — Vol. 59 pp. 1033−1053.
- Monaghan D.T., Wenthold R.T. The Ionotropic Glutamate Receptors. / Humana Press, Totowa, New Jersey, 1997.
- Monyer, H., Sprengel, R., Schoepfer, R., Herb, A., Higuchi, M., lomeli, H., Bunashev, N., Sakmann, B., Seeburg P. H. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. // Science 1992 — vol. 256 — No 22-pp. 1214−1221. .
- Nakanishi S. Molecular diversity of glutamate receptors and implication for brain function // Science 1992 — vol.258 — pp. 597−603.
- Naquet R., Meldrum B.S. Photogenic seizures in baboons. / In: Purpura et al.(Eds.) ExperimentalModels of Epilepsy. A manual for laboratory woker, Raven Press, New York, NY 1972 — pp.373−406.
- Olney J.W. Glutamate receptor hypofunction in schizophrenia? // Arch Gen Psychiatry 1995 Vol. 52 — pp.998−1007.
- Obenaus A, Esclapez M, Houser CR. Loss of glutamate decarboxylase mRNA-containing neurons in the rat dentate gyrus following pilocarpinc-induced seizures. // J Neurosci 1993 — Vol. 13 — 4470−4485.
- Onozuka M., Imai S. Induction of epileptic seizure activity by a specific protein from cobalt-induced epileptogenic cortex of rats. // Brain Research -1990 vol. 507 — pp. 143−145. ' '
- Onozuka, M., Imai S., Ozono S., Sugimura Y. A specific 70 kDa protein induced in the epileptogenic cortex of rats elicits bursting activity and inactivation of potassiym current in snail neurons. // Neuroscience Letters 1990 — Vol. 115 — pp. 49−54.
- Peeters B.W., Van Rijn C. M., Van Luijtelaar E.L., Coenen A.M. Genetics of abcance epilepsy in rats // Behav. Genet. 1990 — Vol. 20 — pp. 453−460.
- Pellegrini-Giampietro. D.E., Bennet M. V., Zukin R.S. Differential expression of three glutamate receptors genes in developing rat brain: an in situ hybridization study. // Proc.Natl.Acad.Sci. 1991 — USA 88 — 4157−4161.
- Plioplys, A. V., Greaves, A., Yoshida W. Anti-CNS antibodies in childhood neurologic disease. //Neuropediatrics 1989 — Vol. 20 — pp. 93−102.
- Popovici, T., Barbin, G., Ben-Ari, Y. Kainic acid induced seizures increase c-fos like protein in hippocampus. // Eur. J. Pharmacol. 1988 Vol. 150 — pp. 405−406.
- Popovici, T., Represa, A., Crepel, V., Barbin, G., Beudoin, M., Ben-Ari, Y. Effect of kainic acid-induced seizures and ischemia on c-fos-like protein in rat brain.//Brain Res.-1990-Vol. 536-pp. 183−194.
- Pumain R, Louvel J, Gastard M, Kurcewicz I, Vergnes M. Responses to N-methyl-D-aspartate are enhanced in rats with Petit Mal-like seizures. // J Neural Transm 1992 — 35th Suppl — pp. 97−108!
- Ribak CE, Hunt CA, Bakay RAE, Oertel WH. A decrease in the number of GABAergic somata is associated with the preferential loss of GABA-ergic terminals at epileptic foci. // Brain Res 1986 — vol. 136 — pp.78−90.
- Ribak CE, Joubrari C, Kesslak JP, Bakay RAE. A selective decrease in the number of GABAergic somata occurs in preseizing monkeys with alumina gel granuloma. // Epilepsy Res 1989 — No 4 — 129−138.
- Rogawski MA. Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiaz-epines. // Trends Pharmacot Sci 1993 — No 14-pp. 325−331.
- Rogers^ S.W., Andrews, P. IT, Gahring, I.C.- Whisenand, T., Cauley, K., Crain, B.,. Hugjes, T., Heinemann, S. F., McNamara J.O. Autoantibodies to glutamate receptor GluR3 in Rasmussen’s encephalitis. // Science Vol. 265 — No 29, pp. 648−651.
- Sato K., Kiyama H., Tohyama M. The differential expression patterns of messenger RNAs encoding non-NMDA glutamate receptors subunits (GluRl-4) in the rat brain. // J. Neurosci. 1993 — No 15 — pp. 2707−2719.
- Scatchard G. The attractions of proteins for smoll molecules and ions// Ann.NJ.Acad.Sci.-1949.-Vol.51-P.660−672.
- Schoepp, D. D., Conn P. J. Metabotropic glutamate receptors in brain function and patology.// TIPS- 1993 -Vol. 14-pp. 13−20.
- Serikawa T., Yamada J. Epileptic seizures in rats homozygous for two mutation, zitter and tremor // J. Hered. 1986 — Vol. 77 — pp. 441−444.
- Seyfried T.N., Glaser G.M. A review of mouse mutants as genetic models of epilepsy // Epilepsia -1985 Vol. 26 — pp. 143−150.
- Sherwin A., Robitaille Y., Quesney F. Exitatory amino acids are elevated in human epileptic cerebral cortex. // Neurology 1988 — Vol. 38 — pp. 920−923.
- Simmonds MA, Home AL. Antagonism of excitatory amino acids by* ' «barbiturates. In: Hicks TP, Lodge D. McLcnnan H, eds. Excitatory amino acid transmission. New York: Alan R. Liss. 1987 pp. 99−105.
- Sheng M., Cummings J., Rolau LA., Jan YN. Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. // Nature 1994 -Vol. 368 — 144−147. •' v '. ¦¦¦
- Shigemoto R., Kinoshita A., Wada E., Nomura S., Mizuno N., Differential presynaptic localization of metabolotropic glutamate receptor subtypes in the rat hippocampus // J. Neuroscience 1997 — No 17 — pp. 7503−7522.
- Sloviter RS. The functional organization of the hippocampal dentate gyms and its relevance to the pathogenesis of temporal lobe epilepsy. // Ann Neurol 1994 -Vol. 35-pp. 640−654.
- Smith SE, Meldrum BS. The glycine-site NMDA receptor antagonist, R-(+)-cis-3-melhyl-3-amino-1 -hydroxypyirrolid-2-one, L-687, 414 is anticonvulsant in baboons.// Eur J Pharmacol --.1992 Vol. 211 -109−111.
- Smith SE., Durmuller N, Meldrum BS. The non-N-methyl-D-aspartate antagonists. GYKI 52 466 and NBQX are anticonvulsant in two animal models of reflex epilepsy. // Eur J Pharmacol 1991 — Vol. 201 — pp. 179−183.
- Steinhauser, Ch., Gallo, V. News on glutamate receptors in glial cells. // TINS 1996 Vol. 19 — No 8 — pp. 339−345.r 131
- Svcinbjomsdottir S, Sander JWAS, Upton D, Thompson PJ, Patsalos PN, Hirt D, Ernre M, Lowe D. Duncan JS. The excitatory amino acid antagonist DCPP-enc (SDZ EAA-494) in patients with epilepsy. // Epilepsy Res 1993 — No 16 — pp. 165−174.
- Tourov A., Ferri R., Del Gracco S., Elia M, Musumeci S.A., Stefannini M. C. Spike morphologgy in PTZ-induced generalized and cobalt-induced partial experimental epilepsy.// Functional neurology -1996 Vol. XI — No 5 — pp. 237 245.
- Tremblay E., Roisin MP., Represa A., Charriaut-Marlangue, Ben-Ari Y. Transient increased density of NMDA binding sites in the developing rat hippocampus. // Brain Res 1988 — Vol. 461 — 393−396.
- Troupin AS, Mendius JR, Cheng F. Risinger MW. MK-801. In: Meldrum BS, Porter RJ, eds. / New anticonvutsanl drugs. Current problems in epilepsy. 1986 -Vol. 4. London: John Libbey — 191−201.
- Tsai C., Gastfriend D.R., Coyle J. T. The glutamatergic basis of human alcoholism. // Am. J. Psychiatry 1995 — Vol. 152 — No. 3 — pp. 332−340.
- Twyman, R. E., Gahring, L. C., Spiess, J., Rogers S. W. Glutamate receptor antibodies activate a subset of receptors and reveal an agonist binding site. // Neuron 1995 — Vol. 14 — pp. 755−762.
- Van Luijtelaar E. L, Coeneri A.M. The WAG/Rij model for generalized absence seizures In: J. Manelis et al. (Eds.) / Advances in Epileptology 1989 — Vol. 17 -Raven Press, New York, NY — pp.78−83.
- Voskuyl R.A., Dingemanse J., Danhov M. Determination of the treshold for convulsions by direct cortical stimulation // Epilepsy Res. 1989 -No 5 — pp. 120 129.
- Washburn M., Nurnberger M., Zhang S., Dingledine R. Diffepential dependence on GluR2 expression of three characteristi features of AMPA receptors. // J. Neurosci.- 1997, No 17-pp. 9393−9406.
- Wenthold R.T., Yokotani N., Doi K., Wada K. Immunochemichal characterization of non-NMDA glutamate receptor using subunit-specific antibodies evidence for hetero-oligomeric structure in rat brain // J. Biol. Chem. — 1995-Vol. 267-pp. 501−507.
- Wisden W, Seeburg PH. GABAA receptor channels: from subunits to functional entities. // Curr Opin Neurobiol 1992 — No 2 — 263−269.
- Wuarin J.P., Kim Y.I., Cepeda C. Synaptic transmission in human neocortex removed for treatment of intractable epilepsia in children. // Ann Neurol 1990 -Vol. 28 -pp. 503−510.
- Yamaguchi S, Donevan SD, Rogawski MA. Anticonvulsant activity of AMPA/kainate antagonists: Comparison of GYKI 52 466 and NBQX in maximal electroshock and chemoconvulsant seizure models. // Epilepsy Res 1993 — No 15: — pp.79−84.
- Zafra, F., Hengerer, B., Leibrock, J., Thoenen, H., Lindholm, D. Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non NMDA glutamate receptors. // EMBO J. 1990 — No.9 — pp. 3545−555.